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| 1 | How useful is rectal endosonography in the staging of rectal cancer?显示文摘It is essential in treating rectal cancer to have adequate preoperative imaging,as accurate staging can influence the management strategy,type of resection,and candidacy for neoadjuvant therapy.In the last twenty years,endorectal ultrasound(ERUS) has become the primary method for locoregional staging of rectal cancer.ERUS is the most accurate modality for assessing local depth of invasion of rectal carcinoma into the rectal wall layers(T stage) .Lower accuracy for T2 tumors is commonly reported,which could lead to sonographic overstaging of T3 tumors following preoperative therapy.Unfortunately,ERUS is not as good for predicting nodal metastases as it is for tumor depth,which could be related to the unclear definition of nodal metastases.The use of multiple criteria might improve accuracy.Failure to evaluate nodal status could lead to inadequate surgical resection.ERUS can accurately distinguish early cancers from advanced ones,with a high detection rate of residual carcinoma in the rectal wall.ERUS is also useful for detection of local recurrence at the anastomosis site,which might require fine-needle aspiration of the tissue.Overstaging is more frequent than understaging,mostly due to inflammatory changes.Limitations of ERUS are operator and experiencedependency,limited tolerance of patients,and limited range of depth of the transducer.The ERUS technique requires a learning curve for orientation and identification of images and planes.With sufficient time and effort,quality and accuracy of the ERUS procedure could be improved. | Taylan Kav Yusuf Bayraktar | 2010 | World Journal of Gastroenterology2010，16，6： | 34 |
| 2 | Outcomes of partial splenic embolization in patients with massive splenomegaly due to idiopathic portal hypertension显示文摘AIM To determine the outcomes of partial splenic em-bolization(PSE) for massive splenomegaly due to idiopathic portal hypertension(IPH).METHODS In this prospective study, we evaluated the charac-teristics and prognosis of consecutive patients with IPH who underwent PSE for all indications at a single medical center between June 2009 and January 2015. The inclusion criteria were: presence of hypersplenism, massive splenomegaly, and resultant pancytopenia. The exclusion criteria were: presence of other diseases causing portal hypertension. During the post-PSE period, the patients were hospitalized. All patients underwent abdominal computed tomography imaging 4 wk post-PSE to determine total splenic and non-infarcted splenic volumes.RESULTS A total of 11 patients, with median age of 33.27 ± 4.8 years, were included in the study. Mean spleen size was 22.9 cm(21-28 cm), and severe hypersplenismwas diagnosed in all patients before PSE. Post-PSE, leukocyte and platelet counts increased significantly, reaching peak levels in the second week with gradual decreases thereafter. Liver function tests did not exhibit significant changes during post-intervention follow-up. All patients developed post-embolization syndrome, and one patient experienced serious complications; all complications were successfully treated with conservative therapy and no death occurred. CONCLUSION Our findings showed that PSE has a lower complication rate than previously-reported surgical complication rates, which supports this intervention as a viable alternative for high-risk operable patients with severe hypersplenism. | Omer Ozturk Gonca Eldem Bora Peynircioglu Taylan Kav Aysegul Gormez Barbaros Erhan Cil Ferhun Balkanci Cenk Sokmensuer Yusuf Bayraktar | 2016 | World Journal of Gastroenterology2016，22，43： | 18 |
