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| 1 | Lubiprostone vs Senna in postoperative orthopedic surgery patients with opioid-induced constipation:A double-blind,active-comparator trial显示文摘AIM:To investigate the efficacy of lubiprostone compared to Senna on bowel symptoms and constipation in post-operative orthopedic patients treated with opioids.METHODS:In this double blind,randomized,active comparator trial,adults who required opioids for analgesia following orthopedic procedures and who were admitted in inpatient rehabilitation were randomized following baseline assessments to lubiprostone(Amitza),orally twice aday or Senna(generic)two capsules administered daily for six days.Subjects were assessed using the patient assessment of constipation(PAC)-symptoms(PAC-SYM)and the PAC-quality of life(PAC-QOL)scales measured at baseline and Day 7;Subjects were assessed daily for secondary measures included the Bristol stool scale bowel consistency,specific bowel symptom score(Nausea,cramping,straining,completeness,abdominal pain,time per lavatory attempt,assistance needed),adverse events and rescue medications required.Function was measured using the functional independence measure(FIM)at admission and discharge;length of stay(LOS)and missed treatments due to gastrointestinal symptoms were also assessed.RESULTS:64 adults were enrolled;56 participants(28 in each group)had baseline and follow up measures and were included in the intention to treat(ITT)analyses.43 participants completed the study,21 in the active lubiprostone and 22 in the active Senna group.The mean age of the participants was 71.5years(SD=11.4 years,range:28-96 years).In the ITT analyses,participants showed significant improvement in bowel symptoms as measured by the PACSYM(mean±SD,-0.28±0.60,range:-1-2.33)and PAC-QOL(mean±SD,0.33±0.81,range:-1.5-2.0)over time,but there were no significant differences between the lubiprostone and Senna groups in mean change in the PAC-SYM(-0.20±0.60 vs-0.36±0.61,P=0.61 respectively)or the PAC-QOL(0.29±0.76 vs0.37±0.87,P=0.61 respectively).The mean change in each bowel symptom also did not significantly differ between treatment groups on ITT analyses,except for completeness of bowel movement,with the Senna group showing greater negative mean change in bowel movement completeness(-0.56±1.01 vs-2.00±1.41,P=0.03)and for reduction of abdominal pain,favoring Senna(-0.14±0.73 vs-0.73±1.08,P=0.04).Fifteen(75%)participants in the lubiprostone and in the Senna group requested rescue treatments.Participants made significant functional improvement from admission to discharge over a median LOS of 12 d,with a mean FIM change of 29.13±13.58 and no significant between group differences(27.0±9.2 vs 31.5±16.6,P=0.27).CONCLUSION:Both lubiprostone and Senna improved constipation-related symptoms and QOL in opioid-induced constipation,with no significant between-group differences. | Christina M Marciniak Santiago Toledo Jungwhalia Lee Michael Jesselson Jillian Bateman Benjamin Grover Joy Tierny | 2014 | World Journal of Gastroenterology2014，20，43： | 7 |
| 2 | Laser-induced white-light emission from graphene ceramics–opening a band gap in graphene显示文摘Recent theoretical and experimental studies have indicated the existence of a new stable phase of carbon with mixed sp^(2) and sp^(3) hybridized bonds—diaphite.Such a two-layered structure with sp^(2)/sp^(3) bonds may be observed after the photostimulation of highly oriented pyrolytic graphene with femtosecond laser pulses.This hidden multistability of graphene may be used to create a semiconducting phase immersed in the semimetallic continuum,resulting in bandgap opening.We demonstrate that bandgap opening and light emission from graphene is possible using continuous-wave laser beams with wavelengths from the visible(405 nm)to the near-infrared range(975 nm).We demonstrate that without the application of cooling,the effective temperature of the emitting sample remains lower than 900 K,which is far below the value predicted by the theory of black-body radiation.Moreover,light emission from a graphene sample may be observed at temperatures as low as 10 K. | Wieslaw Strek Bartlomiej Cichy Lukasz Radosinski Pawel Gluchowski Lukasz Marciniak Mikolaj Lukaszewicz Dariusz Hreniak | 2015 | Light(Science & Applications)2015，4，1： | 6 |
