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| 1 | The prognostic and therapeutic implications of circulating tumor cell phenotype detection based on epithelial-mesenchymal transition markers in the first-line chemotherapy of HER2-negative metastatic breast cancer显示文摘Background:Epithelial-mesenchymal transition(EMT)is implicated in the metastatic process and presents a chal-lenge to epithelial cell adhesion molecule-based detection of circulating tumor cells(CTCs),which have been demon-strated to be a prognostic indicator in metastatic breast cancer.Although evidence has indicated that heterogeneity of CTCs based on EMT markers is associated with disease progression,no standard recommendations have been established for clinical practice.This study aimed to evaluate the prognostic significance of dynamic CTC detection based on EMT for metastatic breast cancer patients.Methods:We enrolled 108 human epidermal growth factor receptor 2-negative metastatic breast cancer patients from the prospective phase III CAMELLIA study and applied the CanPatrol CTC enrichment technique to identify CTC phenotypes(including epithelial CTCs,biphenotypic epithelial/mesenchymal CTCs,and mesenchymal CTCs)in peripheral blood samples.Receiver operating characteristic curve analyses of total CTC count and the proportion of mesenchymal CTCs for predicting the 1-year progression-free survival(PFS)rate were conducted to determine the optimal cut-off values,and Kaplan-Meier analysis and Cox proportional hazards regression analysis were performed to investigate the prognostic value of the cut-off values of both total CTC count and the proportion of mesenchymal CTCs in combination.Results:For predicting the 1-year PFS rate,the optimal cut-off value of total CTC count was 9.5(Area under the curve[AUC]=0.538,95%confidence interval[CI]=0.418-0.657),and that of the proportion of mesenchymal CTCs was 10.7%(AUC=0.581,95%CI=0.463-0.699).We used the two cut-off values in combination to forecast PFS in which the total CTC count was equaled to or exceeded 10/5 mL with the proportion of mesenchymal CTCs surpassed 10.7%.Patients who met the combined criteria had significantly shorter median PFS than did those who did not meet the criteria(6.2 vs.9.9 months,P=0.010).A nomogram was constructed based on the criteria and significant clinicopatho-logical characteristics with a C-index of 0.613(P=0.010).Conclusions: The criteria, which combine the total CTC count and the proportion of mesenchymal CTCs, may be used to monitor therapeutic resistance and predict prognosis in patients with metastatic breast cancer. | Xiuwen Guan Fei Ma Chunxiao Li Shiyang Wu Shangying Hu Jiefen Huang Xiaoying Sun Jiayu Wang Yang Luo Ruigang Cai Ying Fan Qiao Li Shanshan Chen Pin Zhang Qing Li Binghe Xu | 2019 | Cancer Communications2019，39，1： | 15 |
| 2 | Development and validation of a nomogram for predicting the survival of patients with non-metastatic nasopharyngeal carcinoma after curative treatment显示文摘Background: The TNM staging system is far from perfect in predicting the survival of individual cancer patients because only the gross anatomy is considered. The survival rates of the patients who have the same TNM stage disease vary across a wide spectrum. This study aimed to develop a nomogram that incorporates other clinicopathologic factors for predicting the overall survival(OS) of non-metastatic nasopharyngeal carcinoma(NPC) patients after curative treatments.Methods: We retrospectively collected the clinical data of 1520 NPC patients who were diagnosed histologically between November 2000 and September 2003. The clinical data of a separate cohort of 464 patients who received intensity-modulated radiation therapy(IMRT) between 2001 and 2010 were also retrieved to examine the extensibility of the model. Cox regression analysis was used to identify the prognostic factors for building the nomogram. The predictive accuracy and discriminative ability were measured using the concordance index(c-index).Results: We identiied and incorporated 12 independent clinical factors into the nomogram. The calibration curves showed that the prediction of OS was in good agreement with the actual observation in the internal validation set and IMRT cohort. The c-index of the nomogram was statistically higher than that of the 7th edition TNM staging system for predicting the survival in both the primary cohort(0.69 vs. 0.62) and the IMRT cohort(0.67 vs. 0.63).Conclusion: We developed and validated a novel nomogram that outperformed the TNM staging system in predicting the OS of non-metastatic NPC patients who underwent curative therapy. | Wenhua Liang Guanzhu Shen Yaxiong Zhang Gang Chen Xuan Wu Yang Li Anchuan Li Shiyang Kang Xi Yuan Xue Hou Peiyu Huang Yan Huang Hongyun Zhao Ying Tian Chong Zhao Li Zhang | 2016 | Chinese Journal of Cancer2016，35，12： | 6 |
