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| 1 | 肾脏病学的新创意:“肾脏疾病:改善全球预后”(KDIGO)显示文摘慢性肾脏病(CKD)是世界范围的医疗和公共卫生问题,并开始呈现流行性的特点.美国肾脏数据系统(USRDS)的数据提示,终末期肾衰的发病率呈上升趋势,因此对于这一问题的重视日益增加.根据近期USRDS登记系统提供的资料,世界范围内需要肾脏替代治疗(RRT)的终末期肾病(ESRD)患者数目持续上升,其中我国台湾、美国和日本最多(254~365人/100万人)[1].卡塔尔和巴斯克地区的儿童患病率最高,分别为33.7人/100万人和22.7人/100万人;在大于等于20岁患者中患病率最高的是卡塔尔、美国和台湾.在欧洲,德国的患病率最高,2000年为175人/100万人.在RRT仍在发展中的东欧,报道的患病率低于西欧[2]. | Norbert Lameire Garabed Eknoyan Rashad Barsoum Kai-Uwe Eckardt Adeera Levin Nathan Levin Francesco Locatelli Alison Macleod Raymond Vanholder Rowan Walker Haiyan Wang 张路霞 王海燕 | 2005 | 中华肾脏病杂志2005，21，12： | 19 |
| 2 | A unique sequence in the N-terminal regulatory region controls the nuclear localization of KLF8 by cooperating with the C-terminal zinc-fingers显示文摘Kr 眉 p 像像素的因素 8 (KLF8 ) 抄写因素在房间周期前进起一个关键作用, oncogenic 转变,对间充质的转变和侵略上皮。然而,它的原子本地化信号(NLS ) 没被识别。有另外的 KLF monopartite NLS (mNLS ) 和 C2H2 锌手指(ZF ) 的 KLF8 份额,哪个被显示了是为一些另外的 KLF 的 NLS。在这份报告,用指导 PCR 的 mutagenesis 和 immunofluorescent 显微镜学,我们显示出 mNLSs,任何单个 ZF 的删除,或变化的那混乱 Zn2+ 有约束力或联系 DNA 主题没影响 KLF8 的原子本地化。删除 > 然而,从 C 终点的 1.5 ZF 引起了 KLF8 的细胞质的累积。令人惊讶地,氨基酸(aa ) 的删除 151-200 区域几乎从原子核消除了 KLF8。有 PKC 禁止者的 S165A, K171E 或 K171R 变化,或处理导致了部分细胞质的累积。Co-immunoprecipitation 证明 KLF8 与 importin- 交往了,这个相互作用要求了 ZF 主题。aa 1-150 或 201-261 区域的删除独自没改变原子本地化。BrdU 加入和 cyclin D1 倡导者酶试金作为野类型的 KLF8 证明在原子本地化的 KLF8 异种有缺陷者不能支持 DNA 合成或 cyclin D1 倡导者激活。一起拿,这些结果建议 KLF8 有二 NLS,一包围 S165 和 K171 并且另外的是二双人脚踏车 ZF,它为 KLF8 原子本地化和它的细胞的功能的规定是批评的。 | Tina S Mehta Heng Lu Xianhui Wang Alison M Urvalek Kim-Hang H Nguyen Farah Monzur Jojo D Hammond Jameson Q Ma Jihe Zhao | 2009 | Cell Research2009，19，9： | 10 |
| 3 | IL-33 drives the antitumor effects of dendritic cells via the induction of Tc9 cells显示文摘Dendritic cell(DC)tumor vaccines exert their antitumor effects through the induction of effector T cells.We recently identified Tc9 cells as a new potent antitumor effector T cell subset.However,approaches to direct DCs to preferably prime antitumor Tc9 cells should be further exploited.Here,we demonstrate that the addition of interleukin(IL)-33 potently promotes the induction of Tc9 cells by DCs in vitro and in vivo.IL-33 treatment also drives the cytotoxic activities of DC-induced Tc9 cells.Notably,IL-33 treatment enhances cell survival and proliferation of DC-primed CD8+T cells.More importantly,the addition of IL-33 during in vitro priming of tumor-specific Tc9 cells by DCs increases the antitumor capability of Tc9 cells.Mechanistic studies demonstrated that IL-33 treatment inhibits exhaustive CD8+T cell differentiation by inhibiting PD-1 and 2B4 expression and increasing IL-2 and CD127(IL-7 receptor-α,IL-7Rα)expression in CD8+T cells.Finally,the addition of IL-33 further promotes the therapeutic efficacy of DC-based tumor vaccines in the OT-I mouse model.Our study demonstrates the important role of IL-33 in DC-induced Tc9 cell differentiation and antitumor immunity and may have important clinical implications. | Ning Liu Yuxue Jiang Jintong Chen He Nan Yinghua Zhao Xiao Chu Alison Wang Dongjiao Wang Tianxue Qin Sujun Gao Ying Yue Siqing Wang | 2019 | Cellular & Molecular Immunology2019，16，7： | 2 |
| 4 | Role of the P2Y<sub>13</sub> Receptor in the Differentiation of Bone Marrow Stromal Cells into Osteoblasts and Adipocytes显示文摘 | Galadrielle Biver Ning Wang Alison Gartland Isabel Orriss Timothy R. Arnett Jean‐Marie Boeynaems Bernard Robaye | 2013 | Stem Cells2013，，12： | 1 |
| 5 | Expression Profiling of Proliferation and Apoptotic Markers along the Adenoma-Carcinoma Sequence in Familial Adenomatous Polyposis Patients显示文摘 | Jayson Wang Nabil El-Masry Ian Talbot Ian Tomlinson Malcolm R. Alison Mona El-Bahrawy Bita Geramizadeh | 2013 | Gastroenterology Research and Practice2013，，： | 1 |
