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| 1 | Effect of dephytinization on bioavailability of iron,calcium and zinc from infant cereals assessed in the Caco-2 cell model显示文摘AIM:To test the effect of the dephytinization of three different commercial infant cereals on iron, calcium, and zinc bioavailability by estimating the uptake, retention, and transport by Caco-2 cells.METHODS:Both dephytinized (by adding an exogenous phytase) and non-dephytinized infant cereals were digested using an in vitro digestion protocol adapted to the gastrointestinal conditions of infants younger than 6 mo. Mineral cell retention, transport, and uptake from infant cereals were measured using the soluble fraction of the simulated digestion and the Caco-2 cells. RESULTS: Dephytinization of infant cereals significantly increased (P<0.05) the cell uptake efficiency (from 0.66%-6.05% to 3.93%-13%), retention (from 6.04%-16.68% to 14.75%-20.14%) and transport efficiency (from 0.14%-2.21% to 1.47%-6.02%), of iron, and the uptake efficiency (from 5.0%-35.4% to 7.3%-41.6%) and retention (from 4.05%-20.53% to 14.45%-61.3%) of zinc, whereas calcium only cell uptake showed a significant increase (P<0.05) after removing phytate from most of the samples analyzed. A positive relationship (P<0.05) between mineral solubility and the cell uptake and transport efficiencies was observed.CONCLUSION: Removing phytate from infant cereals had a beneficial effect on iron and zinc bioavailability when infant cereals were reconstituted with water. Since in developing countries cereal-based complementary foods for infants are usually consumed mixed with water, exogenous phytase additions could improve the nutritional value of this weaning food. | Carmen Frontela Maria Laura Scarino Simonetta Ferruzza Gaspar Ros Carmen Martínez | 2009 | World Journal of Gastroenterology2009，15，16： | 7 |
| 2 | When sepsis affects the heart: A case report and literature review显示文摘A 59-year-old nursing home patient with Down syndrome was brought to the internal medicine department of our hospital due to fever, cough without expectorate, and dyspnea. A thoracic computed tomography revealed the presence of bilateral basal parenchymal opacities. Her condition deteriorated after admission and troponin reached a peak serum concentration of 16.9 ng/m L. The patient was in cardiogenic shock. In addition to fluid resuscitation, vaso-active amine infusion was administered to achieve hemodynamic stabilization. The differential diagnosis investigated possible pulmonary embolism, myocardial infarction, and myocarditis. Furthermore, a second transthoracic echocardiogram suggested Tako-Tsubo syndrome. This is a septic patient. The purpose of this manuscript is to review studies which formerly examined the possible association between high levels of troponin and mortality to see if it can be considered a positive predictive factor of fatal prognosis as the case of thrombocytopenia, already a positive independent predictive factor of multiple organ failure syndrome, and generally to characterize risk profile in a septic patient. | Giuseppe Clemente Antonino Tuttolomondo Daniela Colomba Rosaria Pecoraro Chiara Renda Vittoriano Della Corte Carlo Maida Irene Simonetta Antonio Pinto | 2015 | World Journal of Clinical Cases2015，3，8： | 5 |
| 3 | Sonic hedgehog signaling controls dentate gyrus patterning and adult neurogenesis in the hippocampus显示文摘The morphogen Sonic Hedgehog(Shh)plays a critical role in the development of different tissues,both in invertebrates and vertebrates.Shh mediates its action via a receptor complex associating two transmembrane proteins:Patched1(Ptch1)and Smoothened(Smo).The repression exerted by Ptch1 on Smo is relieved when Shh,the ligand,binds to Ptch1,which leads to a complex signaling cascade involving the transcription factors of the Gli family and finally,to | Francesca Antonelli Arianna Casciati Simonetta Pazzaglia | 2019 | Neural Regeneration Research2019，14，1： | 4 |
