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| 1 | Proteomic profiling of lipid droplet-associated proteins in primary adipocytes of normal and obese mouse显示文摘在 adipocytes 的类脂化合物微滴用作动物的主要长期的精力存储仓库。正在增加类脂化合物微滴不仅仅是一个静态的中立类脂化合物存储地点,而是事实上有活力、多功能的细胞器的识别。在结构上,类脂化合物微滴由嵌入在或跳了到 phospholipid 层的 phospholipid 单层和蛋白质包围的一个中立类脂化合物核心组成。类脂化合物微滴的表面上的蛋白质对微滴结构和动力学关键。理解类脂化合物有大中央类脂化合物微滴的主要 adipocyte 的联系微滴的 proteome,从 C57BL/6 老鼠的白脂肪质的织物的类脂化合物微滴被孤立。,和由结合的液体层析双人脚踏车团 spectrometry。以前包括 73 的 193 蛋白质的一个总数 unreported 蛋白质被识别。而且,编码同位素的亲密关系标签(ICAT ) 被用来比较类脂化合物的差别在瘦的正常和高脂肪的导致食谱的肥胖的 C57BL/6 老鼠之间的联系微滴的 proteomes。23,蛋白质由 ICAT 分析确定了, 3 蛋白质是起来调整的, 4 蛋白质在从肥胖的老鼠的脂肪质的织物的类脂化合物微滴是下面调整的。重要地,类脂化合物微滴, perilipin A 和 vimentin 的二结构的蛋白质,极大地从肥胖的老鼠在脂肪质的织物的类脂化合物微滴被减少,为类脂化合物的含有的减少的蛋白质机械微滴稳定性。 | Yubo Ding Yibo Wu Rong Zeng Kan Liao | 2012 | Acta Biochimica et Biophysica Sinica2012，44，5： | 3 |
| 2 | Phosphorus deficiency affects multiple macromolecular biosynthesis pathways of Thalassiosira weissflogii显示文摘Phosphorus(P) is one of the key nutrients for the growth of phytoplankton. In this study, we used a method coupling label-free quantitation with liquid chromatography–mass spectrometry(LFQ–LC–MS/MS) to track the change of relative protein abundance between P-replete and P-deficient treatments in a non-model diatom, Thalassiosira weissflogii. Out of the 631 proteins identified, 132 were found to have significant changes in abundance(>1.5 folds) between the two treatments, especially those proteins involved in macromolecular biosynthesis pathways. For example, the up-regulation of sulfolipid biosynthesis protein in the P-deficient culture suggested a switch from using phospholipids to sulfolipids. In addition, the ribosome subunits and tRNA synthetases were down-regulated, which might explain the decrease in protein content in the P-deficient culture. A vacuolar sorting receptor homologous protein was found to be 9.2-folds up-regulated under P-deficiency, indicating an enhancement in the vacuolar sorting pathway for protein degradation. Our results show that T. weissflogii has sophisticated responses in multiple macromolecular metabolism pathways under P-deficiency, a mechanism which can be critical for this species to survive under various levels of P availability in the environment. | WANG Xiuxiu HUANG Bangqin ZHANG Huan | 2014 | Acta Oceanologica Sinica2014，33，4： | 2 |
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