| 3 | Five years' experience with capsule endoscopy in a single center显示文摘Capsule endoscopy (CE) is a novel technology that facilitates highly effective and noninvasive imaging of the small bowel. Although its effi cacy in the evaluation of obscure gastrointestinal bleeding (OGIB) has been proven in several trials, data on uses of CE in different small bowel diseases are rapidly accumulating in the literature, and it has been found to be superior to alternative diagnostic tools in a range of such diseases. Based on literature evidence, CE is recommended as a first-line investigation for OGIB after negative bi-directional endoscopy. CE has gained an important role in the diagnosis and follow-up of Crohn's disease and celiac disease and in the surveillance of small bowel tumors and polyps in selected patients. Capsule retention is the major complication, with a frequency of 1%-2%. The purpose of this review was to discuss the procedure, indications, contraindications and adverse effects associated with CE. We also review and share our five-year experience with CE in various small bowel diseases. The recently developed balloon-assisted enteroscopies have both diagnostic and therapeutic capability. At the present time, CE and balloon-assisted enteroscopies are complementary techniques in the diagnosis and management of small bowel diseases. | Taylan Kav Yusuf Bayraktar | 2009 | World Journal of Gastroenterology2009，15，16： | 14 |
| 4 | Relationship between serum adenosine deaminase levels and liver histology in autoimmune hepatitis显示文摘AIM To evaluate the relationship between serum adenosine deaminase(ADA) levels and histological features in patients with autoimmune hepatitis(AIH).METHODS A total of 80 subjects(52 AIH cases and 28 healthy controls) were included in the study. Patients were diagnosed according to the simplified criteria suggested by the International Autoimmune Hepatitis Group. All of the cases had been diagnosed with AIH between 2010-2015 at Hacettepe University, Department of Gastroenterology. Serum blood samples were collected and stored at-80 ℃ until the biochemical estimation of ADA activity. The diagnosis of patients was confirmed by liver biopsy. Serum ADA > 20 U/L was considered to be high level.RESULTS Mean serum ADA levels were significantly higher in AIH patients than those in healthy controls(25.4 ± 9.6 U/L vs 12.8 ± 2.2 U/L, P < 0.001). Serum ADA levels > 20 U/L were found in 63.5% AIH patients and in 0% healthy controls(P < 0.001). Mean serum ADA levels were significantly increased in each stage of histological activity: 15.2 ± 3.5 U/L for patients with mild interface hepatitis, 23.1 ± 10.0 U/L for patients with moderate interface hepatitis and 30.9 ± 7.0 U/L for patients with severe interface hepatitis(P < 0.001). Correlation analysis showed that there was a positive association between serum ADA levels and histological activity(r = 0.71, P < 0.001). Receiver operating characteristic analysis suggested that 24.5 U/L was the optimum cut-off point of ADA level for severe interface hepatitis(sensitivity 88%, specificity 85.2%, area under thecurve: 0.88).CONCLUSION Because of the positive correlation with inflammatory activity, serum ADA level may be a potential biomarker for predicting or monitoring histological activity in patients with AIH. | Murat Torgutalp Cumali Efe Hakan Babaoglu Taylan Kav | 2017 | World Journal of Gastroenterology2017，23，21： | 10 |
