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| 1 | Biology and treatment of cervical adenocarcinoma显示文摘Uterine cervical adenocarcinoma(ADC) has been increasing in its prevalence world widely despite the decrease of squamous cell carcinoma(SCC). It comprises nearly 20–25% of the all cervical malignancy in developed countries. The worse biological behavior had been reported in patients with intermediateand high risk factors after surgery, and in advanced stage over III, radiotherapy(RT) alone and concurrent chemo-radiotherapy(CCRT) with cisplatin was not always effective. As for chemotherapy(CT), the induction CT has not established, as well. Further molecular targeted therapy(MTT) has been studied. The targets of oncogenic driver mutations were vascular endothelial growth factor(VEGF) in SCC, or tyrosine kinase(TK) of endothelial growth factor receptor 2(EGFR2, Her2/neu)-Ras-MAPK-ERK pathway. Bevacizumab(Bev, anti-VEGF monoclonal antibody) is considered as one of key agent with paclitaxel and carboplatin in SCC, but not for ADC. This article focuses on up-to-date knowledge of biology and possible specific therapeutic directions to explore in the management of cervical ADC. | Satoshi Takeuchi | 2016 | Chinese Journal of Cancer Research2016，28，2： | 13 |
| 2 | Pathogen Recognition and Innate Immunity显示文摘 | Shizuo Akira Satoshi Uematsu Osamu Takeuchi | 2006 | Cell2006，，4： | 11 |
| 3 | Lentinan prolonged survival in patients with gastric cancer receiving S-1-based chemotherapy显示文摘AIM:To examine whether administration of lentinan,purifiedβ-1,3-glucan,can prolong survival in advanced gastric cancer patients receiving S-1-based chemotherapy.METHODS:Since 2004,78 patients with metastatic or recurrent gastric cancer have received S-1-based chemotherapy as first-line treatment.Survival,side effects,and the ratio of granulocytes/lymphocytes(G/L ratio)were compared between 2 groups of patients who received chemo-immunotherapy using lentinan and chemotherapy alone.RESULTS:Median overall survival was significantly longer in the former group than in the latter group[689 d(95%CI:431-2339 d)vs 565 d(95%CI:323-662 d),P=0.0406].In addition,the G/L ratio in patients who received lentinan was maintained around or below 2,which was significantly lower than that in patients who received chemotherapy alone(P<0.001).CONCLUSION:Chemo-immunotherapy with lentinan offers a significant advantage over S-1-based chemotherapy alone in terms of survival in patients with advanced gastric cancer. | Kenji Ina Ryuichi Furuta Takae Kataoka Satoshi Kayukawa Takashi Yoshida Takaya Miwa Yoshitaka Yamamura Yuuki Takeuchi | 2011 | World Journal of Clinical Oncology2011，2，10： | 10 |
| 4 | Role of targeted therapy in metastatic colorectal cancer显示文摘Colorectal cancer(CRC) is a significant cause of cancer-related morbidity and mortality all over the world.Improvements of cytotoxic and biologic agents have prolonged the survival in metastatic CRC(mC RC),with a median overall survival of approximately 2 years and more in the past two decades.The biologic agents that have proven clinical benefits in m CRC mainly target vascular endothelial growth factor(VEGF) and epidermal growth factor receptor(EGFR).In particular,bevacizumab targeting VEGF and cetuximab and panitumumab targeting EGFR have demonstrated sig-nificant survival benefits in combination with cytotoxic chemotherapy in the first-line,second-line,or salvage setting.Aflibercept,ramucirumab,and regorafenib