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| 1 | Iron and liver fibrosis: Mechanistic and clinical aspects显示文摘Liver fibrosis is characterised by excessive deposition of extracellular matrix that interrupts normal liver functionality. It is a pathological stage in several untreated chronic liver diseases such as the iron overload syndrome hereditary haemochromatosis, viral hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and diabetes. Interestingly, regardless of the aetiology, iron-loading is frequently observed in chronic liver diseases. Excess iron can feed the Fenton reaction to generate unquenchable amounts of free radicals that cause grave cellular and tissue damage and thereby contribute to fibrosis. Moreover, excess iron can induce fibrosis-promoting signals in the parenchymal and non-parenchymal cells, which accelerate disease progression and exacerbate liver pathology. Fibrosis regression is achievable following treatment, but if untreated or unsuccessful, it can progress to the irreversible cirrhotic stage leading to organ failure and hepatocellular carcinoma, where resection or transplantation remain the only curative options. Therefore,understanding the role of iron in liver fibrosis is extremely essential as it can help in formulating iron-related diagnostic, prognostic and treatment strategies. These can be implemented in isolation or in combination with the current approaches to prepone detection, and halt or decelerate fibrosis progression before it reaches the irreparable stage. Thus, this review narrates the role of iron in liver fibrosis. It examines the underlying mechanisms by which excess iron can facilitate fibrotic responses. It describes the role of iron in various clinical pathologies and lastly,highlights the significance and potential of iron-related proteins in the diagnosis and therapeutics of liver fibrosis. | Kosha J Mehta Sebastien Je Farnaud Paul A Sharp | 2019 | World Journal of Gastroenterology2019，25，5： | 39 |
| 2 | Through-needle all-optical ultrasound imaging in vivo: a preclinical swine study显示文摘High-frequency ultrasound imaging can provide exquisite visualizations of tissue to guide minimally invasive procedures.Here,we demonstrate that an all-optical ultrasound transducer,through which light guided by optical fibers is used to generate and receive ultrasound,is suitable for real-time invasive medical imaging in vivo.Broad-bandwidth ultrasound generation was achieved through the photoacoustic excitation of a multiwalled carbon nanotube-polydimethylsiloxane composite coating on the distal end of a 300-μm multi-mode optical fiber by a pulsed laser.The interrogation of a high-finesse Fabry–Pérot cavity on a single-mode optical fiber by a wavelength-tunable continuous-wave laser was applied for ultrasound reception.This transducer was integrated within a custom inner transseptal needle(diameter 1.08 mm;length 78 cm)that included a metallic septum to acoustically isolate the two optical fibers.The use of this needle within the beating heart of a pig provided unprecedented realtime views(50 Hz scan rate)of cardiac tissue(depth:2.5 cm;axial resolution:64μm)and revealed the critical anatomical structures required to safely perform a transseptal crossing:the right and left atrial walls,the right atrial appendage,and the limbus fossae ovalis.This new paradigm will allow ultrasound imaging to be integrated into a broad range of minimally invasive devices in different clinical contexts. | Malcolm C Finlay Charles A Mosse Richard J Colchester Sacha Noimark Edward Z Zhang Sebastien Ourselin Paul C Beard Richard J Schilling Ivan P Parkin Ioannis Papakonstantinou Adrien E Desjardins | 2017 | Light(Science & Applications)2017，6，1： | 6 |
| 3 | Bayés syndrome and acute cardioembolic ischemic stroke显示文摘Bayés syndrome is an under-recognized clinical condition characterized by advanced interatrial block.Bayés syndrome is a subclinical disease that manifests electrocardiographically as a prolonged P wave duration>120 ms with biphasic morphology±in the inferior leads.The clinical relevance of Bayés syndrome lies in the fact that is a clear arrhythmological syndrome and has a strong association with supraventricular arrhythmias,particularly atypical atrial flutter and atrial fibrillation.Likewise,Bayés syndrome has been recently identified as a novel risk factor for non-lacunar cardioembolic ischemic stroke and vascular dementia.Advanced