|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Eleven COVID-19 Outbreaks with Local Transmissions Caused by the Imported SARS-CoV-2 Delta VOC-China,July-August,2021显示文摘Starting from December 2019,Wuhan,China,encountered the first outbreak of coronavirus disease 2019(COVID-19)(1-2).The epidemic was successfully suppressed by strict containment so that the number of infected people was reduced to 0 on April 8,2020(3–4).After that,China experienced roughly 3 dozen outbreaks with local transmission caused by imported severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). | Lei Zhou Kai Nie Hongting Zhao Xiang Zhao Bixiong Ye Ji Wang Cao Chen Hong Wang Jiangli Di Jinsong Li Chao Li Zhixiao Chen Ruiqi Ren Peihua Niu Hui Chen Tao Chen Yali Wang Lili Li Bingxue Han Ruhan A Si Chen Dan Li Dan Li Chunxia Jin Xin Zhang Jiangmei Liu Chunyu Xu Yecheng Yao Yenan Feng Zhili Li Bike Zhang Yang Song Peter Hao Yanping Zhang Hao Li Qun Li George F.Gao Guoqing Shi Wenbo Xu | 2021 | China CDC weekly2021，3，41： | 13 |
| 2 | Reproductive management through integration of PGD and MPS-based noninvasive prenatal screening/diagnosis for a family with GJB2-associated hearing impairment显示文摘A couple with a proband child of GJB2(encoding the gap junction protein connexin 26)-associated hearing impairment and a previous pregnancy miscarriage sought for a reproductive solution to bear a healthy child. Our study aimed to develop a customized preconception-to-neonate care trajectory to fulfill this clinical demand by integrating preimplantation genetic diagnosis(PGD), noninvasive prenatal testing(NIPT), and noninvasive prenatal diagnosis(NIPD) into the strategy. Auditory and genetic diagnosis of the proband child was carried out to identify the disease causative mutations. The couple then received in-vitro-fertilization treatment, and eight embryos were obtained for day 5 biopsy. PGD was performed by short-tandem-repeat linkage analysis and Sanger sequencing of GJB2 gene. Transfer of a GJB2 c.235del C heterozygous embryo resulted in a singleton pregnancy. At the 13 th week of gestation, genomic DNA(g DNA) from the trio family and cell-free DNA(cf DNA) from maternal plasma were obtained for assessment of fetal chromosomal aneuploidy and GJB2 mutations. NIPT and NIPD showed the absence of chromosomal aneuploidy and GJB2-associated disease in the fetus, which was later confirmed by invasive procedures and postnatal genetic/auditory diagnosis. This strategy successfully prevented the transmission of hearing impairment in the newborn, thus providing a valuable experience in reproductive management of similar cases and potentially other monogenic disorders. | XIONG WenPing WANG DaYong GAO Yuan GAO Ya WANG HongYang GUAN Jing LAN Lan YAN JunHao ZONG Liang YUAN Yuan DONG Wei HUANG SeXin WU KeLiang WANG YaoShen WANG ZhiLi PENG HongMei LU YanPing XIE LinYi ZHAO Cui WANG Li ZHANG QiuJing GAO Yun LI Na YANG Ju YIN ZiFang HAN Bing WANG Wei CHEN Zi-Jiang WANG QiuJu | 2015 | Science China(Life Sciences)2015，58，9： | 12 |
| 3 | MiR-630 inhibits invasion and metastasis in esophageal squamous cell carcinoma显示文摘食道的有鳞的房间癌(ESCC ) 在最好攻击的恶意之中并且在中国有高发生。MicroRNAs (miRNAs ) 是调整多重 tumorigenic 过程的小内长的 RNA,包括增长,侵略,转移和预后。用 miRNA 表示 proling 分析,我们发现 miR-630 在配对的正常食道的纸巾与那相比在三件 ESCC 织物样品是显著地下面调整的。微分 miR-630 表示随后用量的即时 PCR 被证实。决定 miR-630 下面规定是否能被看作诊断指示物和不利预示的因素,我们与 ESCC 在病人调查了在 miR-630 和 clinicopathological 特征之间的协会。减少的 miR-630 表示总的来说与穷人被联系,这被发现在这些病人的幸存。另外,我们也由指向蛞蝓探索了 miR-630 的生物功能并且调查了在 miR-630 表示和上皮间充质的转变(EMT ) 之间的关联在 vivo 并且在 vitro 的前进。,宫外的 miR-630 表示能禁止增长,侵略和转移 miR-630 击倒的导致的增长,侵略,转移和 EMT 特点。总的来说,我们的学习在 ESCC 作为一个批评新奇调节的人为 miR-630 支持一个角色。 | Li Jin Jun Yi Yanping Gao Siqi Han Zhenyue He Longbang Chen Haizhu Song | 2016 | Acta Biochimica et Biophysica Sinica2016，48，9： | 11 |
