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| 1 | 单开门椎管成形术与全椎板减压融合内固定术治疗脊髓型颈椎病的临床疗效比较显示文摘目的探讨颈后路单开门椎管成形术与全椎板减压侧块螺钉植骨融合内固定术治疗脊髓型颈椎病的临床疗效。方法 2006年9月-2009年9月,对143例多节段(≥3个)脊髓型颈椎病患者分别采用颈后路单开门扩大椎管成形术(A组,87例)及全椎板减压侧块螺钉植骨融合内固定术(B组,56例)治疗,两组患者性别、年龄、病程、病变分型、病变节段等一般资料比较差异均无统计学意义(P>0.05),具有可比性。随访观察并比较两组患者手术时间、术中出血量、术后神经功能恢复[采用日本骨科协会(JOA)17分评分法]及手术并发症发生情况,并对两组患者手术前后颈椎曲率指数(cervical curvature index,CCI)、颈椎活动度(range of motion,ROM)及颈肩部疼痛[采用疼痛视觉模拟评分(VAS)及颈椎功能障碍指数量表(NDI)评分]等指标进行评估。结果两组患者手术时间和术中出血量比较差异均无统计学意义(P>0.05)。两组患者均获随访,随访时间18~30个月,平均24个月。A、B组术后分别有4例(4.60%)和5例(8.93%)出现C5神经根麻痹症状,比较差异无统计学意义(χ2=0.475,P=0.482)。两组术后均无深部感染、假关节形成及螺钉松动需再手术等并发症发生。A组患者术后均无椎板再关门发生;B组患者末次随访时无螺钉脱出、断裂及继发神经损伤等发生。末次随访时A、B组分别有35例(40.23%)和11例(19.64%)有颈部轴性症状,比较差异有统计学意义(χ2=6.612,P=0.009)。两组患者术前JOA评分、CCI、颈椎ROM及VAS评分比较差异均无统计学意义(P>0.05);末次随访时两组JOA评分、颈椎ROM、VAS评分及A组CCI均较术前有显著改善(P<0.05)。末次随访时,A、B组间JOA评分及改善率、VAS评分比较差异均无统计学意义(P>0.05);A组ROM大于B组,CCI小于B组,差异有统计学意义(P<0.05);末次随访时NDI评分,A组在疼痛程度、上举能力、工作、驾车、反应及总分方面均显著优于B组(P<0.05)。结论两种手术方式在术后神经功能改善率上无明显差异,全椎板减压植骨融合内固定术能有效缓解术前疼痛,但颈椎活动度降低较大;单开门椎管成形术并发症较少,近期疗效满意。 | 张杭 孙天威 卢守亮 李清江 Sandip Kumar Yadav | 2012 | 中国修复重建外科杂志2012，26，10： | 13 |
| 2 | Removal efficiency of fluoride by novel Mg-Cr-Cl layered double hydroxide by batch process from water显示文摘The fluoride ion removal from aqueous solution using synthesized Mg-Cr-Cl layered double hydroxide has been reported.Mg-Cr-Cl was characterized by X-ray powder diffraction,Fourier-transform infrared,thermo-gravimetric analysis,differential thermal analysis,and scanning electron microscope.Adsorption experiments were carried out in batch mode as a function of adsorption dosages,contact time,pH,and initial fluoride concentration to get optimum adsorption capacity.The adsorption kinetic study showed that the adsorption process followed first order kinetics.The fluoride removal was 88.5% and 77.4% at pH 7 with an adsorbent dose of 0.6 g/100 mL solution and initial fluoride concentration of 10 mg/L and 100 mg/L,respectively.The equilibrium was established at 40 min.Adsorption experiment data were fitted well with Langmuir isotherm with R 2 = 0.9924.Thermodynamic constants were also measured and concluded that the adsorption process was spontaneous and endothermic in nature.The removal percentage decreased slowly with increasing pH.This process is suitable for industrial effluents.The regeneration of the material is not possible. | Sandip Mandal Swagatika Tripathy Tapswani Padhi Manoj Kumar Sahu Raj Kishore Patel | 2013 | Journal of Environmental Sciences2013，25，5： | 7 |
| 3 | 胸椎黄韧带骨化合并后纵韧带骨化行单纯后路减压治疗的预后影响因素分析显示文摘目的研究胸椎黄韧带骨化症(OLF)合并后纵韧带骨化(OPLL)采用单纯后路减压手术治疗的预后影响因素。方法对2006年1月至2010年6月经手术治疗且完整随访的83例胸椎OLF合并OPLL患者资料进行回顾性分析,对可能影响患者预后的因素,如性别、年龄、病程、术前及术后日本骨科协会(JOA)评分、病变节段、胸椎OPLL骨化类型、胸椎后凸角度、前方胸椎OPLL程度、胸椎OLF减压节段数、术前是否存在二便功能障碍、术后是否存在脑脊液漏及是否合并颈腰椎疾患等因素进行)(χ2检验和Logistic回归统计分析。结果根据术后JOA评分改善率分为优良组(58例)和不良组(25例),两组间年龄、术前JOA评分及病程等患者一般资料无统计学意义(P〉0.05)。在病变节段(χ2=6.290,P=0.043)、OPLL骨化类型(χ2=5.361,P=0.021)和术前存在二便功能障碍(χ2=27.711,P=0.000)等方面差异具有统计学意义;Logistic回归分析发现病变位于上段胸椎(P=0.044)、OPLL鸟嘴型(P=0.023)及术前存在二便功能障碍(P=0.009)与预后影响关系密切。术后24例(28.9%)患者出现脑脊液漏,3例患者术后早期出现深部感染,2例患者术后神经功能恶化。结论上胸段骨化症预后较好,但存在鸟嘴型OPLL、术前存在二便功能障碍的患者预后不良,跳跃性多节段骨化症及合并重度颈腰椎疾患是预后不良的影响因素。 | 孙天威 张黎龙 张杭 卢守亮 Sandip Kumar Yadav | 2012 | 中华外科杂志2012，50，12： | 4 |