are also used in second-line or salvage therapy.Recent retrospective analyses have shown that KRAS or NRAS mutations were negative predictive markers for anti-EGFR therapy.Based on the evidence from large rand-omized clinical trials,personalized therapy is necessary for patients with m CRC according to their tumor biology and characteristics.The aim of this paper was to summarize the results of the major randomized clinical trials and highlight the benefits of the molecular targeted agents in patients with mC RC. | Yoshihito Ohhara Naoki Fukuda Satoshi Takeuchi Rio Honma Yasushi Shimizu Ichiro Kinoshita Hirotoshi Dosaka-Akita | 2016 | World Journal of Gastrointestinal Oncology2016，8，9： | 8 |
| 5 | Fluorescent SiC and its application to white light-emitting diodes显示文摘Fluorescent-SiC(f-SiC),which contains donor and acceptor impurities with optimum concentrations, has high conversion efficiency from NUV to visible light caused by donor-acceptor-pair(DAP) recombination. This material can be used as a substrate for a near UV light-emitting diode(LED) stack,and leads to monolithic white LED device with suitable spectral property for general lighting applications.In this paper,we describe basic technologies of the white LED,such as optical properties of f-SiC substrate,and epitaxial growth of NUV stack on the f-SiC substrate. | Satoshi Kamiyama Motoaki Iwaya Tetsuya Takeuchi Isamu Akasaki Mikael Syvjrvi Rositza Yakimova | 2011 | Journal of Semiconductors2011，32，1： | 5 |
| 6 | Xyloglucan for Generating Tensile Stress to Bend Tree Stem显示文摘响应环境变化,被子植物树由形成紧张木头把他们的茎弄弯,它由充满纤维素的 G 组成(凝胶状) 在纤维房间的墙中的层并且在第二等的木部产生反常张力的应力。我们生产了转基因的白杨植物 overexpressing 在房间墙中减少每特定的多糖,,的几 endoglycanases 第二等的木部由主要、第二等的墙层组成。当水平地放了时,转基因的白杨 overexpressing xyloglucanase 的茎的基础区域不能独自在木部的紧张方面由于低紧张向上弯曲。在野类型的植物, xyloglucan 在多重 layering 期间在 G 层的内部表面被发现。在 situ xyloglucan endotransglucosylase ( XET ),活动证明整个 xyloglucan 的加入,潜在地因为墙紧缩,在内部表面层 S1 和 S2 开始了并且在整个G层开发被保留,当为墙松开的 xyloglucan heptasaccharide ( XXXG )的加入发生在膨胀地区的主要的墙中时。我们建议 xyloglucan 网络被 XET 增强形成在墙界限之间的一个进一步的连接并且分泌了 xyloglucans 以便承受在纤维素 G 层 microfibrils 以内创造的张力的压力。 | Kei'ichi Baba Yong Woo Park Tomomi Kaku Rumi Kaida Miyuki Takeuchi Masato Yoshida Yoshihiro Hosoo Yasuhisa Ojio Takashi Okuyama Toru Taniguchi Yasunori Ohmiya Teiji Kondo Ziv Shani Oded Shoseyov Tatsuya Awano Satoshi Serada Naoko Norioka Shigemi Norioka Takahisa Hayashi | 2009 | Molecular Plant2009，2，5： | 4 |
| 7 | Clinical impact of chemotherapy to improve tumor microenvironment of pancreatic cancer显示文摘A perioperative multimodal strategy including combination chemotherapy and radiotherapy, in addition to surgical resection, has been acknowledged to improve patient prognosis. However chemotherapy has not been actively applied as an immunomodulating modality because of concerns about various immunosuppressive effects. It has recently been shown that certain chemotherapeutic agents could modify tumor microenvironment and host immune responses through several underlying mechanisms such as immunogenic cell death, local T-cell infiltration and also the eradication of immune-suppressing regulatory cells such as regulatory T cells(Tregs) and myeloid-derived suppressor cells. With the better understanding of the cell components in the tumor microenvironment and the effect of chemotherapy to improve tumor microenvironment, it has been gradually clear that the chemotherapeutic agents is two-edged sword to have both immune promoting and suppressing effects. The