| 4 | Identification of a novel mutation in POU3F4 for prenatal diagnosis in a Chinese family with X-linked nonsyndromic hearing loss显示文摘We present the clinical and genetic findings for a Chinese family with X-linked non-syndromic hearing loss in which the affected males showed congenital profound sensorineural hearing impairment. In two affected brothers, the computer tomography of temporal bone showed bilateral dilation of the internal auditory canal with fistulous communication between the lateral canal and the basal cochlear turn, which is consistent with the typical DFNX2 phenotype. A missense mutation (c.647G→A) in the POU3F4 gene caused a substitu- tion from glycine to glutamic acid at position 216 (p.G216E), and this mutation was found to consistently cosegregate with the deafness phenotype in the family. The mutation resulted in the loss of function of the POU3F4 by decreasing the affinity between the protein and DNA, as shown in silico by the structural analysis. Prenatal diagnosis of pregnant proband of this family revealed the c.647G→A muta- tion in DNA extracted from the amniotic fluid surrounding the fetus. The appropriate use of genetic testing and prenatal diagnosis plays a key role in reducing the recurrence of genetic defects in high-risk families. | Jianzhong Li Jing Cheng Yanping Lu Yu Lu Airing Chen YiSun Dongyang Kang Xin Zhang Pu Dai Dongyi Han Huijun Yuan | 2010 | Journal of Genetics and Genomics2010，37，12： | 9 |
| 5 | On the viscosity of magnetic fluid with low and moderate solid fraction显示文摘The design of a pressurized capillary rheometer operating at prescribed temperature is described to measure the viscosity of magnetic fluids(MFs) containing Fe3O4 magnetic nanoparticles(MNPs).The equipment constant of the rheometer was obtained using liquids with predetermined viscosities.Experimentally measured viscosities were used to evaluate different equations for suspension viscosities.Deviation of measured suspension viscosities from the Einstein equation was found to be basically due to the influence of spatial distribution and aggregation of Fe3O4 MNPs.By taking account of the coating layer on MNPs and the aggregation of MNPs in MFs,a modified Einstein equation was proposed to fit the experimental data.Moreover,the influence of external magnetic field on viscosity was also taken into account.Viscosities thus predicted are in good agreement with experimental data.Temperature effect on suspension viscosity was shown experimentally to be due to the shear-thinning behavior of the MFs. | Zhiqiang Ren Yanping Han Ruoyu Hong Jianmin Ding Hongzhong Li | 2008 | Particuology2008，6，3： | 5 |
| 6 | IL-17A-dependent gut microbiota is essential for regulating diet-induced disorders in mice显示文摘The gut microbiota plays a key role in obesity and related metabolic disorders, and multiple factors including diet, host genotype, and age regulate it. Many studies have examined the contribution of extrinsic factors to the regulation of the gut microbiota, but the importance of the host genetic constitution cannot be ignored. Interleukin 17A(IL-17A), a pro-inflammatory cytokine, is important in the defense against infection and diseases. Here, we investigated the association among IL-17, a high-fat diet(HFD), and the gut microbiota. Mice deficient in IL-17A were resistant to diet-induced obesity and related diseases. Compared with the Ⅱ-17^(-/-)mice, wild-type(WT) mice challenged with HFD showed obvious weight fluctuations, such as those seen in type 2 diabetes, and hematological changes similar to those associated with metabolic syndrome. However, housing WT mice and Ⅱ-17a^(-/-)mice together significantly alleviated these symptoms in the WT mice. A metagenomic analysis of the mouse feces indicated that the microbial community compositions of these two groups differed before HFD feeding. The HFD mediated shifts in the gut microbial compositions, which were associated with the mouse phenotypes.We also identified potentially beneficial and harmful species present during this period, and drew networks of the most abundant species. A functional analysis indicated pathway changes in the WT and Ⅱ-17a^(-/-)mice when fed the HFD. Collectively, these data underscore the importance of the host factor IL-17 A in shaping and regulating the gut microbiota, which conversely, influences the host health. | Yujing Bi Chunxiao Li Lin Liu Jiyuan Zhou Zhengchao Li Huimin Deng Chunyan Wu Yanping Han Yajun Song Yafang Tan Xiaoyi Wang Zongmin Du Yujun Cui Yanfeng Yan Fachao Zhi Guangwei Liu Nan Qin Heping Zhang Ruifu Yang | 2017 | Science Bulletin2017，62，15： | 5 |
