维普中文期刊产品整合服务
11503篇 您的检索式:作者名="Brien"
    题名 作者 年代 出处 被引量
1Field Relationships,Geochemistry,Zircon Ages and Evolution of a Late Archaean to Palaeoproterozoic Lower Crustal Section in the Hengshan Terrain of Northern China显示文摘The Hengshan complex forms part of the central zone of the North China Craton and consists predominantly of ductilely-deformed late Archaean to Palaeoproterozoic high-grade, partly migmatitic, granitoid orthogneisses, intruded by mafic dykes of gabbroic composition. Many highly strained rocks were previously misinterpreted as supracrustal sequences and represent mylonitized granitoids and sheared dykes. Our single zircon dating documents magmatic granitoid emplacement ages between 2.52 Ga and 2.48 Ga, with rare occurrences of 2.7 Ga gneisses, possibly reflecting an older basement. A few granitic gneisses have emplacement ages between 2.35 and 2.1 Ga and show the same structural features as the older rocks, indicating that the main deformation occurred after ~2.1 Ga. Intrusion of gabbroic dykes occurred at~1920 Ma, and all Hengshan rocks underwent granulite-facies metamorphism at 1.88-1.85 Ga, followed by retrogression, shearing and uplift.We interpret the Hengshan and adjacent Fuping granitoid gneisses as the lower, plutonic, part of a late Archaean to early Palaeoproterozoic Japan-type magmatic arc, with the upper, volcanic part represented by the nearby Wutai complex. Components of this arc may have evolved at a continental margin as indicated by the 2.7 Ga zircons. Major deformation and HP North China Craton collided to form the Trans-North China orogen. Shear zones in the Hengshan are interpreted as major lower crustal discontinuities post-dating the peak of HP metamorphism, and we suggest that they formed during orogenic collapse and uplift of the Hengshan complex in the late Palaeoproterozoic (<1.85 Ga).A. KRONER S.A. WILDE P.J. O'BRIEN LI Jianghai C.W. PASSCHIER N.P. WALTE LIU Dunyi 2005Acta Geologica Sinica(English Edition)2005,79,5:91
2血管性认知损害诊断的进一步规范化:血管性认知损害分类共识研究组指南显示文摘引言血管性认知损害(vascular cognitive impairment,VCI)诊断共识的缺乏(体现为多种不同评估方案的使用),妨碍了对其理解和治疗的推进.多个国家的大量临床医生和研究人员参与了2个阶段血管性认知损害分类共识研究(Vascular Impairment of Cognition Classification Consensus Study,VICCCS),旨在就VCI的诊断原则(VICCCS-1)和诊断方案(VICCCS-2)达成一致意见.本文提供了VICCCS-2的相关内容.方法使用VICCCS-1达成的原则和已发表的诊断指南作为在线德尔菲(Delphi)调查的参考基点,以期对VCI的临床诊断达成共识.结果共进行了6轮调查,每轮有65~79名专家参与,他们就VICCCS修订的轻度和重度VCI的诊断指南达成共识,并肯定了美国国立神经疾病与卒中研究所-加拿大卒中网(National Institute of Neurological Disorders and Stroke–Canadian Stroke Network,NINDS-CSN)发布的神经心理学评估方案和对影像学检查的推荐意见.讨论VICCCS-2建议规范化应用NINDS-CSN推荐的神经心理学和影像学评估方案诊断VCI,以促进研究协作.Olivia A. Skrobot Sandra E. Black Christopher Chen Charles DeCarli Timo Erkinjuntti Gary A. Ford Rajesh N. Kalaria John O'Brien Leonardo Pantoni Florence Pasquier Gustavo C. Roman Anders Wallin Perminder Sachdev Ingmar Skoog the VICCCS group Yoav Ben-Shlomo Anthony P. Passmore Seth Love Patrick G. Kehoe 朱婷珂 徐俊 2018国际脑血管病杂志2018,26,4:58
