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| 1 | Use of venous-to-arterial carbon dioxide tension difference to guide resuscitation therapy in septic shock显示文摘The mixed venous-to-arterial carbon dioxide(CO_2)tension difference[P(v-a) CO_2]is the difference between carbon dioxide tension(PCO_2) in mixed venous blood(sampled from a pulmonary artery catheter) and the PCO_2 in arterial blood.P(v-a) CO_2 depends on the cardiac output and the global CO_2 production,and on the complex relationship between PCO_2 and CO_2 content.Experimental and clinical studies support the evidence that P(v-a) CO_2 cannot serve as an indicator of tissue hypoxia,and should be regarded as an indicator of the adequacy of venous blood to wash out the total CO_2generated by the peripheral tissues.P(v-a) CO_2 can be replaced by the central venous-to-arterial CO_2 difference(△PCO_2),which is calculated from simultaneous sampling of central venous blood from a central vein catheter and arterial blood and,therefore,more easy to obtain at the bedside.Determining the △PCO_2 during the resuscitation of septic shock patients might be useful when deciding when to continue resuscitation despite a central venous oxygen saturation(SCVO_2) > 70%associated with elevated blood lactate levels.Because high blood lactate levels is not a discriminatory factor in determining the source of that stress,an increased △PCO_2(> 6 mmHg)could be used to identify patients who still remain inadequately resuscitated.Monitoring the △PCO_2 from the beginning of the reanimation of septic shock patients might be a valuable means to evaluate the adequacy of cardiac output in tissue perfusion and,thus,guiding the therapy.In this respect,it can aid to titrate inotropes to adjust oxygen delivery to CO_2 production,or to choose between hemoglobin correction or fluid/inotrope infusion in patients with a too low ScvO_2 related to metabolic demand.The combination of P(v-a) CO_2 or △PCO_2 with oxygen-derived parameters through the calculation of the P(v-a) CO_2 or △PCO_2/arteriovenous oxygen content difference ratio can detect the presence of global anaerobic metabolism. | Jihad Mallat Malcolm Lemyze Laurent Tronchon Beno?t Vallet Didier Thevenin | 2016 | World Journal of Critical Care Medicine2016，5，1： | 25 |
| 2 | Genetic diversity of the hepatitis C virus: Impact and issues inthe antiviral therapy显示文摘The hepatitis C Virus (HCV) presents a high degree of genetic variability which is explained by the combination of a lack of proof reading by the RNA dependant RNA polymerase and a high level of viral replication. The re- sulting genetic polymorphism defines a classification in clades, genotypes, subtypes, isolates and quasispecies. This diversity is known to reflect the range of responses to Interferon therapy. The genotype is one of the pre- dictive parameters currently used to define the antiviral treatment strategy and the chance of therapeutic suc- cess. Studies have also reported the potential impact of the viral genetic polymorphism in the outcome of antivi- ral therapy in patients infected by the same HCV geno- type. Both structural and non structural genomic regions of HCV have been suggested to be involved in the Inter- feron pathway and the resistance to antiviral therapy. In this review, we first detail the viral basis of HCV diversity. Then, the HCV genetic regions that may be implicated in resistance to therapy are described, with a focus on the structural region encoded by the E2 gene and the non- structural genes NS3, NS5A and NS5B. Both mechanisms of the Interferon resistance and of the new antiviral drugs are described in this review. | H Le Guillou-Guillemette S Vallet C Gaudy-Graffin C Payan A Pivert A Goudeau F Lunel-Fabiani | 2007 | World Journal of Gastroenterology2007，13，17： | 6 |
| 3 | Placental accommodations for transport and metabolism during intra-uterine crowding in pigs显示文摘Litter size and birth weights are limited by uterine capacity, defined as the ability of the uterus to maintain the appropriate development of some number of conceptuses. Uterine capacity is the result of the combined effects of uterine, placental and embryo/fetal function. The number of living conceptuses that the uterus is capable of supporting is greater during early gestation compared to later gestation. Plots of log fetal weight versus log placental weight also indicate that fetal weights are less sensitive to reduced placental weight(and therefore reduced intrauterine space) in early gestation compared to late gestation. However, even in late gestation,mechanisms still exist that maintain fetal growth when the size of the placenta is reduced. One such mechanism is likely to be improved development of the folded placental-epithelial/maternal-epithelial bilayer. Fold