| 3 | A Decision-Making Method for Air Combat Maneuver Based on Hybrid Deep Learning Network显示文摘In this paper, a hybrid deep learning network-based model is proposed and implemented for maneuver decision-making in an air combat environment.The model consists of stacked sparse auto-encoder network for dimensionality reduction of high-dimensional,dynamic time series combat-related data and long shortterm memory network for capturing the quantitative relationship between maneuver control variables and the time series combat-related data after dimensionality reduction.This model features: using time series data as the basis of decision-making, which is more in line with the actual decision-making process;using stacked sparse auto-encoder network to reduce the dimension of time series data to predict the result more accurately;in addition, taking the maneuver control variables as the output to control the maneuver, which makes the maneuver process more flexible. The relevant experiments have demonstrated that the proposed model can effectively improve the prediction accuracy and convergence rate in the prediction of maneuver control variables. | LI Bo LIANG Shiyang CHEN Daqing LI Xitong | 2022 | Chinese Journal of Electronics2022，31，1： | 6 |
| 4 | Failure probability estimation of overhead transmission lines considering spatial and temporal variation in severe weather显示文摘Estimation for weather-related failure probability of overhead transmission lines is essential in the reliability assessment of a power system.This paper analyzes the outage and weather data of 110 kV overhead transmission lines in the Guangxi Zhuang Autonomous Region of China during 2011–2014.The result reveals obvious uneven distributions of outage events for time and space due to the spatial and temporal variation of severe weather.Based on the results, an estimation method is proposed in this paper.Split and aggregation is used to smooth the outage and weather data.The poisson model is adopted in our method to investigate the statistic characteristics of transmission line outage events.Regression analysis is applied to obtain the correlation between the weather intensity and history failure rate.Furthermore the method proposed is validated against the empirical outage data. | Shuai YANG Wenjun ZHOU Shiyang ZHU Le WANG Lisha YE Xuezhi XIA Han LI | 2019 | Journal of Modern Power Systems and Clean Energy2019，7，1： | 5 |
| 5 | High Thermoelectric Performance of Cu-Doped PbSe-PbS System Enabled by High-Throughput Experimental Screening显示文摘Recent advances in high-throughput(HTP)computational power and machine learning have led to great achievements in exploration of new thermoelectric materials.However,experimental discovery and optimization of thermoelectric materials have long relied on the traditional Edisonian trial and error approach.Herein,we demonstrate that ultrahigh thermoelectric performance in a Cu-doped PbSe-PbS system can be realized by HTP experimental screening and precise property modulation.Combining the HTP experimental technique with transport model analysis,an optimal Se/S ratio showing high thermoelectric performance has been efficiently screened out.Subsequently,based on the screened Se/S ratio,the doping content of Cu has been subtly adjusted to reach the optimum carrier concentration.As a result,an outstanding peak zT~1:6 is achieved at 873 K for a 1.8 at%Cu-doped PbSe_(0.6)S_(0.4) sample,which is the superior value among the n-type Te-free lead chalcogenides.We anticipate that current work will stimulate large-scale unitization of the HTP experimental technique in the thermoelectric field,which can greatly accelerate the research and development of new high-performance thermoelectric materials. | Li You Zhili Li Quanying Ma Shiyang He Qidong Zhang Feng Wang Guoqiang Wu Qingyi Li Pengfei Luo Jiye Zhang Jun Luo | 2020 | Research2020，，1： | 4 |
