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| 1 | Effects of ammonia exposure on carcass traits and fatty acid composition of broiler meat显示文摘We aimed to study the effects of ammonia on carcass traits, organ indices and fatty acid composition of broilers. Four hundred 21-d-old male Arbor Acres broilers with initial weight 563.52 ± 2.82 g were randomly allotted to 1 of 4 groups treated with ammonia at <3 mg/kg(control),25 ± 3. 50 ± 3, and75 ± 3 mg/kg concentrations. Each group consisted of 4 replicates of 25 birds. Broilers from 21 to 42 d were reared on the net floor in the respiration-metabolism chambers where similar environmental conditions were maintained. At 32 and 42 d of age, carcass traits and organ indices were determined for4 birds per pen. At 42 d of age, fatty acid composition in the breast and thigh muscle of broilers was measured. Results showed as follows: 1) At 32 d, the dressing percentage of broilers exposed to 25 and75 mg/kg ammonia were lower than those in the control group(P < 0.05); eviscerated yield percentage of broilers in the 25 mg/kg ammonia group was also lower(P < 0.05). At 42 d, the dressing percentage of broilers in the ammonia treatments and the thigh muscle percentage of broilers in the 50 and 75 mg/kg ammonia groups were lower(P < 0.05) than those in the control. Breast muscle percentage of broilers exposed to 25 and 50 mg/kg ammonia and eviscerated yield percentage exposed to 50 mg/kg ammonia were lower than those in the control(P < 0.05). 2) The kidney index of broilers(d 32) exposed to ammonia was greater(P < 0.05) than that of the control. At 42 d, hepatic index of broilers exposed to ammonia was increased(P < 0.05), and spleen index was decreased(P < 0.05). 3) At 42 d, stearic(C18:0)and saturated fatty acids(SFA) in the thigh muscle of broilers were higher, while the unsaturated fatty acid:saturated fatty acid(U:F) ratio and unsaturated fatty acid(UFA) were lower in the 50 mg/kg ammonia treatment than in the control group(P < 0.05). In conclusion, ammonia over 25 mg/kg could decline carcass traits and immune organ indices and increase the kidney and hepatic indices. Further,exposure to 50 mg/kg ammonia could also decrease breast and thigh muscle yield percentage while increasing SFA content and decreasing UFA content in the thigh muscle of broilers. | Huan Xing Sujun Luan Yongbo Sun Renna Sa Hongfu Zhang | 2016 | Animal Nutrition2016，，4： | 8 |
| 2 | Optimization on conventional and electric air-cycle refrigeration systems of aircraft: A short-cut method and analysis显示文摘The air-cycle refrigeration system is widely used in commercial and military aircraft,and its efficiency greatly affects aircraft performance.Nowadays,this system requires a more efficient design and optimization method.In this paper,a short-cut optimization method with high efficiency and effectiveness is introduced for both conventional and electric air-cycle refrigeration systems.Based on the system characteristics,a four-layer parameter matching algorithm is designed which avoids computational difficulty caused by simultaneous equations.Fuel penalty is chosen as the objective function of optimization;design variables are reduced based on sensitivity analysis to improve optimization efficiency.The results show that the 3-variable optimization of the conventional air-cycle refrigeration system can obtain almost the same results as the traditional 6-variable optimization in that these two optimizations can both significantly reduce the fuel penalty.However,the computer running time of the 3-variable optimization is much shorter than that of the 6-variable optimization.The optimal fuel penalty of the electric air-cycle refrigeration system is lower than that of the conventional one.This study can provide reference for optimizing the aircycle refrigeration system of aircraft. | Hongsheng JIANG Sujun DONG Hainan ZHANG Fengming AI Zhiwei ZHANG Jun WANG | 2020 | Chinese Journal of Aeronautics2020，33，7： | 6 |
