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| 1 | Effect of dephytinization on bioavailability of iron,calcium and zinc from infant cereals assessed in the Caco-2 cell model显示文摘AIM:To test the effect of the dephytinization of three different commercial infant cereals on iron, calcium, and zinc bioavailability by estimating the uptake, retention, and transport by Caco-2 cells.METHODS:Both dephytinized (by adding an exogenous phytase) and non-dephytinized infant cereals were digested using an in vitro digestion protocol adapted to the gastrointestinal conditions of infants younger than 6 mo. Mineral cell retention, transport, and uptake from infant cereals were measured using the soluble fraction of the simulated digestion and the Caco-2 cells. RESULTS: Dephytinization of infant cereals significantly increased (P<0.05) the cell uptake efficiency (from 0.66%-6.05% to 3.93%-13%), retention (from 6.04%-16.68% to 14.75%-20.14%) and transport efficiency (from 0.14%-2.21% to 1.47%-6.02%), of iron, and the uptake efficiency (from 5.0%-35.4% to 7.3%-41.6%) and retention (from 4.05%-20.53% to 14.45%-61.3%) of zinc, whereas calcium only cell uptake showed a significant increase (P<0.05) after removing phytate from most of the samples analyzed. A positive relationship (P<0.05) between mineral solubility and the cell uptake and transport efficiencies was observed.CONCLUSION: Removing phytate from infant cereals had a beneficial effect on iron and zinc bioavailability when infant cereals were reconstituted with water. Since in developing countries cereal-based complementary foods for infants are usually consumed mixed with water, exogenous phytase additions could improve the nutritional value of this weaning food. | Carmen Frontela Maria Laura Scarino Simonetta Ferruzza Gaspar Ros Carmen Martínez | 2009 | World Journal of Gastroenterology2009，15，16： | 7 |
| 2 | Intracellular zinc is required for intestinal cell survival signals triggered by the inflammatory cytokine TNFα显示文摘 | Giulia Ranaldi Simonetta Ferruzza Raffaella Canali Guido Leoni Peter D. Zalewski Yula Sambuy Giuditta Perozzi Chiara Murgia | 2013 | The Journal of Nutritional Biochemistry2013，，6： | 1 |
| 3 | Intestinal cell culture models: Applications in toxicology and pharmacology显示文摘 | Yula S Ferruzza S Ranaldi G | 2001 | CellBiol Toxicol2001，17，： | 1 |
| 4 | Effects of red wine on ochratoxin A toxicity in intestinal Caco-2/TC7 cells显示文摘 | G. Ranaldi E. Mancini S. Ferruzza Y. Sambuy G. Perozzi | 2006 | Toxicology in Vitro2006，，2： | 1 |
| 5 | Intestinal cell culture models: applications in toxicology and pharmacology 显示文摘 | Sambuy Y Ferruzza S Ranaldi G | 2001 | Cell Biol Toxicol2001，17，： | 1 |
| 6 | Serum-reduced and serum-free media for differentiation of Caco-2 cells显示文摘 | Ferruzza S Rossi C Sambuy Y | | 0，，： | 1 |
| 7 | The transport of lysine across monolayers of human cultured intestinal cells (Caco-2)depends on Napositive-dependent and Napositive-independent mechanisms on different plasma membrane domains显示文摘 | Ferruzza Simonetta Ranaldi | 1995 | Journal of Nutrition1995，125，10： | 1 |
| 8 | Metal chelates of 2 - hydroxy - 4 - methylthiobutanoie acid in animal feeding: preliminary investigations on stability and bioavailability显示文摘 | Predieri G Tegoni M Cinti E Leonardi G Ferruzza S | 2003 | Journal of Inorganic Biochemistry2003，95，： | 1 |
| 9 | Intestinal cell culture models: applications In oxicology and pharmacology 显示文摘 | Sambuy Y Ferruzza S Ranaldi G | 2001 | Cell Biol Toxicol2001，17，： | 1 |
| 10 | Metal chelates of 2 - hydroxy -4 - methylthiobutanoic acid in animal feeding: Part 2:further characterizations,in vitro and in vivo investigations 显示文摘 | Predieri G Elviri L Tegoni M Zagnoni I Cinti E Biagi G Ferruzza S Leonardi G | 2005 | Journal of Inorganic Biochemistry2005，99，： | 1 |
| 11 | Effects of red wine on ochratoxin A toxicity in intestinal Caco-2/TC7 cells显示文摘 | G. Ranaldi E. Mancini S. Ferruzza Y. Sambuy G. Perozzi | 2006 | Toxicology in Vitro2006，，2： | 1 |
| 12 | Mechanisms of defence from Fe(II)toxicity in human intestinal Caco-2 cells显示文摘 | Natoli M Felsani A Ferruzza S | | 0，，08： | 1 |
| 13 | Copper treatment alters the permeability of tight junctions in cultured human intestinal Caco-2 cells显示文摘 | Ferruzza S Scarino M L Rotilio G | 1968 | American Journal of Physiology1968，28，3： | 1 |
| 14 | Intracellular zinc is required for intestinal cell survival signals triggered by the inflammatory cytokine TNFα显示文摘 | Ranaldi G Ferruzza S Canali R | 2013 | The Journal of nutritional biochemistry2013，24，6： | 1 |
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