| 4 | Property mapping of polycrystalline diamond coatings over large area显示文摘Large-area polycrystalline diamond(PCD)coatings are important for fields such as thermal management,optical windows,tribological moving mechanical assemblies,harsh chemical environments,biological sensors,etc.Microwave plasma chemical vapor deposition(MPCVD)is a standard technique to grow high-quality PCD films over large area due to the absence of contact between the reactive species and the filament or the chamber wall.However,the existence of temperature gradients during growth may compromise the desired uniformity of the final diamond coatings.In the present work,a thick PCD coating was deposited on a 100-mm silicon substrate inside a 915-MHz reactor;the temperature gradient resulted in a non-uniform diamond coating.An attempt was made to relate the local temperature variation during deposition and the different properties of the final coating.It was found that there was large instability inside the system,in terms of substrate temperature(as high asΔT=212℃),that resulted in a large dispersion of the diamond coating’s final properties:residual stress(-15.8 GPa to+6.2 GPa),surface morphology(octahedral pyramids with(111)planes to cubo-octahedrals with(100)flat top surfaces),thickness(190μm to 245μm),columnar growth of diamond(with appearance of variety of nanostructures),nucleation side hardness(17 GPa to 48 GPa),quality(Raman peak FWHM varying from 5.1 cm^(-1) to 12.4 cm^(-1) with occasional splitting).This random variation in properties over large-area PCD coating may hamper reproducible diamond growth for any meaningful technological application. | Awadesh Kumar MALLIK Sandip BYSAKH Monjoy SREEMANY Sudakshina ROY Jiten GHOSH Soumyendu ROY Joana Catarina MENDES Jose GRACIO Someswar DATTA | 2014 | Journal of Advanced Ceramics2014，3，1： | 4 |
| 5 | BMP与后纵韧带骨化症易患性的研究进展显示文摘目的综述BMP与后纵韧带骨化症(ossification of the posterior longitudinal ligament,OPLL)易患性的研究进展。方法查阅近年国内外有关BMP与OPLL易患性的相关参考文献并进行总结。结果 BMP基因的单核苷酸多态性(single nucleotide polymorphisms,SNPs)产生微效累加效应增加对OPLL的易感性,多种环境因素可通过增加BMPs基因的表达,促进OPLL的发生、发展。结论 BMPs易感基因的SNPs可促进个体对OPLL的易感性,SNPs的累加效应及与环境因素的相互作用则可影响个体对OPLL易患性的高低。 | 方钊 孙天威 Sandip Kumar Yadav | 2012 | 中国修复重建外科杂志2012，26，10： | 3 |
| 6 | Discovery and preclinical development of ⅢM-160, a Bergenia ciliatabased anti-inflammatory and anti-arthritic botanical drug candidate显示文摘Objective: Bergenia ciliata(Haw.) Sternb. is used in the Indian traditional system of medicine to treat various ailments including rheumatism and to heal wounds. The objective of the present study was to perform a preclinical characterization of the B. ciliata-based botanical extract IIIM-160.Methods: ⅢM-160 was chemically standardized and analyzed for heavy metal content, aflatoxins,pesticides and microbial load. The in vitro and in vivo efficacies were determined in suitable models of inflammation, arthritis and nociception. An acute oral toxicity study was performed in Swiss albino mice.A suitable oral formulation was developed and characterized.Results: Bergenin was found to be the major component(9.1% w/w) of ⅢM-160. The botanical lead displayed inhibition of lipopolysaccharide-induced production of proinflammatory cytokines in THP-1 cells, with selectivity toward interleukin-6(IL-6) and had an excellent safety-window. It showed anti-inflammatory, anti-arthritic and antinociceptive activity in animal models and was not toxic at oral doses up to 2 g/kg in Swiss-albino mice. The gastroretentive, sustained-release capsule formulation showed sustained-release of the bergenin over the period of 24 h, resulting in improved plasma-exposure of bergenin in Sprague–Dawley rats.Conclusion: The dual-activity of IL-6 inhibition and antinociception marks the suitability of ⅢM-160 for treating rheumatoid arthritis. This study will serve as the benchmark for further research on this botanical formulation. | Sandip B.Bharate Vikas Kumar Sonali S.Bharate Bikarma Singh Gurdarshan Singh Amarinder Singh Mehak Gupta Deepika Singh Ajay Kumar Surjeet Singh Ram A.Vishwakarma | 2019 | Journal of Integrative Medicine2019，17，3： | 3 |
