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| 1 | First China ocean reflection experiment using coastal GNSS-R显示文摘It is a new way for oceanographic remote sensing using the GNSS-Reflection technique. Sea waves, tides and sea surface wind can be obtained by analyzing the direct and reflected GPS signals from sea surface. It has become an advanced field concerned by many researchers. In this paper the first China Ocean Reflection Experiment (CORE) with the coastal GNSS-R in the southeast is reported and the method to retrieve oceanographic parameters with the direct and reflected GPS signals is studied. The primary retrievals of Significant Wave Height (SWH) are presented and also compared with the meas-urements from Ultrasonic Wave Gauge (UWG) in situ. | WANG Xin SUN Qiang ZHANG XunXie LU DaRen SHAO LianJun HU Xiong RUFFINI Giulio DUNNE Stephen FRANCOIS Soulat | 2008 | Chinese Science Bulletin2008，53，7： | 15 |
| 2 | Epac2-deficiency leads to more severe retinal swelling, glial reactivity and oxidative stress in transient middle cerebral artery occlusion induced ischemic retinopathy显示文摘Ischemia occurs in diabetic retinopathy with neuronal loss, edema, glial cell reactivity and oxidative stress. Epacs, consisting of Epac1 and Epac2, are c AMP mediators playing important roles in maintenance of endothelial barrier and neuronal functions. To investigate the roles of Epacs in the pathogenesis of ischemic retinopathy, transient middle cerebral artery occlusion(t MCAO) was performed on Epac1-deficient(Epac1-/-) mice, Epac2-deficient(Epac2-/-) mice, and their wild type counterparts(Epac1+/+ and Epac2+/+). Two-hour occlusion and 22-hour reperfusion were conducted to induce ischemia/reperfusion injury to the retina. After t MCAO, the contralateral retinae displayed similar morphology between different genotypes. Neuronal loss, retinal edema and increase in immunoreactivity for aquaporin 4(AQP4), glial fibrillary acidic protein(GFAP), peroxiredoxin 6(Prx6) were observed in ipsilateral retinae. Epac2-/- ipsilateral retinae showed more neuronal loss in retinal ganglion cell layer, increased retinal thickness and stronger immunostaining of AQP4, GFAP, and Prx6 than those of Epac2+/+. However, Epac1-/- ipsilateral retinae displayed similar pathology as those in Epac1+/+ mice. Our observations suggest that Epac2-deficiency led to more severe ischemic retinopathy after retinal ischemia/reperfusion injury. | LIU Jin YEUNG Patrick Ka Kit CHENG Lu LO Amy Cheuk Yin CHUNG Stephen Sum Man CHUNG Sookja Kim | 2015 | Science China(Life Sciences)2015，58，6： | 12 |
| 3 | Iron metabolism, oxidative stress, and neonatal brain injury显示文摘The brain injury associated with neonatal hypoxia ischemia(HI)is a major contributor to neonatal mortality and neurodevelopment retardation.Approximately 30–40%of infants with brain injury will die and 20–40%of survivors will develop significant neurological disorders and lifelong disability,such as | Qing Lu Stephen M.Black | 2016 | Neural Regeneration Research2016，11，5： | 5 |
| 4 | Hybrid speciation via inheritance of alternate alleles of parental isolating genes显示文摘It is increasingly realized that homoploid hybrid speciation(HHS),which involves no change in chromosome number,is an important mechanism of speciation.HHS will likely increase in frequency as ecological and geographical barriers between species are continuing to be disrupted by human activities.HHS requires the establishment of reproductive isolation between a hybrid and its parents,but the underlying genes and genetic mechanisms remain largely unknown.In this study,we reveal by integrated approaches that reproductive isolation originates in one homoploid hybrid plant species through the inheritance of altemate