cellular components of the tumor microenvironment include infiltrating T lymphocytes, dendritic cells, regulatory T cells, tumor associated macrophages, myeloid derived suppressor cells and cancer associated fibroblasts. Based on the better understanding of tumor microenvironment following chemotherapy, the treatment protocol could be modified as personalized medicine and the prognosis of pancreas cancer would be more improved utilizing multimodal chemotherapy. Here we review the recent advances of chemotherapy to improve tumor microenvironment of pancreatic cancer, introducing the unique feature of tumor microenvironment of pancreatic cancer, interaction between anti-cancer reagents and these constituting cells and future prospects. | Takahiro Tsuchikawa Shintaro Takeuchi Toru Nakamura Toshiaki Shichinohe Satoshi Hirano | 2016 | World Journal of Gastrointestinal Oncology2016，8，11： | 3 |
| 8 | Multicenter study of the long-term outcomes of endoscopic submucosal dissection for early gastric cancer in patients 80 years of age or older显示文摘 | Nobutsugu Abe Takuji Gotoda Toshiaki Hirasawa Shu Hoteya Kenji Ishido Yosuke Ida Hiroyuki Imaeda Eiji Ishii Atsushi Kokawa Chika Kusano Tadateru Maehata Satoshi Ono Hirohisa Takeuchi Masanori Sugiyama Shinichi Takahashi | 2012 | Gastric Cancer2012，，1： | 2 |
| 9 | A randomized phase-II trial comparing sequential and concurrent paclitaxel with oral or parenteral fluorinated pyrimidines for advanced or metastatic gastric cancer显示文摘 | Kazuhiro Nishikawa Satoshi Morita Takanori Matsui Michiya Kobayashi Yoji Takeuchi Ikuo Takahashi Seiji Sato Yumi Miyashita Akira Tsuburaya Junichi Sakamoto Yoshihiro Kakeji Hideo Baba | 2012 | Gastric Cancer2012，，4： | 2 |
| 10 | Medium-scale indentation tests on sea ice at various speeds显示文摘 | Devinder S. Sodhi Takahiro Takeuchi Naoki Nakazawa Satoshi Akagawa Hiroshi Saeki | 1998 | Cold Regions Science and Technology1998，，3： | 1 |
| 11 | Recent advance in the treatment of hilar cholangiocarcinoma: hepatectomy with vascular resection显示文摘 | Masaru Miyazaki Fumio Kimura Hiroaki Shimizu Hiroyuki Yoshidome Masayuki Ohtsuka Atsushi Kato Hideyuki Yoshitomi Satoshi Nozawa Katsunori Furukawa Noboru Mitsuhashi Dan Takeuchi Kousuke Suda Isaku Yoshioka | 2007 | Journal of Hepato-Biliary-Pancreatic Surgery2007，，5： | 1 |
| 12 | A novel endoscopic submucosal dissection technique for proton pump inhibitor-refractory gastroesophageal reflux disease显示文摘 | Kazuhiro Ota Toshihisa Takeuchi Satoshi Harada Shoko Edogawa Yuichi Kojima Takuya Inoue Kazuhide Higuchi | 2014 | Scandinavian Journal of Gastroenterology2014，，12： | 1 |
| 13 | Use of electroporation to accelerate the skin permeability enhancing actionn of oleic acid显示文摘 | Kohji Miyawaki Satoshi Kami-yabu | 2000 | Biol Pharm Bull2000，23，7： | 1 |
| 14 | Recent advance in the treatment of hilar cholangiocarcinoma: hepatectomy with vascular resection显示文摘 | Masaru Miyazaki Fumio Kimura Hiroaki Shimizu Hiroyuki Yoshidome Masayuki Ohtsuka Atsushi Kato Hideyuki Yoshitomi Satoshi Nozawa Katsunori Furukawa Noboru Mitsuhashi Dan Takeuchi Kousuke Suda Isaku Yoshioka | 2007 | Journal of Hepato - Biliary - Pancreatic Surgery2007，，5： | 1 |
| 15 | An environmental contaminant, benzo(a)pyrene, induces oxidative stress-mediated interleukin-8 production in human keratinocytes via the aryl hydrocarbon receptor signaling pathway显示文摘 | Gaku Tsuji Masakazu Takahara Hiroshi Uchi Satoshi Takeuchi Chikage Mitoma Yoichi Moroi Masutaka Furue | 2011 | Journal of Dermatological Science2011，，1： | 1 |