| 3 | Major complications following exenteration in cases of pelvic malignancy:A 10-year experience显示文摘瞄准:在妇产科、直肠的恶意的取出肚肠以后分析主要复杂并发症。方法:有妇产科的恶意的 22 个病人并且 6 与直肠的恶意经历了在 1996 和 2005 之间的盆腔脏器除去术(PE ) 。 PE 在71.4%盒子中为主要恶意被执行(在 13 的外阴癌症,在 5 直肠的癌症,在 1 的颈的癌症和 Bartholin 分别地是在 1 种情况中的腺癌症并且在28.6%盒子中的周期性的恶意(在 5 的颈的癌症,在 1 的卵巢的癌症,在 1 的子宫的肉瘤和在 1 种情况中的直肠的癌症分别地)。以后的 PE,全部的 PE 和前面的 PE 最经常被执行。结果:包含泌尿道感染或伤口裂开的起作用的领域里的主要复杂并发症发生在 12 个病人(42.9%) 。早复杂并发症包括了从骶的丛,成年呼吸窘迫症候群(ARDS ) ,血栓静脉炎,尖锐肾衰竭,膀胱机能障碍,输尿管损坏,重新操作和肺的栓子的巨大的流血。尿失禁作为迟了的复杂并发症在 2 个女人被观察。在 1 个病人,肾造口术由于有的复杂并发症与胃肠道连接了的广泛的肾盂积水膨出和 1 个病人在 1 个病人被执行。死亡率是 7% ,哪个内部起作用的死亡占了 3.5% 。主要复杂并发症经常在与周期性的恶意影响那些的先进主要外阴癌症发生了。结论:PE 比到有周期性的癌症的那些对有主要外阴、直肠的癌症的病人更有益。固有的复杂并发症的知识和 PE 的病态是必要的。 | Dariusz Wydra Janusz Emerich Sambor Sawicki Katarzyna Ciach Andrzej Marciniak | 2006 | World Journal of Gastroenterology2006，12，7： | 5 |
| 4 | Endoplasmic reticulum stress signaling in disease显示文摘 | Marciniak SJ Ron D | 2006 | Physiol Rev2006，86，4： | 1 |
| 5 | Effect of modest salt reduction on blood pressure, urinary albumin, and pulse wave velocity in white, black, and Asian mild hypertensives 显示文摘 | HE FJ MARCINIAK M VISAGIE E | 2009 | Hypertension2009，54，3： | 1 |
| 6 | High energy laser weapons: technology overview 显示文摘 | Glen P Perram Michael A Marciniak | 2004 | SPIE2004，，5414： | 1 |
| 7 | Endoplasmic reticulum stress signaling in disease 显示文摘 | Marciniak S J Ron D | 2006 | Physiol Rev2006，86，4： | 1 |
| 8 | Limit strains in the process of stretch-forming sheet metal 显示文摘 | Marciniak Z Kuczynski K | 1967 | Int J Mech Sci1967，9，： | 1 |
| 9 | The cost of treating anxiety: the medical and demographic correlates that impact total medical costs 显示文摘 | Marciniak MD I_age MJ Dunayevich E | 2005 | Depress Anxiety2005，21，4： | 1 |
| 10 | Routing optimization inoptical burst switching networks:a multi-pathrouting approach 显示文摘 | Klinkowski M Marciniak M | 2010 | Graphs and Algorithms inCommunication Networks2010，，： | 1 |
| 11 | Limit strains in the proces-ses of stretch-forming sheet metal 显示文摘 | MARCINIAK Z KUCZYNSKI K | 1967 | International Journal ofMechanical Sciences1967，9，9： | 1 |
| 12 | Urinary incontinence in adults with cerebral palsy: prevalence, type, and effects on par- ticipation显示文摘 | Marciniak C O'Shea SA Lee J | 2014 | PMR2014，6，2： | 1 |
| 13 | Collision-free finish toolpaths from visibility data显示文摘 | Balasubramaniam Mahadevan Sarma Sanjay E Marciniak Krzyztof | 2003 | Comouter-Aided Desien2003，35，4： | 1 |
| 14 | Fluoroscopic guidance of Arndt endobronchial blocker placement for single-lung ventilation in small children 显示文摘 | Marciniak B Fayoux P H6brard A | 2008 | Acta Anaesthesiol Scand2008，52，7： | 1 |
| 15 | Endoplasmic reticulum stress signaling in disease 显示文摘 | Marciniak S Ron D | 2006 | Physiol Rev2006，86，： | 1 |
| 16 | Analysis of uncertainties in infrared camera measurements of a turbofan engine in an altitude test cell显示文摘 | Morris T A Marciniak M A Wollenweber G C | 2006 | Infrared physics & technology2006，48，2： | 1 |
| 17 | CHOP induces death by promoting protein synthesis and oxidation in the stressed en- doplasmic reticulum显示文摘 | Marciniak S J Yun C Y Oyadomari S | 2004 | Genes Dev2004，18，24： | 1 |
| 18 | Limit strains in the processes of stretch-forming sheet metal 显示文摘 | Marciniak Z Kuczynski K | 1967 | International Journal of Mechani- cal Science1967，7，： | 1 |
| 19 | Heteroplasmy of Mouse mtDNA Is Genetically Unstable and Results in Altered Behavior and Cog- nition 显示文摘 | Sharpley M S Marciniak C Eckel- Mahan K | 2012 | Ce112012，151，2： | 1 |
| 20 | Limit strains in the process of stretch-forming sheet metal 显示文摘 | Marciniak Z Kuczynski K | 1967 | International Journal of Mechanical Sciences1967，9，9： | 1 |
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