|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Heme oxygenase-1 overexpression increases liver injury after bile duct ligation in rats显示文摘AIM: To investigate the effects of heme oxygenase-1 (HO-1) against oxidant-induced injury caused by bile duct ligation (BDL). METHODS: Either cobalt protoporphyrin (CoPP), a HO-1 inducer, or saline were injected intraperitoneally in male SD-rats. Three days later, BDL or sham-operations were performed. Rats were sacrificed 3 wk after BDL and livers were harvested for histology. Fibrosis was evaluated by sirius red staining and image analysis. Alpha-smooth muscular actin, which indicates activation of stellate cells, was detected by immunohistochemical staining, and cytokine and collagen-Ⅰα (Col-Ⅰα) mRNA expression was detected using RNase protection assays. RESULTS: Serum alanine transaminase increased 8-fold above normal levels one day after BDL. Surprisingly, enzyme release was not reduced in rats receiving CoPP. Liver fibrosis was evaluated 3 wk after BDL and the sirius red-positive area was found to be increased to about 7.8%. However, in CoPP pretreated rats sirius red- positive areas were increased to about 11.7% after BDL. Collagen-Ⅰα and TGF-β mRNA increased significantly by BDL. Again, this effect was increased by HO-1 overexpression.CONCLUSION: Hepatic fibrosis due to BDL is not reduced by the HO-1 inducer CoPP. In contrast, HO-1 overexpression increases liver injury in rats under conditions of experimental chronic cholestasis. | Matthias Froh Lars Conzelmann Peter Walbrun Susanne Netter Reiner Wiest Michael D Wheeler Mark Lehnert Takehiko Uesugi Jurgen Scholmerich Ronald G Thurman | 2007 | World Journal of Gastroenterology2007，13，25： | 4 |
| 2 | Role of HSP-90 for increased nNOS-mediated vasodilation in mesenteric arteries in portal hypertension显示文摘AIM:To explore the role of heat shock protein-90 (HSP-90) for nitrergic vasorelaxation in the splanchnic circulation in rats with and without portal hypertension. METHODS: Neuronal nitric oxide synthase (nNOS) and HSP-90 were analyzed by immunofluorescence, western blotting and co-immunoprecipitation in the mesenteric vasculature and isolated nerves of portal-vein-ligated (PVL) rats and sham operated rats. In vitro perfused de-endothelialized mesenteric arterial vasculature was preconstricted with norepinephrine (EC80) and tested for nNOS-mediated vasorelaxation by periarterial nerve stimulation (PNS, 2-12 Hz, 45V) before and after incubation with geldanamycin (specific inhibitor of HSP-90 signalling, 3 μg/mL) or L-NAME (non-specific NOSblocker, 10-4 mol/L). RESULTS: nNOS and HSP-90 expression was significantly increased in mesenteric nerves from PVL as compared to sham rats. Moreover, nNOS and HSP-90 were visualized in mesenteric nerves by immunofluorescence and immunoprecipitation of nNOS co-immunoprecitated HSP-90 in sham and PVL rats. PNS induced a frequencydependent vasorelaxation which was more pronounced in PVL as compared to sham rats. L-NAME and geldanamycin markedly reduced nNOS-mediated vasorelaxation abrogating differences between the study groups. The effect of L-NAME and geldanamycin on nNOS-mediated vasorelaxation was significantly greater in PVL than in sham animals. However, no difference in magnitude of effect between L-NAME and geldanamycin was noted. CONCLUSION: HSP-90 acts as a signalling mediator of nNOS-dependent nerve mediated vascular responses in mesenteric arteries, and the increased nitrergic vasorelaxation observed in portal hypertension is mediated largely by HSP-90. | Lukas Moleda Lars Jurzik Matthias Froh Erwin Gbele Claus Hellerbrand Rainer H Straub Jürgen Schlmerich Reiner Wiest | 2010 | World Journal of Gastroenterology2010，16，15： | 4 |
| 3 | Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice显示文摘 | Takehiko Uesugi Matthias Froh Gavin E. Arteel Blair U. Bradford Ronald G. Thurman | 2001 | Hepatology2001，，1： | 2 |
| 4 | The voices of breastfeeding resource nurses显示文摘 | Froh E B Flynn-Roth R Barton S | 2015 | Journal of Obstetric Gynecologic & Neonatal Nursing2015，44，3： | 1 |
| 5 | Optimization of stabilization and carbonization treatment of PAN fibers and structural characterization of the resulting carbon fibers显示文摘 | Fitzer E Frohs W Heins M | 1987 | Carbon1987，24，4： | 1 |
| 6 | Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice 显示文摘 | UESUGI T FROH M ARTEEL G E | 2001 | Hepatology2001，34，1： | 1 |
| 7 | The use of technologies to support human milk &breastfeeding 显示文摘 | Froh EB Hallowell S Spatz DL | 2015 | J Pediatr Nurs2015，30，3： | 1 |
| 8 | Gratitude and the reduced costs of materialism in adolescents显示文摘 | Froh J J Emmons R A Card N A | 2011 | Journal of Happiness Studies2011，，12： | 1 |
| 9 | Couming Blessings Versus Burdens: An Experimental Investigation of Gratitude and Subjective Well-Being in Daily Life 显示文摘 | JJ Froh WJ Sefick RA Emmons | 2008 | Journal of School Psychology2008，46，： | 1 |
| 10 | Making meaning of pumping for mothers of infants with congenital diaphragmatic hernia 显示文摘 | Froh EB Deatrick JA Curley MAQ | 2015 | J Obstet Gynecol Neonatal Nurs2015，44，3： | 1 |
| 11 | Measuringgratitude in youth ; Assessing the psychometric propertiesof adult gratitude scales in children and adolescents 显示文摘 | FROH J J FAN J EMMONS R A ET AL | 2011 | Psychological assessment2011，23，2： | 1 |
| 12 | Optimization of stabilization and carbonization treatment of PAN fibres and structural characterization of the resulting carbon fibres显示文摘 | Fitzer E Frohs W Heine M | 1986 | Carbon1986，24，4： | 1 |
| 13 | Optimization of stabilization and carbonization treatment of PAN fibers and structural characterization of the resulting carbon fibers显示文摘 | Fitzer E Frohs W Heine M | 1986 | Carbon1986，24，4： | 1 |
| 14 | Gratitude and subjective well-being in early adolescence: examining gender differences 显示文摘 | FROH J J YURKEWICZ C KASHDAN | 2009 | Journal of Adolescence2009，32，： | 1 |
| 15 | Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat显示文摘 | Lehmann TG Wheeler MD Froh M | 2003 | Transplantation2003，76，1： | 1 |
| 16 | Gratitude and subjective well - being in early adolescence : examining gender differences 显示文摘 | Froh JJ Yurkewicz C Kashdan TB | 2009 | J Ad- olesc2009，32，3： | 1 |
| 17 | TNFalpha is required for cholestasis-induced liver fibrosis in the mouse显示文摘 | Gabele E Froh M Arteel G E | | 0，，03： | 1 |
| 18 | Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat显示文摘 | Lehmann TG Wheeler MD Froh M | 2003 | Transplantation2003，76，1： | 1 |
| 19 | Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice 显示文摘 | Uesugi T Froh M Arteel GE | 2001 | Hepatology2001，34，1： | 1 |
| 20 | ICAM-1 is involved in the mechanism of alcohol-induced liver injury: studies with knockout mice显示文摘 | Kono H Uesugi T Froh M etal | 2001 | Am J Physiol Gastrointest Liver Physiol2001，280，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员