| 6 | An adaptive dwell time scheduling model for phased array radar based on three-way decision显示文摘Real-time resource allocation is crucial for phased array radar to undertake multi-task with limited resources,such as the situation of multi-target tracking,in which targets need to be prioritized so that resources can be allocated accordingly and effectively.A three-way decision-based model is proposed for adaptive scheduling of phased radar dwell time.Using the model,the threat posed by a target is measured by an evaluation function,and therefore,a target is assigned to one of the three possible decision regions,i.e.,positive region,negative region,and boundary region.A different region has a various priority in terms of resource demand,and as such,a different radar resource allocation decision is applied to each region to satisfy different tracking accuracies of multi-target.In addition,the dwell time scheduling model can be further optimized by implementing a strategy for determining a proper threshold of three-way decision making to optimize the thresholds adaptively in real-time.The advantages and the performance of the proposed model have been verified by experimental simulations with comparison to the traditional twoway decision model and the three-way decision model without threshold optimization.The experiential results demonstrate that the performance of the proposed model has a certain advantage in detecting high threat targets. | LI Bo TIAN Linyu CHEN Daqing LIANG Shiyang | 2020 | Journal of Systems Engineering and Electronics2020，31，3： | 3 |
| 7 | UAV Maneuvering Decision-Making Algorithm Based on Twin Delayed Deep Deterministic Policy Gradient Algorithm显示文摘Aiming at intelligent decision-making of unmanned aerial vehicle(UAV)based on situation information in air combat,a novelmaneuvering decision method based on deep reinforcement learning is proposed in this paper.The autonomous maneuvering model ofUAV is established byMarkovDecision Process.The Twin DelayedDeep Deterministic Policy Gradient(TD3)algorithm and the Deep Deterministic Policy Gradient(DDPG)algorithm in deep reinforcement learning are used to train the model,and the experimental results of the two algorithms are analyzed and compared.The simulation experiment results show that compared with the DDPG algorithm,the TD3 algorithm has stronger decision-making performance and faster convergence speed and is more suitable for solving combat problems.The algorithm proposed in this paper enables UAVs to autonomously make maneuvering decisions based on situation information such as position,speed,and relative azimuth,adjust their actions to approach,and successfully strike the enemy,providing a new method for UAVs to make intelligent maneuvering decisions during air combat. | Bai Shuangxia Song Shaomei Liang Shiyang Wang Jianmei Li Bo Neretin Evgeny | 2022 | Journal of Artificial Intelligence and Technology2022，2，1： | 3 |
| 8 | Can arbuscular mycorrhiza and fertilizer management reduce phosphorus runoff from paddy fields?显示文摘Our study sought to assess how much phosphorus(P) runoff from paddy fields could be cut down by fertilizer management and inoculation with arbuscular mycorrhizal fungi. A field experiment was conducted in Lalin River basin, in the northeast China: six nitrogen–phosphorus–potassium fertilizer levels were provided(0, 20%, 40%, 60%, 80%, and 100% of the recommended fertilizer supply), with or without inoculation with Glomus mosseae. The volume and concentrations of particle P(PP) and dissolved P(DP) were measured for each runoff during the rice growing season. It was found that the seasonal P runoff, including DP and PP, under the local fertilization was 3.7 kg/ha, with PP, rather than DP, being the main form of P in runoff water. Additionally, the seasonal P runoff dropped only by 8.9% when fertilization decreased by 20%; rice yields decreased with declining fertilization. We also found that inoculation increased rice yields and decreased P runoff at each fertilizer level and these effects were lower under higher fertilization. Conclusively, while rice yields were guaranteed arbuscular mycorrhizal inoculation and fertilizer management would play a key role in reducing P runoff from paddy fields. | Shujuan Zhang Li Wang Fang Ma Xue Zhang Zhe Li Shiyang Li Xiaofeng Jiang | 2015 | Journal of Environmental Sciences2015，27，7： | 3 |