| 5 | Effects of dexmedetomidine and dexketoprofen on the conduction block of rat sciatic nerve显示文摘Dexmedetomidine is a selective α2-adrenoceptor agonist that is used because of its sedative,anxiolytic,and analgesic effects.Dexketoprofen,which is used as an analgesic,is a nonselective nonsteroidal anti-inflammatory drug (NSAID).The use of dexmedetomidine and dexketoprofen as adjuvants to local anesthetics for the peripheral nerve is gradually increasing.In this study,we aimed to investigate the effects of different doses of dexmedetomidine and dexketoprofen on conduction block of rat sciatic nerve.The isolated sciatic nerve from adult rats was transferred to a nerve chamber.The compound action potentials (CAPs) were recorded from stimulated nerve with electrophysiological methods.Dexmedetomidine (n = 8) and dexketoprofen (n = 8) were administered in the chamber with cumulative concentrations of 10–9 to 10–5 M,and the CAPs were recorded for 5 and 10 minutes.The CAP parameters were calculated.Both dexmedetomidine and dexketoprofen significantly depressed all CAP parameters in a dose-dependent manner compared with the control group,i.e.,the group in which rats did not receive treatment.CAP parameters showed there was no significant difference in nerve conduction inhibition between dexmedetomidine and dexketoprofen.Higher doses of dexmedetomidine suppressed the conduction in the fast-conducting fibers;however,dexketoprofen was found to suppress the conduction in the slow-conducting fibers in a time-dependent manner and suppress the conduction in the medium- and slow-conducting fibers in a dose-dependent manner.These findings suggest that dexmedetomidine and dexketoprofen exhibit better anesthetic effects on peripheral nerve through different ways of action.The experimental procedures were approved by the Necmettin Erbakan University on January 30,2013 (approval No.2013-024). | Sengal Bagci Taylan Hulagu Bariskaner | 2020 | Neural Regeneration Research2020，15，5： | 8 |
| 6 | 西南少数民族药食两用植物“茴香菖蒲”不同部位的挥发油成分研究显示文摘茴香菖蒲Acorus macrospadiceus是贵州等地少数民族常用的药食两用植物。该文采用水蒸气蒸馏法提取茴香菖蒲叶片和根状茎的挥发油,结合气相色谱-质谱(GC-MS)联用技术分别对其挥发油进行成分分析,经计算机谱库检索(NIST14.0,NIST14.0s)和人工解析,应用峰面积百分比法计算相对含量。结果显示,从茴香菖蒲叶片和根状茎中分别分离出了30和43个色谱峰,分别鉴定出25和36个化合物,鉴定出的化合物的相对含量占各自挥发油总量的97.85%和97.18%。茴香菖蒲叶片和根状茎中挥发油的主要成分均为草蒿脑(estragole),其相对含量占各自挥发油总量的93.56%和71.62%。茴香菖蒲叶片和根状茎挥发油中均含有草蒿脑、β-石竹烯(β-caryophyllene)、茴香烯(trans-anethole)、β-榄香烯(β-elemene)、莰醇(endo-borneol)等14种挥发性成分,其相对含量分别占各自挥发油总量的96.98%和77.47%,但各成分含量在不同部位中的含量存在一定差异,且具有各自独特的挥发油成分。通过对茴香菖蒲不同部位挥发性成分的分析与研究,结合植物资源自身特点发现,其叶片更具有开发利用前景。另外,应注意茴香菖蒲在作为药用时,要与石菖蒲A.tatarinowii加以区分。该文为茴香菖蒲的进一步开发和可持续利用提供了理论参考。 | 舒航 Taylan Morcol 郑杰 赵丽丹 Edward J.Kennelly 龙春林 | 2018 | 中国中药杂志2018，43，9： | 6 |
| 7 | Current state and controversies in fertility preservation in women with breast cancer显示文摘On average,over 25000 women are diagnosed with breast cancer under the age of 45 annually in the United States.Because an increasing number of young women delay childbearing to later life for various reasons,a growing population of women experience breast cancer before completing childbearing.In this context,preservation of fertility potential of breast cancer survivors has become an essential concept in modern cancer care.In this review,we will outline the currently available fertility preservation options for women with breast cancer of reproductive age,discuss the controversy behind hormonal suppression for gonadal protection against chemotherapy and highlight the importance of timely referral by cancer care providers. | Enes Taylan Kutluk H Oktay | 2017 | World Journal of Clinical Oncology2017，8，3： | 4 |