alleles at genes that determine parental premating isolation.The parent species of this hybrid species are reproductively isolated by differences in flowering time and survivorship on soils containing high concentrations of iron.We found that the hybrid species inherits alleles of parental isolating major genes related to flowering time from one parent and alleles of major genes related to iron tolerance from the other parent.In this way,it became reproductively isolated from one parent by the difference in flowering time and from the other by habitat adaptation(iron tolerance).These findings and further modeling results suggest that HHS may occur relatively easily via the inheritance of alternate parental premating isolating genes and barriers. | Zefu Wang Yuanzhong Jiang Hao Bi Zhiqiang Lu Yazhen Ma Xiaoyue Yang Ningning Chen Bin Tian Bingbing Liu Xingxing Mao Tao Ma Stephen P.DiFazio Quanjun Hu Richard J.Abbott Jianquan Liu | 2021 | Molecular Plant2021，14，2： | 4 |
| 5 | Pharmacokinetic and toxicity study of intravitreal erythropoietin in rabbits显示文摘瞄准:为潜在的临床的使用学习 intravitreal erythropoietin (EPO ) 的 pharmacokinetics 和毒性。方法:为毒性学习,有 EPO 的 intravitreal 注射(IVit ) 的 4 个组(60 只兔子) 被学习(10U, 100U,或 1 000U ) 每为单个注射的眼睛和为每月的注射的 0.6 U/eye (在兔子的设计治疗学的水平)(6 ×) 。眼睛检查,闪光网膜电图(尔格) ,和荧光黄 angiography (FA ) 在注射前后被执行。兔子在不同间隔为组织学的学习被打死。为 pharmacokinetic 学习,在进左眼睛的 5 U EPO 的 IVit 以后, 44 只兔子在不同间隔,和 EPO 层次被打死在玻璃,水,视网膜和浆液被连接酶的免疫分析吸着剂试金。结果:根本,时间,点检验了,眼睛在正常限制以内。没有重要尔格或 FA 变化被观察。视网膜的组织学仍然保持未改变。在眼睛的分隔空间的 EPO 的 pharmacokinetic 侧面如下被总结。EPO 在的半衰期时间玻璃,水并且浆液分别地是 2.84, 3.24 和 2.12 d;并且 C 最大 分别地是 4615.75, 294.31 和 1.60 U/L。在注射眼睛的视网膜的 EPO 集中在 6 h 追随者注射在 1.36 U/g 蛋白质达到顶点,与观察是 3.42 d 的半衰期。结论:在一个宽范围的 EPO 的 IVit 很好被容忍,为兔子的保险箱看。在直到比治疗学的层次高的 10 褶层的剂量, EPO 与更快的清理有 pharmacokinetic 侧面,它为阵发性的 IVit 是有利的。 | Jing-fa ZHANG Ya-lan WU Jing-ying XU Wen YE Yu ZHANG Huan WENG Wo-dong SHI Guo-xu XU Luo LU Wei DAI Stephen H SINCLAIR Wei-ye LI Guo-tong XU | 2008 | Acta Pharmacologica Sinica2008，29，11： | 4 |
| 6 | Temporal and spatial comparisons of angiosperm diversity between eastern Asia and North America显示文摘Comparative approaches that examine floras with similar environments, but different diversity patterns, provide good opportunities to elucidate how uneven distributions of biodiversity were assembled. Eastern Asia(EA) and North America north of Mexico(NA;see definitions of EA and NA in Fig. S1 A) share similar geographical environments with comparable latitude, land area and climate. | Haihua Hu Jianfei Ye Bing Liu Lingfeng Mao Stephen A.Smith Russell L.Barrett Pamela S.Soltis Douglas E.Soltis Zhiduan Chen Limin Lu | 2022 | National Science Review2022，9，6： | 3 |
| 7 | Nodeless superconductivity in the kagome metal CsV_(3)Sb_(5)显示文摘The recently discovered kagome metal series AV3Sb5(A=K, Rb, Cs) exhibits topologically nontrivial band structures, chiral charge order and superconductivity, presenting a unique platform for realizing exotic electronic states. The nature of the superconducting state and the corresponding pairing symmetry are key questions that demand experimental clarification. Here, using a technique based on the tunneling diode oscillator, the magnetic penetration depth ?λ(T) of CsV3Sb5 was measured down to 0.07 K. A clear exponential behavior in ?λ(T) with marked deviations from a T or T2 temperature dependence was observed at low temperatures, indicating an absence of nodal quasiparticles. Temperature dependence of the superfiuid density and electronic specific heat can be described by two-gap s-wave superconductivity, consistent with the presence of multiple Fermi surfaces in CsV3Sb5. These results evidence nodeless superconductivity in CsV3Sb5 under ambient pressure, and constrain the allowed pairing symmetry. | Weiyin Duan Zhiyong Nie Shuaishuai Luo Fanghang Yu Brenden R.Ortiz Lichang Yin Hang Su Feng Du An Wang Ye Chen Xin Lu Jianjun Ying Stephen DWilson Xianhui Chen Yu Song Huiqiu Yuan | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，10： | 3 |
