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| 1 | Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype显示文摘AIM: To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS: Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial lymph node (MLN) cells was measured by ELISA. Immunohistochemistry was performed to detect intestinal dendritic cells (DCs) within the colonic tissue, and the effect of the calcitriol analog on DCs was investigated. RESULTS: Treatment with ZK191784 resulted in significant amelioration of disease with a reduced histological score in acute and chronic intestinal inflammation. In animals with acute DSS colitis, down- regulation of colonic inflammation was associated with a dramatic reduction in the secretion of the proinflammatory cytokine interferon (IFN)-γ and a significant increase in intereleukin (IL)-10 by MLN cells. Similarly, in chronic colitis, IL-10 expression in colonic tissue increased 1.4-fold when mice were treated with ZK191784, whereas expression of the Th1-specific transcription factor T-beta decreased by 81.6%. Lower numbers of infiltrating activated CD11c+ DCs were found in the colon in ZK191784-treated mice with acute DSScolitis, and secretion of proinflammatory cytokines by primary mucosal DCs was inhibited in the presence of the calcitriol analog. CONCLUSION: The calcitriol analog ZK191784 demonstrated significant anti-inflammatory properties in experimental colitis that were at least partially mediated by the immunosuppressive effects of the derivate on mucosal DCs. | Ulrike G Strauch Florian Obermeier Nicole Grunwald Nadja Dunger Heiko C Rath Jürgen Schlmerich A Steinmeyer U Zügel HH Herfarth | 2007 | World Journal of Gastroenterology2007，13，48： | 4 |
| 2 | Loss of CD103^+ intestinal dendritic cells during colonic inflammation显示文摘AIM:To investigate possible differences in dendritic cells(DC)within intestinal tissue of mice before and after induction of colitis. METHODS:Mucosal DC derived from intestinal tissue,as well as from mesenteric lymph nodes and spleen,were analyzed by fluorescence activated cell sorting(FACS) analysis.Supernatants of these cells were analyzed for secretion of different pro-and anti-inflammatory cytokines. Immunohistochemistry and immunofluorescence were performed on cryosections of mucosal tissue derived from animals with colitis as well as from healthy mice. RESULTS:It was shown that DC derived from healthy intestinal lamina propria(LP)represented an immature phenotype as characterized by low-level expression of costimulatory cytokines.In contrast to DC from spleen and mesenteric lymph nodes(MLN)that secreted proinflammatory cytokines,LP-DC produced high levels of the anti-inflammatory cytokine IL-10.After induction of mu-rine colitis in a CD4 + CD62L + transfer model or in chronic Dextran sulfate sodium-colitis,a marked increase of activated CD80 + DC could be observed within the inflamed colonic tissue.Interestingly,in contrast to splenic DC,a significant population of DC within MLN and colonic LP expressed the mucosal integrin CD103 which was lost during colitis. CONCLUSION:The constitutive secretion of antiinflammatory cytokines by immature DC within the intestinal LP might regulate the homeostatic balance between mucosal immunity and tolerance.CD103 + DC could mediate this important function. | Ulrike G Strauch Nicole Grunwald Florian Obermeier Sonja Gürster Heiko C Rath | 2010 | World Journal of Gastroenterology2010，16，1： | 2 |
| 3 | Smoking increases the risk of extraintestinal manifestations in Crohn's disease显示文摘AIM:To demonstrate a high prevalence of extraintestinal manifestations(EIMs)in a prospective populationbased cohort of inflammatory bowel disease(IBD)patients at first diagnosis as well as during the early course of the disease.METHODS:EIMs are common in patients with IBD.Data on the frequency of EIMs have mostly been assessed in patients from tertiary centers;however,data about the prevalence of EIMs at first diagnosis as well as factors influencing their incidence during the early course of disease from prospective population-based cohorts are scarce.We present data of patients of our population-based'Oberpfalz cohort'(Bavaria,Germany)from first diagnosis(up to 3 mo after first diagnosis)as well as during the early course of the disease.Possible risk factors were assessed by calculating the relative risk(RR)as well as using logistic regression analysis.RESULTS:In total,data of 257 newly diagnosed patients with IBD were evaluated[161 Crohn’s disease(CD),96 ulcerative colitis(UC)].Median duration of follow-up was 50 mo after first diagnosis.In 63.4%of all patients(n=163),an EIM was diagnosed at any point during the observation period.At first diagnosis,patients with CD had a significantly increased risk of an EIM[n=69(42.9%)]compared with UC patients[n=21(21.9%);P<0.001;RR=1.96;95%CI:1.30-2.98].Active smoking increased the risk of CD patients developing an EIM during the early course of the disease,but notably not of UC patients(P=0.046;RR=1.96;95%CI:1.01-3.79).In addition,using logistic regression analysis,the need for IBD-related surgery and a young age at first diagnosis were identified as risk factors for the development of an EIM in CD patients.No association with EIMs was found for the factors sex,localization of the disease and positive family history of IBD.In contrast,no key factors which increased the risk of development of an EIM could be identified in UC patients.CONCLUSION:We found a high prevalence of EIM in this cohort at first diagnosis and during the early course of the disease.In patients with CD,smoking,need for surgery and younger age at first diagnosis were risk factors for the development of an EIM. | Claudia Ott Angela Takses Florian Obermeier Elisabeth Schnoy Martina Müller | 2014 | World Journal of Gastroenterology2014，20，34： | 2 |
