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| 1 | Lipid peroxidation and antioxidant status in colorectal cancer显示文摘AIM: Reactive oxygen species (ROS) can induce carcinogenesis via DNA injury. Both enzymatic and non-enzymatic parameters participate in cell protection against harmful influence of oxidative stress. The aim of the present study was to assess the levels of final lipid peroxidation products like malondialdehyde (MDA) and 4-hydroxy-2-nonenal (4-HNE) in primary colorectal cancer. Moreover, we analysed the activity of main antioxidative enzymes, superoxide dismutase (Cu, Zn-SOD),catalase (CAT), glutathione peroxidase (GSH-Px) and glutathione reductase (GSSRG-R) and the level of nonenzymatic antioxidants (glutathione, vitamins C and E).METHODS: Investigations were conducted in 81 primary colorectal cancers. As a control, the same amount of sample was collected from macroscopically unchanged colon regions of the most distant location to the cancer.Homogenisation of specimens provided 10% homogenates for our evaluations. Activity of antioxidant enzymes and level of glutathione were determined by spectrophotometry.HPLC revealed levels of vitamins C and E and served as a method to detect terminal products of lipid peroxidation in colorectal cancer.RESULTS: Our studies demonstrated a statistically significant increase in the level of lipid peroxidation products (MDA-Adc.muc.-2.65±0.48 nmol/g, Adc. G3-2.15±0.44 nmol/g, clinical Ⅳ stage 4.04±0.47 nmol/g, P<0.001 and 4-HNE-Adc.muc.-0.44±0.07 nmol/g, Adc. G3-0.44±0.10 nmol/g, clinical Ⅳstage 0.52±0.11 nmol/g, P<0.001) as well as increase of Cu,Zn-SOD (Adc.muc.-363±72 U/g, Adc. G3-318±48 U/g,clinical Ⅳ stage 421±58 U/g, P<0.001), GSH-Px (Adc.muc.-2143±623 U/g, Adc. G3-2005±591 U/g, clinical Ⅳ stage 2467±368 U/g, P<0.001) and GSSG-R (Adc. muc.-880±194 U/g,Adc. G3-795±228 U/g, dinical Ⅳ stage 951±243 U/g, P<0.001)in primary tumour comparison with normal colon (MDA1.39±0.15 nmol/g, HNE-0.29±0.03 nmol/g, Cu, Zn-SOD-117±25 U/g, GSH-Px-1723±189 U/g, GSSG-R-625±112 U/g)especially in mucinous and G3-grade adenocarcinomas as well as clinical Ⅳ stage of colorectal cancer. We also observed a decrease of CAT activity (Adc.muc. -40±14 U/g,clinical Ⅳ stage 33±18 U/g vs84±17 U/g, P<0.001) as well as a decreased level of reduced glutathione (clinical Ⅳ stage 150±48 nmol/g vs 167±15 nmol/g, P<0.05) and vitamins C and E (vit. C-clinical Ⅳ stage 325±92 nmol/g vs 513±64 nmol/g, P<0.001; vit. E-clinical Ⅳ stage 13.3±10.3nmol/g vs37.5±5.2 nmol/g).CONCLUSION: Colorectal carcinogenesis is associated with serious oxidative stress and confirms that gradual advancement of oxidative-antioxidative disorders is followed by progression of colorectal cancer. | Elzbieta Skrzydlewska Stanislaw Sulkowski Mariusz Koda Bogdan Zalewski Luiza Kanczuga-Koda Mariola Sulkowska | 2005 | World Journal of Gastroenterology2005，11，3： | 12 |
| 2 | Levels of v5 and v6 CD44 splice variants in serum of patients with colorectal cancer are not correlated with pT stage,histopathological grade of malignancy and clinical features显示文摘AIM:This study was designed to compare the levels of v5 and v6 splice variants of CD44 evaluated using ELISA test in the serum of patients with colorectal cancer in different stages of progression of the disease estimated in pT stage according to WHO score, histopathological grade of malignancy and some clinicopathological features.METHODS:The serum obtained from 114 persons with colorectal adenocarcinomas was examined using ELISA method, pT stage and grade of malignancy of the tumour were examined in formalin fixed and paraffin embedded materials obtained during operation.RESULTS:Only the level of CD44 v5 in the serum of patients before operation with G2 pT4 tumour was lower than that in other probes and the difference was statistically significant.We did not find any other correlations between the level of v5 and v6 CD44 variants and other evaluated parameters.CONCLUSION:The level of CD44 v5 and v6 estimated by ELISA test in the serum can not be used as a prognostic factor in colorectal cancer. | Bogdan Zalewski | 2004 | World Journal of Gastroenterology2004，10，4： | 8 |
| 3 | Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: Rationale and Design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)显示文摘 | Paul M Ridker Tom Thuren Andrew Zalewski Peter Libby | 2011 | American Heart Journal2011，，4： | 2 |
