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| 1 | Hepatitis C virus molecular evolution:Transmission,disease progression and antiviral therapy显示文摘Hepatitis C virus(HCV)infection represents an important public health problem worldwide.Reduction of HCV morbidity and mortality is a current challenge owned to several viral and host factors.Virus molecular evolution plays an important role in HCV transmission,disease progression and therapy outcome.The high degree of genetic heterogeneity characteristic of HCV is a key element for the rapid adaptation of the intrahost viral population to different selection pressures(e.g.,host immune responses and antiviral therapy).HCV molecular evolution is shaped by different mechanisms including a high mutation rate,genetic bottlenecks,genetic drift,recombination,temporal variations and compartmentalization.These evolutionary processes constantly rearrange the composition of the HCV intrahost population in a staging manner.Remarkable advances in the understanding of the molecular mechanism controlling HCV replication have facilitated the development of a plethora of direct-acting antiviral agents against HCV.As a result,superior sustained viral responses have been attained.The rapidly evolving field of anti-HCV therapy is expected to broad its landscape even further with newer,more potent antivirals,bringing us one step closer to the interferon-free era. | Maria Victoria Preciado Pamela Valva Alejandro Escobar-Gutierrez Paula Rahal Karina Ruiz-Tovar Lilian Yamasaki Carlos Vazquez-Chacon Armando Martinez-Guarneros Juan Carlos Carpio-Pedroza Salvador Fonseca-Coronado Mayra Cruz-Rivera | 2014 | World Journal of Gastroenterology2014，20，43： | 6 |
| 2 | Localized intra-abdominal fibromatosis of the small bowel mimicking a gastrointestinal stromal tumor: A case report显示文摘Intra-abdominal fibromatosis (IAF) is a benign mesenchymal lesion that can occur throughout the gastrointestinal tract. Although rare, it is the most common primary tumor of the mesentery and can develop at any age. We describe a rare case of primary IAF involving the mesentery and small bowel which clinically, macroscopically and histologically mimicked malignant gastrointestinal stromal tumor (GIST). This report highlights the fact that benign IAF can be misdiagnosed as a malignant GIST localized in the mesentery or arising from the intestinal wall. Their diagnostic discrimination is essential because of their very different biological behaviors and the fact that the introduction of effective therapies involving tyrosine kinase inhibitor STI571 (imatinib mesylate) has greatly changed the clinical approach to intra-abdominal stromal spindle cell tumors. | Piergiuseppe Colombo Daoud Rahal Fabio Grizzi Vittorio Quagliuolo Massimo Roncalli | 2005 | World Journal of Gastroenterology2005，11，33： | 2 |
| 3 | Numerical Simulation and Control of Two-Phase Flow with Evaporation in a Vertical Tube Submitted to a Conjugate Heat Transfer显示文摘 | Ghazali Mebarki Samir Rahal | 2013 | Journal of Energy and Power Engineering2013，7，7： | 2 |
| 4 | DNA typing by microbead arrays and PCR- SSP:Apparent false- negative or -positive hybridization or amplification signals dLclose new HLA - B and - DRB1 alleles 显示文摘 | Rahal M Kervaire B Villard J | 2008 | Tissue Antigens2008，71，3： | 1 |
| 5 | Preliminary results of a randomized trial comparing neoadjuvant chemotherapy plus radiotherapy alone in stage Ⅳ (N2 M0) undifferentiated nasopharyngeal carcinoma显示文摘 | Cvitkovic E Eschwege F Rahal M | 1996 | Int J Radiat Oncol Biol Phys1996，35，3： | 1 |
| 6 | Paracrine-acting adiponectin promotes mammary epithelial differentiation and synergizes with genistein to enhance transcriptional response to estrogen receptor β signaling 显示文摘 | Rahal OM Simmen RC | 2011 | Endocrinology2011，152，9： | 1 |
| 7 | Considerations in control and transmission of nosocomial infections due to multi-drug resistant:Acinetobacter baumannii显示文摘 | Urban C Maurer-Segal Rahal JJ | | 0，，： | 1 |
| 8 | GHRH receptor of little mice contains a missense mutation in the extraceL lular domain that disrupts receptor function显示文摘 | Godfrey P Rahal J O Beamer W G | 1993 | Nat Genet1993，4，： | 1 |
| 9 | Class restriction of cephalosporin use to control total cephalosporin resistance in nosocomial Klebsiella显示文摘 | Rahal J J Urban C Horn D | 1998 | JAMA1998，280，14： | 1 |
| 10 | Influence of chemical and mechanical polishing on water sorption and solubility of denture base acrylic resins显示文摘 | Rahal JS Mesquita MF Henriques GE | 2004 | Braz Dent J2004，15，3： | 1 |
| 11 | Classrestriction of cephalosporin use to control total cephalosporin resistance in nosoconnial klebsiella 显示文摘 | Rahal I J Wrban B Horn D | 1998 | JA- MA1998，280，41： | 1 |
| 12 | In vivo and in vitro evaluation of an Acetobacter xylinum synthesized microbial cellulose membrane intended forguided tissue repair显示文摘 | Mendes PN Rahal SC Pereira-Junior OC et M | 2009 | Acta Vet Scand2009，51，： | 1 |
| 13 | 查看详情显示文摘 | Rahal CS Textor SC Breen JF | | 0，，： | 1 |
| 14 | Risk factors for duct ectasia显示文摘 | RAHAL R M DE FREITAS-JUNIOR R PAULINELLI R R | | 0，，04： | 1 |
| 15 | Nosocomoal antibiotic resistance in multiple Gram-negative species,experience at one hospital with squeezing the resistance balloon at multiple sites显示文摘 | Rahal JJ Urban C Segal-Manrer S | 2002 | CID2002，34，： | 1 |
| 16 | Dose dense neoadjuvant sequential chemotherapy in the wanagenent of locally advancel breast Cancer: a plase II study 显示文摘 | Ezzae A A Rahal M A jurim D | 2003 | Pro Am Soc Clin Oncol2003，22，1： | 1 |
| 17 | Flashover mechanism of high voltage insulators显示文摘 | Rahal M Huraux C | 1979 | IEEE Transactions on Power Apparatus and Systems1979，98，6： | 1 |
| 18 | In vitro double and triple bacteri- cidal activities of doripenem, pnlymyxin B, and rifampin against muhidrug - resistant Acinetobacter baumannii , Pseudomona~ aerugi- nosa , Klebsiella pneumoniae , and Escherichia coli 显示文摘 | Urban C Mariano N Rahal JJ | 2010 | Antimierob Agents Chemother2010，54，： | 1 |
| 19 | High-dose ifosfamide(HDI)in metastatic synovial sarcoma:the Institut Gustave Roussy experience显示文摘 | Rahal AS Cioffi A Rahal C | | 0，，： | 1 |
| 20 | Mechanical Properties of concrete with recycled coarse aggregate显示文摘 | K Rahal | 2007 | Building and Environment2007，42，1： | 1 |
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