| 3 | Retardant effect of dihydroartemisinin on ulcerative colitis in a JAK2/STAT3-dependent manner显示文摘Dihydroartemisinin(DHA)is a semi-synthetic derivative and the main active metabolite of artemisinin.The purpose of this study was to investigate the effect of DHA on the ulcerative colitis(UC)in both in vivo and in vitro models.Weight,survival rate,colon length,and Disease Activity Index score were used to evaluate the severity of colitis.Reverse transcription quantitative polymerase chain reaction and enzyme-linked immunosorbent assay were used to detect the expressions of cytokines interleukin(IL)-1,IL-1β,IL-4,IL-6,IL-10,IL-12,and tumor necrosis factor-α(TNF-α).The expressions of Janus kinase 2(JAK2)and signal transducer and activator of transcription 3(STAT3),and the phosphorylation of JAK2(p-JAK2)and STAT3(p-STAT3),were measured by western blot analysis.Western blot analysis and immunohistochemistry were used to detect the expressions of tight junction proteins.We found that the weights and colon lengths of mice in dextran sodium sulfate(DSS)+DHA group were significantly lower and longer than those in the DSS group,respectively.Compared with those in the DSS group,the expressions of IL-1β,IL-6,IL-17,and TNF-αin the DSS+DHA and DSS+5-aminosalicylic acid(5-ASA)groups were decreased,while the expressions of IL-4 and IL-10 were significantly upregulated.DHA largely increased the expressions of zonula occludens-1 and occludin.Western blot analysis and/or immunohistochemical staining analysis showed that the expressions of JAK2,STAT3,p-JAK2,and p-STAT3 in DSS+DHA and DSS+5-ASA groups were significantly lower than those in DSS group.DHA has a specific therapeutic effect on UC.The anti-inflammatory mechanism of DHA is related to the blockage of the JAK2/STAT3 signaling pathway.These findings provide evidence that DHA may be a useful drug and is expected to become a promising new treatment for human UC. | Mingrui Jiang Guangjun Zhong Yichao Zhu Liuhua Wang Yuzhe He Qiannan Sun Xiaoqing Wu Xiaolan You Sujun Gao Dong Tang Daorong Wang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，9： | 6 |
| 4 | SEMA3A-mediated crosstalk between prostate cancer cells and tumor-associated macrophages promotes androgen deprivation therapy resistance显示文摘Androgen deprivation therapy(ADT)is an important treatment strategy that can be used to delay the progression of prostate cancer.However,after an initial response,which varies significantly among patients,the disease eventually progresses despite the low levels of testosterone in the systemic circulation.1 The mechanism underlying the progression of prostate cancer to castration-resistant prostate cancer(CRPC)is not yet clear,and further investigation is needed. | Fei Liu Chao Wang Hai Huang Yue Yang Lihe Dai Sujun Han Nianzeng Xing Shancheng Ren | 2021 | Cellular & Molecular Immunology2021，18，3： | 5 |
| 5 | Global features and trends of the tropopause derived from GPS/CHAMP RO data显示文摘The global characteristics and trends of the tropopause physical parameters,height and temperature,obtained from the GPS/CHAMP radio occultation(RO) data in the period from Jul.2001 to Oct.2008,were modeled and analyzed in this work.The global distribution and variation of these parameters with latitude were estimated and analyzed using the Empirical Orthogonal Function(EOF),which was introduced to reveal the possible relationship between the tropopause variations and global climate change.The tropopause height and temperature varied with latitude.The results obtained by using the Empirical Orthogonal Function analysis suggested a recent rise in tropopause height and decrease in tropopause temperature;and also partly supported the argument that the global rise in the tropopause is consistent with global climate change.These results also revealed that the tropopause height increased mainly in the Polar regions,particularly in the South Polar region,as well as the regions where human activity is relatively significant,and decreased in the areas that are sparsely populated or have less human activity,such as the tropic region and south hemisphere.This paper also confirms that the GPS/LEO RO data are more reliable and can be effectively used to analyze the tropopause physical parameters. | HAN TingTing PING JinSong ZHANG SuJun | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，2： | 4 |
