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| 1 | Activation of Defense Response Pathways by OGs and Fig22 Elicitors in Arabidopsis Seedlings显示文摘 | Carine Denoux Roberta Galletti Nicole Mammarella Suresh Gopalan Danièle Werck Giulia De Lorenzo Simone Ferrari Frederick M. Ausubel Julia Dewdney | 2008 | Molecular Plant2008，1，3： | 13 |
| 2 | Chemotherapy for hepatocellular carcinoma:The present and the future显示文摘Hepatocellular carcinoma(HCC) is the most common primary tumor of the liver. Its relationship to chronic liver diseases, in particular cirrhosis, develops on a background of viral hepatitis, excessive alcohol intake or metabolic steatohepatitis, leads to a high incidence and prevalence of this neoplasia worldwide. Despite the spread of HCC, its treatment it's still a hard challenge, due to high rate of late diagnosis and to lack of therapeutic options for advanced disease. In fact radical surgery and liver transplantation, the most radical therapeutic approaches, are indicated only in case of early diagnosis. Even local therapies, such as transarterial chemoembolization, find limited indications, leading to an important problem regarding treatment of advanced disease. In this situation, until terminal HCC occurs, systemic therapy is the only possible approach, with sorafenib as the only standard treatment available. Anyway, the efficacy of this drug is limited and many efforts are necessary to understand who could benefit more with this treatment. Therefore, other molecules for a targeted therapy were evaluated, but only regorafenib showed promising results. Beside molecular target therapy, also cytotoxic drugs, in particular oxaliplatinand gemcitabine-based regimens, and immune-checkpoint inhibitors were tested with interesting results. The future of the treatment of this neoplasia is linked to our ability to understand its mechanisms of resistance and to find novel therapeutic targets, with the objective to purpose individualized approaches to patients affected by advanced HCC. | Marco Le Grazie Maria Rosa Biagini Mirko Tarocchi Simone Polvani Andrea Galli | 2017 | World Journal of Hepatology2017，9，21： | 11 |
| 3 | 863 genomes reveal the origin and domestication of chicken显示文摘Despite the substantial role that chickens have played in human societies across the world,both the geographic and temporal origins of their domestication remain controversial.To address this issue,we analyzed 863 genomes from a worldwide sampling of chickens and representatives of all four species of wild jungle fowl and each of the five subspecies of red jungle fowl(RJF).Our study suggests that domestic chickens were initially derived from the RJF subspecies Gallus gallus spadiceus whose present-day distribution is predominantly in southwestern China,northern Thailand and Myanmar.Following their domestication,chickens were translocated across Southeast and South Asia where they interbred locally with both RJF subspecies and other jungle fowl species.In addition,our results show that the White Leghorn chicken breed possesses a mosaic of divergent ancestries inherited from other subspecies of RJF.Despite the strong episodic gene flow from geographically divergent lineages of jungle fowls,our analyses show that domestic chickens undergo genetic adaptations that underlie their unique behavioral,morphological and reproductive traits.Our study provides novel insights into the evolutionary history of domestic chickens and a valuable resource to facilitate ongoing genetic and functional investigations of the world's most numerous domestic animal. | Ming-Shan Wang Mukesh Thakur Min-Sheng Peng Yu Jiang Laurent Alain Francois Frantz Ming Li Jin-Jin Zhang Sheng Wang Joris Peters Newton Otieno Otecko Chatmongkon Suwannapoom Xing Guo Zhu-Qing Zheng Ali Esmailizadeh Nalini Yasoda Hirimuthugoda Hidayat Ashari Sri Suladari Moch Syamsul Arifin Zein Szilvia Kusza Saeed Sohrabi Hamed Kharrati-Koopaee Quan-Kuan Shen Lin Zeng Min-Min Yang Ya-Jiang Wu Xing-Yan Yang Xue-Mei Lu Xin-Zheng Jia Qing-Hua Nie Susan Joy Lamont Emiliano Lasagna Simone Ceccobelli Humpita Gamaralalage Thilini Nisanka Gunwardana Thilina Madusanka Senasige Shao-Hong Feng Jing-Fang Si Hao Zhang Jie-Qiong Jin Ming-Li Li Yan-Hu Liu Hong-Man Chen Cheng Ma Shan-Shan Dai Abul Kashem Fazlul Haque Bhuiyan Muhammad Sajjad Khan Gamamada Liyanage Lalanie Pradeepa Silva Thi-Thuy Le Okeyo Ally Mwai Mohamed Nawaz Mohamed Ibrahim Megan Supple Beth Shapiro Olivier Hanotte Guojie Zhang Greger Larson Jian-Lin Han Dong-Dong Wu Ya-Ping Zhang | 2020 | Cell Research2020，30，8： | 7 |
| 4 | A new HCV corean antigen assay based on disassociation of imm me complexes : an alternative to molecular biology in the dingnosis of early HCV infection显示文摘 | Aperehe S Le Marrec N Simon N | 2003 | Transfusion2003，3，： | 1 |