| 7 | PhaseⅡstudy of induction chemotherapy followed by concurrent chemoradiotherapy with raltitrexed and cisplatin in locally advanced nasopharyngeal carcinoma显示文摘Objective:For locally advanced nasopharyngeal carcinoma(LA-NPC)patients,high incidences of distant metastases and severe treatment related toxicities are the main obstacles needed to be overcome.Raltitrexed,a specific thymidylate synthase inhibitor with a convenient administration schedule,has an acceptable and manageable toxicity,and possesses radio-sensitizing properties.To investigate the efficacy and safety of raltitrexed and cisplatin induction chemotherapy and concurrent chemoradiotherapy(IC+CCRT)in patients with LA-NPC,a phaseⅡclinical study was conducted.Methods:Sixty eligible patients with LA-NPC were enrolled into this study.A raltitrexed-cisplatin combination was used as part of an IC+CCRT regimen.Raltitrexed-cisplatin IC was given once every 3 weeks(q3 w)for two cycles,followed by raltitrexed-cisplatin based CCRT q3 w for two cycles.Intensity-modulated radiotherapy(IMRT)was given for all enrolled patients.Results:All patients were included in survival analysis according to the intent-to-treat principle.The objective response rate(ORR)3 months after treatment was 98%.The 2-year overall survival(OS)rate was 92%.The median relapse-free survival(RFS)time was 30.5[95%confidence interval(95%CI),28.4-32.3]months.The 2-year RFS rate was 85%.The 2-year local failure-free survival(LFFS)rate was 97%and the 2-year distant metastasis-free survival(DMFS)rate was 88%.Acute toxicities were mostly grade 2 and 3 reactions in bone marrow suppression,gastrointestinal side effect and oropharyngeal mucositis.Only two patients occurred grade 4 acute toxicities,one was bone marrow suppression and the other was dermatitis radiation.Conclusions:The combination of raltitrexed and cisplatin has a comparable efficacy to those in standard firstline therapy. | Yuan Wu Xueyan Wei Zilong Yuan Hongbin Xu Yanping Li Ying Li Liu Hu Guang Han Yu Qian Desheng Hu | 2020 | Chinese Journal of Cancer Research2020，32，5： | 4 |
| 8 | Statin therapy improves response to interferon alfa and ribavirin in chronic hepatitis C: A systematic review and meta-analysis显示文摘 | Qianqian Zhu Na Li Qunying Han Pingping Zhang Cuiling Yang Xiaoyan Zeng Yanping Chen Yi Lv Xi Liu Zhengwen Liu | 2013 | Antiviral Research2013，，3： | 3 |
| 9 | Transcriptomic Response to Yersinia pestis:RIG-I Like Receptor Signaling Response Is Detrimental to the Host against Plague显示文摘Bacterial pathogens have evolved various mechanisms to modulate host immune responses for successful infection.In this study,RNAsequencing technology was used to analyze the responses of human monocytes THP1 to Yersinia pestis infection.Over 6000 genes were differentially expressed over the 12 h infection.Kinetic responses of pathogen recognition receptor signaling pathways,apoptosis,antigen processing,and presentation pathway and coagulation system were analyzed in detail.Among them,RIG-I-like receptor(RLR) signaling pathway,which was established for antiviral defense,was significantly affected.Mice lacking MAVS,the adaptor of the RLR signahng pathway,were less sensitive to infection and exhibited lower IFN-P production,higher Thl-type cytokines IFN-y and IL-12 production,and lower Th2-type cytokines EL-4 and IL-13 production in the serum compared with wild-type mice.Moreover,infection of pathogenic bacteria other than Y.pestis also altered the expression of the RLR pathway,suggesting that the response of RLR pathway to bacterial infection is a universal mechanism. | Zongmin Du Huiying Yang Yafang Tan Guang Tian Qingwen Zhang Yujun Cui Yanfeng Yan Xiaohong Wu Zuyun Chen Shiyang Cao Yujing Bi Yanping Han Xiaoyi Wang Yajun Song Ruifu Yan | 2014 | Journal of Genetics and Genomics2014，41，7： | 2 |