| 6 | Effect of alloying elements on microstructure, mechanical and damping properties of Cr-Mn-Fe-V-Cu high-entropy alloys显示文摘A series of new Cr-Mn-Fe-V-Cu high-entropy alloys were prepared by arc melting and suction casting.It is found that with the addition of Cu, the structure of the alloys evolved from BCC + BCC1 phases to BCC + FCC phases. With increase of Cu, the volume fraction of the Cu-Mn-rich FCC phase increased, and the morphology of the FCC phase transformed from granular particles to long strips and blocks. Compared with other reported HEAs, the Cr-Mn-Fe-V-Cu HEAs exhibit a good balance between strength and ductility. The CrMn0.3 FeVCu0.06 alloy with granular FCC particles exhibits the highest compressive yield strength(1273 MPa) and excellent ductility(ε_f= 50.7%). Quantitative calculations for different strengthening mechanisms demonstrate that dislocation and precipitate strengthening are responsible for high strength of the CrMn0.3 FeVCu0.06 alloy, while the solid solution strengthening effect is very low because of its small atomic-size difference. In addition, the CrMn0.3 FeVCu0.06 alloy exhibits good damping capacity due to its high dislocation and interface damping effects. Therefore, the dislocation density and distribution of FCC phase are the crucial factors for improvement of both mechanical properties and damping capacity of the HEAs. | Ruokang Song Fan Ye Chenxi Yang Sujun Wu | 2018 | Journal of Materials Science & Technology2018，34，11： | 4 |
| 7 | Highly efficient pure white polymer light-emitting devices based on poly(N-vinylcarbazole) doped with blue and red phosphorescent dyes显示文摘Efficient white-polymer-light-emitting devices (WPLEDs) have been fabricated with a single emitting layer containing a hole-transporting host polymer,poly(N-vinylcarbzole),and an electron-transporting auxiliary,1,3-bis[(4-tert-butylphenyl)-1,3,4-oxadiazolyl]-phenylene,codoped with two phosphorescent dyes:Iridium(III)bis (2-(4,6-difluorophenyl)-pyridinato-N,C2') picolinate (FIrpic) and home-made Ir-G2 for blue and red emission,respectively.With the structure of ITO/PEDOT:PSS 4083(40 nm)/emission layer(80 nm)/Ba(4 nm)/Al(120 nm),the device showed a maximal luminous efficiency (LE) of 13.5 cd A-1(corresponding to an external quantum efficiency (EQE) of 6.8%),and a peak power efficiency (PE) of 6.5 lm W-1 at 6.0 V.Meanwhile,the device exhibited pure white emission with Commission Internationale de l'Eclairage (CIE) coordinates of (0.34,0.35) at a current density of 12 mA cm-2,which is very close to the equi-energy white point with CIE coordinates of (0.33,0.33).The device performance can be further optimized when more balanced hole/electron injection is achieved by incorporating a lower conducting type anode buffer layer (PEDOT:PSS) and incorporating poly[(9,9-bis(3'-(N,N-dimethylamino)propyl)-2,7-fluorenene)-alt-2,7-(9,9-dioctyfluorene)] (PFN) as an electron injection layer at the cathode.The optimized device showed an LE of 24.6 cd A-1 (with an EQE of 14.1%),while the peak power efficiency reached 12.66 lm W-1.Moreover,the WPLEDs showed good electroluminescence (EL) stability over a wide range of operating current density and luminance. | HU SuJun ZOU JianHua ZHOU GuiJiang LI DongYun WU HongBin SU ShiJian WONG Wai-Yeung YANG Wei PENG JunBiao CAO Yong | 2011 | Science China Chemistry2011，54，4： | 4 |
| 8 | STRUCTURE DESIGN OF THE BEIJING SPECTROMETERⅢBEAM PIPE显示文摘The Beijing spectrometerⅢ(BESⅢ)beam pipe is in the center of the BESⅢ,which is the detector of the upgrade project of Beijing electron and positron collider(BEPCⅡ).Electrons and positrons collide in the BESⅢbeam pipe.According to the demands of the BEPCⅡ,a key program of Chinese Academy of Sciences,the BESⅢbeam pipe is designed based on the finite elements analysis.The BESⅢbeam pipe is installed in the inner cylinder of the BESⅢdrift chamber.As a vacuum tube,the BESⅢbeam pipe is designed as 1000 mm in length,63 mm in inner diameter and 114 mm in outer diameter,respectively.The BESⅢbeam pipe consists of a central beryllium pipe cooled by EDM-1,the oil No.1 for electric discharge machining,and two extended copper pipes cooled by deionized water(DW).The three parts are jointed by vacuum welding.Factors taken into account in the design are as follows.