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| 1 | Sirtuin deacetylases in neurodegenerative diseases of aging显示文摘Sirtuin 酶是高度保存的蛋白质 deacetylases 的一个家庭为他们的活动取决于菸碱腺嘌 dinucleotide (NAD+) 。在哺乳动物有七 sirtuins,这些蛋白质被 modulating 精力新陈代谢, genomic 稳定性和压力抵抗与热量的限制和老化连接了。Sirtuin 酶是在包括癌症,糖尿病,煽动性的混乱和 neurodegenerative 疾病的许多人的疾病的潜在的治疗学的目标。sirtuin 活动的调整被显示了包括 Alzheimer 的疾病影响几形成总数的 neurodegenerative 混乱的功课, Parkinson 的疾病,亨廷顿的疾病, amyotrophic 侧面的硬化和针、球根的肌肉发达的萎缩。Sirtuins 能由 modulating 抄写因素活动并且直接影响 neurodegenerative 混乱的前进 deacetylating proteotoxic 种类。这里,我们在几形成总数的 neurodegenerative 疾病描述 sirtuin 蛋白质目标并且讨论在这些混乱调制 sirtuin 活动的混合物的治疗学的潜力。 | Adrianna Z Herskovits Leonard Guarente | 2013 | Cell Research2013，23，6： | 13 |
| 2 | SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β‐catenin显示文摘 | Petra Simic Kayvan Zainabadi Eric Bell David B. Sykes Borja Saez Sutada Lotinun Roland Baron David Scadden Ernestina Schipani Leonard Guarente | 2013 | EMBO Mol Med2013，，3： | 2 |
| 3 | SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle显示文摘 | Takashi Nakagawa David J. Lomb Marcia C. Haigis Leonard Guarente | 2009 | Cell2009，，3： | 2 |
| 4 | The Sir2 family of protein deacety- lases 显示文摘 | Blander G Guarente L | 2004 | Annu Rev Biocbem2004，73，： | 1 |
| 5 | The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms显示文摘 | Kaeberlein M McVey M Guarente L | 1999 | Genes Dev1999，13，19： | 1 |
| 6 | SIRT1 and other sirtuins in metabo- lism 显示文摘 | Chang H C Guarente L | 2014 | Trends in Endocrinology & Metabolism2014，25，3： | 1 |
| 7 | The Sir2 family of protein deacetylases显示文摘 | BLANDER G GUARENTE L | 2004 | Annu Rev Biochem2004，73，5： | 1 |
| 8 | The Sir2 family of protein deacetylases 显示文摘 | Blander G Guarente L | 2004 | Annu Rev Biochem2004，73，2： | 1 |
| 9 | The SIRT3 divining rod points to oxidative stress 显示文摘 | Bell E L Guarente L | 2011 | Mol Cell2011，42，5： | 1 |
| 10 | Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans显示文摘 | Tissenbaum HA Guarente L | | 0，，6825： | 1 |
| 11 | Mitochondria-a nexus for aging, calorie restriction, and sirtuins 显示文摘 | Guarente L | 2008 | Cell2008，132，2： | 1 |
| 12 | The Sir2 family of protein deacetylases 显示文摘 | Blander G Guarente L | 2004 | Annu Rev Biochem2004，73，： | 1 |
| 13 | Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae显示文摘 | Lin SJ Defossez PA Guarente L | 2000 | Science2000，289，5487： | 1 |
| 14 | Genetics and the specificity of the ag-ing process显示文摘 | Hekimi S Guarente L | 2003 | Science2003，299，5611： | 1 |
| 15 | The Sir2 family of protein deacetylases显示文摘 | Blander G Guarente L | 2004 | Ann Rev Biochem2004，73，： | 1 |
| 16 | Calorie restriction, SIRT1 and metabolism: understanding longevity 显示文摘 | Bordone L Guarente L | 2005 | Nature Reviews Molecular Cell Biology2005，6，4： | 1 |
| 17 | How does calorie restriction work?显示文摘 | Koubova J Guarente L | 2003 | Genes Dev2003，17，3： | 1 |
| 18 | How does calorie restriction work显示文摘 | Koubova J Guarente L | 2003 | Genes Dev2003，17，3： | 1 |
| 19 | Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans 显示文摘 | Tissenbaum HA Guarente L | 2001 | Nature2001，410，6825： | 1 |
| 20 | Molecular biolo- gy of aging显示文摘 | Johnson F B Sinclair D A Guarente L | 1999 | Cell1999，96，2： | 1 |
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