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| 1 | Predictors of response to antiviral therapy in patients with chronic hepatitis C from Pakistani population显示文摘背景丙肝病毒(HCV ) 在全世界组成一个主要公共健康问题,特别在开发象巴基斯坦一样的国家。在这研究,我们估计了在长期的丙肝病人的治疗在这研究由性,年龄,和病毒的 load.Methods 分类的干扰素(INF ) 的结果,有遗传型 3 的 750 个 HCV 积极病人被选择,从哪个 616 完成了全部治疗。他们的个人历史,支持处理的 HCV RNA 和浆液丙氨酸 transaminase (中高音) 是 quantified.Patients 与 INF- 2b 的联合治疗被对待 300 万个单位(三次一个星期) 正 ribavirin (1000-1200mg 每天) 为 24 个星期。在 24 个星期以后,他们的 HCV RNA 和浆液中高音水平是从 616 个病人,的 quantified.Results (63.5%) 391 对治疗学的政体(加 ribavirin 的 INF- 2b ) 作出回应。在应答者之中, 27.1% 是男人, 36.4% 是女人。最好的治疗反应在有 Iow 的病人被观察病毒的负担 8 ?????牴湡睳汥 吗?? | Hafsa Aziz Muhammad Amin Athar Shahnaz Murtaza Javaid Irfan Yasir Waheed Iram Bilal Abida Raza | 2011 | Chinese Medical Journal2011，，9： | 6 |
| 2 | Rapid virological response tailors the duration of treatment in hepatitis C virus genotype 3 patients treated with pegylated interferon alfa-2a and ribavirin in Pakistan显示文摘 | Uzma Gill Hafsa Aziz Muzaffar Lateef Gill | 2013 | International Journal of Infectious Diseases2013，，： | 1 |
| 3 | Analysis of variables and interactions among variables associated with a sustained virological response to pegylated interferon alfa-2a plus ribavirin in hepatitis C virus genotype 3-infected patients显示文摘 | Hafsa Aziz Abida Raza Yasir Waheed Uzma Gill Muzaffar Lateef Gill | 2012 | International Journal of Infectious Diseases2012，，8： | 1 |
| 4 | Evaluation of prognostic factors for Peg Interferon alfa-2b plus ribavirin treatment on HCV infected patients in Pakistan显示文摘 | Hafsa Aziz Muzaffar Latif Gil Yasir Waheed Uzama Adeeb Abida Raza Iram Bilal Muhammad Amin Athar | 2011 | Infection Genetics and Evolution2011，，3： | 1 |
| 5 | Numerical Solutions of Fractional Variable Order Differential Equations via Using Shifted Legendre Polynomials显示文摘In this manuscript,an algorithm for the computation of numerical solutions to some variable order fractional differential equations(FDEs)subject to the boundary and initial conditions is developed.We use shifted Legendre polynomials for the required numerical algorithm to develop some operational matrices.Further,operational matrices are constructed using variable order differentiation and integration.We are finding the operationalmatrices of variable order differentiation and integration by omitting the discretization of data.With the help of aforesaid matrices,considered FDEs are converted to algebraic equations of Sylvester type.Finally,the algebraic equations we get are solved with the help of mathematical software like Matlab or Mathematica to compute numerical solutions.Some examples are given to check the proposed method’s accuracy and graphical representations.Exact and numerical solutions are also compared in the paper for some examples.The efficiency of the method can be enhanced further by increasing the scale level. | Kamal Shah Hafsa Naz Thabet Abdeljawad Aziz Khan Manar A.Alqudah | 2023 | Computer Modeling in Engineering & Sciences2023，，2： | 0 |
| 6 | A case of a patient infected with a hepatitis C virus genotype 3a multidrug resistant variant in Pakistan显示文摘Background:Approximately 10 million people in Pakistan are infected with the hepatitis C virus(HCV).Most patients develop chronic hepatitis,with rare cases of spontaneous clearance.However,little is known about multidrug resistant viral variants in Pakistan.Findings:This case study describes a 47-year-old male diagnosed with chronic HCV genotype 3a infection in 2003.After an initial diagnosis of viral infection,the patient remained treatment naïve for 5 years.He received two therapy cycles of interferon(IFN)plus ribavirin(RBV)in 2007 and 2010,however,he was non-responsive to the therapy.The patient then received an additional two treatment cycles of pegylated IFNα-2b plus RBV(in 2011 and 2013);he was still non-responsive.In 2016,the patient underwent sofosbuvir plus RBV combination therapy,however,the sustained virological response was still not achieved.The host genetic factor was found to be heterozygous guanine and thymine(GT)and cytosine and thymine(CT)genotypes of rs8099917 and rs12979860 polymorphism of IL28B,respectively.Phylogenetic analysis suggests that the resistant variant belong to an out-group and may require triple therapy.Conclusions:This is the first case that reports on a HCV-infected individual who was a non-responder to multiple IFN therapies in Pakistan.Further studies are needed to understand multidrug-resistant HCV variants in the Pakistani population. | Asad Zia Muhammad Ali Hafsa Aziz Muhammad Zia Zabta Khan Shinwari Abida Raza | 2018 | Infectious Diseases of Poverty2018，7，1： | 0 |
| 7 | Prediction of promiscuous T cell epitopes in RNA dependent RNA polymerase of Chikungunya virus显示文摘Objective: To explore RNA dependent RNA polymerase of Chikungunya virus(CHIKV) and develop T cell based epitopes with high antigenicity and good binding affinity for the human leukocyte antigen(HLA) classes as targets for epitopes based CHIKV vaccine. Methods: In this study we downloaded 371 non-structural protein 4 protein sequences of CHIKV belonging to different regions of the world from the US National Institute of Allergy and Infectious Diseases(NIAID) virus pathogen resource database. All the sequences were aligned by using CLUSTALW software and a consensus sequence was developed by using Uni Pro U Gene Software version 1.2.1. PropredⅠand Propred software were used to predict HLAⅠ and HLAⅡ binding promiscuous epitopes from the consensus sequence of non-structural protein 4 protein. The predicted epitopes were analyzed to determine their antigenicity through Vaxijen server version 2.0. All the HLAⅠ binding epitopes were scanned to determine their immunogenic potential through the Immune Epitope Database(IEDB). All the predicted epitopes of our study were fed to IEDB database to determine whether they had been tested earlier. Results: Twenty two HLA class Ⅱ epitopes and eight HLA classⅠepitopes were predicted. The promiscuous epitopes WMNMEVKII at position 486–494 and VRRLNAVLL at 331–339 were found to bind with 37 and 36 of the 51 HLA class Ⅱ alleles respectively. Epitope MANRSRYQS at position 58–66 and epitopes YQSRKVENM at positions 64–72 were predicted to bind with 12 and 9 HLAⅠI alleles with antigenicity scores of 0.754 9 and 1.013 0 respectively. Epitope YSPPINVRL was predicted to bind 18 HLAⅠ alleles and its antigenicity score was 1.425 9 and immunogenicity score was 0.173 83. This epitope is very useful in the preparation of a universal vaccine against CHIKV infection. Conclusions: Epitopes reported in this study showed promiscuity, antigenicity as well as good binding affinity for the HLA classes. These epitopes will provide the baseline for development of efficacious vaccine for CHIKV. | Yasir Waheed Sher Zaman Safi Muzammil Hasan Najmi Hafsa Aziz Muhammad Imran | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，8： | 0 |
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