3小麦不同器官氮素累积分布动态规律的研究(英文)显示文摘在自然条件下 ,研究了 4个小麦基因型各组织器官氮素的动态分布与累积变化。结果表明 :基因型间在叶、茎、颖壳、叶鞘未包被的穗下节部分的氮素含量和籽粒蛋白质含量上存在着显著差异。叶片是前期组织氮素的重要贮存器官和籽粒灌浆中氮素的主要供给源。叶片组织氮素的含量在幼苗期最高 ,而叶氮总量的累积则在孕穗期最多。籽粒蛋白质含量和蛋白质产量的提高伴随着各组织器官氮素水平的下降。氮肥的施用可显著提高各器官组织氮素的含量 ,进而提高籽粒蛋白质含量。孕穗后 5次取样的各器官组织氮素含量与籽粒蛋白质含量绝大多数呈显著正相关。因此 ,在小麦品质育种工作中 ,结合组织氮素进行选择 ,可有效地提高选择效果 。侯有良 L.O'Brien 钟改荣 2001作物学报2001,27,4:35
4应用微卫星分型方法进行大熊猫父亲鉴定显示文摘选用18对大熊猫特异的微卫星引物对成都动物园、成都大熊猫繁育研究基地的大熊猫幼子及其母亲和可疑父亲DNA作了PCR扩增。扩增产物在ABI373测序仪上做基因扫描。应用Genotyper672软件处理分型数据,经Cervus2.0软件对亲子关系进行分析。结果表明,在母子关系确实的情况下,18个基因座联合的父亲鉴定排除概率E为0.999921,置信度为95%。而在母子关系不清的条件下,E=0.994109,但置信度低于80%。由于圈养大熊猫的母子关系都是确实的。因此,基因型分析的结果能有效确认出这些大熊猫之间的父子关系。但要准确鉴定出野生大熊猫的亲缘关系,我们还需更多的微卫星标记。张志和 沈富军 孙姗 Victor A.David 张安居 Stephen J.O'Brien 2003遗传2003,25,5:36
5Nitrate Transport, Sensing, and Responses in Plants显示文摘氮(N) 是影响植物生长和开发的必要 macronutrient。N 是叶绿素,氨基酸, nucleic 酸,和第二等的代谢物的一个重要部件。硝酸盐是在土壤的最丰富的 N 来源之一。因为硝酸盐和其它 N 营养素经常正在限制,植物开发了复杂机制在可变环境保证营养素的足够的供应。硝酸盐全神贯注于根并且由硝酸盐 transporters 动员了到另外的机关。硝酸盐察觉到激活局部地并且在整个植物水平在分子、新陈代谢、生理、发展的回答之上侵犯的发信号的小径。与 genomics 技术和基因工具的来临,在我们硝酸盐和另外的 N 滋养的回答的理解的重要进展在过去的十年被完成了。而且,从单个种利用在分叉的个人在场的自然多型性的技术在揭开是必要的新部件。然而,仍然在我们硝酸盐发信号怎么在植物影响生物过程的理解有差距。而且,我们仍然缺乏识别的所有规章的因素怎么交往的一个综合看法或串音安排植物典型地展出的无数 N 回答。在这评论,我们提供由哪个硝酸盐全部被察觉到并且搬运植物的机制的更新的概述。我们讨论发信号的部件并且怎么在植物局部地并且全球性为发展回答与神经质的小径察觉到串音的硝酸盐。理解硝酸盐怎么在植物影响植物新陈代谢,生理学,和生长和开发对为持续农业改进庄稼关键。Jose A. O'Brien Andrea Vega Eleonore Bouguyon Gabriel Krouk Alain Gojon Gloria Coruzzi Rodrigo A. Gutierrez 2016Molecular Plant2016,9,6:32
6建筑中人行为模拟研究现状和展望显示文摘人行为是影响建筑能耗的重要因素,近几年成为建筑能耗模拟领域的研究热点。在过去的几十年中已有大量的相关研究,致力于通过实测建立事件或环境相关的人行为模型,但是,目前的人行为研究中还需要进一步发展,以满足工程实际的需要。本文回顾了人行为研究的研究现状,总结了在研究方法上现存的问题,从数据采集、模型建立、模型验证和软件开发4个从建模到应用的阶段,提出了人行为研究的未来展望。并讨论了人行为研究中尚存在的一些共性问题,例如:在实测中应进一步探讨采样的规模和实验室研究的可行性,建立人行为模型时应明确模型面向的应用层次,合理的数学形式、参数选择的方法、多因素多行为多人的模拟等尚待研究,针对模型的验证应以实际应用为指向确定验证的指标,采取科学有效的验证方法,以及在人行为相关软件的开发中,应定义良好的软件结构和接口,建立统一的描述框架,以相对独立的模块形式实现和模拟软件的交互。希望这些探讨能为将来的人行为研究提供新的思路,以推动人行为和建筑能耗模拟事业的发展。燕达 丰晓航 王闯 Hong Tianzhen William O’Brien H.Burak Gunay Farhang Tahmasebi Ardeshir Mahdavi 2015建筑科学2015,31,10:23
7血管性认知障碍的诊断标准:国际血管性行为与认知障碍学会的申明显示文摘长期以来,脑血管病(CVD)就被认为是认知损害的一个重要原因,但是有关脑血管病后认知障碍的概念化却有着一段多变的历史。'动脉变硬'或脑的动脉粥样硬化是'老化'的原因,是存在已久的观点,在20世纪60年代受到了来自英格兰纽卡斯尔的神经病理学研究的质疑。这些研究表明,血管性痴呆(vascular dementia,Va D)与超过一定程度的多发性脑梗死有关。徐岩 郭起浩 Sachdev P Kalaria R O'Brien J Skoog I Alladi S Black SE Blacker D Blazer DG Chen C Chui H Ganguli M Jellinger K Jeste DV Pasquier F Paulsen J Prins N Rockwood K Roman G Scheltens P 2014神经病学与神经康复学杂志2014,11,3:19
8普通小麦营养器官氮素和果聚糖的运转显示文摘研究了普通小麦营养器官氮素和果聚糖的运转及其与籽粒产量和蛋白质含量的关系。结果表明 ,基因型间营养器官在氮素和果聚糖的累积和运转方面存在显著差异。高蛋白质基因型营养器官氮素累积多且转移也多 ,后期吸收较少 ;而低蛋白质基因型则正好相反。叶片是氮素的主要贮存器官 ,果聚糖则主要贮存在茎鞘。增施氮肥提高了营养器官氮素的累积和运转 ,但降低了果聚糖的累积和运转。叶片、茎鞘、全株营养器官总氮素的运转与籽粒蛋白质含量呈正相关 ;茎鞘、全株营养器官总果聚糖的运转与籽粒产量呈正相关。果聚糖的运转与籽粒蛋白质含量呈负相关 ,与氮素的运转则无相关。侯有良 钟改荣 L.O'Brien 2002中国农业科学2002,35,9:17
