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| 1 | Bile acids evoke placental inflammation by activating Gpbar1/NF-κB pathway in intrahepatic cholestasis of pregnancy显示文摘Intrahepatic cholestasis of pregnancy(ICP)is a cholestatic disorder with potentially deleterious consequences for fetuses.Although a clear correlation between the elevated levels of maternal serum bile acids and deficient fetal outcome has been established in clinical practice,the underlying mechanisms remain elusive.Herein,we report that bile acids induce NF-κB pathway activation via G protein-coupled bile acid receptor 1(Gpbar1),with consequent upregulation of inflammatory genes in trophoblasts,leading to aberrant leukocyte infiltration and inflammation in placenta.Ursodeoxycholic acid(UDCA),a drug used clinically to treat ICP,competes with other bile acids for binding with Gpbar1 and thus inhibits bile acid-induced inflammatory response in trophoblasts and improves fetal survival in pregnant rats with obstructive cholestasis.Notably,inhibition of NF-κB by andrographolide is more effective than UDCA in benefiting placentas and fetuses.Thus,anti-inflammation therapy targeting Gpbar1/NF-κB pathway could be effective in suppressing bile acid-induced inflammation and alleviating ICP-associated fetal disorders. | YouHua Zhang YouDong Pan ChangDong Lin YaJuan Zheng Hao Sun HaiLong Zhang JunLei Wang MengYa Yuan Tao Duan QiaoLing Du JianFeng Chen | 2016 | Journal of Molecular Cell Biology2016，8，6： | 8 |
| 2 | IntegrinαEβ7^(+)T cells direct intestinal stem cell fate decisions via adhesion signaling显示文摘Intestinal stem cell(ISC)differentiation is regulated precisely by a niche in the crypt,where lymphocytes may interact with stem and transient amplifying(TA)cells.However,whether and how lymphocyte–stem/TA cell contact affects ISC differentiation is largely unknown.Here,we uncover a novel role of T cell–stem/TA cell contact in ISC fate decisions.We show that intestinal lymphocyte depletion results in skewed ISC differentiation in mice,which can be rescued by T cell transfer.Mechanistically,integrinαEβ7 expressed on T cells binds to E-cadherin on ISCs and TA cells,triggering E-cadherin endocytosis and the consequent Wnt and Notch signaling alterations.BlockingαEβ7−E-cadherin adhesion suppresses Wnt signaling and promotes Notch signaling in ISCs and TA cells,leading to defective ISC differentiation.Thus,αEβ7^(+)T cells regulate ISC differentiation at single-cell level through cell–cell contact-mediatedαEβ7−E-cadherin adhesion signaling,highlighting a critical role of the T cell–stem/TA cell contact in maintaining intestinal homeostasis. | Shiyang Chen Yajuan Zheng Xiaojuan Ran Hui Du Hua Feng Lei Yang Yating Wen Changdong Lin Shihui Wang Mengwen Huang Zhanjun Yan Dianqing Wu Hongyan Wang Gaoxiang Ge An Zeng Yi Arial Zeng Jianfeng Chen | 2021 | Cell Research2021，31，12： | 3 |
| 3 | Ceftazidime is a potential drug to inhibit SARS-CoV-2 infection in vitro by blocking spike protein-ACE2 interaction显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)has spread globally as a severe pandemic,which is caused by a novel coronavirus named Severe Acute Respiratory Syndrome coronavirus 2(SARS-CoV-2).1 COVID-19 is a serious threat to healthcare systems,economies,and is devastating to some populations,such as the elderly and those with comorbidities.It is likely to coexist with human beings for a long time.Unfortunately,there is still no effective cure for COVID-19,especially the critically ill patients. | ChangDong Lin Yue Li YueBin Zhang ZhaoYuan Liu Xia Mu Chenjian Gu Jing Liu Yutang Lr GuoHui Li JianFeng Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 4 | Protein C receptor is a therapeutic stem cell target in a distinct group of breast cancers显示文摘Breast cancer is a heterogeneous disease.In particular,triple-negative breast cancer(TNBC)comprises various molecular subgroups with unclear identities and currently has few targeted treatment options.Our previous study identified protein C receptor(Procr)as