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| 1 | Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors显示文摘Multipotent 神经干细胞为房间治疗保持大诺言。到导致的 pluripotent 干细胞以及成熟神经原的成纤维细胞的 reprogramming 建议可能性没有首先建立 pluripotency,把一个严重地区分的体的房间变换成一个 multipotent 状态。这里,我们证明房间从中层导出的那 Sertoli 能直接被变换成拥有神经干细胞性质的一个 multipotent 状态。导致的神经干细胞(iNSCs ) 表示多重 NSC 特定的标记,展出类似于正常 NSC 的全球基因表示侧面,并且能够自强并且区分功能的神经原进神经胶质并且 electrophysiologically。为酷氨酸 hydroxylase (TH ) 积极的导出 iNSC 的神经原污点, γ -aminobutyric 酸,和胆碱 acetyltransferase。另外, iNSCs 能熬过并且产生跟随移植进有牙齿的回转的触处。iNSCs 的产生可以为疾病建模和再生药有重要含意。 | Chao Sheng Qinyuan Zheng Jianyu Wu Zhen Xu Libin Wang Wei Li Haijiang Zhang Xiao-Yang Zhao Lei Liu Ziwei Wang Changlong Guo Hua-Jun Wu Zhonghua Liu Liu Wang Shigang He Xiu-Jie Wang Zhiguo Chen Qi Zhou | 2012 | Cell Research2012，22，1： | 31 |
| 2 | Transplantation of neurotrophin-3-transfected bone marrow mesenchymal stem cells for the repair of spinal cord injury显示文摘Bone marrow mesenchymal stem cell transplantation has been shown to be therapeutic in the repair of spinal cord injury. However, the low survival rate of transplanted bone marrow mesenchymal stem cells in vivo remains a problem. Neurotrophin-3 promotes motor neuron survival and it is hypothesized that its transfection can enhance the therapeutic effect. We show that in vitro transfection of neurotrophin-3 gene increases the number of bone marrow mesenchymal stem cells in the region of spinal cord injury. These results indicate that neurotrophin-3 can promote the survival of bone marrow mesenchymal stem cells transplanted into the region of spinal cord injury and potentially enhance the therapeutic effect in the repair of spinal cord injury. | Yuzhen Dong Libin Yang Lin Yang Hongxing Zhao Chao Zhang Dapeng Wu | 2014 | Neural Regeneration Research2014，9，16： | 16 |
| 3 | Generation of dopaminergic neurons directly from mouse fibroblasts and fibroblast-derived neural progenitors显示文摘 | Chao Sheng Qinyuan Zheng Jianyu Wu Zhen Xu Lisi Sang Libin Wang Changlong Guo Wanwan Zhu Man Tong Lei Liu Wei Li Zhong-Hua Liu Xiao-Yang Zhao Liu Wang Zhiguo Chen Qi Zhou | 2012 | Cell Research2012，22，4： | 12 |
| 4 | Treatment of multiple sclerosis by transplantation of neural stem cells derived from induced pluripotent stem cells显示文摘Multiple sclerosis(MS) is an autoimmune disease of the central nervous system(CNS), with focal T lymphocytic infiltration and damage of myelin and axons. The underlying mechanism of pathogenesis remains unclear and there are currently no effective treatments. The development of neural stem cell(NSC) transplantation provides a promising strategy to treat neurodegenerative disease. However, the limited availability of NSCs prevents their application in neural disease therapy. In this study, we generated NSCs from induced pluripotent stem cells(iPSCs) and transplanted these cells into mice with experimental autoimmune encephalomyelitis(EAE), a model of MS. The results showed that transplantation of iPSC-derived NSCs dramatically reduced T cell infiltration and ameliorated white matter damage in the treated EAE mice. Correspondingly, the disease symptom score was greatly decreased, and motor ability was dramatically rescued in the iPSC-NSC-treated EAE mice, indicating the effectiveness of using iPSC-NSCs to treat MS. Our study provides pre-clinical evidence to support the feasibility of treating MS by transplantation of iPSC-derived NSCs. | Chao Zhang Jiani Cao Xiaoyan Li Haoyu Xu Weixu Wang Libin Wang Xiaoyang Zhao Wei Li Jianwei Jiao Baoyang Hu Qi Zhou Tongbiao Zhao | 2016 | Science China(Life Sciences)2016，59，9： | 9 |