9小麦干物质、果聚糖和氮的积累分配及其与籽粒产量和品质的关系显示文摘 在200kg/hm2施N条件下,对17个澳大利亚小麦品种的干物质、果聚糖、氮的积累分配及其与籽粒产量(GY)、籽粒氮产量(GNY)及籽粒氮含量(GNC)的关系进行了研究。结果表明,干物质、果聚糖和氮积累的模式相似,在叶片、茎秆和植株中分别于开花期、乳熟期和成熟期积累到最大值。在开花前,茎秆是贮存果聚糖的主要器官,叶片是氮的主要贮存器官,而在花期后,籽粒成为贮存果聚糖和氮最多的器官,其次为茎秆。从乳熟期至成熟期,随着干物质、果聚糖和氮在营养器官中积累的降低,GY、GNY和籽粒果聚糖积累快速增加。在多数取样期,植株干物质积累和果聚糖积累与GY和GNY呈极显著正相关,与GNC呈负相关;成熟期植株氮积累与GY呈显著负相关,与GNC显著正相关;在花期后,叶片和茎秆氮积累与GY和GNY呈显著负相关。赵万春 高翔 董剑 Bonnett D G O'Brien L 2005西北农林科技大学学报(自然科学版)2005,33,3:14
10Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury显示文摘BACKGROUND: The exact mechanism by which cyclooxy- genase-2 (COX-2) promotes inflammation in pancreatitis in obscure. This study was undertaken to investigate the role of COX-2 inhibition in an animal model of pancreati- tis , a disease process characterized by a systemic inflamma- tory response and ensuing neutrophil-mediated lung injury. METHODS: Pancreatitis was induced in 24 Sprague-Daw- ley rats by intraperitoneal injection of 20% L-arginine (500 mg/100 g body weight). The animals were randomized into 3 groups (8 rats in each group); controls and rats with pancreatitis intravenously resuscitated with either normal saline (0.9% NaCl 3 ml/kg) at 24 and 48 hours or COX-2 inhibitor (parecoxib 1 mg/kg). Pancreatic and lung inju- ries were assessed histologically. Lung injury was assessed utilizing wet;dry ratio and myeloperoxidase activity to in- dicate pulmonary neutrophil infiltration. A Western blot was used to determine COX-2 protein expression in pancrea- tic tissue. RESULTS: The animals treated with COX-2 inhibitors dis- played significantly less pancreatic and lung injuries than their normal saline counterparts. Histological pancreatic and lung injury scores were significantly reduced (P <0.05) in the COX-2 treated group. Lung wet: dry ratios were sig- nificantly improved and pulmonary neutrophil infiltration was attenuated in the COX-2 group (P<0.05). Western blot analysis confirmed attenuated COX-2 protein expression. CONCLUSION: This study shows, for the first time in a rat model, that adjuvant COX-2 inhibition significandy attenu- ates the severity of both pancreatitis and its associated sys- temic inflammatory response and end-organ injury.Gavin O'Brien Conor J Shields Desmond C Winter John P Dillon 2005Hepatobiliary & Pancreatic Diseases International2005,4,1:12
11小麦谷蛋白亚基的组成及含量与谷蛋白聚合体大分子的关系及其对面包烘焙品质的影响显示文摘含有高分子量谷蛋白亚基 (HMW -GS) 5 + 10的生物型小麦与 2 + 12的生物型小麦相比 ,前者谷蛋白具有更大的分子量分布。高低分子量谷蛋白亚基的比例对于谷蛋白聚合体分子量的大小起着重要的作用 ,谷蛋白聚合体的体积越大 ,含有的高低分子量谷蛋白亚基的比例越高。SDS非可溶性谷蛋白含有较高比例的高低分子量谷蛋白亚基 ,并且其分子量要比可溶性谷蛋白聚合体的大。谷蛋白聚合体分子量分布的差异是不同小麦品种面包烘焙品质存在差异的重要因素。王凤成 朱金宝 K.Khan L.O’Brien 陈万义 2004中国粮油学报2004,19,3:12
12父母参与NICU患儿护理的优势与挑战显示文摘在围产期护理发展之前,新生儿都是在家庭出生并由其父母和助产士进行护理。自20世纪初期,医院开始为新生儿、早产儿提供医疗服务和专业护理,取代了父母的家庭护理。1979年护士出现短缺,爱沙尼亚塔林儿童医院新生儿病房开展了一个新的护理模式,该项目规定:新生儿全天24 h由父母看护,必要的时候医护人员给予帮助;尽可能的提倡母乳喂养;尽量减少医疗技术使用。李变 张欣 Warre R O'Brien K Lee SK 2015中国新生儿科杂志2015,30,6:12
