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| 1 | Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection显示文摘AIM: Clinical and experimental data suggest that gut-derived endotoxins are an important pathogenic factors for progression of chronic liver disease. Recently, a C-T (-159)polymorphism in the promoter region of the CD14 gene was detected and found to confer increased CD14 expression and to be associated with advanced alcoholic liver damage. Here, we investigated this polymorphism in patients with less advanced alcoholic liver disease (ALD)and chronic hepatitis C virus (HCV) infection.METHODS: CD14 genotyping was performed by PCR-RFLP analysis in (a) 121 HCV patients, (b) 62 patients with alcohol-associated cirrhosis (Alc-Ci), (c) 118 individuals with heavy alcohol abuse without evidence of advanced liver damage (Alc-w/o Ci), and (d) 247 healthy controls.Furthermore, serum levels of soluble CD14 (sCD14) and transaminases were determined.RESULTS: The TT genotype was significantly more frequent in Alc-Ci compared to Alc-w/o Ci or controls (40.3% vs 23.7% or 24.0%, respectively). In Alc-w/o Ci,serum levels of transaminases did not differ significantly between patients with different CD14 genotypes. In HCV patients, TT-homozygotes had significantly higher sCD14 levels and sCD14 serum levels were significantly higher in patients with advanced fibrosis or cirrhosis. However,no association was found between CD14 genotypes and histological staging or grading.CONCLUSION: Considering serum transaminases as surrogate markers for alcoholic liver damage, the CD14 polymorphism seems to exhibit different effects during the course of ALD. Differences in genotype distribution between cirrhotic HCV patients and alcoholics and the known functional impact of this polymorphism on CD14 expression levels further indicate differences in the pathophysiological role of CD14 and CD14-mediated lipopolysaccharides signal transduction with regard to the stage as well as the type of the underlying liver disease. | C Meiler M Mühlbauer M Johann A Hartmann B Schnabl N Wodarz G Schmitz J Schlmerich C Hellerbrand | 2005 | World Journal of Gastroenterology2005，11，38： | 3 |
| 2 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 3 | Early clinical worsening in patients with TIA or minor stroke: The Austrian Stroke Unit Registry显示文摘 | J Ferrari M Knoflach S Kiechl J Willeit S Schnabl L Seyfang W Lang | 2010 | Neurology2010，，2： | 2 |
| 4 | Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia显示文摘 | Shehata M Schnabl S Demirtas D | 2010 | {H}Blood2010，，14： | 1 |
| 5 | Role of TLR9 in hepatic stellate cells and experimental liver fibrosis 显示文摘 | Ggbele E M/ihlbauer M Dorn C Weiss TS Froh M Schnabl B Wiest R Sch61merich J Obermeier F Hellerbrand C | 2008 | Biochem Biophys Res Commun2008，376，2： | 1 |
| 6 | Following tetraploidy in maize, a short deletion mec- hanism removed genes preferentially from one of the two homologs显示文摘 | Woodhouse M R Schnable J C Pedersen B S | 2010 | Plos Biology2010，8，10： | 1 |
| 7 | The roles of aldehyde dehydrogenases (ALDHs) in the PDH bypass of Arabidopsis显示文摘 | Wei Y L Lin M Oliver D J Schnable P S | | 0，，： | 1 |
| 8 | Role of TLR9 in hepatic stellate cellsand experimental liver fibrosis 显示文摘 | Gabele E Miihlbauer M Dorn C Weiss T S Froh M Schnabl B | 2008 | Biochem BiophysRes Commun2008，376，： | 1 |
| 9 | Association of DHODH haplotype variants and response to leflunomide treat-ment in rheumatoid arthritis 显示文摘 | O'Doherty C Schnabl M Spargo L | 2012 | Pharmaco genomics2012，13，12： | 1 |
| 10 | Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10显示文摘 | Schnabl B Hu K Muhlbauer M | 2005 | Biochem Biophys Res Commun2005，335，1： | 1 |
| 11 | Locking free two- layer Timoshenko beam element with interlayer slip 显示文摘 | Schnabl S Saje M Turk G | 2007 | Finite Elements in Analysis and Design2007，43，9： | 1 |
| 12 | Effects of trans-acting genetic modifiers on meiotic recombination across the a1-sh2 interval of maize显示文摘 | YANDEAU-NELSON M D NIKOLAU B J SCHNABLE P S | 2006 | Genetics2006，174，： | 1 |
| 13 | The B73 maize genome:Complexity,diversity,and dynamics显示文摘 | Schnable P S Ware D Fulton R S Stein J C Wei F Pasternak S Liang C Zhang J Fulton L Graves T A Minx P Reily A D Courtney L Kruchowski S S Tomlinson C Strong C Delehaunty K Fronick C Courtney B Rock S M Belter E Du F Kim K Abbott R M Cotton M Levy A Marche | | 0，，5956： | 1 |
| 14 | Portable LED-Array VIS-NIR spectrophotometer/nephelometer显示文摘 | SCHNABLE J G M GROCHOWSKI P J WILHELM L | 1998 | Field Analytical Chrmistry and Technology1998，2，1： | 1 |
| 15 | Reconstitution of PTEN activity by CK2inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia显示文摘 | Shehata M Schnabl S Demirtas D | 2010 | Blood2010，116，14： | 1 |
| 16 | Role of TLR9 in hepatic stellate cells and experimental liver fibrosis显示文摘 | Erwin G?bele Marcus Mühlbauer Christoph Dorn Thomas S. Weiss Matthias Froh Bernd Schnabl Reiner Wiest Jürgen Sch?lmerich Florian Obermeier Claus Hellerbrand | 2008 | Biochemical and Biophysical Research Communications2008，，2： | 1 |
| 17 | Low temperature atmos pheric pressure plasma sources for microbial decontamination显示文摘 | Ehlbeck J Schnable U Polak M | 2011 | Journal of Phvsics D: ADolied Physics2011，44，1： | 1 |
| 18 | Soft-decision decoding ofReed-Muller codes as generalized multiple concatenatedcodes 显示文摘 | SCHNABL G BOSSERT M | 1995 | Information Theory IEEE Transactions on1995，41，1： | 1 |
| 19 | Locking-free two-layer Timoshenko beam element with interlayer slip显示文摘 | Schnabl S Saje M Turk G | 2007 | Finite Elements in Analysis and Design2007，43，70： | 1 |
| 20 | The B73 maize genome:complexity,diversity,and dynamics显示文摘 | Schnable P.S Ware D Fulton R.S Stein J.C Wei F Pasternak S Liang C Zhang J Fulton L Graves T.A Minx P Reily A.D Courtney L Kruchowski S.C Tomlinson C Strong C Delehaunty K Fronick C Courtney B Rock S.M Belter E Du F Kim K Abbott R.M Cotton M Levy A Marche | | 0，，： | 1 |
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