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| 1 | SEMA3A-mediated crosstalk between prostate cancer cells and tumor-associated macrophages promotes androgen deprivation therapy resistance显示文摘Androgen deprivation therapy(ADT)is an important treatment strategy that can be used to delay the progression of prostate cancer.However,after an initial response,which varies significantly among patients,the disease eventually progresses despite the low levels of testosterone in the systemic circulation.1 The mechanism underlying the progression of prostate cancer to castration-resistant prostate cancer(CRPC)is not yet clear,and further investigation is needed. | Fei Liu Chao Wang Hai Huang Yue Yang Lihe Dai Sujun Han Nianzeng Xing Shancheng Ren | 2021 | Cellular & Molecular Immunology2021，18，3： | 5 |
| 2 | Global features and trends of the tropopause derived from GPS/CHAMP RO data显示文摘The global characteristics and trends of the tropopause physical parameters,height and temperature,obtained from the GPS/CHAMP radio occultation(RO) data in the period from Jul.2001 to Oct.2008,were modeled and analyzed in this work.The global distribution and variation of these parameters with latitude were estimated and analyzed using the Empirical Orthogonal Function(EOF),which was introduced to reveal the possible relationship between the tropopause variations and global climate change.The tropopause height and temperature varied with latitude.The results obtained by using the Empirical Orthogonal Function analysis suggested a recent rise in tropopause height and decrease in tropopause temperature;and also partly supported the argument that the global rise in the tropopause is consistent with global climate change.These results also revealed that the tropopause height increased mainly in the Polar regions,particularly in the South Polar region,as well as the regions where human activity is relatively significant,and decreased in the areas that are sparsely populated or have less human activity,such as the tropic region and south hemisphere.This paper also confirms that the GPS/LEO RO data are more reliable and can be effectively used to analyze the tropopause physical parameters. | HAN TingTing PING JinSong ZHANG SuJun | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，2： | 4 |
| 3 | Forkhead domain mutations in FOXA1 drive prostate cancer progression显示文摘Dear Editor,F0XA1 (Forkhead Box Protein A1)is a pioneer transcription factor (TF) that functions to loosen the compact chromatin structure to facilitate binding of other TFs such as estrogen receptor and androgen receptor (AR).1,2 AR is a nuclear receptor functioning as a ligand-dependent TF that plays a pivotal role in driving the initiation of prostate cancer (Pca) and the development of castration-resistant Pca (CRPC). | Shuai Gao Sujun Chen Dong Han David Barrett Wanting Han Musaddeque Ahmed Susan Patalano Jill A. Macoska Housheng Hansen He Changmeng Cai | 2019 | Cell Research2019，29，9： | 3 |
| 4 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
| 5 | Implementation of the Earth-based planetary radio occultation inversion technique显示文摘The planetary radio occultation technique is one of the earliest suggested and achieved methods to detect the planetary atmosphere,and has been conducted by almost every deep space planetary probe.The principles,modules,inversion results and primary analysis of the SHAO Planetary Occultation observation Processing system(SPOPs) are presented in this paper.Utilizing open-loop and closed-loop Doppler residual data of the Mars Express radio occultation experiment provided by ESA PSA and NASA PDS,the temperature,pressure,molecular number density profiles of Martian atmosphere and electron density profiles of the ionosphere are successfully retrieved,and the results are validated by the released radio science level 04 products of the ESA MaRS group.This system can also process the atmosphere radio occultation observations of other planets and theirs natural satellites.The implementation of the planetary radio occultation technique is of significance to China's YH-1 Mars exploration project,as well as for future planetary exploration missions from China. | ZHANG SuJun PING JinSong HAN TingTing MAO XiaoFei HONG ZhenJie | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，7： | 2 |
| 6 | Analysis of the current situation and trends of the incidence of prostate cancer in China显示文摘 | Han Sujun Zhang Siwei Han Wanqing | 2013 | J Clin Oncol2013，18，4： | 1 |
| 7 | The percentage of peripheral blood blasts on day 7 of induction chemotherapy predicts response to therapy and survival in patients with acute myeloid leukemia显示文摘 | Gao Sujun Tan Yehui Liu Xiaoliang Su Long Yu Ping Han Wei Cui Jiuwei Li Wei | 2014 | Chinese Medical Journal2014，，2： | 1 |
| 8 | Comparative risk of acute kidney injury among cancer patients treated with immune checkpoint inhibitors显示文摘With the development and introduction of immune checkpoint inhibitors(ICIs)in cancer patients,immune-related side effects have increasingly attracted attention.However,the risks of immune-related renal toxicity are poorly characterized.In this study,we performed a network meta-analysis(NMA)of ICI-related randomized clinical trials(RCTs)to elucidate the comparative risk of acute kidney injury(AKI)in cancer patients receiving different ICIs.We also sought to identify other factors potentially affecting the risk of AKI.PubMed and EMBASE were searched for peer-reviewed trial reports published between January 2000 and May 2021.Eligible studies were RCTs studying ICIs in cancer patients and reporting AKI data.We performed a frequentist NMA to evaluate the risk ratios for grade 1-5 and grade 3-5 AKI between the treatment groups.We also assessed the