| 9 | Advances in Studies on Interaction between Selenium and Heavy Metal Cadmium显示文摘Selenium is an essential functional element of the human body,and the issue of selenium accompanying heavy metals is receiving much concern.This paper expounded the form of existence of selenium and cadmium in soil and influencing factors of their bioavailability,and further elaborated the interaction between selenium and cadmium.On the basis,it provided references for further studies on the interaction between selenium and cadmium,and provided basis for establishing selenium-enriched barrier technology for crops. | Liping PAN Yongxian LIU Yanfei HUANG Mengling NONG Shiyang LU Jinping CHEN Yuying ZHAO Liumei XIONG Xiu LAN Kebing LI | 2017 | Asian Agricultural Research2017，9，8： | 3 |
| 10 | Metasurface-based subtractive color filter fabricated on a 12-inch glass wafer using a CMOS platform显示文摘Optical color filters are widely applied in many areas including display,imaging,sensing,holography,energy harvest,and measurement.Traditional dye-based color filters have drawbacks such as environmental hazards and instability under high temperature and ultraviolet radiation.With advances in nanotechnology,structural color filters,which are based on the interaction of light with designed nanostructures,are able to overcome the drawbacks.Also,it is possible to fabricate structural color filters using standard complementary metal-oxide-semiconductor(CMOS)fabrication facilities with low cost and high volume.In this work,metasurface-based subtractive color filters(SCFs)are demonstrated on 12-inch(300-mm)glass wafers using a CMOS-compatible fabrication process.In order to make the transmissive-type SCF on a transparent glass wafer,an in-house developed layer transfer process is used to solve the glass wafer handling issue in fabrication tools.Three different heights of embedded silicon nanopillars(110,170,and 230 nm)are found to support magnetic dipole resonances.With pillar height and pitch variation,SCFs with different displayed colors are achieved.Based on the resonance wavelength,the displayed color of the metasurface is verified within the red-yellow-blue color wheel.The simulation and measurement results are compared and discussed.The work provides an alternative design for high efficiency color filters on a CMOS-compatible platform,and paves the way towards mass-producible large-area metasurfaces. | ZHENGJI XU NANXI LI YUAN DONG YUAN HSING FU TING HU QIZE ZHONG YANYAN ZHOU DONGDONG Li SHIYANG ZHU NAVAB SINGH | 2021 | Photonics Research2021，9，1： | 3 |
| 11 | Quality of information disclosure, property rights, and bank loans: A bank heterogeneity perspective显示文摘Using the context of the financial reform and the development of the non-state sector in China in the past decade, we examine the roles that the quality of information disclosure and property rights play in the allocation of different types of bank credit. We find that foreign banks and policy banks exercise ‘‘financial discrimination,' and that local commercial banks, large state- owned commercial banks, national joint-stock banks, local city commercial banks, and rural commercial banks not only exercise financial discrimination but also provide significant ‘‘financial support' to non-state-owned enterprises by providing more lending opportunities and larger loans. However, when enterprises commit information disclosure violations, the local commercial banks, national joint-stock banks, local city commercial banks, and rural commercial banks reverse their credit decisions and begin to exercise financial dis- crimination against non-state-owned enterprises. At the same time, large stateowned commercial banks continue to provide financial support to non-state-owned enterprises. We also find that the quality of the information disclosed by enterprises has a moderating effect rather than an intermediary effect on the relationship between property rights and bank loans. Overall, the results of this paper shine new light on the market-oriented reform of the banking industry, and provide new empirical evidence for the presence of financial discrimination in the supply of bank credit. Our findings also have practical implications for solving the financing difficulties of non-state-owned enterprises. | Xichan Chen Wanli Li Shiyang Hu Xing Liu | 2019 | China Journal of Accounting Research2019，，1： | 2 |