| 5 | Systemic microvas- cular shunting through hyperdynamic capillaries after acute physiological disturbances following cardiopulmonary by- pass显示文摘 | Koning NJ Simon LE Asfar P | 2014 | Am J Physiol Heart Circ Physiol2014，307，7： | 1 |
| 6 | The human amygdaia and pain: evidence from neuroimaging 显示文摘 | Simons LE Moulton EA Linnman C | 2014 | Hum Brain Mapp2014，35，2： | 1 |
| 7 | Understanding the pathway between the transplant experience and health-related quality of life outcomes in adolescents 显示文摘 | Simons LE Anglin G Warshaw BL | 2008 | Pediatric Transplant2008，12，2： | 1 |
| 8 | Global quantitative analysis of protein expression and phosphorylation status in the liver of the medaka fish ( Oryzias latipes ) exposed to microcystin-LR显示文摘 | Karim Mezhoud Danièle Praseuth Simone Puiseux-Dao Jean-Christophe Fran?ois Cécile Bernard Marc Edery | 2007 | Aquatic Toxicology2007，，2： | 1 |
| 9 | A new HCV core anti- gen assay based on disassociation of immune complexes: an alternative to molecular biology in the diagnosis of early HCV infection 显示文摘 | Laperche S Le Marrec N Simon N | 2003 | Transfu- sion2003，43，7： | 1 |
| 10 | The use of bacterial spore formers as probiotics显示文摘 | Huynh A. Hong Le Hong Duc Simon M. Cutting | 2004 | FEMS Microbiology Reviews2004，，4： | 1 |
| 11 | Effects of probiotics on the composition of the intestinal microbiota following antibiotic therapy显示文摘 | Susan F. Plummer Iveta Garaiova Tinnu Sarvotham Simon L. Cottrell Stephanie Le Scouiller Mark A. Weaver James Tang Philippa Dee John Hunter | 2005 | International Journal of Antimicrobial Agents2005，，1： | 1 |
| 12 | EULAR Sjogren's Syndrome Disease Activity Index(ESSDAI):Development of a consensus systemic disease activity index in primary Sjogren's syndrome显示文摘 | Raphaèle S Philippe R Simon B | 2010 | Ann Rheum Dis doi2010，，06： | 1 |
| 13 | Optimisation for interconnected energy hub system with combined ground source heat pump and borehole thermal storage显示文摘Ground source heat pumps (GSHP)give zerocarbon emission heating at a residential level.However,as the heat is discharged,the temperature of the ground drops, leading to a poorer efficiency.Borehole inter-seasonal thermal storage coupled with GSHP maintains the efficiency at a high level.To adequately utilize the high performance of combined GSI-IP and the borehole system to further increase system efficiency and reduce cost,such a combined heating system is incorporated into the interconnected multi-carrier system to support the heat load of a community.The borehole finite element (FE) model and an equivalent borehole transfer function are proposed and respectively applied to the optimisation to analyze the variation of GSHP performance over the entire optimisation time horizon of 24h.The results validate the borehole transfer function,and the optimisation computation time is reduced by 17 times compared with the optimisation using the FE model. | Da HUO Wei WEI Simon Le BLOND | 2018 | Frontiers in Energy2018，12，4： | 1 |
| 14 | The sat2002 competition显示文摘 | Simon L Le Berre D Hirsch E | 2005 | Accepted for publication in Annals of Mathematics and Artificial Intelligence(AMAI)2005，43，： | 1 |
| 15 | Parental response to children's pain: The moderating impact of children's emotional distress on symptoms and disability 显示文摘 | Claar RL Simons LE Logan DE | 2008 | Pain2008，138，1： | 1 |
| 16 | Premixed calcium phosphate cements: synthesis, physical properties, and cell cytotoxicity显示文摘 | Xu HH Carey LE Jr Simon CG | 2007 | Dent Mater2007，23，4： | 1 |
| 17 | Gut Hormone Profiles Following Bariatric Surgery Favor an Anorectic State, Facilitate Weight Loss, and Improve Metabolic Parameters显示文摘 | Carel W. le Roux Simon J. B. Aylwin Rachel L. Batterham Cynthia M. Borg Frances Coyle Vyas Prasad Sandra Shurey Mohammad A. Ghatei Ameet G. Patel Stephen R. Bloom | 2006 | Annals of Surgery2006，，1： | 1 |
| 18 | The SSN ontology of the W3C semantic sensor network incubator group显示文摘 | Michael Compton Payam Barnaghi Luis Bermudez Raúl García-Castro Oscar Corcho Simon Cox John Graybeal Manfred Hauswirth Cory Henson Arthur Herzog Vincent Huang Krzysztof Janowicz W. David Kelsey Danh Le Phuoc Laurent Lefort Myriam Leggieri Holger Neuhaus A | 2012 | Web Semantics: Science Services and Agents on the World Wide Web2012，，： | 1 |
| 19 | Premixed rapid-setting calcium phosphate composites for bone repair显示文摘 | Carey LE Xu HK Simon CG | 2005 | Biomaterials2005，26，24： | 1 |
| 20 | A study of 609 HLA haplotypes marking for the hemoehromatosis gene: (1) mapping of the gene near the HLA-A locus and characters required to define a heterozygous population and (2) hypothesis concerning the underlying cause oS hemochromatosis-HLA association 显示文摘 | Simon M Le Mignon L Fauchet R | 1987 | Am J Hum Genet1987，41，89： | 1 |
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