| 7 | Pathological abnormalities in splenic vasculature in non-cirrhotic portal hypertension:Its relevance in the management of portal hypertension显示文摘BACKGROUND Portal hypertension(PH)is associated with changes in vascular structure and function of the portosplenomesenteric system(PSMS).This is referred to as portal hypertensive vasculopathy.Pathological abnormalities of PSMS has been described in the literature for cirrhotic patients.Raised portal pressure and hyperdynamic circulation are thought to be the underlying cause of this vasculopathy.In view of this,it is expected that pathological changes in splenic and portal vein similar to those reported in cirrhotic patients with PH may also be present in patients with non-cirrhotic PH(NCPH).AIM To investigate pathological abnormalities of splenic vein in patients with NCPH,and suggest its possible implications in the management of PH.METHODS A prospective observational study was performed on 116 patients with NCPH[Extrahepatic portal vein obstruction(EHPVO):53 and non-cirrhotic portal fibrosis(NCPF):63]who underwent proximal splenorenal shunt(PSRS),interposition shunt or splenectomy with devascularization in JIPMER,Pondicherry,India,a tertiary level referral center,between 2011-2016.All patients were evaluated by Doppler study of PSMS,computed tomography portovenogram and upper gastrointestinal endoscopy.An acoustic resonance forced impulse(ARFI)scan and abdomen ultrasound were done for all cases to exclude cirrhosis.Intraoperative and histopathological assessment of the harvested splenic vein was performed in all.The study group was divided into delayed and early presentation based on the median duration of symptoms(i.e.108 mo).RESULTS The study group comprising of 116 patients[77(66%)females and 39(34%)males]with NCPH had a median age of 22 years.Median duration of symptoms was 108 mo.The most common presentation in both EHPVO and NCPF patients was upper gastrointestinal bleeding(hematemesis and melena).The ARFI scan revealed a median score of 1.2(1.0-1.8)m/s for EHPVO and 1.5(0.9-2.8)m/s for NCPF.PSRS was performed in 84 patients(two of whom underwent interposition PSRS using a 10 mm Dacron graft);splenoadrenal shunt in 9;interposition mesocaval shunt in 5;interposition 1st jejunal to caval shunt in 1 patient and devascularization with splenectomy in 17 patients.Median presplenectomy portal pressure was 25(range:15-51)mm Hg.In 77%cases,the splenic vein was abnormal upon intraoperative assessment.Under macroscopic examination,wall thickening was observed in 108(93%),venous thrombosis in 32(28%)and vein wall calcification in 27(23%)cases.Upon examination under a surgical magnification loupe,21(18%)patients had intimal defects in the splenic vein.Histopathological examination of veins was abnormal in all cases.Medial hypertrophy was noted in nearly all patients(107/116),while intimal fibrosis was seen in 30%.Ninety one percent of patients with intimal fibrosis also had venous thrombosis.Vein wall calcification was found in 22%,all of whom had intimal fibrosis and venous thrombosis.The