| 6 | Pregnancy after Hematopoietic Cell Transplantation: A Report from the Late Effects Working Committee of the Center for International Blood and Marrow Transplant Research (CIBMTR)显示文摘 | Alison W. Loren Eric Chow David A. Jacobsohn Maria Gilleece Joerg Halter Sarita Joshi Zhiwei Wang Kathleen A. Sobocinski Vikas Gupta Gregory A. Hale David I. Marks Edward A. Stadtmauer Jane Apperley Jean-Yves Cahn Harry C. Schouten Hillard M. Lazarus Bipi | 2011 | Biology of Blood and Marrow Transplantation2011，，2： | 1 |
| 7 | Ovarian Cancer Pathogenesis: A Model in Evolution显示文摘 | Alison M. Karst Ronny Drapkin Tian-Li Wang | 2009 | Journal of Oncology2009，，： | 1 |
| 8 | Hollow CoFe<SUB>2</SUB>O<SUB>4</SUB> nanospheres as a high capacity anode material for lithium ion batteries显示文摘 | Ying Wang Dawei Su Alison Ung Jung-ho Ahn Guoxiu Wang | 2012 | Nanotechnology2012，，5： | 1 |
| 9 | Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β显示文摘Progranulin(PGRN)has recently emerged as a key player in a subset of frontotemporal dementias(FTD).Numerous mutations in the progranulin gene have been identified in patients with familial or sporadic frontotemporal lobar degeneration(FTLD).In order to understand the molecular mechanisms by which PGRN deficiency leads to FTLD,we examined activity of PGRN in mouse cortical and hippocampal neurons and in human neuroblastoma SH-SY5Y cells.Treatment of mouse neurons with PGRN protein resulted in an increase in neurite outgrowth,supporting the role of PGRN as a neurotrophic factor.PGRN treatment stimulated phosphorylation of glycogen synthase kinase-3 beta(GSK-3β)in cultured neurons.Knockdown of PGRN in SH-SY5Y cells impaired retinoic acid induced differentiation and reduced the level of phosphorylated GSK-3β.PGRN knockdown cells were also more sensitized to staurosporineinduced apoptosis.These results reveal an important role of PGRN in neurite outgrowth and involvement of GSK-3βin mediating PGRN activity.Identification of GSK-3βactivation as a downstream event for PGRN signaling provides a mechanistic explanation for PGRN activity in the nervous system.Our work also suggest that loss of axonal growth stimulation during neural injury repair or deficits in axonal repair may contribute to neuronal damage or axonal loss in FTLD associated with PGRN mutations.Finally,our study suggests that modulating GSK-3βor similar signaling events may provide therapeutic benefits for FTLD cases associated with PGRN mutations. | Xue Gao Alvin P.Joselin Lei Wang Amar Kar Payal Ray Andrew Bateman Alison M.Goate Jane Y.Wu | 2010 | Protein & Cell2010，1，6： | 1 |
| 10 | C-terminal variants of the P2X7 receptor are associated with prostate cancer progression and bonemetastasis–evidence from clinical and pre-clinical data显示文摘Dear Editor Bone is the most common site for metastasis in prostate cancer(PCa),and identifying clinically useful biomarkers to predict the risk of currently incurable bone metastases is a major priority in PCa research.Extracellular adenosine triphosphate(ATP)was shown to be a major biochemical constituent of the tumor microenvironment and regulates the tumor and host interactions by acting at P2 purinergic receptors.Among the P2 receptors,the ion channel P2X purinergic receptor 7(P2X7R)has an unusually long C-terminus containing 200 amino acids,which forms the molecular basis for the unique bi-function of P2X7R promoting cancer cell proliferation or inducing membrane permeabilization and apoptosis,upon activation by a low or high concentration of ATP,respectively. | Haiping Song Hector Manuel Arredondo Carrera Alexandria Sprules Ying Ji Tongsong Zhang Jiepei He Eleanor Lawrence Alison Gartland Jian Luo Ning Wang | 2023 | Cancer Communications2023，43，3： | 0 |