| 5 | Nanoparticles carrying neurotrophin-3-modified Schwann cells promote repair of sciatic nerve defects显示文摘Schwann cells and neurotrophin-3 play an important role in neural regeneration,but the secretion of neurotrophin-3 from Schwann cells is limited,and exogenous neurotrophin-3 is inactived easily in vivo.In this study,we have transfected neurotrophin-3 into Schwann cells cultured in vitro using nanoparticle liposomes.Results showed that neurotrophin-3 was successfully transfected into Schwann cells,where it was expressed effectively and steadily.A composite of Schwann cells transfected with neurotrophin-3 and poly(lactic-co-glycolic acid) biodegradable conduits was transplanted into rats to repair 10-mm sciatic nerve defects.Transplantation of the composite scaffold could restore the myoelectricity and wave amplitude of the sciatic nerve by electrophysiological examination,promote nerve axonal and myelin regeneration,and delay apoptosis of spinal motor neurons.Experimental findings indicate that neurotrophin-3 transfected Schwann cells combined with bridge grafting can promote neural regeneration and functional recovery after nerve injury. | Haibin Zong Hongxing Zhao Yilei Zhao Jingling Jia Libin Yang Chao Ma Yang Zhang Yuzhen Dong | 2013 | Neural Regeneration Research2013，8，14： | 7 |
| 6 | An enhanced hybrid and adaptive meta-model based global optimization algorithm for engineering optimization problems显示文摘由于在高效率和精确性之间的好平衡,元模型基于优化算法是一个重要全球优化范畴并且广泛地被使用了。更好解决高度非线性并且集中的工程优化问题,一个提高的混血儿和适应元模型基于的计算全球优化(电子火腿) 首先在这个工作被建议。重要区域更改方法(IRU ) 和不同采样尺寸策略在优化方法被建议提高表演。由使用自动、可伸缩的策略,重要区域将根据搜索结果适应地被更新改进产生精确和集中率。不平的采样策略和集中的采样策略在优化的不同阶段被使用高效地改进搜索并且避免过早地在一个小设计空格聚在一起的结果。新优化算法的有效性被与不同变量凳子标记优化问题作比较到六个优化方法验证。电子火腿优化方法然后被使用优化实际否定泊松比率(NPR ) 的设计参数在这个工作的碰撞盒子。结果显示建议电子火腿在优化计算有高精确性和效率集中的问题和罐头广泛地在设计工业被使用。 | ZHOU Guan DUAN LiBin ZHAO WanZhong WANG ChunYan MA ZhengDong GU JiChao | 2016 | Science China(Technological Sciences)2016，59，8： | 4 |
| 7 | TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2显示文摘Tripartite motif(TRIM)family proteins are important effectors of innate immunity against viral infections.Here we identified TRIM35 as a regulator of TRAF3 activation.Deficiency in or inhibition of TRIM35 suppressed the production of type I interferon(IFN)in response to viral infection.777m35-deficient mice were more susceptible to influenza A virus(IAV)infection than were wild-type mice.TRIM35 promoted the RIG-Imediated signaling by catalyzing Lys63-linked polyubiquitination of TRAF3 and the subsequent formation of a signaling complex with VISA and TBK1.IAV PB2 polymerase countered the innate antiviral immune response by impeding the Lys63-linked polyubiquitination and activation of TRAF3.TRIM35 mediated Lys48-linked polyubiquitination and proteasomal degradation of IAV PB2,thereby antagonizing its suppression of TRAF3 activation.Our in vitro and in vivo findings thus reveal novel roles of TRIM35,through catalyzing Lys63-or Lys48-linked polyubiquitination,in RIG-I antiviral immunity and mechanism of defense against IAV infection. | Nan Sun Li Jiang Miaomiao Ye Yihan Wang Guangwen Wang Xiaopeng Wan Yuhui Zhao Xia Wen Libin Liang Shujie Ma Liling Liu Zhigao Bu Hualan Chen Chengjun Li | 2020 | Protein & Cell2020，11，12： | 4 |
| 8 | Automorphism group of Green ring of Sweedler Hopf algebra显示文摘让 H 2 是 Sweedlers 4-dimensional Hopf 代数学和 r (H 2) 是 H 2 的相应格林戒指。在这份报纸,我们调查格林戒指 r 的自守组(H 2) 和格林代数学 F (H 2)= r (H 2) F 在 F 是一块地的地方,其特征不等于 2。我们证明自守 r 组织( H 2)对 K 4是克莱因组,和 F 的自守组的 K 4,同形( H 2)是2和 G 的 semidirect 产品,吗在哪儿 G = F { 1/2 }与敢甠?潴?给的增加?慥獲? | Tingting JIA Ruju ZHAO Libin LI | 2016 | Frontiers of Mathematics in China2016，11，4： | 3 |
| 9 | STRUCTURE DESIGN OF THE BEIJING SPECTROMETERⅢBEAM PIPE显示文摘The Beijing spectrometerⅢ(BESⅢ)beam pipe is in the center of the BESⅢ,which is the detector of the upgrade project of Beijing electron and positron collider(BEPCⅡ).Electrons and positrons collide in the BESⅢbeam pipe.According to the demands of the BEPCⅡ,a key program of Chinese Academy of Sciences,the BESⅢbeam pipe is designed based on the finite elements analysis.The BESⅢbeam pipe is installed in the inner cylinder of the BESⅢdrift chamber.As a vacuum tube,the BESⅢbeam pipe is designed as 1000 mm in length,63 mm in inner diameter and 114 mm in outer diameter,respectively.The BESⅢbeam pipe consists of a central beryllium pipe cooled by EDM-1,the oil No.1 for electric discharge machining,and two extended copper pipes cooled by deionized water(DW).The three parts are jointed by vacuum welding.Factors taken into account in the design are as follows.