| 12 | Investigation on Reduction of Pressure Fluctuation for a Double-Suction Centrifugal Pump显示文摘Double-suction centrifugal pumps have been applied extensively in many areas,and the significance of pressure fluctuations inside these pumps with large power is becoming increasingly important.In this study,a double-suction centrifugal pump with a high-demand for vibration and noise was redesigned by increasing the flow uniformity at the impeller discharge,implemented by combinations of more than two parameters.First,increasing the number of the impeller blades was intended to enhance the bounding effect that the blades imposed on the fluid.Subsequently,increasing the radial gap between the impeller and volute was applied to reduce the rotor-stator interaction.Finally,the staggered arrangement was optimized to weaken the efficacy of the interference superposition.Based on numerical simulation,the steady and unsteady characteristics of the pump models were calculated.From the fluctuation analysis in the frequency domain,the dimensionless pressure fluctuation amplitude at the blade passing frequency and its harmonics,located on the monitoring points in the redesigned pumps(both with larger radial gap),are reduced a lot.Further,in the volute of the model with new impellers staggered at 12°,the average value for the dimensionless pressure fluctuation amplitude decreases to 6%of that in prototype pump.The dimensionless rootmean-square pressure contour on the mid-span of the impeller tends to be more uniform in the redesigned models(both with larger radial gap);similarly,the pressure contour on the mid-section of the volute presents good uniformity in these models,which in turn demonstrating a reduction in the pressure fluctuation intensity.The results reveal the mechanism of pressure fluctuation reduction in a double-suction centrifugal pump,and the results of this study could provide a reference for pressure fluctuation reduction and vibration performance reinforcement of doublesuction centrifugal pumps and other pumps. | Qianqian Li Shiyang Li Peng Wu Bin Huang Dazhuan Wu | 2021 | Chinese Journal of Mechanical Engineering2021，34，1： | 2 |
| 13 | Collaborative assembly-mediated siRNA delivery for relieving inflammation-induced insulin resistance显示文摘Obesity plays a primary causative role in insulin resistance and hyperglycemia that contributes to type 2 diabetes.Excess lipid storage in the liver renders activation of the resident macrophages and chronic secretion of inflammatory mediators,therefore causing or aggravating insulin resistance.Herein,we develop collaborative assemblies using a“one-pot”synthesis method for macrophage-specific delivery of small interfering RNAs(siRNAs)that target the inflammatory proteins.Ternary nanocomplex(NC)composed of the siRNA molecule,a synthetic thiol-bearing methacrylated hyaluronic acid(sm-HA)and protamine forms through an electrostatic-driven physical assembly,which is chemically crosslinked to acquire the collaboratively assembled nanocapsule(cNC)concurrently.The obtained cNC displays significantly higher stability than NC.Functional moieties as flexible assembly units can be easily equipped on cNC for long circulation,active targeting,or controlled siRNA release.cNC-F decorated with folic acid,a macrophage-targeting ligand promotes the siRNA accumulation in the activated macrophages in the liver of the obese mouse model.cNC-F loaded with siRNA targeting inflammatory indicators efficiently control the macrophage inflammatory response by reducing the expression of the inflammatory proteins(>40%reduction)and ameliorating the insulin resistance symptoms of the obese mice. | Shiyang Shen Li Zhang Mengru Li Zhizi Feng Huixia Li Xiao Xu Shiqi Lin Ping Li Can Zhang Xiaojun Xu Ran Mo | 2020 | Nano Research2020，13，11： | 2 |
| 14 | Integration of high-performance spin-orbit torque MRAM devices by 200-mm-wafer manufacturing platform显示文摘We demonstrate in-plane field-free-switching spin-orbit torque(SOT)magnetic tunnel junction(MTJ)devices that are capable of low switching current density,fast speed,high reliability,and,most importantly,manufactured uniformly by the 200-mm-wafer platform.The performance of the devices is systematically studied,including their magnetic properties,switch-ing behaviors,endurance and data retention.The successful integration of SOT devices within the 200-mm-wafer manufactur-ing platform provides a feasible way to industrialize SOT MRAMs.It is expected to obtain excellent performance of the devices by further optimizing the MTJ film stacks and the corresponding fabrication processes in the future. | Hongchao Zhang Xiangyue Ma Chuanpeng Jiang Jialiang Yin Shuqin Lyu Shiyang Lu Xiantao Shang Bowen Man Cong Zhang Dandan Li Shuhui Li Wenjing Chen Hongxi Liu Gefei Wang Kaihua Cao Zhaohao Wang Weisheng Zhao | 2022 | Journal of Semiconductors2022，43，10： | 2 |