| 11 | Positional behavior and canopy use of black snub-nosed monkeys Rhinopithecus strykeri in the Gaoligong Mountains,Yunnan,China显示文摘Studies on positional behavior and canopy use are essential for understanding how arboreal animals adapt their morphological characteristics and behaviors to the challenges of their environment.This study explores canopy and substrate use along with positional behavior in adult black snub-nosed monkeys Rhinopithecus strykeri,an endemic,critically endangered primate species in Gaoligong Mountains,southwest China.Using continuous focal animal sampling,we collected data over a 52-month period and found that R.strykeri is highly arboreal primarily using the high layers of the forest canopy(15–30 m),along with the terminal zone of tree crowns(52.9%),medium substrates(41.5%),and oblique substrates(56.8%).We also found sex differences in canopy and substrate use.Females use the terminal zones(56.7%versus 40.4%),small/medium(77.7%versus 60.1%),and oblique(59.9%versus 46.5%)substrates significantly more than males.On the other hand,males spend more time on large/very large(39.9%versus 22.3%)and horizontal(49.7%versus 35.2%)substrates.Whereas both sexes mainly sit(84.7%),and stand quadrupedally(9.1%),males stand quadrupedally(11.5%versus 8.3%),and bipedally(2.9%versus 0.8%)more often than females.Clamber,quadrupedalism,and leap/drop are the main locomotor modes for both sexes.Rhinopithecus strykeri populations never enter canopies of degenerated secondary forest and mainly use terminal branches in the middle and upper layers of canopies in intact mid-montane moist evergreen broadleaf forest and hemlock coniferous broadleaf mixed forests across their habitat. | Yin Yang Dionisios Youlatos Alison M Behie Roula Al Belbeisi Zhipang Huang Yinping Tian Bin Wang Linchun Zhou Wen Xiao | 2022 | Current Zoology2022，68，4： | 0 |
| 12 | Defect passivation on cast-mono crystalline screen-printed cells显示文摘演员组单音的水晶的硅晶片包含结晶的缺点,它能严重地影响太阳能电池的电的表演。这份报纸证明适用的加氢在中等温度处理到完成的屏幕出版房间能使钝化在比加氢远好的演员组单音的水晶的硅晶片以内的脱臼簇在标准商业开火条件期间收到了。多达 2% 的效率改进绝对与高脱臼密度在晶片上被表明。照明的影响被调查在退火期间操作氢的费用状态并且发现了不在在这研究使用的晶片上重要。这发现与断定从激光照明的增加的 H - 或 H 0 为在脱臼簇以内的断然控告的摇的契约的进一步的钝化负责的类似的晶片上的以前的研究相反。 | Alison WENHAM Lihui SONG Malcolm ABBOTT Iskra ZAFIROVSKA Sisi WANG Brett HALLAM Catherine CHAN Allen BARNETT Stuart WENHAM | 2017 | Frontiers in Energy2017，11，1： | 0 |
| 13 | Shape dependent protein-induced stabilization of gold nanoparticles:From a protein corona perspective Special Collection:Distinguished Australian Researchers显示文摘Gold nanoparticles(AuNPs)are promising materials for many bioapplications.However,upon contacting with biological media,AuNPs undergo changes.The interaction with proteins results in the so-called protein corona(PC)around AuNPs,leading to the new bioidentity and optical properties.Understanding the mechanisms of PC formation and its functions can help us to utilise its benefits and avoid its drawbacks.To date,most of the previous works aimed to understand the mechanisms governing PC formation and focused on the spherical nanoparticles,although non-spherical nanoparticles are designed for a wide range of applications in biosensing.In this work,we investigated the differences in PC formation on spherical and anisotropic AuNPs(nanostars in particular)from the joint experimental(extinction spectroscopy,zeta potential and surface-enhanced Raman scattering[SERS])and computational methods(the finite element method and molecular dynamics[MD]simulations).We discovered that protein does not fully cover the surface of anisotropic nanoparticles,leaving SERS hot-spots at the tips and high curvature edges‘available’for analyte binding(no SERS signal after pre-incubation with protein)while providing protein-induced stabilization(indicated by extinction spectroscopy)of the AuNPs by providing a protein layer around the particle’s core.The findings are confirmed from our MD simulations,the adsorption energy significantly decreases with the increased radius of curvature,so that tips(adsorption energy:2762.334 kJ/mol)would be the least preferential binding site compared to core(adsorption energy:11819.263 kJ/mol).These observations will help the development of new nanostructures with improved sensing and targeting ability. | Anastasiia Tukova Yihan Nie Mohammad Tavakkoli Yaraki Ngoc Thanh Tran Jiaqiu Wang Alison Rodger Yuantong Gu Yuling Wang | 2023 | Aggregate2023，4，4： | 0 |
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