13中国及其他分布区域野生虎的系统地理学和遗传起源研究进展显示文摘世界野生虎(Pantheratigris)传统上被划分为8个亚种,其中3个亚种已于20世纪灭绝,而剩余种群的生存仍然受到偷猎、栖息地丧失和片断化的威胁。作为唯一栖息着4个现存虎亚种的国家,中国在世界虎的保护事业中负有重要责任,然而其野生和圈养虎的分类地位却仍然不确定。最近一项研究(Luoetal,2004)从所有现存野生虎分布地区(包括中国)采集了134份“基准样品”(即原产野外或有确定地域起源的个体生物样品),对虎的系统地理学、种群结构以及遗传起源进行了全面分析。所用的分子标记包括四千碱基对的线粒体DNA、30个核基因组微卫星位点,以及MHC-DRB基因。研究结果表明,虽然虎的整体遗传多态性较低,但是种群分化程度很高,它们被划分为6个,而不是5个现存亚种(1)西伯利亚虎(P.t.altaica);(2)苏门答腊虎(P.t.sumatrae);(3)孟加拉虎(P.t.tigris);(4)华南虎(P.t.amoyensis);(5)印支虎(P.t.corbetti);(6)新定义的亚种马来虎,暂命名为P.t.Jacksoni。由于所研究样本量有限,目前暂定的华南虎亚种还需进一步确定。现有华南虎圈养种群包括遗传关系相距较远的两支一支与印支虎(P.t.corbetti)无异;而另一支则与其他种群均相距甚远,可能代表了真正的华南虎(P.t.amoyensis)。利用分子生物学方法对中国动物园中圈养虎的遗传起源调查亟待进行,以确认该圈养种群整体的遗传独特性或者非独特性。换言之,这将是确认华南虎是否仍然存在的关键。罗述金 Jae-heup Kim Warren E.Johnson Dale G.Miquelle 黄世强 潘文石 James L.D.Smith Stephen J.O'Brien 2006Zoological Research2006,27,4:10
14Family integrated care:Supporting parents as primary caregivers in the neonatal intensive care unit显示文摘Family integrated care (FICare) is a collaborative model of neonatal care which aims to address the negative impacts of the neonatal intensive care unit (NICU) environment by involving parents as equal partners, minimizing separation, and supporting parent-infant closeness. FICare incorporates psychological, educational, communication, and environmental strategies to support parents to cope with the NICU environment and to prepare them to be able to emotionally, cognitively, and physically care for their infant. FICare has been associated with improved infant feeding, growth, and parent wellbeing and self-efficacy;important mediators for long-term improved infant neurodevelopmental and behavioural outcomes. FICare implementation requires multi-disciplinary commitment, staff motivation, and sufficient time for preparation and readiness for change as professionals relinquish power and control to instead develop collaborative partnerships with parents. Successful FICare implementation and culture change have been applied by neonatal teams internationally, using practical approaches suited to their local environments. Strategies such as parent and staff meetings and relational communication help to break down barriers to change by providing space for the co-creation of knowledge, the negotiation of caregiving roles and the development of trusting relationships. The COVID-19 pandemic highlighted the vulnerability within programs supporting parental presence in neonatal units and the profound impacts of parent-infant separation. New technologies and digital innovations can help to mitigate these challenges, and support renewed efforts to embed FICare philosophy and practice in neonatal care during the COVID-19 recovery and beyond.Chandra Waddington Nicole Rvan Veenendaal Karel O’Brien Neil Patel for the International Steering Committee for Family Integrated Care 2021Pediatric Investigation2021,5,2:9