depth, and therefore the maternal fetal interactive surface, increases as gestation advances and is greater in placenta from small fetuses. On the fetal side of the placenta, the epithelial bilayer is embedded in stromal tissue. Glycosaminoglycans are major components of stroma, including hyaluronan and heparan sulfate. Hyaluronidases and heparanases are present within placental tissues, and likely play roles in modification of stromal components to facilitate fold development. Glycosaminoglycans are polymers of forms of glucose(glucosamine, glucuronic acid, iduronic acid)suggesting that glycosaminoglycan synthesis may compete with the glucose needs of the developing fetus.Pig conceptuses are fructogenic, such that a substantial portion of glucose transferred from mother to fetus is converted to fructose. Fructose is an intermediate product in the synthesis of glucosamine from glucose, and glucosamine is linked to regulation of trophoblast cell proliferation through regulation of m TOR. These findings suggest a link between glucose, fructose, glucosamine synthesis, GAG production, and placental morphogenesis,but the details of these interactions remain unclear. In addition, recent placental epithelial transcriptome analysis identified several glucose, amino acid, lipid, vitamin, mineral and hormone transporter mechanisms within the placenta. Further elucidation of mechanisms of placental morphogenesis and solute transport could provide clues to improving nutrient transport to the pig fetus, potentially increasing litter size and piglet birth weights. | Jeffrey L Vallet Anthony K Mc Neel Jeremy R Miles Bradley A Freking | 2015 | Journal of Animal Science and Biotechnology2015，6，2： | 5 |
| 4 | Postconditioning in focal cerebral ischemia: Role of the mitochondrial ATP-dependent potassium channel显示文摘 | Emmanuel Robin Malika Simerabet Sidi Mohammed Hassoun Sebastien Adamczyk Benoit Tavernier Benoit Vallet Régis Bordet Gilles Lebuffe | 2010 | Brain Research2010，，： | 2 |
| 5 | Predictive factors for rhabdomyolysis after bariatric surgery 显示文摘 | LAGANDRE S ARNALSTEEN L VALLET B | 2006 | Obes Surg2006，16，10： | 1 |
| 6 | Experimental study of thermal stratification in ventilated confined spaces显示文摘 | Bouzinaoui A Vallete P Lemoine F | 2005 | Int J of Heat and Mass Transfer2005，48，19： | 1 |
| 7 | Cell-surface Expression of the Channel Activating Protease xCAP-1 Is Required for Activation of ENaC in the Xenopus Oocyte显示文摘 | Vallet V Pfister C Lolling J | 2002 | J Am Soc Nephrol (S1046 - 6673 )2002，13，3： | 1 |
| 8 | Vascular endothelial cell dyafunction in septic shock显示文摘 | Wiel E Vallet B | 2001 | Crit Care Med2001，，： | 1 |
| 9 | Central venous arterial carbon dioxide difference: an additional target for goal - directed therapy in septic shock显示文摘 | Vallee F Vallet B Mathe O | 2008 | Intensive Care Med2008，34，8： | 1 |
| 10 | Yeno-arterial CO2 difference during regional ischemic or hypoxie hypoxia 显示文摘 | Vallet B Teboul JL Cain S | 2000 | J Appl Physiol2000，89，4： | 1 |
| 11 | Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease显示文摘 | Vallet S Mukherjee S Vaghela N | 2010 | Proc Natl Acad Sci U S A2010，107，： | 1 |
| 12 | An adaptation of the vector-space model for ontology-based information retrieval显示文摘 | CASTELLS P FERNANDEZ M VALLET D | 2007 | IEEE transactions on knowledge and data engineering2007，19，2： | 1 |
| 13 | Thalidomide and lenalidomide: Mechanism-based potential drug combinations显示文摘 | Sonia Vallet Antonio Palumbo Noopur Raje Mario Boccadoro Kenneth C. Anderson | 2008 | Leukemia & Lymphoma2008，，7： | 1 |
| 14 | Silicon incorporation in hydroxyapatite obtained by controlled crystallization显示文摘 | Arcos D Rodriguez Carvajal J Vallet Regi M | 2004 | Chem Mater2004，16，6： | 1 |
| 15 | Endothelial cell dysfunction and coagulation显示文摘 | Vallet B | 2001 | Crit Care Med2001，29，7： | 1 |
| 16 | Venous oxygen saturation as a physio- logic transfusion trigger显示文摘 | Vallet B Robin E Lebuffe G | 2010 | Crit Care2010，14，2： | 1 |
| 17 | An adaptation of the vector-space model for ontology-based information retrieval 显示文摘 | CASTELLS P FERNANDEZ M VALLET D | 2007 | IEEE Transactions on Knowledge and Data Engineering2007，19，2： | 1 |
| 18 | A coupled NMR and MS isotopic method for the authentication of natural vinegars显示文摘 | Gérald Remaud Claude Guillou Claude Vallet Gérard J. Martin | 1992 | Fresenius’ Journal of Analytical Chemistry1992，，4： | 1 |
| 19 | Nitric oxide scavenging mod ulates mitochondrial dysfunction induced by hypoxia/reoxygenation 显示文摘 | Robin E Derichard A Vallet B | 2011 | Pharmacol Rep2011，63，1： | 1 |
| 20 | Bench-to-bedside review: Endothelial cell dysfunction in severe sepsis: a role in organ dysfunction? 显示文摘 | | 2003 | Crit Care2003，7，： | 1 |
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