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77篇 您的检索式：作者名="Cirstea"

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	题名	作者	年代	出处	被引量
1	Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing显示文摘Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating osteoporosis,a common disease of the elderly population. Here, unbiased kinome RNAi screening in primary murine osteoblasts identified cyclin-dependent kinase 5(Cdk5) as a suppressor of osteoblast differentiation in both murine and human preosteoblastic cells. Cdk5 knockdown by si RNA, genetic deletion using the Cre-lox P system, or inhibition with the small molecule roscovitine enhanced osteoblastogenesis in vitro. Roscovitine treatment significantly enhanced bone mass by increasing osteoblastogenesis and improved fracture healing in mice. Mechanistically, downregulation of Cdk5 expression increased Erk phosphorylation, resulting in enhanced osteoblast-specific gene expression. Notably, simultaneous Cdk5 and Erk depletion abrogated the osteoblastogenesis conferred by Cdk5 depletion alone, suggesting that Cdk5 regulates osteoblast differentiation through MAPK pathway modulation. We conclude that Cdk5 is a potential therapeutic target to treat osteoporosis and improve fracture healing.	Mubashir Ahmad Benjamin Thilo Krüger Torsten Kroll Sabine Vettorazzi Ann-Kristin Dorn Florian Mengele Sooyeon Lee Sayantan Nandi Dilay Yilmaz Miriam Stolz Naveen Kumar Tangudu David Carro Vázquez Johanna Pachmayr Ion Cristian Cirstea Maja Vujic Spasic Aspasia Ploubidou Anita Ignatius Jan Tuckermann	2022	Bone Research2022，10，3：	2
2	Feedback and cognition in armmotor skill reacquisition after stroke 显示文摘	Cirstea C M Ptito A Levin M F	2006	Stroke2006，37，5：	1
3	General uniqueness results and variation speed for blow-up solutions of elliptic equa- tions显示文摘	CIRSTEA F DU Y	2005	Proc London Math Soc2005，91，：	1
4	FPGA design methodology for industrial control systems-a review显示文摘	Monmasson E Cirstea M N	2007	Industrial Electronics IEEE Transactions on2007，54，4：	1
5	Inhibition of autophagy by ACY-1215, a selective HDAC6 inhibitor accelerates carfilzomib- induced cell death in multiple 显示文摘	Mishima Y Santo L Cirstea DD	2013	Blood (ASH Annual Meeting Abstracts)2013，122，：	1
6	Dual inhibition of akt/mammalian target of rapamycin pathway by nanopar- tide albumin-bound-rapamyein and perifosine induces an- titumor activity in multiple myeloma显示文摘	Cirstea D Hideshima T Rodig S	2010	Mol Cancer T- her2010，9，4：	1
7	FPGA design methodology for industrial control systems-a review显示文摘	MONMASSON E CIRSTEA M N	2007	IEEE Transactions on In-dustrial Electronics2007，54，4：	1
8	Artificial linear episome-based protein expression system for protozoon Leishmania tarentolae 显示文摘	Kushnir S Cirstea I C Basiliya L	2011	Mol Bioehem Parasitol2011，176，2：	1
9	Application of accel- erated electron beam and microwave irradiation to biological waste treatment显示文摘	Martin DI Margaritescu I Cirstea E	2005	Vacuum2005，77，4：	1
10	General uniqueness results and variation speed for blow-up solutions of elliptic equations显示文摘	Cirstea F C Du Y H	2005	ProcLondon Math Soc2005，91，45：	1
11	A VHDL Success-Story:Electric Drive System Using Neural Controller显示文摘	Marcian Cirstea Andrei Dinu Malcolm McComick	2000	Proceeding of VIVF 2000 Workshop2000，，：	1
12	Uniqueness of the blow-up boundary solution of logistic equation with absorption显示文摘	Cirstea F C RSdulescu V	2002	C R AcadSci Paris Ser I2002，335，44：	1
13	Existence and NonExistence Results for a Quasilinear Problem with Nonlinear Boundary Condition显示文摘	CIRSTEA F C S RADULESCU V	2000	J Math AnalAppl2000，244，1：	1
14	In vivo and in vitro effects of a novel anti-Dkk1 neutralizing antibody in multiple myeloma显示文摘	Samantha Pozzi Mariateresa Fulciniti Hua Yan Sonia Vallet Homare Eda Kishan Patel Loredana Santo Diana Cirstea Teru Hideshima Linda Schirtzinge Stuart Kuhstoss Kenneth C. Anderson Nikhil Munshi David Scadden Henry M. Kronenberg Noopur Raje	2013	Bone2013，，2：	1
15	Combination of nab - rapamycin and perifosine induces synergistic cytotoxicity and antitumor activity via autophagy and apoptosis in multiple myeloma ( MM ) 显示文摘	Cirstea D Hideshirrm T Pozzi S	2008	Blood2008，112，：	1
16	Boundary blow-up in nonlinear elliptic equations of Bieberach-Rademacher type显示文摘	Cirstea F C RSdulescu V	2007	Trans AmerMath Soc2007，，：	1
17	Feedback and Cognition in Ann Mo- tor Skill Reacquisition After Stroke 显示文摘	Cirstea CM Ptito A Levin MF	2006	Stroke2006，37，：	1
18	Application of accelerated electron beam and microwave irradiation to biological waste treatment显示文摘	Martin DI Margaritescu I Cirstea E	2005	Vacuum2005，，：	1
19	Dual Inhibition of Akt/Mammalian Target of Rapamycin Pathway by Nanoparticle Albumin-Bound-Rapamycin and Perifosine Induces Antitumor Activity in Multiple Myeloma显示文摘	Cirstea D Hideshima T Rodig S	2010	Mol Cancer Ther2010，9，：	1
20	FPGA design method- ology for industrial control systems - a review显示文摘	MONMASSON E CIRSTEA M N	2007	IEEE Transactions on Industrial Electronics2007，54，4：	1

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