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| 1 | Analysis of a reduced-ML algorithm in BLAST显示文摘The performance of ML algorithm is much better than other algorithms in the MIMO wireless communication system. However, it is based on the expense of an increase in the complexity. A reduced maximum likelihood (RML) algorithm is proposed in this paper, which derives from the combination of the ML and ZF algorithms. It is shown that the complexity of RML is far lower than that of ML, while in the same performance condition by both theoretic analyses and simulation. | PAN Wen JIANG ZhanJun DU ZhengFeng WANG Yan YOU XiaoHu | 2008 | Science in China(Series F)2008，51，12： | 6 |
| 2 | The influence of different underlying surface on sand-duststorm in northern China显示文摘In thispaper,a quantitative research on the relationship between differentunderlying surface and sand-duststorm has been made by using 40 years meteorologicaldata offive differenttypes of underlying surface in northern China,which include farmland,grassland,sandland,gobiand saltcrust. These metrologicaldata comprise sand-duststorm days and strong wind days.By analyzing,we can find that there are certain correlations between the days of sand-dust storm and strong wind for differentunderlying surface,which has greatinfluence on sand-duststorm.Butthere are pronounced differences in differenttypes ofunderlying surface.The sand-duststorm days ofgrassland,gobiand saltcrust,with smallerinterannualvariation are obviously less than strong wind days.On the other hand,the sand-duststorm days offarmland and sandland increase evidently,even in many years,are much more than strong wind days.The differencesare mainly induced by the influencing mechanism of different underlying surface on sand-dust storm. Grassland, gobi and salt crust with stable underlying surface are not prone to sand-dust storm under strong wind condition. W hereas, the underlying surface offarmland and sandland isunstable,thatiseasy to induce sand-duststorm under strong wind condition. | SONG Yang QUAN Zhanjun LIU Lianyou YAN Ping CAO Tong | 2005 | Journal of Geographical Sciences2005，15，4： | 4 |
| 3 | IntegrinαEβ7^(+)T cells direct intestinal stem cell fate decisions via adhesion signaling显示文摘Intestinal stem cell(ISC)differentiation is regulated precisely by a niche in the crypt,where lymphocytes may interact with stem and transient amplifying(TA)cells.However,whether and how lymphocyte–stem/TA cell contact affects ISC differentiation is largely unknown.Here,we uncover a novel role of T cell–stem/TA cell contact in ISC fate decisions.We show that intestinal lymphocyte depletion results in skewed ISC differentiation in mice,which can be rescued by T cell transfer.Mechanistically,integrinαEβ7 expressed on T cells binds to E-cadherin on ISCs and TA cells,triggering E-cadherin endocytosis and the consequent Wnt and Notch signaling alterations.BlockingαEβ7−E-cadherin adhesion suppresses Wnt signaling and promotes Notch signaling in ISCs and TA cells,leading to defective ISC differentiation.Thus,αEβ7^(+)T cells regulate ISC differentiation at single-cell level through cell–cell contact-mediatedαEβ7−E-cadherin adhesion signaling,highlighting a critical role of the T cell–stem/TA cell contact in maintaining intestinal homeostasis. | Shiyang Chen Yajuan Zheng Xiaojuan Ran Hui Du Hua Feng Lei Yang Yating Wen Changdong Lin Shihui Wang Mengwen Huang Zhanjun Yan Dianqing Wu Hongyan Wang Gaoxiang Ge An Zeng Yi Arial Zeng Jianfeng Chen | 2021 | Cell Research2021，31，12： | 3 |
| 4 | Carbon seal materials with superior mechanical properties and fine-grained structure fabricated by a new process显示文摘 | Zhanjun Liu Quangui Guo Yan Song Jingli Shi Jinren Song Lang Liu | 2006 | Materials Letters2006，，8： | 1 |
| 5 | Antifertility Effects of Orally Administration of Low Dose Gossypol Acetic Acid Combined with Methyltestosterone Plus Ethinyl Estradiol on Male Rat显示文摘Objective To investigate the feasibility and optimal regimen of orally administration of low dose gossypol acetic acid(GA) combined with methyltestosterone(MT) plus ethinyl estradiol(EE) for contraception in males. Methods Wistar male rats were randomly assigned into four groups,20 in each group. Animals in group A or B were administered daily with 1% methyl cellulose or GA(12 mg/kg) suspended in 1% methyl cellulose,respectively. Rats in group C or D took firstly GA 12 mg/kg+MT 20 mg/kg+EE 0.1 mg/kg or MT 20 mg/kg+EE 0.1 mg/kg,in a suspension with 1% methyl cellulose,via gastric intubation. After the infertilities were initiated(6 weeks for group C,8 weeks for group D) ,GA was served alone while MT+EE were withdrawn in rats