| 4 | Selection and characterization of mixed starter cultures for lactic acid fermentation of carrot, cabbage, beet and onion vegetable mixtures显示文摘 | Nancy J. Gardner Tony Savard Paule Obermeier Gary Caldwell Claude P. Champagne | 2001 | International Journal of Food Microbiology2001，，3： | 2 |
| 5 | Deletion of a Stay-Green Gene Associates with Adaptive Selection in Brassica napus显示文摘叶绿素层次响应改变环境关于植物生长和生理的粘性提供重要信息。停留绿色基因黄得非(NYE1 ) 1 被相信在老朽期间调整叶绿素降级,附随地影响轻收获的建筑群的拆卸并且间接地因此影响光合作用。我们识别了带与增加的叶绿素内容,并且与轻收获的复杂、光合的反应中心(希腊语的第二十三个字母和 PSII ) 的 upregulated 表示联系的 NYE1 删除的 Brassica 马来麝就职基因。有相关基因背景的就职的种子油内容的比较分析揭示了 B。马来麝 NYE1 基因删除(bnnye1 ) 影响了油累积,并且连接不平衡签名建议地点由在 oilseed B 繁殖服从于人工的选择。马来麝形式。在 allopolyploid B 的三不同生态型之间的 haplotype 差异组(haplogroups ) 的比较分析。马来麝和它的 A-subgenome 双祖先, Brassica rapa,从亚洲 B 显示了 bnnye1 删除的那基因渗入。rapa 进冬季类型 B。马来麝可能同时改进了它的改编到播种秋天的油菜籽经验丰富的更凉爽的环境。 | Lunwen Qian Kai Voss-Fels Yixin Cui Habib U. Jan Birgit Samans Christian Obermeier Wei Qian Rod J. Snowdon | 2016 | Molecular Plant2016，9，12： | 2 |
| 6 | Tamoxifen resistance in MCF7 cells promotes EMT-like behaviour and involves modulation of beta-catenin phosphorylation 显示文摘 | Hiscox S Jiang WG Obermeier K | 2006 | Int J Cancer2006，118，2： | 1 |
| 7 | Development, mainte nance and disruption of the blood-brain harrier显示文摘 | Obermeier B Daneman R Ransohoff RM | 2013 | Nat Med2013，19，12： | 1 |
| 8 | Development, maintenance and disruption of the blood-brain barrier 显示文摘 | Obermeier B Daneman R Ransohoff RM | 2013 | Nat Med2013，19，12： | 1 |
| 9 | The incidence of inflammatory bowel disease in a rural region of Southern Germany: a prospective population-based study显示文摘 | Claudia Ott Florian Obermeier Sabine Thieler Daniela Kemptner Alexandra Bauer Jürgen Sch?lmerich Gerhard Rogler Antje Timmer | 2008 | European Journal of Gastroenterology & Hepatology2008，，9： | 1 |
| 10 | Microactuators and their technologies显示文摘 | Thielicke E Obermeier E | 2000 | Mechatronics2000，，10： | 1 |
| 11 | Does early improve- ment triggered by antidepressants predict response/remission? Analysis of data from a naturalistic study on a large sample of inpatients with major depression显示文摘 | Henkel V Seemu Iler F Obermeier M | 2009 | Affect Disord2009，115，3： | 1 |
| 12 | High temperature 10 bar pressure sensor based on 3C-SIC/SOI for turbine control applica- tions 显示文摘 | Zappe S Franklin J Obermeier E | 2000 | Silicon Carbide and Related Materials2000，353，3： | 1 |
| 13 | Clq/TNF-related protein-3 ( CTRP-3 ) is secreted by visceral adipose tissue and exerts antiinflammatory and antifibrotie effects in primary human colonic fibroblasts显示文摘 | Hofmann C Chen N Obermeier F | 2011 | Inflamm Bowel Dis2011，17，12： | 1 |
| 14 | The wide-ranging application of po- lysilicon layer in solid-state sensors 显示文摘 | Kopystynski P Obermeier E | 1989 | Sensors and Actuators1989，17，： | 1 |
| 15 | Use of liquefaction-induced features for palaeoseismic analysis:An overview of how seismic liquefaction features can be distinguished from other features and how their regional distribution and properties of source sediment can be used to infer the location and strength of Holocene paleo-earthquakes显示文摘 | Obermeier S F | 1996 | Engineering Geology1996，44，： | 1 |
| 16 | Contrasting activity of cytosin-guanosin dinucleotide oligonucleotides in mice with experimental colitis显示文摘 | Obermeier F Dunger N Strauch UG Grunwald N Herfarth H Scholmerich J | 2003 | Clin Exp Immunol2003，134，2： | 1 |
| 17 | Clq/TNF-related protein 3 (CTRP-3) is secreted by visceral adipose tissue and exerts antiinflammatory and antifibrotic effects in primary human colonic fibroblasts显示文摘 | Hoffmann C Chen N Obermeier F | 2011 | Inflamm Bowel Dis2011，17，12： | 1 |
| 18 | High Prevalence but Insufficient Treatment of Iron-Deficiency Anemia in Patients with Inflammatory Bowel Disease: Results of a Population-Based Cohort显示文摘 | Claudia Ott Anne Liebold Angela Takses Ulrike G. Strauch Florian Obermeier P. Gionchetti | 2012 | Gastroenterology Research and Practice2012，，： | 1 |
| 19 | Cancer-related microangiopathic hemolytic anemia: clinical and laboratory features in 168 re- ported cases 显示文摘 | Lechner K Obermeier HL | 2012 | Medicine (Baltimore)2012，91，4： | 1 |
| 20 | Growth inhibition of Staphylococcus aureus induced by low-frequency electric and electromagnetic fields显示文摘 | OBERMEIER A MATL FLORIAN D FRIESS W | 2009 | Bioelectromagnetics2009，30，4： | 1 |
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