absolute incidence of AKI in the ICI-containing arm using traditional direct meta-analysis.Once significant heterogeneity was detected in a traditional direct meta-analysis,multivariable meta-regression analysis was applied to identify factors that significantly affected the absolute incidence of AKI.A total of 85 RCTs were included in this study.In the NMA for the risk of grade 1-5 and 3-5 AKI,ipilimumab showed a significantly higher risk than avelumab and durvalumab,whereas 1 mg/kg nivolumab plus 3 mg/kg ipilimumab(N1I3)showed a significantly higher risk than other groups.In terms of treatment ranking,durvalumab±low-dose tremelimumab and avelumab were consistently among the top three safest treatments for grade 1-5 or 3-5 AKI,whereas N1I3,ipilimumab and tremelimumab were consistently among the top three treatments with the highest risk for grade 1-5 or 3-5 AKI.Compared with other cancers,renal cell carcinoma and urothelial carcinoma showed a significantly higher risk of AKI.The incidence of AKI was significantly higher with ICI+chemotherapy than with ICI monotherapy.In this NMA involving largescale up-to-date ICI trials,we demonstrated the comparative safety of existing ICI drugs for grade 1-5 and grade 3-5 AKI.Based on data from the ICI arms of these trials,we also revealed several potential risk factors for immune-related AKI,including tumor type and treatment paradigm. | Fei Liu ZixianWang Xiaofan Li Zhen Zhang Yue Yang Junquan Chen Dinghua Chen Lingling Wu Xiangyu Liu Sujun Han Fangming Wang Wasilijiang Wahafu Yibo Gao Shancheng Ren Nianzeng Xing Guangyan Cai Xiangmei Chen | 2023 | Cancer Communications2023，43，2： | 1 |
| 9 | Microstructure evolution of an ultra-high strength metal alloy with tempering temperature显示文摘Optical microscopy (OM) and transmission electron microscopy (TEM) were used to investigate the effect of tempering temperature on the experimental extra-high carbon steels. It is found that tempering reaction can reduce austenite content and influence the stability of the austenite. As-normalized microstructure is a mixture of twinned martensite and retained austenite. Tempered at 250 °C for 2 h, lath martensite can occasionally be found nearby the diffusionally decomposed austenite area. It also is found that tempering at 650 °C for 2 h, nanoparticles of carbides precipitate in the martensite and decomposed austenite. | WU Sujun HU Bin HAN Bo | 2012 | Rare Metals2012，31，5： | 0 |
| 10 | A new method to determine the tropopause显示文摘The tropopause has a complex structure and some interference information may exist in high-resolution global positioning system(GPS)/low earth-orbiting(LEO)radio occultation(RO)data.The position of the tropopause cannot be accurately determined using traditional cold point tropopause(CPT)and lapse rate tropopause(LRT)algorithms.In this paper,an integrative algorithm is developed to determinate tropopause parameters.The algorithm is applied to GPS/COSMIC RO data to obtain a global distribution of the height and temperature of the tropopause.This algorithm improves the utilization rate of GPS/LEO RO data by 30%compared with that from the traditional CPT method.The rationality and reliability of GPS/LEO RO data in probing the Earth's atmosphere are verified by our study of the tropopause using COSMIC data. | HAN Tingting PING Jinsong ZHANG Sujun YANG Guogen | 2013 | Advances in Polar Science2013，24，3： | 0 |
| 11 | Consensus on safety management of novel hormonal therapy for advanced prostate cancer显示文摘Prostate cancer(PCa)is one of the most prevalent malignant tumors in men,accompanied by high incidence and mortality rates.Novel hormonal therapy(NHT)has emerged as the primary treatment for advanced PCa,providing noticeable clinical benefits.However,the diverse range of adverse events(AEs)associated with NHT may influence both treatment efficacy and patients'quality of life.In light of the latest international clinical research evidence and recommendations from domestic and foreign guidelines,this consensus aims to provide a comprehensive overview of the common AEs experienced during NHT for advanced PCa patients.Additionally,it seeks to develop a hierarchical approach to more efficiently manage AEs,presenting valuable insights for clinical medication and adverse reaction management. | Sujun Han Shudong Cheng Degang Ding Jianming Guo Zhisong He Baiye Jin Zhigang Ji Tianxin Lin Yuanjie Niu Weijun Qin Benkang Shi Jinkai Shao Xi'nan Sheng Qiang Wei Xin Wang Xinghuan Wang Shujie Xia Wanhai Xu Qing Zou Xiongbing Zu Renu Eapen Chi‐Fai Ng Hirotsugu Uemura Hiroji Uemura Cheol Kwak Jae Young Joung Marniza Saad Edmund Chiong Nianzeng Xing | 2023 | UroPrecision2023，1，2： | 0 |
| 12 | Design and Application of Electronic Atlas of Ornamental Flora in the Daqing Area显示文摘The electronic atlas of ornamental flora in the Daqing area selects 265 species of plants from 84 families.The video studio X5 software is used to edit and process pictures and text materials,and professional templates are used to make a media playback video combining picture materials,text description,background music,and subtitle dub.Each plant is provided with a Latin scientific name,Chinese name,taxonomic status,habitat,application and other morphological characteristics description and identification pictures.This paper expounds on the design idea and the whole production process of the atlas.The atlas is easy to search and browse and can provide a necessary reference for gardeners,botany lovers and students to know ornamental plants correctly,and to research,develop and utilize ornamental plants. | ZHANG Meiping GUO Xiaohong HE Lin HAN Wenge JIANG Sujun | 2020 | Journal of Landscape Research2020，12，2： | 0 |
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