①The wall thickness of the central beryllium pipe should be designed as small as possible to reduce the multi-scattering and improve the particle momentum resolution.And the wall thickness of the extended copper pipe should be designed as large as possible to protect the detectors from the backgrounds.②The BESⅢbeam pipe must be sufficiently cooled to avoid the damage and prevents its influence to the BESⅢdrift chamber(DC)operation.The inner surface temperature of the DC inner cylinder must be maintained at 293±2 K.③The magnetic permeability of the materials used in the BESⅢbeam pipe must be less than 1.05 H/m to avoid large magnetic field distortions.④The static pressure of the vacuum chamber of the BESⅢbeam pipe must be less than 800μPa.The simulating results show that the designed structure oftbe BESⅢbeam pipe satisfies the requirements mentioned above.The structure design scheme is evaluated and adopted by the headquarters of BEPCⅡ. | ZHENG Lifang JI Quan WANG Li LI xunfeng XU Shaowang DONG Sujun ZHAO Libin LIU Jianping | 2008 | Chinese Journal of Mechanical Engineering2008，21，3： | 3 |
| 9 | Haploidentical hematopoietic cell transplantation for severe acquired aplastic anemia: a case-control study of post-transplant cyclophosphamide included regimen vs. anti-thymocyte globulin & colony-stimulating factor-based regimen显示文摘Dear Editor,Haploidentical allogeneic hematopoietic stem cell transplantation(haplo-HSCT),a curative therapy for severe aplastic anemia(SAA)patients,has been used clinically for decades.Two models,not involving ex vitro T-cell depletion,have been adopted for haplo-HSCT in patients with SAA.The first is referred to as the'Beijing protocol'(Xu et al.,2017),and comprises a conditioning regimen using busulfex(BU),cyclophosphamide(CY). | Lanping Xu Bin Fu Wenjing Wang Yajing Xu Depei Wu Shunqing Wang Qifa Liu Linghui Xia Sujun Gao Ming Jiang Jianmin Wang Xi Zhang Hai Bai Huiren Chen Chunfu Li Xiaojun Huang | 2020 | Science China(Life Sciences)2020，63，6： | 3 |
| 10 | Forkhead domain mutations in FOXA1 drive prostate cancer progression显示文摘Dear Editor,F0XA1 (Forkhead Box Protein A1)is a pioneer transcription factor (TF) that functions to loosen the compact chromatin structure to facilitate binding of other TFs such as estrogen receptor and androgen receptor (AR).1,2 AR is a nuclear receptor functioning as a ligand-dependent TF that plays a pivotal role in driving the initiation of prostate cancer (Pca) and the development of castration-resistant Pca (CRPC). | Shuai Gao Sujun Chen Dong Han David Barrett Wanting Han Musaddeque Ahmed Susan Patalano Jill A. Macoska Housheng Hansen He Changmeng Cai | 2019 | Cell Research2019，29，9： | 3 |
| 11 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
| 12 | Electroluminescence performances of 1,1-bis(4-(N,N-dimethylamino)phenyl)-2,3,4,5-tetraphenylsilole based polymers in three cathode architectures显示文摘A new silole monomer with two 4-(N,N-dimethylamino)phenyl substitutions on silicon atom as designed and synthesized.Three copolymers PF-N-HPS1,PF-N-HPS10 and PF-N-HPS20 were then obtained by copolymerizations of 2,7-fluorene derivatives with the silole monomer at feed ratios of 1%,10%,and 20%.Their UV-vis absorption,electrochemical,photoluminescent,and electroluminescent (EL) properties were investigated.PF-N-HPS possessed HOMO levels of 5.25-5.58 eV,and showed green emissions.Using PF-N-HPS as the emissive layer,three different polymer light-emitting diodes were fabricated as device A with ITO/PEDOT/PF-N-HPS/Al,device B with ITO/PEDOT/PF-N-HPS/Ba/Al,and device C with ITO/PEDOT/PF-N-HPS/TPBI/Ba/Al.For the device A,PF-N-HPS only showed very low EL efficiency of 0.06-0.33 cd/A,indicating that the Al cathode could not inject electron efficiently to the emissive polymers containing the 4-(N,N-dimethylamino)phenyl groups.For the device B,low work function Ba supplied better electron injections,and the EL efficiency could be improved to 0.85-1.44 cd/A.TPBI with a deep HOMO level of 6.2 eV could enhance electron transport and hole blocking.Thus modified recombinations and largely elevated EL efficiency of 4.56-7.96 cd/A were achieved for the device C.The separation of the emissive layer and metal cathode with the TPBI layer may also suppress exciton quenching at the cathode interface. | LIU ZhiTian HU SuJun ZHANG LinHua CHEN JunWu PENG JunBiao CAO Yong | 2013 | Science China Chemistry2013，56，8： | 2 |