proportion of patients with pathological abnormalities in the splenic vein were significantly greater in the delayed presentation group as compared to the early presentation group.CONCLUSION Pathological changes in the splenic vein similar to those in cirrhotic patients with PH are noted in NCPH.We recommend that PH in NCPH be treated as systemic and pulmonary hypertension equivalent in the gastrointestinal tract,and that early aggressive therapy be initiated to reduce portal pressure and hemodynamic stress to avoid potential lethal effects. | Shahana Gupta Biju Pottakkat Surendra Kumar Verma Raja Kalayarasan Sandip Chandrasekar A Ajith Ananthakrishna Pillai | 2020 | World Journal of Gastrointestinal Surgery2020，12，1： | 3 |
| 8 | Impact of FDG-PET and -PET/CT imaging in the clinical decision-making of ovarian carcinoma: an evidence-based approach显示文摘 | Vandana Kumar Dhingra Purushottam Kand Sandip Basu | 2012 | Women’s Health2012，，： | 1 |
| 9 | Polyurethane adhesive system from biomaterial-based polyol for bonding wood显示文摘 | Sandip D Desai Jigar V Patel Vijay Kumar Sinha | 2003 | International Journal of Adhesion and Adhesives2003，23，： | 1 |
| 10 | Oxidative Stress, Prooxidants, and Antioxidants: The Interplay显示文摘 | Anu Rahal Amit Kumar Vivek Singh Brijesh Yadav Ruchi Tiwari Sandip Chakraborty Kuldeep Dhama Afaf K. El-Ansary | 2014 | BioMed Research International2014，，： | 1 |
| 11 | Support vector regression with parameter tuning assisted by differential evolution technique:Study on pressure drop of slurry flow in pipeline显示文摘 | SANDIP KUMAR LAHIRI KARTIK CHANDRA GHANTA | 2009 | Korean Journal of Chemical Engineering2009，26，5： | 1 |
| 12 | Polyurethane adhesive system from biomaterial - based polyol for bonding wood 显示文摘 | Sandip D DesaiJigar V PatelVijay Kumar Sinha | 2003 | International Journal of Adhesion and Adhesives2003，，23： | 1 |
| 13 | Role of Modern Imaging Techniques for Diagnosis of Infection in the Era of 18F-Fluorodeoxyglucose Positron Emission Tomography显示文摘 | Rakesh Kumar Sandip Basu Drew Torigian | 2008 | Clin Microbiol Rev2008，21，1： | 1 |
| 14 | Polyurethane adhesive system from biomaterial-based polyol for bonding wood 显示文摘 | Sandip D Desai Jigar V Patel Vijay Kumar Sinha | 2003 | International Journal of Adhesion and Adhesives2003，，23： | 1 |
| 15 | Primula munroi的产自东喜马拉雅的一个新亚种——P.munroissp.schizocalyx(英文)显示文摘 | Sandip Kumar Basak Gour Gopal Maiti | 2001 | 植物分类学报2001，39，5： | 1 |
| 16 | Polyurethane adhesive system from biomaterial-based polyol for bonding wood显示文摘 | Sandip D Desai Jigar V Patel Vijay Kumar Sinha | 2003 | International Journal of Adhesion and Adhesives2003，23，： | 1 |
| 17 | Polyester poly based polyurethane adhesive:Effect of treat- ment on rubber surface显示文摘 | Sandip D Desai Anurag L Emanuel Vijay Kumar Sinha | 2003 | J Polym Res2003，10，3： | 1 |
| 18 | Failure of a superheater tube显示文摘 | Goutam Das Sandip Ghosh Chowdhury Ashok Kumar Ray | | 0，，： | 1 |
| 19 | Studies on black tea ( Camellia sinensis ) extract as a potential antioxidant and a probable radioprotector显示文摘 | Sandip Pal Chabita Saha Subrata Kumar Dey | 2013 | Radiation and Environmental Biophysics2013，，2： | 1 |
| 20 | Genic markers for wild abortive (WA) cytoplasm based male sterility and its fertility restoration in rice显示文摘 | Umakanta Ngangkham Swarup K. Parida Sandip De K. Anand Raj Kumar Ashok K. Singh Nagendra K. Singh Trilochan Mohapatra | 2010 | Molecular Breeding2010，，2： | 1 |
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