| 10 | Capacitive Performances of Reduced Graphene Oxide Hydrogel Prepared by Using Sodium Hypophosphite as Reducer显示文摘减少的 graphene 氧化物(rGOHGs ) 的 hydrogels 通过对待被综合了与钠次磷酸盐的各种各样的集中相配(不 2 在热水的状况下面的 PO 2) 。结果表明 rGOHGs 的结构与集中的增加一起变化不 2 PO 2 。与低集中准备的 rGO 表不 2 PO 2 展览更多成波形并且更大的特定的表面区域比与高集中准备的那些不 2 PO 2 。rGOHGs 的电容的表演的大小表明 rGOHGs 与低集中准备了不 2 PO 2 拥有更大的特定的电容(C s ) 与高集中比那准备了不 2 在低周期的 voltammetry 扫描的 PO 2 评价。然而, rGOHGs 与高集中准备了不 2 PO 2 拥有更大的 C 以比那些的高扫描率,更多的稳定性和更好高率的能力的 s 在低集中准备了。rGOHGs 的结构和性质能被控制集中调整,这被相信不 2 PO 2 根据要求。 | Cuixian Liu Gaoyi Han Yunzhen Chang Yaoming Xiao Yanping Li Miaoyu Li Haihan Zhou | 2016 | Chinese Journal of Chemistry2016，34，1： | 2 |
| 11 | Transcriptional regulation of the waaAE-coaD operon by PhoP and RcsAB in Yersinia pestis biovar Microtus显示文摘亲爱的编辑, | Lei Liu Nan Fang Yicheng Sun Huiying Yang Yiquan Zhang Yanping Han Dongsheng Zhou Ruifu Yang | 2014 | Protein & Cell2014，5，12： | 2 |
| 12 | Traditional Chinese Medicine guidelines for coronavirus disease 2019显示文摘OBJECTIVE:To summarize the evidence from Traditional Chinese Medicine(TCM)practice in the treatment of coronavirus disease 2019(COVID-19)and provide timely clinical practice guidance.METHODS:The guidelines were developed in accordance with the World Health Organization rapid guideline process.The evidence on TCM for COVID-19 from published guidelines,direct and indirect published clinical evidence,first hand clinical data,and expert experience and consensus were collected.The grading of recommendations assessment,development and evaluation(GRADE)method was used to grade the evidence and make the recommendations.RESULTS:Based on the available evidence,the guidelines recommended 17 Chinese medicines for COVID-19:2 Chinese herbal granules,7 Chinese patent medicines,and 8 Chinese herbal injections.CONCLUSION:As the literature search was conducted on March,any subsequent versions of these guidelines require an up-to-date literature review.We hope that the evidence summary in these guidelines will be helpful in global efforts to address COVID-19. | Liang Ning Ma Yanfang Wang Jingya Li Huizhen Wang Xiaohui Jiao Liwen Liu Bin Ma Yan Zhao Chen Luo Xufei Zhao Siya Lu Meng Cao Jin Hu Wenpin Zhang Hairong Liu Guoxiu Lu Cheng Liu Mengyu Li Li Han Xuejie Liu Yuqi Wang Liying Zhao Xueyao Wei Dongfeng Bai Jing Sun Mingyu Yang Yong Wu Xiaodan Chen Yaolong Shi Nannan Wang Yanping Wang Yongyan | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 2 |
| 13 | Role of mannose recep- tor in oligochitosan-mediated stimulation of macrophage function 显示文摘 | Yanping Han Luhang Zhao Zhijun Yu | 2005 | Int Immunopharmacol2005，5，10： | 1 |
| 14 | Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival显示文摘 | Xiaolan Zhou Jin Lin Wang John Lu Yanping Song Keith S. Kwak Qingsheng Jiao Robert Rosenfeld Qing Chen Thomas Boone W. Scott Simonet David L. Lacey Alfred L. Goldberg H.Q. Han | 2010 | Cell2010，，4： | 1 |
| 15 | A general model of pulverized coal devolatilization 显示文摘 | Weibiao Fu Yanping Zhang Hongqiao Han | 1989 | Fuel1989，68，： | 1 |
| 16 | IL21 and IL21R polymorphisms and their interactive effects on serum IL-21 and IgE levels in patients with chronic hepatitis B virus infection显示文摘 | Na Li Qianqian Zhu Zhu Li Qunying Han Jinghong Chen Yi Lv Yawen Wang Xiaoyan Zeng Yanping Chen Cuiling Yang Zhengwen Liu | 2013 | Human Immunology2013，，： | 1 |
| 17 | 显示文摘 | Li Yanping Bai Yunfei Han Gaoyi | 2013 | Sensors and Ac- tuators B2013，185，： | 1 |
| 18 | A general model of pulverized coal devolatilization显示文摘 | Fu Weibiao Zhang Yanping Han Hongqiao | 1989 | FUEL1989，68，4： | 1 |
| 19 | Decarburization mechanism of RH-MFB refining process显示文摘The overall decarburization mechanism can be divided into the decarburization in bulk molten steel and float- ing of CO against static pressure, the decarburization on the surface of argon bubbles and splashing particles. On the basis of each conception the RH-MFB decarburization mathematical model has been built according to the thermodynamic and mass conservation principle, and contributions of every decarburization mechanism were discussed and analyzed. | Chuanji Han Liqun Ai Bosong Liu Jun Zhang Yanping Bao Kaike Cai | 2006 | Journal of University of Science and Technology Beijing2006，13，3： | 1 |
| 20 | A general model of pulverized coal devolatilization显示文摘 | Fu Weibiao Zhang Yanping Han Hongqiao | 1989 | Fuel1989，68，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员