15艾滋病的治疗与控制显示文摘感染人类免疫缺陷病毒(HIV)会造成免疫系统致命的进行性的破坏,导致各种被定义为获得性免疫缺陷综合征的机会性感染的发生.HIV感染有CD4表达的细胞,这是主要的病毒受体,见于辅助T淋巴细胞和单核/巨噬细胞.HIV原发感染常引起急性的病毒综合征,表现为发热、皮疹、腹泻和不适,伴有极高水平的血循环病毒水平,在淋巴结、脑和其它储存单位中发生感染.急性期的终结以特异性的HIV免疫应答为标志,包括HIV抗体的出现,对抗体的检测被用于诊断试验.随后的慢性而隐匿的病变期通常没有症状.病毒血症低下但始终存在,在数年的病程中CD4-;T细胞逐渐耗竭.随着病变的加重,CD4-;T细胞会加速丢失,并伴有循环病毒的增多,后者可用血浆HIV RNA检测加以量化(病毒载量).CD4+;T细胞降低至200个/mm3以下时可伴有各种机会性感染的出现.即使没有可确诊为AIDS的疾病出现,CD;T细胞计数低于200个/mm3也可考虑诊断为AIDS.William A O’Brien 2001中国性病艾滋病防治2001,7,1:7
16The American Society for Gastrointestinal Endoscopy PIVI (Preservation and Incorporation of Valuable Endoscopic Innovations) on real-time endoscopic assessment of the histology of diminutive colorectal polyps显示文摘Douglas K. Rex Charles Kahi Michael O’Brien T.R. Levin Heiko Pohl Amit Rastogi Larry Burgart Tom Imperiale Uri Ladabaum Jonathan Cohen David A. Lieberman 2011Gastrointestinal Endoscopy2011,,3:7
17The low FODMAP diet improves gastrointestinal symptoms in patients with irritable bowel syndrome: a prospective study显示文摘R. H. Roest B. R. Dobbs B. A. Chapman B. Batman L. A. O’Brien J. A. Leeper C. R. Hebblethwaite R. B. Gearry 2013Int J Clin Pract2013,,9:7
18Tissue Nitrogen and Fructan Translocation in Bread Wheat显示文摘Translocation of previously accumulated nitrogen and carbohydrates from vegetative tissue of the wheat plant is a major assimilate source for grain filling. This study was conducted to examine genotype differences in nitrogen and fructan translocation and their relationships to grain yield and protein content. Effects indicated that significant genotype differences existed for nitrogen accumulation at anthesis and fructan at milk stage and their translocation. Two high protein genotypes, Cunningham and PST90-19, accumulated more nitrogen before anthesis and had greater nitrogen translocation, but lower post-anthesis nitrogen uptake,than two low protein genotypes, SUN109A and TM56. Among plant parts, leaves were the major storage for tissue nitrogen and provided the overwhelming proportion of the total nitrogen translocation, whereas for fructan accumulation and translocation it was the stems. The two high protein genotypes had a higher percentage of their grain nitrogen derived from nitrogen translocation, while for the two low protein ones, it was from postanthesis nitrogen uptake and assimilation. Increasing nitrogen application increased nitrogen accumulation and translocation, but decreased fructan accumulation and translocation. High grain protein content was associated with high nitrogen translocation from leaves, stems and the total plant, while high grain yield was related to high fructan translocation from stems and the total plant. Fructan translocation was negatively correlated to grain protein content. Nitrogen and fructan translocation were not correlated with each other.L.O' Brien 2002Agricultural Sciences in China2002,1,9:7