| 8 | 未处理或上游法处理后精子的DNA碎片能否预测使用赠卵ICSI后的妊娠?显示文摘本研究比较了未处理的精子和上游法处理后精子中的DNA碎片值(SDF)预测使用赠卵ICSI后妊娠的可能性。总共81例不孕女性接受通过夫精和赠卵ICSI后的胚胎移植。这种方式排除了目前公认的影响精子DNA修复的女方因素。在ICSI受精时,同时使用DNA碎片率检测试剂盒(Halosperm)进行盲法检测未处理的和上游法处理后精液中的精子DNA碎片。经上游法处理后的精液样本中SDF值呈显著下降。有趣的是,未处理的或上游法处理后精液样本中的SDF值均能预测妊娠。通过ROC曲线和其衍生的约登指数计算得出未处理前和上游法处理后精子sDF的临界值分别是24.8%和17.5%。未处理精子SDF预测妊娠的敏感性和特异性分别为75%和69%,而上游法处理后的精子SDF预测妊娠的敏感性和特异性分别是78%和73%。虽然SDF值增高与生育呈负相关,但我们发现在精子筛选降低sDF值后再与赠卵进行ICSI并不能保证获得妊娠。这表明目前的技术手段对于一些DNA损伤仍无法探及,从而相对影响辅助生殖成功的机率。因此,我们认为对目前的“冰山模式”作一些修饰后可以用来解释SDF在生育中的作用。 | Jaime Gosálvez Pedro Caballero Carmen López-Fernández Leonor Ortega José Andrés Guijarro José Luís FernAndez Stephen D Johnston Rocio Nufiez-Calonge | 2013 | Asian Journal of Andrology2013，15，6： | 3 |
| 9 | Sedimentology of reefal buildups of the Xiannüdong Formation(Cambrian Series 2),SW China显示文摘The reefs in the Xiannüdong Formation(Cambrian Series 2) are the oldest archaeocyathan–microbial bioconstructions in China,but the details of their microbial structures have not been previously described.However,a new section at Tangjiahe site,northern Sichuan Province,contains very well-preserved microbial fabrics that provide these details,and is described in this study.The Tangjiahe section contains three levels of reefal buildups that were constructed by a consortium of archaeocyaths and calcimicrobes in varying proportions.The lowest(oldest) reefal buildup is a calcimicrobial biostrome,possibly in the form of a wide mound with a low relief(unconfirmed due to outcrop limitation),which was formed by Epiphyton with rare small archaeocyaths,and is sandwiched by flat-pebble conglomerates.The middle reefal buildup is a high-relief calcimicrobial mound,enclosed by oolites,that was built by intergrown Renalcis and Tarthinia.Archaeocyath fossils are uncommon,and were bound into the framework by microbial carbonates.The uppermost(youngest) reefal buildup is a low-relief archaeocyathan mound lacking calcimicrobes but partly having microbially-clotted textures attached on archaeocyaths.Calcimicrobes built or aided archaeocyaths to form the framework of Tangjiahe reefs.The three buildups formed in low-energy lagoons behind ooid shoals,and the environment was nutrient-rich due to terrigenous influx from adjacent lands.Tangjiahe reefs thus resemble most Early Cambrian reefs,in settings consistent with eutrophic,calm environments,and are characterized by the domination or aid of calcimicrobial components in framework construction. | Hao Tang Stephen Kershaw Xiu-Cheng Tan Hong Liu Fei Li Cheng Shen Fei-Fan Lu Xue-Fei Yang | 2019 | Journal of Palaeogeography2019，8，2： | 3 |
| 10 | Growing Operational Use of FY-3 Data in the ECMWF System显示文摘This paper reviews the data quality and impact of observations from the FY-3 satellite series used operationally in the ECMWF system. This includes data from the passive microwave radiometers MWHS-1, MWHS-2 and MWRI, as well as observations from the radio occultation receiver GNOS. Evaluations against background equivalents show that the quality of the observations is broadly comparable to that of similar instruments on other polar-orbiting satellites, even though biases for the passive microwave observations can be somewhat larger and more complex for some channels. An observing system experiment shows that the FY-3 instruments jointly contribute significantly to the forecast skill in the ECMWF system. Positive impact of up to 2% is seen for most variables out to the day-2 forecasts over hemispheric scales, with significant benefits for total column water vapor or for temperature and wind in the stratosphere out to day 4. | Niels BORMANN David DUNCAN Stephen ENGLISH Sean HEALY Katrin LONITZ Keyi CHEN Heather LAWRENCE Qifeng LU | 2021 | Advances in Atmospheric Sciences2021，38，8： | 3 |