| 16 | The Relationship Between the Anatomy of the Nuchal Ligament and Postoperative Axial Pain After Cervical Laminoplasty: Cadaver and Clinical Study显示文摘 | Atsushi Ono Yoshikazu Tonosaki Takuya Numasawa Kanichiro Wada Yoshihito Yamasaki Toshihiro Tanaka Gentaro Kumagai Shuichi Aburakawa Kazunari Takeuchi Toru Yokoyama Kazumasa Ueyama Yasuyuki Ishibashi Satoshi Toh | 2012 | Spine2012，，26： | 1 |
| 17 | Helicobacter pylori infection is positively associated with gallstones: a large-scale cross-sectional study in Japan显示文摘 | Yu Takahashi Nobutake Yamamichi Takeshi Shimamoto Satoshi Mochizuki Mitsuhiro Fujishiro Chihiro Takeuchi Yoshiki Sakaguchi Keiko Niimi Satoshi Ono Shinya Kodashima Toru Mitsushima Kazuhiko Koike | 2014 | Journal of Gastroenterology2014，，5： | 1 |
| 18 | Performanc e evaluation of ECG compression algorithms by reconstruction error and diagnosti c response显示文摘 | Takeuchi Satoshi Ohsawa Norihito | 1993 | IEICE Trans Inf & Syst1993，76，12： | 1 |
| 19 | Phase 1/2 study of concurrent chemoradiotherapy with weekly irinotecan hydrochloride for advanced/recurrence uterine cancer:A multi-institutional study of Kansai Clinical Oncology Group显示文摘Objective:Concurrent chemoradiotherapy using cisplatin was thought to be standard treatment for squamous cell carcinoma of cervix,but it had not been effective for adenocarcinoma.Concurrent chemoradiotherapy using irinotecan hydrochloride(CPT-11)had been effective for colorectal cancer,thus,we chose CPT-11 as a candidate for gynecologic adenocarcinoma.To evaluate the maximum tolerated dose(MTD)of weekly CPT-11 with external pelvic radiotherapy,a phase 1/2 study was conducted according to modified Fibonacci method.Methods:Eligible patients were advanced uterine cancer with measurable diseases[performance score(PS):0-2].Study period was from August 1 st,2002 to December 31 st,2008.The starting dose level(DL)of CPT-11 was 30 mg/m2(DL1)given weekly for 4 weeks.Subsequently,dose escalation was scheduled in 10 mg/m2 increments to 60 mg/m^2(DL4).The fixed radiotherapy consisted of whole pelvic 1.8 Gy/d,once a day in weekday for five weeks and it amounted to 45 Gy(25 fractions)in total.Results:Seventeen patients were enrolled.As for toxicities,one(1/17:5.9%)grade(G)4 neutropenia lasting 7 days had been seen in DL4.G2 diarrhea was identified in 35.3%(6/17)of the patients,and 11.8%(2/17)G3 diarrhea was observed in DL3 and DL4.Thus,the MTD of CPT-11 was defined as dose of 60 mg/m^2.The recommended dose was decided as 50 mg/m^2.The response rate was 88.2%[9 complete response(CR),3 partial response(PR),3 stable disease(SD),2 not evaluable(NE)].Disease control rate at 1 month after treatment completion was 100%but distant metastases were found in 24%(4/17)in longer outcome.Conclusions:MTD was 60 mg/m^2 and recommended dose was set as 50 mg/m2.This concurrent chemoradiation using weekly CPT-11 was feasible at 50 mg/m^2,and it might be effective even in adenocarcinoma of the uterus. | Satoshi Takeuchi Haruo Kuroboshi Taisuke Mori Kimihiko Ito Eiji Kondo Tsutomu Tabata Yoshio Itani Ryuji Kawaguchi Kyosuke Takeuchi Toshinori Soejima Ryohei Sasaki | 2020 | Chinese Journal of Cancer Research2020，32，2： | 1 |
| 20 | Location of thalamic neurons mediating vestibulo-cortical pathway in cats显示文摘 | Satoshi Matsuo Hiromi Takeuchi Hisaaki Ikoma | 1999 | Yonago Acta medica1999，42，： | 1 |
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