①The wall thickness of the central beryllium pipe should be designed as small as possible to reduce the multi-scattering and improve the particle momentum resolution.And the wall thickness of the extended copper pipe should be designed as large as possible to protect the detectors from the backgrounds.②The BESⅢbeam pipe must be sufficiently cooled to avoid the damage and prevents its influence to the BESⅢdrift chamber(DC)operation.The inner surface temperature of the DC inner cylinder must be maintained at 293±2 K.③The magnetic permeability of the materials used in the BESⅢbeam pipe must be less than 1.05 H/m to avoid large magnetic field distortions.④The static pressure of the vacuum chamber of the BESⅢbeam pipe must be less than 800μPa.The simulating results show that the designed structure oftbe BESⅢbeam pipe satisfies the requirements mentioned above.The structure design scheme is evaluated and adopted by the headquarters of BEPCⅡ. | ZHENG Lifang JI Quan WANG Li LI xunfeng XU Shaowang DONG Sujun ZHAO Libin LIU Jianping | 2008 | Chinese Journal of Mechanical Engineering2008，21，3： | 3 |
| 10 | Parameter studies and evaluation principles of delamination damage in laminated composites显示文摘Delamination represents one of the most severe failure modes in composite laminates,especially when they are subjected to uniaxial compression loads.The evaluation of the delamination damage has always been an essential issue of composite laminates for durability and damage tolerance in engineering practice.Focusing on the most typical and representative elliptical delamination issue,an analytical model simultaneously considering the conservative buckling process and non-conservative delamination propagation process is implemented.Various computational cases considering different delamination depths,directions,aspect ratios,and areas are established,and the predicted results based on the analytical model are carefully compared.Effects of these geometrical delamination parameters on the buckling,delamination propagation,and failure behaviors of composite laminates are thoroughly analyzed,and innovative evaluation principles of the delamination damage have been concluded.It is found that the delamination area is the key factor that truly affecting the failure behaviors of delaminated composites,and the local/global buckling and failure loads show clear linearity with the delamination area,whilst the delamination depth and direction only have slight effects. | Kangkang WANG Libin ZHAO Haiming HONG Jianyu ZHANG Yu GONG | 2021 | Chinese Journal of Aeronautics2021，34，7： | 3 |
| 11 | Irreducible Z+-modules of near-group fusion ring K(Z3, 3)显示文摘 | Chengtao YUAN Ruju ZHAO Libin LI | 2018 | Frontiers of Mathematics in China2018，13，4： | 3 |
| 12 | Variation of crystal orientation during epitaxial growth of dendrites by laser deposition显示文摘A nickel-based superalloy was deposited onto a single crystal substrate based on epitaxial laser metal forming(E-LMF). The microstructure development in two depositions has been researched. For the first time, the crystal orientation of dendrites varying beyond 20° was found when the dendrites deflected in deposition. In addition, a new grain boundary was found between different orientation dendrites in a grain, and the detected grain boundary angle was 23°. The result shows that flowing field in laser pool is responsible for this phenomenon. | Guowei Wang Jingjing Liang Yizhou Zhou Libin Zhao Tao Jin Xiaofeng Sun | 2018 | Journal of Materials Science & Technology2018，34，4： | 3 |
| 13 | Model Investigation on Composite Failure Prediction of π-Joint Structures显示文摘This paper was concerned with the tensile mechanics behavior of the composite π-joint under static tensile loading. The numerical strength analysis methodology was presented containing the basis assumption for the analysis, the material modeling, and the selected element type. It was assumed that the composite ply had transverse isotropic material properties and the adhesive had linear elastic properties. With the goal of the strength analysis to determine the onset of the damage initiation and the ultimate failure load, two stiffness degradation models were discussed and a modified maximum stress failure criteria was presented. To verify the numerical model, a pull-off test scheme was performed and the experimental data of five specimens were given. The experimental results indicate that the damage initiation location and the failure load were consistent with numerical predictions and verified the feasibility of the numerical model. | Zhao Libin Qin Tianliang Huanghai Liang Xianzhu Chang Haifeng Cao Zhenghua | 2009 | 稀有金属材料与工程2009，38，A03： | 2 |