| 13 | JIVET Research on Texel Sheep显示文摘The present study was conducted to explore ways of JIVET research on Texel sheep,and to provide technical support for the improvement of the JIVET technology system for research on Texel sheep.Superovulation was conducted on 4-8-week old Texel sheep,and in-vivo ovum collection,in-vitro oocyte maturation and fertilization,and fertilized-embryo culture and transplantation were adopted to perform JIVET research on Texel sheep.The results showed that 296 available oocytes were obtained at an average of 74 oocytes per sheep;205 fertilized eggs were obtained at the 2-4 cell stage at an average of 51.25 eggs per sheep and a cleavage rate of 69.26%;and 66 of the fertilized eggs were transplanted to 11 receptor sheep.Six sheep were conceived at a conception rate of 54.55%,and 11 lambs were born.These results indicated that the present test could be used as a method for the study of JIVET technique on Texel sheep. | Yangyi MAO Huidi LUO Xi LI Peng ZHAO Jun LI Sujun WU Hongyu GUO | 2020 | Agricultural Biotechnology2020，9，5： | 2 |
| 14 | A digital open-loop Doppler processing prototype for deep-space navigation显示文摘A prototype based on digital radio technology with associated open-loop Doppler signal processing techniques has been developed to measure a spacecraft's line-of-sight velocity. The prototype was tested in China's Chang'E-1 lunar mission relying on S-band telemetry signals transmitted by the sat-ellite,with results showing that the residuals had a RMS value of ~3 mm/s (1σ ) using 1-sec integration,which is consistent with the Chinese conventional USB (Unified S-Band) tracking system. Such preci-sion is mainly limited by the short-term stability of the atomic (e.g. rubidium) clock at the uplink ground station. It can also be improved with proper calibration to remove some effects of the transmission media (such as solar plasma,troposphere and ionosphere),and a longer integration time (e.g. down to 0.56 mm/s at 34 seconds) allowed by the spacecraft dynamics. The tracking accuracy can also be in-creased with differential methods that may effectively remove most of the long-term drifts and some of the short-term uncertainties of the uplink atomic clock,thereby further reducing the residuals to the 1 mm/s level. Our experimental tracking data have been used in orbit determination for Chang'E-1,while other applications (such as the upcoming YH-1 Mars orbiter) based on open-loop Doppler tracking will be initiated in the future. Successful application of the prototype to the Chang'E-1 mission in 2008 is believed to have great significance for China's future deep space exploration. | JIAN NianChuan SHANG Kun ZHANG SuJun WANG MingYuan SHI Xian PING JingSong YAN JianGuo TANG GeShi LIU JunZe QIU Shi FUNG Lai-Wo ZHANG Hua WANG Zhen GOU Wei | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，12： | 2 |
| 15 | Characteristics and performance of 10kW class all-vanadium redox-flow battery stack显示文摘 | Ping Zhao Huamin Zhang Hantao Zhou Jian Chen Sujun Gao Baolian Yi | 2006 | Journal of Power Sources2006，，2： | 2 |
| 16 | Review on the Application of Bamboo-Based Materials in Construction Engineering显示文摘Due to the continuously increasing demand for building materials across the world,it is necessary to use renewable materials in place of the existing nonrenewable materials in construction projects.Bamboo is a fast-growing flowering plant that may be used as a renewable material in construction.The use of bamboo in the construction of buildings can improve its long-term carbon fixation capacity and economic benefits.Although bamboo has the advantages of superior performance,low carbon content,high energy-saving and emission-reducing capacity,bamboo is an anisotropic material,which has many factors affecting its material performance,large variability of material performance,lack of systematic research,and the use of bamboo as the main building material is not always limited.This paper systematically summarizes the research status of bamboo as a building material from the aspects of bamboo composition,gradation,material properties,bamboo building components,connection nodes,and use of artificial boards.On this basis,some constructive suggestions are put forward for the further study of bamboo in the field of architecture. | Biqing Shu Zhongping Xiao Lu Hong Sujun Zhang Chen Li Naiqiang Fu Xiaoning Lu | 2020 | Journal of Renewable Materials2020，8，10： | 2 |