| 4 | Instrumental and bio-monitoring of heavy metal and nanoparticle emissions from diesel engine exhaust in controlled environment显示文摘In the present article we characterized the emissions at the exhaust of a Common Rail (CR) diesel engine, representative of lightduty class, equipped with a catalyzed diesel particulate filter (CDPF) in controlled environment. The downstream exhausts were directly analyzed (for PM, CO, CO2, O2, HCs, NOx) by infrared and electrochemical sensors, and SEM-EDS microscope; heavy metals were chemically analyzed using mosses and lichens in bags, and glass-fibre filters all exposed at the engine exhausts. The highest particle emission value was in the 7–54 nm size range; the peak concentration rose until one order of magnitude for the highest load and speed. Particle composition was mainly carbonaceous, associated to noticeable amounts of Fe and silica fibres. Moreover, the content of Cu, Fe, Na, Ni and Zn in both moss and lichen, and of Al and Cr in moss, was significantly increased. Glass-fibre filters were significantly enriched in Al, B, Ba, Cu, Fe, Na, and Zn. The role of diesel engines as source of carbonaceous nanoparticles has been confirmed, while further investigations in controlled environment are needed to test the catalytic muffler as a possible source of silica fibres considered very hazardous for human health. | Simonetta Giordano Paola Adamo Valeria Spagnuolo Bianca Maria Vaglieco | 2010 | Journal of Environmental Sciences2010，22，9： | 2 |
| 5 | Hepato-splenic lymphoma:a rare entity mimicking acute hepatitis:A case report显示文摘We reported a case of non-Hodgkin's lymphoma where liver involvement was the predominant clinical manifestation. A 27-year old man presented wiht markedly elevated serum aspartate aminotrasferase, alanine aminotransferase and lactate dehydrogenase, reduced prothrombin activity, thrombocytopenic purpura and hepato-splenomegaly without adenopathy. Viral, toxic,autoimmune and metabolic liver diseases were excluded.Bone marrow biopsy showed an intracapillary infiltration of T-lymphocytes with no evidence of lipid storage disease.Because of a progressive spleen enlargement, splenectomy was performed. Histological examination showed lymphomatous intrasinuses invasion of the spleen.Immunohistochemical investigation revealed the T phenotype of the neoplastic cells: CD45+, CD45RO+,CD3+, CD4-, CD8-, TIA1-. About 50 % of the lymphoid cells expressed CD56 antigen. The diagnosis of hepatosplenic T cell lymphoma was done. The patient was treated with chemotherapy, which induced a complete remission. Eighteen months later, he had a first relapse with increased aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase,thrombocytopenic purpura and blast in the peripheral blood.In spite of autologous bone marrow transplantation, he died twenty months after the diagnosis. Even in the absence of a mass lesion or lymphoadenopathy, hepatosplenic Tcell lymphoma should be considered in the differential diagnosis of a patient whose clinical course is atypical for acute hepatic dysfunction. | Federico Perfetto Roberto Tarquini Francesco Mancuso Simonetta di Lollo Silvia Tozzini Giampiero Bellesi Giacomo Laffi | 2003 | World Journal of Gastroenterology2003，9，6： | 2 |
| 6 | From chronic liver disorders to hepatocellular carcinoma: Molecular and genetic pathways显示文摘Hepatocarcinogenesis is a process attributed to progressive genomic changes that alter the hepatocellular phenotype producing cellular intermediates that evolve into hepatocellular carcinoma (HCC). During the preneoplastic phase, the liver is often the site of chronic hepatitis and/or cirrhosis, and these conditions induce liver regeneration with accelerated hepatocyte cycling in an organ that is otherwise proliferatively at rest. Hepatocyte regeneration is accelerated by upregulation of mitogenic pathways involving molecular and genetic mechanisms. Hepatic growth factors, inhibitors and triggers may also play a role. This process leads to the production of monoclonal populations of aberrant and dysplastic hepatocytes that have telomerase reexpression, microsatellite instability, and occasionally structural aberrations in genes and chromosomes. Development of dysplastic hepatocytes in foci and nodules and the emergence of HCC are associated with the accumulation