of groups C and D. The treatment was ceased after 18 weeks and some males from group C were permitted to recover. Fertility testing,10 males per group,was served for determining infertility or restoration of fertility in treated rats. Examinations of histology and biochemistry in treated rats were used to examine the morphologic influences on sperm,testis,epididymides and viscera,and biochemical changes in blood. The growth and development of F1 generation of the rats would also be tested in a series of behavioral tests. Results Ten rats from group C were infertile at week 6 after treatment,and the fulfilled infertility was maintained with low-dose GA(12 mg/kg) only daily. Six weeks after cessation of treatment,all of treated males recovered their fertility. However,8 of 10 rats from group D were in sterility at 6th week of treatment and all at 8th week oftreatment,but the infertility could not be kept with the similar dose GA alone later on. Moreover,no adverse effects were found in our present experiments. Conclusion Administration of oral low dose GA combined with MT and EE as loading dose could successfully induce infertility in short term,whereafter the efficacy could completely be maintained by similar low dose of GA alone for long term. The combined regimen should be safe,effective,reversible and long term,and then optimal and promised contraception for male. | Zhanjun YANG Wei-san YE Lan WANG Yan GUO She-pu XUE | 2008 | Journal of Reproduction and Contraception2008，19，4： | 1 |
| 6 | A polymorphism at the miR-502 binding site in the 3′ untranslated region of the SET8 gene is associated with the risk of epithelial ovarian cancer显示文摘 | Cuiju Wang Zhanjun Guo Chensi Wu Yan Li Shan Kang | 2012 | Cancer Genetics (-)2012，，7： | 1 |
| 7 | Distinct chemokines selectively induce HIV-1 gp120-integrinα4β7 binding via triggering conformer-specific activation ofα4β7显示文摘Dear Editor,Gut associated lymphoid tissue(GALT)is the principal site where human immunodeficiency virus 1(HIV-1)replicates.CD4^(+) T cells residing in GALT are predominant targets of HIV-1 during the acute phase of infection.CD4^(+) T cells expressing a high level of gut-homing receptor integrin α4β7 are more susceptible to productive infection by HIV-1. | Shu Wang ChangDong Lin Yue Li ZhaoYuan Liu JunLei Wang YouHua Zhang ZhanJun Yan YueBin Zhang GuoHui Li JianFeng Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 0 |
| 8 | Highly sensitive nanozyme strip:An effective tool for forensic material evidence identification显示文摘During criminal case investigations,blood evidence tracing is critical for criminal investigation.However,the blood stains are often cleaned or covered up after the crime,resulting in trace residue and difficult tracking.Therefore,a highly sensitive and specific method for the rapid detection of human blood stains remains urgent.To solve this problem,we established a nanozyme-based strip for rapid detection of blood evidence with high sensitivity and specificity.To construct reliable nanozyme strips,we synthesized CoFe_(2)O_(4) nanozymes with high peroxidase-like activity by scaling up to gram level,which can be supplied for six million tests,and conjugated antibody as a detection probe in nanozyme strip.The developed CoFe_(2)O_(4) nanozyme strip can detect human hemoglobin(HGB)at a concentration as low as 1 ng/mL,which is 100 times lower than the commercially available colloidal gold strips(100 ng/mL).Moreover,this CoFe_(2)O_(4) nanozyme strip showed high generality on 12 substrates and high specificity to human HGB among 13 animal blood samples.Finally,we applied the developed CoFe_(2)O_(4) nanozyme strip to successfully detect blood stains in three real cases,where the current commercial colloidal gold strip failed to do.The results suggest that the CoFe_(2)O_(4) nanozyme strip can be used as an effective on-scene detection method for human blood stains,and can further be used as a long-term preserved material evidence for traceability inquiry. | Juanji Hong Zhanjun Guo Dihan Duan Yi Zhang Xin Chen Yongjiu Li Zheng Tu Lei Feng Lei Chen Xiyun Yan Lizeng Gao Minmin Liang Demin Duan | 2024 | Nano Research2024，17，3： | 0 |
| 9 | 发热通过Hsp90-α4整合素热感应信号通路促进T淋巴细胞迁移显示文摘文章简介发热是机体受到病原体感染、产生损伤或者炎症后的一种复杂的生理应激反应。发热可以促进淋巴细胞迁移到次级淋巴器官或者炎症部位而促进免疫反应,对免疫稳态维持和免疫监视非常重要,但是目前对发热调控淋巴细胞黏附和迁移的机制还不清楚。本研究中,课题组发现:发热可以通过热休克蛋白90(heat shock protein 90,Hsp90)诱导α4整合素活化并传递下游信号通路。 | 林昶东 张有华 Kun Zhang YaJuan Zheng Ling Lu HaiShuang Chang Hui Yang YanRong Yang YaoYing Wan ShiHui Wang MengYa Yuan ZhanJun Yan RongGuang Zhang YongNing He GaoXiang Ge Dianqing Wu 陈剑峰 | 2020 | 科学新闻2020，，2： | 0 |