| 17 | Quantitative analysis of secretome from adipocytes regulated by insulin显示文摘Adipocyte 是经由肽和蛋白质的分泌物在另外的机关涉及精力的存储和版本,而且在精力新陈代谢的规定的不仅一个中央播放器。在胰岛素抵抗和类型的致病期间 2 糖尿病, adipocytes 受到胰岛素的增加的层次,它可以在 adipokines 的分泌物上有主要影响。我们承担了劈得开的编码同位素的亲密关系标签(cICAT ) ,没有标签的 quantitation 来临鉴别是差别的能分泌的因素由 3T3-L1 adipocytes 藏匿了与或没有胰岛素处理并且确定。cICAT 和没有标签的结果的联合,有 317 蛋白质,预言或注解同样能分泌的蛋白质。在这些能分泌的蛋白质之中, 179 蛋白质和 53 蛋白质分别地显著地起来调整、下面调整。77 的一个总数报导 adipokines 在我们的学习被确定,例如 adiponectin,组织蛋白酶 D, cystatin C, resistin,和 transferrin。这些 adipokines 的西方的污点分析从集体 spectrometry 证实了量的结果,并且由增加胰岛素剂量揭示了这些蛋白质的个性化的 secreting 模式。另外, 240 蛋白质是在我们的学习,其大多数在胰岛素处理之上起来调整从 3T3-L1 adipocytes 分泌了蛋白质最新被识别并且确定。进一步全面的生物信息学分析表明在细胞外的矩阵受体相互作用小径和 glycan 结构降级小径的能分泌的蛋白质由胰岛素刺激是显著地起来调整的。 | Hu Zhou Yuanyuan Xiao Rongxia Li Shangyu Hong Sujun Li Lianshui Wang Rong Zeng Kan Liao | 2009 | Acta Biochimica et Biophysica Sinica2009，41，11： | 2 |
| 18 | IL-33 drives the antitumor effects of dendritic cells via the induction of Tc9 cells显示文摘Dendritic cell(DC)tumor vaccines exert their antitumor effects through the induction of effector T cells.We recently identified Tc9 cells as a new potent antitumor effector T cell subset.However,approaches to direct DCs to preferably prime antitumor Tc9 cells should be further exploited.Here,we demonstrate that the addition of interleukin(IL)-33 potently promotes the induction of Tc9 cells by DCs in vitro and in vivo.IL-33 treatment also drives the cytotoxic activities of DC-induced Tc9 cells.Notably,IL-33 treatment enhances cell survival and proliferation of DC-primed CD8+T cells.More importantly,the addition of IL-33 during in vitro priming of tumor-specific Tc9 cells by DCs increases the antitumor capability of Tc9 cells.Mechanistic studies demonstrated that IL-33 treatment inhibits exhaustive CD8+T cell differentiation by inhibiting PD-1 and 2B4 expression and increasing IL-2 and CD127(IL-7 receptor-α,IL-7Rα)expression in CD8+T cells.Finally,the addition of IL-33 further promotes the therapeutic efficacy of DC-based tumor vaccines in the OT-I mouse model.Our study demonstrates the important role of IL-33 in DC-induced Tc9 cell differentiation and antitumor immunity and may have important clinical implications. | Ning Liu Yuxue Jiang Jintong Chen He Nan Yinghua Zhao Xiao Chu Alison Wang Dongjiao Wang Tianxue Qin Sujun Gao Ying Yue Siqing Wang | 2019 | Cellular & Molecular Immunology2019，16，7： | 2 |
| 19 | Implementation of the Earth-based planetary radio occultation inversion technique显示文摘The planetary radio occultation technique is one of the earliest suggested and achieved methods to detect the planetary atmosphere,and has been conducted by almost every deep space planetary probe.The principles,modules,inversion results and primary analysis of the SHAO Planetary Occultation observation Processing system(SPOPs) are presented in this paper.Utilizing open-loop and closed-loop Doppler residual data of the Mars Express radio occultation experiment provided by ESA PSA and NASA PDS,the temperature,pressure,molecular number density profiles of Martian atmosphere and electron density profiles of the ionosphere are successfully retrieved,and the results are validated by the released radio science level 04 products of the ESA MaRS group.This system can also process the atmosphere radio occultation observations of other planets and theirs natural satellites.The implementation of the planetary radio occultation technique is of significance to China's YH-1 Mars exploration project,as well as for future planetary exploration missions from China. | ZHANG SuJun PING JinSong HAN TingTing MAO XiaoFei HONG ZhenJie | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，7： | 2 |
| 20 | Characteristics and performance of 10 k W class all-vanadium redox-flow battery stack显示文摘 | Zhao Ping Zhang Huamin Zhou Hantao Chen Jian Gao Sujun Yi Baolian | 2006 | Journal of Power Sources2006，162，2： | 1 |
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