a surface marker on mammary stem cells(MaSCs)located in the basal layer of the normal mammary gland.Given the possible connection of TNBC with basal layer stem cells,we conducted comparative analyses of Procr in breast cancers of mouse and human origin.In mouse mammary tumors,we showed that Procr+cells are enriched for cancer stem cells(CSCs)in Wnt1 basal-like tumors,but not in Brea basal-like tumors or PyVT luminal tumors.In human cancers,PROCR was robustly expressed in half of TNBC cases.Experiments with patient-derived xenografts(PDXs)revealed that PROCR marks CSCs in this discrete subgroup(referred to as PROCR+TNBC).Interfering with the function of PROCR using an inhibitory nanobody reduced the CSC numbers,arrested tumor growth and prevented rapid tumor recurrence.Our data suggest a key role of MaSC in breast tumorigenesis.Moreover,our work indicates that PROCR can be used as a biomarker to stratify TNBC into clinically relevant subgroups and may provide a novel targeted treatment strategy for this clinically important tumor subtype. | Daisong Wang Xin Hu Chunye Liu Yingying Jia Yiqin Bai Cheguo Cai Jingqiang Wang Lanyue Bai Ruikai Yang ChangDong Lin Yi-Rong Liu Shan Li Feng Qiao Ling Yao Li Chen Gaoxiang Ge Hai Jiang Dianfan Li Lin Li JianFeng Chen Zhi-Ming Shao Yi Arial Zeng | 2019 | Cell Research2019，29，10： | 2 |
| 5 | Study onSwitching Characteristics of Reversely Switched Dynistor with N Buffer Layer显示文摘 | Lin Liang Cheng Liu Changdong Chen | | lEEE Transaction on Plasma Science0，，： | 1 |
| 6 | Correction To:Ceftazidime is a potential drug to inhibit SARS-CoV-2 infection in vitro by blocking spike protein-ACE2 interaction显示文摘After online publication of the article1 we noticed an error in citations for affiliation in the supplementary materials published in this article.The citations for affiliation in the article were reordered during the production process to match the order of authors in the author group.Unfortunately,this was not reflected in the supplementary material. | ChangDong Lin Yue Li YueBin Zhang ZhaoYuan Liu Xia Mu Chenjian Gu Jing Liu Yutang Li GuoHui Li JianFeng Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，7： | 0 |
| 7 | Distinct chemokines selectively induce HIV-1 gp120-integrinα4β7 binding via triggering conformer-specific activation ofα4β7显示文摘Dear Editor,Gut associated lymphoid tissue(GALT)is the principal site where human immunodeficiency virus 1(HIV-1)replicates.CD4^(+) T cells residing in GALT are predominant targets of HIV-1 during the acute phase of infection.CD4^(+) T cells expressing a high level of gut-homing receptor integrin α4β7 are more susceptible to productive infection by HIV-1. | Shu Wang ChangDong Lin Yue Li ZhaoYuan Liu JunLei Wang YouHua Zhang ZhanJun Yan YueBin Zhang GuoHui Li JianFeng Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 0 |
| 8 | Identification and characterization of a monoclonal antibody blocking the SARS-CoV-2 spike protein–ACE2 interaction显示文摘Because COVID-19 has spread as a global pandemic,the development of therapeutics for this disease,such as neutralizing antibodies that can efficiently block SARS-CoV-2 infection,is urgently needed.During the infection of host cells by SARS-CoV-2,the spike(S)glycoprotein of SARS-CoV-2 plays the most crucial roles in viral entry and cell fusion.The S protein includes two components,the S1 and S2 subunits.The S1 subunit is vital in determining tissue tropism and host ranges and consists of the N-terminal domain and C-terminal receptor-binding domain(RBD).1,2 Of note,the RBD of the S protein(S-RBD)supports the binding of the S protein to angiotensin-converting enzyme 2(ACE2)on host cells,contributing to cell entry by SARS-CoV-2.3 Therefore,the S-RBD is widely used for the development of neutralizing antibodies,small-molecule inhibitors and vaccines. | MengYa Yuan YaoYing Wan Cui Liu Yue Li\ZhaoYuan Liu ChangDong Lin JianFeng Chen | 2021 | Cellular & Molecular Immunology2021，18，6： | 0 |
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