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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Virulence regulator AphB en-hances toxR transcription in Vibrio cholerae显示文摘 | Xu X Stern AM Liu Z | 2010 | BMC Microbiol2010，10，1： | 1 |
| 3 | Differentiation of mesothelioma from adenocarcinoma in serous effusions:the role of hyaluronic acid and CD44 localization 显示文摘 | Afify AM Stern R Michael CW | 2005 | Diagn Cytopathol2005，32，3： | 1 |
| 4 | Activation of receptor for advanced glycosylation end products:a mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis显示文摘 | Schmidt AM Yan SD Wautier JL Stern D | 1999 | Circ Res1999，84，5： | 1 |
| 5 | What is the RAGE? The receptor for advanced glycation endproducts(RAGE) and the dark side of glucose显示文摘 | Stern D Schmidt AM | 1997 | Eur J Clin Inves1997，27，： | 1 |
| 6 | Does HLA type predispose some individuals to Cancer显示文摘 | Little AM Stern PL | 1999 | Mol Med Today1999，5，8： | 1 |
| 7 | Safety and immunogenicity of TA-HPV,a recombinant vaccinia virus expressing modified human papillomavirus(HPV)-16 and HPV-18 E6 and E7 genes,in women with progressive cervical cancer显示文摘 | Kaufmann AM Stern PL Rankin EM | 2002 | Clin Cancer Res2002，8，12： | 1 |
| 8 | Virulence regulator AphB enhances toxR transcription in Vibrio cholerae显示文摘 | Xu X Stern AM Liu Z | 2010 | BMC Microbiol2010，10，： | 1 |
| 9 | Safety and immunogenicity of TA-HPV,a recombinant vaccinia virus expressing modified human papillomavirus (HPV)-16 and HPV-18 E6 and E7 genes,in women with progressive cervical cancer显示文摘 | Kaufmann AM Stern PL Rankin EM | 2002 | Clin Cancer Res2002，8，12： | 1 |
| 10 | Bronchial artery embolization to control hemoptysis in cystic fibrosis显示文摘 | Cohen AM Doershuk CF Stern RC | 1990 | Radiology1990，175，2： | 1 |
| 11 | Increased prevalence of undernutrition in Parkinson's disease and its relationship to clinical disease parameters 显示文摘 | Markus HS Tomkins AM Stern GM | 1993 | J Neural Transm Park Dis Dement Sect1993，5，2： | 1 |
| 12 | Overview:treatment of cryptococcal meningi tis显示文摘 | Sugar AM Stern J J Dupont B | 1990 | Rev Infect Dis1990，12，3： | 1 |
| 13 | Endothelial cells in physiology and in the pathophysiology of vascular disorders 显示文摘 | Pollak ES Buck CA Loscalzo J Zimmerman GA McEver RP Pober JS Wick TM Konkle BA Schwartz BS Barnathan ES McCrae KR Hug BA Schmidt AM Stern DM | 1998 | Blood1998，91，10： | 1 |
| 14 | Safety and immuno- genicity of TA-HPV, a recombinant vwcinia virus expressing mod- ified human papillomavirus (HPV) -16 and HPV-18 E6 and E7 genes, in women with progressive cervical cancer 显示文摘 | Kaufmann AM Stern PL Rankin EM | 2002 | Clin Cancer Res2002，8，12： | 1 |
| 15 | Activation of receptor for advanced glycation end products:a mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis显示文摘 | Schmidt AM Yan SD Wautier JL Stern D | 1999 | Circ Res1999，84，5： | 1 |
| 16 | Repetitive extragenic palindromic sequences:a major component of the bacterial genome 显示文摘 | Stern M J Ames G F Smith N J | 1984 | Cell1984，37，3： | 1 |
| 17 | A therosclerosis and diabetes:The RAGE connection显示文摘 | Schmidt AM Stern D | 2000 | Curr Atheroscler Rep2000，2，： | 1 |
| 18 | Differentiation of mesothelioma from adenocarcinoma in serous effusions:the role of hyaluronic acid and CD44 localization显示文摘 | Afify AM Stern R Michael CW | | 0，，03： | 1 |
| 19 | Differentiation of mesothelioma from adenocarcinoma in serous effusions: the role of hyaluronic acid and CIN4 localization 显示文摘 | Afify AM Stern R Michael CW | 2005 | Diagn Cytopathol2005，32，3： | 1 |
| 20 | Differentiation of mesothelioma from adenocarcinoma in serous effusions: the role of hyaluronic acid and CD44 localization 显示文摘 | Afify AM Stern R Michael CW | 2005 | Diagn Cytopathol2005，32，3： | 1 |
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