| 4 | SLC26A4 mutation testing for hearing loss associated with enlargement of the vestibular aqueduct显示文摘Pendred syndrome(PS) is characterized by autosomal recessive inheritance of goiter associated with a defect of iodide organification, hearing loss, enlargement of the vestibular aqueduct(EVA), and mutations of the SLC26A4 gene. However, not all EVA patients have PSor SLC26A4 mutations. Two mutant alleles of SLC26A4 are detected in 1/4 of North American or European EVA populations, one mutant allele is detected in another 1/4 of patient populations, and no mutations are detected in the other 1/2. The presence of two mutant alleles of SLC26A4 is associated with abnormal iodide organification, increased thyroid gland volume, increased severity of hearing loss, and bilateral EVA. The presence of a single mutant allele of SLC26A4 is associated with normal iodide organification, normal thyroid gland volume, less severe hearing loss and either bilateral or unilateral EVA. When other underlying correlations are accounted for, the presence of a cochlear malformation or the size of EVA does not have an effect on hearing thresholds. This is consistent with observations of an Slc26a4 mutant mouse model of EVA in which hearing loss is independent of endolymphatic hydrops or inner ear malformations. Segregation analyses of EVA in families suggest that the patients carrying one mutant allele of SLC26A4 have a second, undetected mutant allele of SLC26A4, and the probability of a sibling having EVA is consistent with its segregation as an autosomal recessive trait. Patients without any mutations are an etiologically heterogeneous group in which siblings have a lower probability of having EVA. SLC26A4 mutation testing can provide prognostic information to guide clinical surveillance and management, as well as the probability of EVA affecting a sibling. | Taku Ito Julie Muskett Parna Chattaraj Byung Yoon Choi Kyu Yup Lee Christopher K Zalewski Kelly A King Xiangming Li Philine Wangemann Thomas Shawker Carmen C Brewer Seth L Alper Andrew J Griffith | 2013 | World Journal of Otorhinolaryngology2013，3，2： | 2 |
| 5 | Ecohydrology — the scientific background to use ecosystem properties as management tools toward sustainability of water resources显示文摘 | Maciej Zalewski | 2000 | Ecological Engineering2000，，1： | 2 |
| 6 | Intracellular zinc is required for intestinal cell survival signals triggered by the inflammatory cytokine TNFα显示文摘 | Giulia Ranaldi Simonetta Ferruzza Raffaella Canali Guido Leoni Peter D. Zalewski Yula Sambuy Giuditta Perozzi Chiara Murgia | 2013 | The Journal of Nutritional Biochemistry2013，，6： | 1 |
| 7 | Thermal and hemodynamicresponse to whole-body cryostimulation in healthy subjects显示文摘 | Zalewski P Klawe JJ Pawlak J | 2013 | Cryobiology2013，66，3： | 1 |
| 8 | Interleukin-lbeta inhi- bition and the prevention of recurrent cardiovascular events : ration- ale and design of the canakinumab anti-inflammatory thrombosis outcomes study (CANTOS) 显示文摘 | Ridker PM Thuren T Zalewski A | 2011 | Am Heart J2011，162，4： | 1 |
| 9 | Plasma vegf-a and its soluble receptor r1 correlate with the clinical stage of colorectal cancer显示文摘 | Mysliwiec P Piotrowski Z Zalewski B | 2004 | Rocz Akad Med Bialymst2004，49，1： | 1 |
| 10 | Zinc metabolism in airway epithelium and airway inflammation: Basic meehanisrns and clinical targets显示文摘 | Zalewski PD Truong - Tran AQ Grosser D | 2005 | Pharmacol Therapeut2005，105，2： | 1 |
| 11 | Role of lipoprotein-associated phospholipase A2 in atherosclerosis and its potential as a therapeutic target 显示文摘 | Macphee CH Nelson J Zalewski R | 2006 | Current Opinion in Pharmacology2006，6，2： | 1 |
| 12 | Role of lipoprotein-associated phospholipase A2 in atherosclerosis and its potential as a therapeutic target显示文摘 | Macphee CH Nelson J Zalewski A | 2006 | Curr Opin Pharmacol2006，6，2： | 1 |
| 13 | Human epicardial adipose tissue is a source of inflammatory mediators 显示文摘 | Mazurek T Zhang L Zalewski A | 2003 | Circulation2003，108，20： | 1 |
| 14 | Spectral resPonse self-calibration and interpolation of silicon photodiodes 显示文摘 | Geist J Zalewski E F Schaefer A R | 1980 | Applied Optics1980，19，22： | 1 |
| 15 | Apoptotic effect of cyanobacterial extract on rat hepatocytes and human lymphocytes显示文摘 | Mankiewicz J Tarczynska M Fladmark KE Doskeland SO Walter Z Zalewski M | 2001 | Environ Toxicol2001，16，3： | 1 |
| 16 | MDR - 1 gene polymorphisms and clinical course of steroid - responsive nephrotic syndrome in children显示文摘 | Wasilewska A Zalewski G Chyczewski L | 2007 | Pediatr Nephrol2007，22，1： | 1 |
| 17 | Lipoprotein-associated phospholipase A2(Lp-PLA2) activity, an emerging CV risk marker, can be inhibited in atherosclerotic lesions and plasma by novel phar- macologic intervention : The results of a muhicenter clinical study显示文摘 | Johnson A Zalewski A Janmohamed S | 2004 | Circulation2004，110，： | 1 |
| 18 | Rationale for the 'Floodplain Declaration' from environmental conservation toward sustainability science显示文摘 | Zalewski M | | 0，，： | 1 |
| 19 | Proton induced radiation effects on optical glasses显示文摘 | Silverglate P Zalewski E Petrone P | | 0，，： | 1 |
| 20 | Ecohydrology:The scientific background to use ecosystem properties as management tools toward sustainability of water resources显示文摘 | Zalewski M | | 0，，01： | 1 |
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