| 14 | Local Precise Large Deviations for Independent Sums in Multi-Risk Model显示文摘In this paper, we study the case of independent sums in multi-risk model. Assume that there exist k types of variables. The ith are denoted by {Xij, j ≥ 1}, which are i.i.d.with common density function fi(x) ∈ OR and finite mean, i = 1,..., k. We investigate local large deviations for partial sums k i=1Sni= k i=1 nij=1Xij. | Jinghai FENG Panpan ZHAO Libin JIAO | 2014 | Journal of Mathematical Research with Applications2014，34，2： | 2 |
| 15 | Uncertainty evaluation for bearing fatigue property of CFRP double-lap,single-bolt joints显示文摘The considerable uncertainty in mechanical properties of composite bolted joints not only prevents advanced composite materials from efficient applications,but also threatens the safety and reliability of the aircraft structures.In this paper,the uncertainty in bearing fatigue properties of a CFRP double-lap,single-bolt joint was evaluated by combing a Progressive Fatigue Damage Model(PFDM)with the interval analysis method.In the PFDM,a residualstrain-based gradual material degradation model and a strain-based fatigue failure criterion were combined with a micromechanics-based sudden material degradation model to predict fatigue properties of the joint.Based on the interval analysis,the key uncertain parameters,which were firstly picked out from eighteen structural parameters of the joint,were described by estimated intervals,and the envelope cases were determined to estimate the lower and upper bounds of fatigue properties of the joint.The predicted results have the same tendency with the experimental results in literatures,which indicates that the PFDM combined with the interval analysis shows potential in efficiently evaluating the fatigue reliability of the complex bolted joints with an adequate accuracy. | Meijuan SHAN Fengrui LIU Wen YANG Libin ZHAO Jianyu ZHANG | 2022 | Chinese Journal of Aeronautics2022，35，3： | 1 |
| 16 | Fatigue delamination growth rates and thresholds of composite laminates under mixed mode loading显示文摘 | Jianyu Zhang Lei Peng Libin Zhao Binjun Fei | 2012 | International Journal of Fatigue2012，，： | 1 |
| 17 | A joint call for actions to advance taxonomy in China显示文摘Taxonomy plays an important role in understanding the origin, evolution, and ecological functionality of biodiversity. There are large number of unknown species yet to be described by taxonomists, which together with their ecosystem services cannot be effectively protected prior to description. Despite this, taxonomy has been increasingly underrated insufficient funds and permanent positions to retain young talents. Further, the impact factordriven evaluation systems in China exacerbate this downward trend, so alternative evaluation metrics are urgently necessary. When the current generation of outstanding taxonomists retires,there will be too few remaining taxonomists left to train the next generation. In light of these challenges, all co-authors worked together on this paper to analyze the current situation of taxonomy and put out a joint call for immediate actions to advance taxonomy in China. | Chaodong Zhu Arong Luo Ming Bai Michael COrr Zhonge Hou Siqin Ge Jun Chen Yibo Hu Xuming Zhou Gexia Qiao Hongzhi Kong Limin Lu Xiaohua Jin Lei Cai Xinli Wei Ruilin Zhao Wei Miao Qingfeng Wang Zhongli Sha Qiang Lin Meng Qu Jianping Jiang Jiatang Li Jing Che Xuelong Jiang Xiaoyong Chen Lianming Gao Zongxin Ren Chunlei Xiang Shixiao Luo Donghui Wu Dong Liu Yanqiong Peng Tao Su Chenyang Cai Tianqi Zhu Wanzhi Cai Xingyue Liu Hu Li Huaijun Xue Zhen Ye Xuexin Chen Pu Tang Shujun Wei Hong Pang Qiang Xie Feng Zhang Feng Zhang Xianjin Peng Aibing Zhang Taiping Gao Changfa Zhou Chen Shao Libin Ma Zhaoming Wei Yunxia Luan Ziwei Yin Wu Dai Cong Wei Xiaolei Huang Jingxian Liu Xiangsheng Chen Tianci Yi Zhisheng Zhang Zhulidezi Aishan Qin Li Hongying Hu | 2022 | Zoological Systematics2022，47，3： | 1 |