| 15 | Taking the pulse of COVID-19:a spatiotemporal perspective显示文摘The sudden outbreak of the Coronavirus disease(COVID-19)swept across the world in early 2020,triggering the lockdowns of several billion people across many countries,including China,Spain,India,the U.K.,Italy,France,Germany,Brazil,Russia,and the U.S.The transmission of the virus accelerated rapidly with the most confirmed cases in the U.S.,India,Russia,and Brazil.In response to this national and global emergency,the NSF Spatiotemporal Innovation Center brought together a taskforce of international researchers and assembled implementation strategies to rapidly respond to this crisis,for supporting research,saving lives,and protecting the health of global citizens.This perspective paper presents our collective view on the global health emergency and our effort in collecting,analyzing,and sharing relevant data on global policy and government responses,human mobility,environmental impact,socioeconomical impact;in developing research capabilities and mitigation measures with global scientists,promoting collaborative research on outbreak dynamics,and reflecting on the dynamic responses from human societies. | Chaowei Yang Dexuan Sha Qian Liu Yun Li Hai Lan Weihe Wendy Guan Tao Hu Zhenlong Li Zhiran Zhang John Hoot Thompson Zifu Wang David Wong Shiyang Ruan Manzhu Yu Douglas Richardson Luyao Zhang Ruizhi Hou You Zhoua Cheng Zhong Yifei Tian Fayez Beaini Kyla Carte Colin Flynn Wei Liu Dieter Pfoser Shuming Bao Mei Li Haoyuan Zhang Chunbo Liu Jie Jiang Shihong Du Liang Zhao Mingyue Lu Lin Li Huan Zhou Andrew Ding | 2020 | International Journal of Digital Earth2020，13，10： | 2 |
| 16 | Coupling magnetic particles with flocculants to enhance demulsification and separation of waste cutting emulsion for engineering applications显示文摘Magnetic particles were coupled with a flocculant to enhance the demulsification and separation of waste cutting emulsions.The optimal magnetic particle size and critical magnetic field conditions were investigated to achieve large-scale engineering application of magnetic demulsification separation for waste cutting emulsion treatment.The micro-scale magnetic particles were found to show comparable effects to nano-scale magnetic particles on enhancing the demulsification and separation of cutting emulsions,which are beneficial for broadening the selectivity of low-cost magnetic particles.The critical magnetic separation region was determined to be an area 40 mm from the magnetic field source.Compared to the flocculant demulsification,the magnetic demulsification separation exhibited a significant advantage in accelerating flocs-water separation by decreasing the separation time of flocs from 180-240 min to less than 15 min,compressing the flocs by reducing the floc volume ratio from 60%-90%to lower than 20%,and showing excellent adaptability to the variable properties of waste cutting emulsions.Coupled with the design of the magnetic disk separator,continuous demulsification separation of the waste cutting emulsion was achieved at 1.0 t/hr for at least 10 hr to obtain clear effluent with 81%chemical oxygen demand removal and 89%turbidity reduction.This study demonstrates the feasibility of applying magnetic demulsification separation to large-scale continuous treatment of waste emulsion.Moreover,it addresses the flocs-water separation problems that occur in practical flocculant demulsification engineering applications. | Yongjiao Xiong Baoqiang Wu Xiangfeng Huang Chenlu Li Bin Lu Jia Liu Lijun Lu Shiyang Li Kaiming Peng | 2021 | Journal of Environmental Sciences2021，33，7： | 2 |
| 17 | Binary modifiers for the determination of zinc in pure copper and nickel-based alloy by longitudinal Zeeman electrothermal atomic absorption spectrometry 显示文摘 | CHEN Shiyang CHANG Chiani LI Chunlien | 2005 | Anal Chim Acta2005，550，： | 1 |
| 18 | Local mild hypothermia with thrombolysis for acute ischemic stroke within a 6-h window显示文摘 | Min Bi Qilin Ma Shiyang Zhang Jianpeng Li Yidan Zhang Longting Lin Suijun Tong Desheng Wang | 2011 | Clinical Neurology and Neurosurgery2011，，： | 1 |
| 19 | FT-IR and raman spectroscopic study of hydrated borates 显示文摘 | Li Jun Xia Shuping Gao Shiyang | 1995 | Spectrochemica Acta1995，51，4： | 1 |
| 20 | Experimental Study on the Heat Transfer Characteristics of Subcooled Flow Boiling with Cast Iron Heating Surface显示文摘 | Shiyang Hua Ronghua Huang Zhi Li Pei Zhou | 2014 | Applied Thermal Engineering2014，，： | 1 |
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