19Fluidization of nano and sub-micron powders using mechanical vibration显示文摘The fluidization behavior of nano and sub-micron powders belonging to group C of Geldart's classification was studied in a mechanically vibrated fiuidized bed(vibro-fiuidized bed) at room temperature. Pretreated air was used as the fiuidizing gas whereas SiO2,Al2O3,TiO2,ZrSi,BaSO4 were solid particles. Mechanical vibration amplitudes were 0.1,0.25,0.35,0.45 mm,while the frequencies were 5,20,30,40 Hz to investigate the effects of frequency and amplitude of mechanical vibration on minimum fiuidization velocity,bed pressure drop,bed expansion,and the agglomerate size and size distribution. A novel technique was employed to determine the apparent minimum fluidization velocity from pressure drop signals. Richardson-Zaki equation was employed as nano-particles showed fiuid like behavior when fiuidized. The average size of agglomerates formed on top of the bed was smaller than those at the bottom. Size distribution of agglomerates on top was also more uniform compared to those near the distributor. Larger agglomerates at the bottom of the bed formed a small fraction of the bed particles. Average size of submicron agglomerates decreased with increasing the frequency of vibration,however nano particles were less sensitive to change in vibration frequency. Mechanical vibration enhanced the quality of fluidization by reducing channeling and rat-holing phenomena caused by interparticle cohesive forces.Souresh Kaliyaperumal Shahzad Barghi Lauren Briens Sohrab Rohani Jesse Zhu 2011Particuology2011,9,3:6
20Multi-length scale modeling of carburization,martensitic microstructure evolution and fatigue properties of steel gears显示文摘Multi-length scale modeling is performed to(i)predict the carburized case depth of SAE8620 steel gears by solving the Fick’s second law of diffusion,(ii)model the martensitic microstructure evolution in a grain inside the carburized case as well as to study the effect of stress cycling on retained austenite(RA)and martensite using a 3D phase-field model,(iii)simulate the effect of carburization and different RA contents on macroscale fatigue behavior of SAE8620 steel spur gear using the finite element method.The diffusion model predicts that the case depth increases with increasing heat treatment time and temperature.The phase-field simulations show that RA can transform to martensite during fatigue loading,where the extent of the transformation will depend on the type of stresses applied,i.e.stresses in a high stress regime or low stress regime of fatigue loading.Reverse transformation of martensite to austenite is also observed in low RA sample under high stress regime.The macroscale simulations show that the carburized case with high RA gives rise to better fatigue life compared to that with low RA.Edward Charles Henry Crawford O’Brien Hemantha Kumar Yeddu 2020Journal of Materials Science & Technology2020,47,14:5
返回顶部 每页显示:
共576页 首页 上一页 第1页 下一页 末页 /576 跳转

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1 渝公网安备 50019002500403号 违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费