of irreversible structural alterations in genes and chromosomes even if the genomic basis of the malignant phenotype is largely heterogeneous. Therefore, a malignant hepatocyte phenotype may be produced by changes in genes acting through different regulatory pathways, thus producing several molecular variants of HCC. On these bases, a key point for future research will be to determine whether the deletions are specific, due to particular loci in the minimally deleted regions of affected chromosome arms, or whether they are nonspecific with loss of large portions of chromosomes or entire chromosome arms leading to passive deletion of loci. The final aim is the possibility of identifying a step where carcinogenetic processes could be terminated. | Enzo Ierardi Rosa Rosania Mariangela Zotti Floriana Giorgio Simonetta Prencipe Nicola Della Valle Vincenzo De Francesco Carmine Panella | 2010 | World Journal of Gastrointestinal Oncology2010，2，6： | 2 |
| 7 | Usefulness of ultrasound lung comets as a nonradiologic sign of extravascular lung water显示文摘 | Zoltan Jambrik Simonetta Monti Vincenzo Coppola Eustachio Agricola Gaetano Mottola Massimo Miniati Eugenio Picano | 2004 | The American Journal of Cardiology2004，，10： | 2 |
| 8 | Midterm assessment of the host population's perceptions of 1996 Summer Olympics: Support, attendance,benefits, and liabilities显示文摘 | Mihalik B J Simonetta L | 1999 | Journal of Travel Research1999，37，2： | 1 |
| 9 | Comparison of 3 clinical models for predicting the probability of pulmonary embolism 显示文摘 | Massimo Miniati Matteo Bottai Simonetta Monti | 2005 | Medicine2005，84，2： | 1 |
| 10 | Intracellular zinc is required for intestinal cell survival signals triggered by the inflammatory cytokine TNFα显示文摘 | Giulia Ranaldi Simonetta Ferruzza Raffaella Canali Guido Leoni Peter D. Zalewski Yula Sambuy Giuditta Perozzi Chiara Murgia | 2013 | The Journal of Nutritional Biochemistry2013，，6： | 1 |
| 11 | The Incentives Balance Test in the EU Microsoft Case: A Pro-innovation 'Economics-based' Approach? 显示文摘 | Simonetta Vezzoso | 2006 | ECLR2006，，： | 1 |
| 12 | A method to assess genomic DNA methylation using highperformance liquid chromatography/electrospray ionization mass spectrometry显示文摘 | Simonetta F Sang-Woon Choi Gregory G | 2002 | Anal Chem2002，74，： | 1 |
| 13 | Electrochemical treatment as a pre-oxidative step for algae removal using Chlorella vulgaris as a model organism and BDD anodes显示文摘 | Michele Mascia Annalisa Vacca Simonetta Palmas | | 0，，： | 1 |
| 14 | Innovative magnetic resonance imaging diagnostic agents based on paramagnetic Gd(Ⅲ)complexes显示文摘 | Silvio A Walter D Simonetta GC | 2002 | Peptide Science2002，66，6： | 1 |
| 15 | A midterm assessment of host population's perceptions of the 1996 Summer Olympics: support, attendance,benefits and liabilities显示文摘 | Mihalik B J Simonetta L | 1998 | Journals of Travel Research1998，37，2： | 1 |
| 16 | Are HLA class II and immunoglobulin constant region genes involved in the pathogenesis of mixed cryoglobulinemia type II after hepatitis C virus infection?显示文摘 | Antonio Amoroso Monica Berrino Lorena Canale Maura Cornaglia Simonetta Guarrera Gina Mazzola Silvana Savoldi Francesco Scolari Matti S?llberg Massimo Clementi Armando Gabrielli | 1998 | Journal of Hepatology1998，，1： | 1 |
| 17 | Aroma analysis by GC/MS and electronic nose dedicated to Negroamaro and Primitivo typical Italian Apulian wines显示文摘 | Simonetta Capone Maria Tufariello Luca Francioso Giovanni Montagna Flavio Casino Alessandro Leone Pietro Siciliano | 2012 | Sensors & Actuators: B Chemical2012，，： | 1 |
| 18 | Interleu- kin 7 influences FOXP3 + CD4+ regulatory T cells pe- ripheral homeostasis显示文摘 | Simonetta F Gestermann N Martinet KZ | 2012 | PLoS One2012，7，36： | 1 |
| 19 | Restriction of fetal growth has a differential impact on fetal prolactin and prolactin receptor mRNA expression显示文摘 | Phillips ID Anthony RY Simonetta G | 2001 | J Neuroendocrinol2001，13，2： | 1 |
| 20 | Methotrexate-induced toxic leukoencephalopathy显示文摘 | GOWAN G M HERRINGTON J D SIMONETTA A B | 2002 | Pharmacotherapy2002，22，9： | 1 |
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