| 11 | The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice显示文摘 | Premysl Bercik Emmanuel Denou Josh Collins Wendy Jackson Jun Lu Jennifer Jury Yikang Deng Patricia Blennerhassett Joseph Macri Kathy D. McCoy Elena F. Verdu Stephen M. Collins | 2011 | Gastroenterology2011，，2： | 2 |
| 12 | Neo- and Paleopolyploidy contribute to the species diversity of Asplenium the most species-rich genus of ferns显示文摘Polyploidy 广泛地在植物的进化被看作一个主要过程,但是多倍体种类差异的累积仍然是争论的。一些最近的研究与他们的双祖先相比在 neopolyploids 建议了增加的扑灭风险。多倍体蕨纲植物的高比例被期望主要被 neopolyploids 形成,而 paleopolyploid 种类被预言在整个染色体复制成立的 clades 被聚类。这里,我们由在导出的蕨纲植物家庭 Aspleniaceae 探索 polyploidy 的进化测试这预言。家庭有全球分布并且在所有蕨纲植物之中显示出多倍体 taxa 的最高的频率。测试假设,我们用代表 292 种类的 883 个标本的叶绿体 DNA 序列获得了全面发展史。所有出版染色体计数被印射到这个种系发生的框架上以便探索多倍体的进化。我们 Aspleniaceae 的历史上为几整个染色体复制恢复了证据。超过 tetraploid 水平的多倍体的种系发生的关系建议那 tetraploid Asplenium 种可能在这个家庭的某 clades 作为主要进化播放器代替了他们的双祖先。 | Harald Schneider Hong-Mei Liu Yan-Fen Chang Daniel Ohlsen Leon R. Perrie Lara Shepherd Michael Kessler Dirk N. Karger Sabine Hennequin Jeannine Marquardt Stephen Russell Stephen Ansell Ngan Thi Lu Peris Kamau Josmaily Loriga Ledis Regalado Jochen Heinrichs Atsushi Ebihara Alan R. Smith Mary Gibby | 2017 | Journal of Systematics and Evolution2017，55，4： | 2 |
| 13 | Identification of QTLs and candidate genes for physiological traits associated with drought tolerance in cotton显示文摘Background:Cotton is mainly grown for its natural fiber and edible oil.The fiber obtained from cotton is the indispensable raw material for the textile industries.The ever changing climatic condition,threatens cotton production due to a lack of sufficient water for its cultivation.Effects of drought stress are estimated to affect more than 50%of the cotton growing regions.To elucidate the drought tolerance phenomenon in cotton,a backcross population was developed from G.tomentosum,a drought tolerant donor parent and G.hirsutum which is highly susceptible to drought stress.Results:A genetic map of 10888 SNP markers was developed from 200 BC_2F_2 populations.The map spanned 4191.3 centi-Morgan(c M),with an average distance of 0.1047 c M,covering 51%and 49%of At and Dt sub genomes,respectively.Thirty stable Quantitative trait loci(QTLs)were detected,in which more than a half were detected in the At subgenome.Eighty-nine candidate genes were mined within the QTL regions for three traits:cell membrane stability(CMS),saturated leaf weight(SLW)and chlorophyll content.The genes had varied physiochemical properties.A majority of the genes were interrupted by introns,and only 15 genes were intronless,accounting for 17%of the mined genes.The genes were found to be involved molecular function(MF),cellular component(CC)and biological process(BP),which are the main gene ontological(GO)functions.A number of mi RNAs were detected,such as mi R164,which is associated with NAC and MYB genes,with a profound role in enhancing drought tolerance in plants.Through RT-q PCR analysis,5 genes were found to be the key genes involved in enhancing drought tolerance in cotton.Wild cotton harbors a number of favorable alleles,which can be exploited to aid in improving the narrow genetic base of the elite cotton cultivars.The detection of 30 stable QTLs and 89 candidate genes found to be contributed by the donor parent,G.tomentosum,showed the significant genes harbored by the wild progenitors which can be exploited in developing more robust cotton genotypes with diverse tolerance levels to various environmental stresses.Conclusion:This was the first study involving genome wide association mapping for drought tolerance traits in semi wild cotton genotypes.It offers an opportunity for future exploration of these genes in developing highly tolerant cotton cultivars to boost cotton production. | MAGWANGA Richard Odongo LU Pu KIRUNGU Joy Nyangasi CAI Xiaoyan ZHOU Zhongli AGONG Stephen Gaya WANG Kunbo LIU Fang | 2020 | Journal of Cotton Research2020，3，1： | 2 |