| 10 | HBV precore G1896A mutation promotes growth of hepatocellular carcinoma cells by activating ERK/MAPK pathway显示文摘Chronic hepatitis B virus(HBV)infection is one of the leading causes of hepatocellular carcinoma(HCC).The HBV genome is prone to mutate and several variants are closely related to the malignant transformation of liver disease.G1896A mutation(G to A mutation at nucleotide 1896)is one of the most frequently observed mutations in the precore region of HBV,which prevents HBeAg expression and is strongly associated with HCC.However,the mechanisms by which this mutation causes HCC are unclear.Here,we explored the function and molecular mechanisms of the G1896A mutation during HBV-associated HCC.G1896A mutation remarkably enhanced the HBV replication in vitro.Moreover,it increased tumor formation and inhibited apoptosis of hepatoma cells,and decreased the sensitivity of HCC to sorafenib.Mechanistically,the G1896A mutation could activate ERK/MAPK pathway to enhanced sorafenib resistance in HCC cells and augmented cell survival and growth.Collectively,our study demonstrates for the first time that the G1896A mutation has a dual regulatory role in exacerbating HCC severity and sheds some light on the treatment of G1896A mutation-associated HCC patients. | Baoxin Zhao Hongxiu Qiao Yan Zhao Zhiyun Gao Weijie Wang Yan Cui Jian Li Zhanjun Guo Xia Chuai Sandra Chiu | 2023 | Virologica Sinica2023，38，5： | 0 |
| 11 | Prediction of high-density polyethylene pyrolysis using kinetic parameters based on thermogravimetric and artificial neural networks显示文摘Pyrolysis is considered an attractive option and a promising way to dispose waste plastics.The thermogravimetric experiments of high-density polyethylene(HDPE)were conducted from 105℃ to 900℃ at different heating rates(10℃/min,20℃/min,and 30℃/min)to investigate their thermal pyrolysis behavior.We investigated four methods including three model-free methods and one modelfitting method to estimate dynamic parameters.Additionally,an artificial neural network model was developed by providing the heating rates and temperatures to predict the weight loss(wt.%)of HDPE,and optimized via assessing mean squared error and determination coefficient on the test set.The optimal MSE(2.6297×10^(−2))and R^(2) value(R^(2)>0.999)were obtained.Activation energy and preexponential factor obtained from four different models achieves the acceptable value between experimental and predicted results.The relative error of the model increased from 2.4%to 6.8%when the sampling frequency changed from 50 s to 60 s,but showed no significant difference when the sampling frequency was below 50 s.This result provides a promising approach to simplify the further modelling work and to reduce the required data storage space.This study revealed the possibility of simulating the HDPE pyrolysis process via machine learning with no significant accuracy loss of the kinetic parameters.It is hoped that this work could potentially benefit to the development of pyrolysis process modelling of HDPE and the other plastics. | Xiaoxiao Yin Junyu Tao Guanyi Chen Xilei Yao Pengpeng Luan Zhanjun Cheng Ning Li Zhongyue Zhou Beibei Yan | 2023 | Frontiers of Environmental Science & Engineering2023，17，1： | 0 |
| 12 | Synthesis of highly ordered AgNPs-coated silica photonic crystal beads for sensitive and reproducible 3D SERS substrates显示文摘3 D highly ordered silver nanoparticles(AgNPs) coated silica photonic crystal beads(Ag/SPCBs) were prepared and exploited as a novel surface enhanced Raman scattering(SERS) substrate.The monodisperse and size-controlled SPCBs were prepared via self-assembly of silica nanoparticles process using a simple microfluidic device.Then the Ag/SPCBs were easily obtained by in situ growth of AgNPs onto the NH_(2)-modified SPCBs.Field emitting scanning electron microscopy(SEM) and energy dispersive X-ray spectrometry(EDX) were used to characterize the Ag/SPCBs.The effect of silica nanoparticle size and AgNO_(3) concentration on the SERS performance of the resultant Ag/SPCBs substrate were discussed in detail.The results indicate that the Ag/SPCBs have highest SERS signals when silica nanoparticle size is250 nm and AgNO_(3) concentration is 0.8 mg/mL.Using malachite green(MG) as model analyte,the Ag/SPCBs substrate displayed a high sensitivity and a wide linear range for MG.The well-designed Ag/SPCBs show high uniformity and excellent reproducibility,and can be used as an effective SERS substrate for sensitive assay application. | Juan Li Wanling Li Yan Rao Feng Shi Suhua Yu Huizhen Yang Lingfeng Min Zhanjun Yang | 2021 | Chinese Chemical Letters2021，32，1： | 0 |
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