| 18 | Bearing Failure Optimization of Composite Double-Lap Bolted Joints Based on a Three-Step Strategy Marked By Feasible Region Reduction and Model Decoupling显示文摘To minimize the mass and increase the bearing failure load of composite double-lap bolted joints,a three-step optimization strategy including feasible region reduction,optimization model decoupling and optimization was presented.In feasible region reduction,the dimensions of the feasible design region were reduced by selecting dominant design variables from numerous multilevel parameters by sensitivity analyses,and the feasible regions of variables were reduced by influence mechanism analyses.In model decoupling,the optimization model with a large number of variables was divided into various sub-models with fewer variables by variance analysis.In the third step,the optimization sub-models were solved one by one using a genetic algorithm,and the modified characteristic curve method was adopted as the failure prediction method.Based on the proposed optimization method,optimization of a double-lap single-bolt joint was performed using the ANSYS®code.The results show that the bearing failure load increased by 13.5%and that the mass decreased by 8.7%compared with those of the initial design of the joint,which validated the effectiveness of the three-step optimization strategy. | Fengrui Liu Wanting Yao Xinhong Shi Libin Zhao Jianyu Zhang | 2020 | Computers, Materials & Continua2020，，2： | 1 |
| 19 | Effect Mechanisms of Hygrothermal Environments on Failure of Single-Lap and Double-Lap CFRP-Aluminum Bolted Joints显示文摘The high demands for load-carrying capability and structural efficiency of composite-metal bolted joints trigger in-depth investigations on failure mechanisms of the joints in hygrothermal environments.However,few studies have been presented to exhaustively reveal hygrothermal effects on the failure of CFRP-metal bolted joints,which differ from CFRP-CFRP or metal-metal bolted joints because of the remarkably different material properties of CFRPs and metals.In this paper,hygrothermal effects on tensile failures of single-lap and double-lap CFRP-aluminum bolted joints were experimentally and numerically investigated.A novel numerical model,in which a hygrothermal-included progressive damage model of composites was established and elastic-plastic models of metals were built,was proposed to predict the failures of the CFRP-metal bolted joints in hygrothermal environments and validated by corresponding experiments.Different failure mechanisms of single-lap and double-lap CFRP-aluminum bolted joints,under 23°C/Dry and 70°C/Wet conditions,were revealed,respectively.It follows that both the collapse failures of the single-lap and double-lap bolted joints were dominated by the bearing failure of the CFRP hole laminate in the two conditions,indicating that the hygrothermal environment did not change the macro failure modes of the joints.However,the hygrothermal environment considerably shortened the damage propagation processes and reduced the strength of the joints.Besides,the hygrothermal environment weakened the load-transfer capability of the single-lap joint more severely than the double-lap joint because it aggravated the secondary bending effects of the single-lap joint obviously. | Meijuan Shan Libin Zhao Wei Huang Fengrui Liu Jianyu Zhang | 2020 | Computer Modeling in Engineering & Sciences2020，，4： | 1 |
| 20 | Unilateral optic nerve transection up-regulate Hsp70 protein expression in lateral geniculate nucleus of rats 显示文摘 | Zhao Li Wang Ning li Jiang Libin | 2006 | Neurosci Lett2006，404，12： | 1 |
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