| 8 | General characteristics of patients with electrolyte imbalance admitted to emergency department显示文摘BACKGROUND:Fluid and electrolyte balance is a key concept to understand for maintaining homeostasis,and for a successful treatment of many metabolic disorders.There are various regulating mechanisms for the equilibrium of electrolytes in organisms.Disorders of these mechanisms result in electrolyte imbalances that may be life-threatening clinical conditions.In this study we defined the electrolyte imbalance characteristics of patients admitted to our emergency department.METHODS:This study was conducted in the Emergency Department(ED) of Uludag University Faculty of Medicine,and included 996 patients over 18 years of age.All patients had electrolyte imbalance,with various etiologies other than traumatic origin.Demographic and clinical parameters were collected after obtaining informed consent from the patients.The ethical committee of the university approved this study.RESULTS:The mean age of the patients was 59.28±16.79,and 55%of the patients were male.The common symptoms of the patients were dyspnea(14.7%),fever(13.7%),and systemic deterioration(11.9%);but the most and least frequent electrolyte imbalances were hyponatremia and hypermagnesemia,respectively.Most frequent findings in physical examination were confusion(14%),edema(10%) and rales(9%);and most frequent pathological findings in ECG were tachycardia in24%,and atrial fibrillation in 7%of the patients.Most frequent comorbidity was malignancy(39%).Most frequent diagnoses in the patients were sepsis(11%),pneumonia(9%),and acute renal failure(7%).CONCLUSIONS:Electrolyte imbalances are of particular importance in the treatment of ED patients.Therefore,ED physicians must be acknowledged of their fluid-electrolyte balance dynamics and general characteristics. | Arif Kadri Balci Ozlem Koksal Ataman Kose Erol Armagan Fatma Ozdemir Taylan Inal Nuran Oner | 2013 | World Journal of Emergency Medicine2013，4，2： | 3 |
| 9 | Factors Associated With Response to Therapy and Outcome of Patients With Primary Biliary Cirrhosis With Features of Autoimmune Hepatitis显示文摘 | Ersan Ozaslan Cumali Efe Alexandra Heurgué–Berlot Taylan Kav Chiara Masi Tugrul Purnak Luigi Muratori Yücel Ustündag Solange Bresson–Hadni Gérard Thiéfin Thomas D. Schiano Staffan Wahlin Paolo Muratori | 2014 | Clinical Gastroenterology and Hepatology2014，，： | 3 |
| 10 | One-year experience in the retinopathy of prematurity: frequency and risk factors, short-term results and follow-up显示文摘· AIM: As a result of the increase in premature births and the advances in neonatal intensive care, retinopathy of prematurity (ROP) remains one of the most important causes of childhood blindness worldwide. The main factors in the development of ROP are gestational age, birth weight and oxygen therapy. ROP continues to gain importance due to the increasing survival rates of more immature babies. · METHODS: Between January 2007 and October 2008, 203 premature infants treated at the Neonatal Intensive Care Unit (NNICU) were prospectively enrolled and the relationship between known risk factors and the occurance of ROP was studied. · RESULTS: ROP in various stages developed in 86 cases (42.4%). Statistically significant correlations were found between the development of ROP and birth weight (P < 0.0001) gestational age (P <0.0001), oxygen treatment and its duration (P <0.0001 and P =0.002), mechanical ventilation (MV) and its duration (P =0,0001 and P =0.0001), apnea(P = 0.001), intraventricular hemorrhage (IVH) (P =0.046), sepsis (P =0.0001), use of erythropoietin (EPO) (P =0.003), the number of blood transfusions and frequency (P =0.0001 and