| 14 | Biologically Inspired Design of Context-Aware Smart Products显示文摘The rapid development of information and communication technologies(ICTs)and cyber-physical systems(CPSs)has paved the way for the increasing popularity of smart products.Context-awareness is an important facet of product smartness.Unlike artifacts,various bio-systems are naturally characterized by their extraordinary context-awareness.Biologically inspired design(BID)is one of the most commonly employed design strategies.However,few studies have examined the BID of context-aware smart products to date.This paper presents a structured design framework to support the BID of context-aware smart products.The meaning of context-awareness is defined from the perspective of product design.The framework is developed based on the theoretical foundations of the situated function-behavior-structure ontology.A structured design process is prescribed to leverage various biological inspirations in order to support different conceptual design activities,such as problem formulation,structure reformulation,behavior reformulation,and function reformulation.Some existing design methods and emerging design tools are incorporated into the framework.A case study is presented to showcase how this framework can be followed to redesign a robot vacuum cleaner and make it more context-aware. | Ang Liu Ivan Teo Diandi Chen Stephen Lu Thorsten Wuest Zhinan Zhang Fei Tao | 2019 | Engineering2019，5，4： | 2 |
| 15 | Characterization of the Birefringence in Fiber Bragg Gratings Fabricated With an Uhrafast-Infrared Laser显示文摘 | Lu Ping Dan Grobnic Stephen J Mihailov | 2007 | IEEE JLT2007，25，3： | 1 |
| 16 | Productivity Growth and its Components in Chinese Agriculture after Reforms显示文摘 | Shunxiang Wu David Walker Stephen Devadoss Yao-Chi Lu | 2001 | Review of Development Economics2001，5，3： | 1 |
| 17 | Azetidinones as vasopressin V1a antagonists显示文摘 | Christophe D. Guillon Gary A. Koppel Michael J. Brownstein Michael O. Chaney Craig F. Ferris Shi-fang Lu Karine M. Fabio Marvin J. Miller Ned D. Heindel David C. Hunden Robin D.G. Cooper Stephen W. Kaldor Jeffrey J. Skelton Bruce A. Dressman Michael P. Cl | 2006 | Bioorganic & Medicinal Chemistry2006，，5： | 1 |
| 18 | Chronic Gastrointestinal Inflammation Induces Anxiety-Like Behavior and Alters Central Nervous System Biochemistry in Mice显示文摘 | Premysl Bercik Elena F. Verdu Jane A. Foster Joseph Macri Murray Potter Xiaxing Huang Paul Malinowski Wendy Jackson Patricia Blennerhassett Karen A. Neufeld Jun Lu Waliul I. Khan Irene Corthesy–Theulaz Christine Cherbut Gabriela E. Bergonzelli Stephen M. | 2010 | Gastroenterology2010，，6： | 1 |
| 19 | Characterization of the birefringence in fiber bragg gratings fabricated with an ultrafast-infrared laser显示文摘 | PING Lu DAN G STEPHEN J M | 2007 | J Lightwave Technol2007，25，3： | 1 |
| 20 | Propensity Score-based Comparison of Long-term Outcomes With 3-Dimensional Conformal Radiotherapy vs Intensity-Modulated Radiotherapy for Esophageal Cancer显示文摘 | Steven H. Lin Lu Wang Bevan Myles Peter F. Thall Wayne L. Hofstetter Stephen G. Swisher Jaffer A. Ajani James D. Cox Ritsuko Komaki Zhongxing Liao | 2012 | International Journal of Radiation Oncology Biology Physics2012，，5： | 1 |
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