interatrial block can be a risk for embolic stroke due to its known sequelae of left atrial dilation,left atrial electromechanical dysfunction or atrial tachyarrhythmia(paroxysmal or persistent atrial fibrillation),conditions predisposing to thromboembolism.Bayés syndrome may be responsible for some of the unexplained ischemic strokes and shall be considered and investigated as a possible cause for cryptogenetic stroke.In summary,Bayés syndrome is a poorly recognized cardiac rhythm disorder with important cardiologic and neurologic implications. | Adrià Arboix Lucía Martí Sebastien Dorison María José Sánchez | 2017 | World Journal of Clinical Cases2017，5，3： | 3 |
| 4 | The binding of pullulan modified cholesteryl nanogels to Aβ oligomers and their suppression of cytotoxicity 显示文摘 | SEBASTIEN B HARUKO T KAZUNARI A | 2009 | Biomaterials2009，30，29： | 1 |
| 5 | Genome-wide Analysis of Arabidpopsis Pentatricopetide Repeat Proteins Reveals their Essential Role in Organelle Biogenesis 显示文摘 | CLAIRE L CHARLES A SEBASTIEN A | 2004 | The Plant Cell2004，16，： | 1 |
| 6 | Effects of organochlorine insecticides on MAP Kinase pathways in human HaCaT keratinocytes: key role of reactive oxygen species显示文摘 | Nathalie L Sebastien A | 2005 | Toxicology science2005，86，2： | 1 |
| 7 | Unsteady side loads in a thrust- optimized contour nozzle at hysteresis regime显示文摘 | Sebastien D Nguyen A T | 2004 | AIAA Journal2004，42，9： | 1 |
| 8 | Traceability, liability, and incentives for food safety and quality显示文摘 | Sebastien P Daniel A | 2008 | American Agricultural Economics Association2008，90，1： | 1 |
| 9 | Identification of virus - encoded microRNAs 显示文摘 | Sebastien PFEFFER Mihaela ZAVOLAN Friedrich A GRASSER | 2004 | Science2004，304，5671： | 1 |
| 10 | Copper solubility and speciation of in situ contamination soils: effects Of copper level, pH and organic matter显示文摘 | Sebastien S Mcbride M B Norvell W A | 1997 | Water Air Soil Pollut1997，100，： | 1 |
| 11 | Traceability, liability, and incentives for food safety and quality显示文摘 | Sebastien Pouliot Daniel A Sumner | 2008 | American Journal of Agricultural Economics2008，90，1： | 1 |
| 12 | TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans显示文摘 | A VALANCE WASJINGTON SEBASTIEN GIBOT ISMAEL ACEVEDO JAMES GATTIS | 2009 | Clinical Investigation2009，119，6： | 1 |
| 13 | An infrared and theoretical study about the 'XCN' band formation: Reactivity of HNCO with NH3 astrophysical ice laboratory analogues and the spontaneous production of OCN-显示文摘 | Sebastien R Thierry C Alain A | 2003 | Physical Chemistry2003，107，44： | 1 |
| 14 | Copper solubility and speciation of in situ contamination soils: effects of copper level, pH and organic matter显示文摘 | Sebastien S McBride M B Norvell W A | 1997 | Water Air and Soil Pollution1997，100，： | 1 |
| 15 | Novel biodegradable films made from chitosan and poly (lactic acid) with antifungal properties against mycotoxinogen strains显示文摘 | Sebastien F Stephane G Copinet A | 2006 | Carbohyd Polym2006，65，： | 1 |
| 16 | Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells显示文摘 | Rashid S Tamir Corbineau Sebastien Hannan Nick Marciniak Stefan J Miranda Elena Alexander Graeme Huang-Doran Isabel Griffin Julian Ahrlund-Richter Lars Skepper Jeremy Semple Robert Weber Anne Lomas David A Vallier Ludovic | 2010 | Journal of Clinical Investigation2010，，9： | 1 |
| 17 | Celecoxib induces apoptosis by inhibiting 3-phosphoinositide-dependent protein kinase-1 activity in the human colon cancer HT-29 cell line显示文摘 | Sebastien A Sophle P Chantal B | 2002 | Biol Chem2002，277，27： | 1 |
| 18 | Differential regulation by Ambient pH of putative virulence factor secretion by the phytopathogenic fungus Botrytis cinerea 显示文摘 | Sebastien M Sylvie A Bernard L | 2003 | FEMS Microbiology Ecology2003，43，： | 1 |
| 19 | Novel biodegradable films made from chitosan and poly(lactic acid) with antifungal properties against mycotoxinogen strains显示文摘 | Sebastien F Stephane G Copinet A | 2006 | Carbohydrate Polymers2006，65，2： | 1 |
| 20 | The absence of intrarenal ACE protects against hypertension显示文摘 | Gonzalez-Villalobos Romer A Janjoulia Tea Fletcher Nicholas K Giani Jorge F Nguyen Mien TX Riquier-Brison Anne D Seth Dale M Fuchs Sebastien Eladari Dominique Picard Nicolas Bachmann Sebastian Delpire Eric Peti-Peterdi Janos Navar L Gabriel | 2013 | Journal of Clinical Investigation2013，，5： | 1 |
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