P =0.0001), surfactant application (P =0.0001), the presence of patent ductus arteriosus (PDA) (P =0.001) or bronchopu- lmonary dysplasia (BPD) (P =0.0001). No significant correlations were found between the occurance of ROP and maternal pre-eclampsia (P =0.293), multiple pregnancy (P = 0.218), or hyperbilirubinemia (P =0.494). Severity of ROP was related significantly with birth weight (P =0.0001), but no significant correlation between severity of ROP and gestational age was present. · CONCLUSION: Early description and reduction of the risk factors related with the occurance of ROP with the help of routine screening programs may warrant the prevention of visual loss, however early ophthalmic diagnosis and treatment are still mandatory to provide better visual rehabilitation. · | Sariaydin Mehmet Atlihan Fusun Calkavur Sebnem Olukman Ozgur Ercan Gulten Ozturk Arif Taylan Kaya Kilic Fatma Gokaslan Filiz Altinyaprak Derya Malatyali Rana | 2011 | International Journal of Ophthalmology(English edition)2011，4，6： | 2 |
| 11 | Finite element simulation of magnesium alloy sheet forming at elevated temperatures显示文摘 | Hariharasudhan Palaniswamy Gracious Ngaile Taylan Altan | 2003 | Journal of Materials Processing Tech2003，，1： | 2 |
| 12 | 新型经脉络膜上腔引流房水植入装置Suprajet的疗效观察(英文)显示文摘目的:评估一种由睫状体前和脉络膜上腔引流房水的新型植入装置Suprajet的有效性和安全性。方法:该项研究使用5只兔子。每只兔子的一眼植入Suprajet。引流器通过位于上方的透明角膜切口,经由前房置入脉络膜上腔。引流器近端位于睫状体根部,远端位于脉络膜上腔。兔子饲养、观察4wk。使用Tonopen AVIA测量术前和术后的眼压。最后一次随访观察时,兔子被牺牲处死,眼球摘除,进行大体上和组织学的观察评估。结果:术前眼压为18.6±6.1mmH g。术后1wk眼压为8.4±1.1mmH g。术后2wk 1只兔子死亡。因此,仅有4只兔子进行了后续观察。术后2wk眼压为11.0±2.8mmH g,术后3wk为9.50±3.1mmH g,术后4wk为11.3±3.3mmH g。与术前平均眼压相比,仅第1周的平均眼压显著降低(P=0.042),术后2wk、3wk和术后4wk的平均眼压无明显变化(P=0.66,P=0.66,P=0.102)。术中并发症包括3眼少量出血。术后2d出血已经完全吸收。对摘除眼球的大体观察发现,1眼中引流器的远端位于玻璃体内,而不是位于脉络膜上腔;其它3眼引流器的远端位于脉络膜上腔。所有眼中,近端都位于前房角。对摘除眼的组织学检查发现:不规则的胶原蛋白束和纤维沉积,包括引流器周围大量的成纤维细胞和组织细胞。结论:这一项初始动物研究显示,青光眼中Suprajet植入是一项有前景的术式。需要进行更进一步的研究以评估其有效性和安全性。 | Uzeyir Gunenc Gul Arikan Ferim Gunenc Banu Lebe Sitki Eren Elvan Ocmen Arif Taylan Ozturk | 2017 | 国际眼科杂志2017，17，10： | 2 |
| 13 | A hybrid methodology of fuzzy grey relation for de- termining multi attribute customer preferences of edible oil original re- search article 显示文摘 | OSMAN TAYLAN | 2013 | Applied Soft Computing2013，13，5： | 1 |
| 14 | Characteristics of invertase partitioned in poly (ethylene glycol)/magnesium sulfate aqueous two-phase system显示文摘 | Taylan Karkas' Sec'il Onal | 2012 | Biochemical EngineeringJournal2012，60，2： | 1 |
| 15 | Freestyle perforator-based V-Y advancement flap for reconstruction of soft tissue defects at various anatomic regions显示文摘 | Yildirim S Taylan G | 2007 | Ann Plast Surg2007，58，5： | 1 |
| 16 | Effects of ultrasound on the reaction step of boric acid production process from colemanite显示文摘 | Taylan N Gurbuz H Bulutcu A N | 2007 | Ultrasonics Sonochemistrv2007，14，5： | 1 |
| 17 | Prediction of forming limits and parameters in the tube hydroforming process 显示文摘 | Muammer Koc Taylan Ahan | 2002 | International Journal of Machine Tools & Manufacture2002，42，1： | 1 |
| 18 | Computer Aided Simulation of Cold Roll Forming-A Computer Program for Simple Section profiles显示文摘 | Taylan Altan | 1996 | Journal of Materials Processing Technology1996，59，： | 1 |
| 19 | Finite element simulation of magnesium alloy sheetforming at elevated temperature显示文摘 | Hariharasudhan Palaniswamy Gracious Ngaile Taylan Altan | 2004 | Journal of Material Processing Technology2004，146，1： | 1 |
| 20 | Overall stability performance of alter- native hull forms 显示文摘 | TAYLAN M | 2002 | Ocean engineering2002，29，13： | 1 |
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