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| 1 | Computational study of different venturi and orifice type hydrodynamic cavitating devices显示文摘This paper reports optimization of various geometrical parameters of two types of hydrodynamic cavitation reactors(HC) such as venturi type and orifice type. Mostly orifice and venturi nozzles are used as HC reactor, a simple valve can also be used to cause cavitation which depends on geometry and area of opening. Different operating and geometrical parameters such as divergence angle, throat height/diameter to length ratio, number of holes and inlet pressure to the cavitating device were selected to study the inception, growth and dynamics of cavities. In this work, a comprehensive computational fluid dynamics simulation is performed to numerically investigate the 3-D flow behaviors within HC reactors using cavitational model with standard k-ε Turbulence model. The study of different geometries of venturi type HC reactor(like slit, circular and elliptical) shows that 1:1 of the ratio of throat height/diameter to length ando 6.5 of divergence angle is an optimum geometry for best cavitational activity. In case of orifice, 1:3 of the ratio of diameter to length is best for cavitation and an increase in the total flow area increases the cavitational yield. | Kuldeep Virendra Kumar SAHARAN | 2016 | Journal of Hydrodynamics2016，28，2： | 11 |
| 2 | Neuroprotective Effect of Chrysophanol as a PI3K/AKT/mTOR Signaling Inhibitor in an Experimental Model of Autologous Blood-induced Intracerebral Hemorrhage显示文摘Objective Intracerebral hemorrhage(ICH)refers to predominant,sporadic,and non-traumatic bleeding in the brain parenchyma.The PI3K/AKT/mTOR signaling pathway is an important signal transduction pathway regulated by enzyme-linked receptors and has many biological functions in mammals.It plays a key role in neuronal metabolism,gene expression regulation,and tissue homeostasis in the healthy and diseased brain.Methods In the present study,the role of the PI3K/AKT/mTOR pathway inhibitor chrysophanol(CPH)(10 mg/kg and 20 mg/kg,orally)in the improvement of ICH-associated neurological defects in rats was investigated.Autologous blood(20µL/5 min/unilateral/intracerebroventricular)mimics ICH-like defects involving cellular and molecular dysfunction and neurotransmitter imbalance.The current study also included various behavioral assessments to examine cognition,memory,and motor and neuromuscular coordination.The protein expression levels of PI3K,AKT,and mTOR as well as myelin basic protein and apoptotic markers,such as Bax,Bcl-2,and caspase-3,were examined using ELISA kits.Furthermore,the levels of various neuroinflammatory cytokines and oxidative stress markers were assessed.Additionally,the neurological severity score,brain water content,gross brain pathology,and hematoma size were used to indicate neurological function and brain edema.Results CPH was found to be neuroprotective by restoring neurobehavioral alterations and significantly reducing the elevated PI3K,AKT,and mTOR protein levels,and modulating the apoptotic markers such as Bax,Bcl-2,and caspase-3 in rat brain homogenate.CPH substantially reduced the inflammatory cytokines like interleukin(IL)-1β,IL-6,and tumor necrosis factor-α.CPH administration restored the neurotransmitters GABA,glutamate,acetylcholine,dopamine,and various oxidative stress markers.Conclusion Our results show that CPH may be a promising therapeutic approach for overcoming neuronal damage caused by the overexpression of the PI3K/AKT/mTOR signaling pathway in ICH-induced neurological dysfunctions in rats. | Kuldeep Singh JADAUN Sidharth MEHAN Aarti SHARMA Ehraz Mehmood SIDDIQUI Sumit KUMAR NaifALSUHAYMI | 2022 | Current Medical Science2022，42，2： | 5 |
| 3 | Donors for Resistance to Brown Planthopper Nilaparvata lugens(St?l) from Wild Rice Species显示文摘Out of 1 989 wild accessions sown in seed boxes for screening, only 1 003 wild accessions with good germination were screened against brown planthopper(BPH), Nilaparvata lugens(St?l) under greenhouse conditions. The collection comprised of accessions from 11 wild species and African cultivated rice. The germplasm was screened for BPH following standard seed box screening technique in the greenhouse. As many as 159 accessions were identified as resistant during the year 2012 based on one year screening. A selected set of BPH resistant accessions were screened again during 2013. Based on the two years screening, seven accessions of O. nivara(AA), one accession of O. officinalis(CC), seven accessions of O. australiensis(EE), five accessions of O. punctata(BB and BBCC) and nine accessions of O. latifolia(CCDD) were confirmed to be resistant to BPH. So far no BPH resistance genes have been identified and designated from O. nivara and O. punctata, hence these may act as new sources of resistance. | Preetinder S. SARAO Gurpreet K. SAHI Kumari NEELAM Gurjit S. MANGAT Bhaskar C. PATRA Kuldeep SINGH | 2016 | Rice science2016，23，4： | 5 |
| 4 | Development and Identification of Novel Rice Blast Resistant Sources and Their Characterization Using Molecular Markers显示文摘To develop and characterize introgression lines for leaf and neck blast resistance, 326 introgression lines were developed using various accessions of six different AA genome wild species in the genetic background of elite Indian varieties like PR114 and Pusa 44 and were screened for blast resistance. Stringent phenotyping coupled with genotyping using gene based markers led to the identification of four resistant introgression lines, which showed promising resistance and do not possess any of the tested genes. Furthermore, multi-location screening confirmed the field resistance of the four introgression lines to both leaf and neck blast. Molecular characterization of these introgression lines using genome-wide simple sequence repeat markers revealed the presence of small percentage of wild Oryza genome introgrssion. So these lines can be used for mapping and identification of novel leaf and neck blast resistance genes. Thus, these four introgression lines can be considered as new genetic resources for blast resistance. | S.J.S.RAMA DEVI Kuldeep SINGH B.UMAKANTH B.VISHALAKSHI P.RENUKA K.VIJAY SUDHAKAR M.S.PRASAD B.C.VIRAKTAMATH V.RAVINDRA BABU M.S.MADHAV | 2015 | Rice science2015，22，6： | 4 |
| 5 | Case Report: Fatal case of disseminated BCG infection in an infant born to a mother taking infliximab for Crohn’s Disease显示文摘 | Kuldeep Cheent Jonathan Nolan Sohail Shariq Liina Kiho Arabinda Pal Jayantha Arnold | 2010 | Journal of Crohn’s and Colitis2010，，5： | 3 |
| 6 | Dengue:epidemiology,prevention and pressing need for vaccine development显示文摘Dengue fever is a mosquito born viral infection,and the complicated form of dengue is dengue hemorrhagic fever(DHF).In the recent decades incidence and distribution of dengue has increased dramatically.Dengue viruses belong to family flaviviridae with four serotypes and are transmitted mainly by mosquito Aedes aegypti.Today almost two-fifth of world’s population (2.5 million) is at risk of dengue and no specific antiviral drug or vaccine is available against it.Uncontrolled population growth in Africa and South East Asia has increased number of susceptible hosts in urban and semi urban areas.About 40%of world population resides in the high risk area for dengue transmission.According to latest estimates by WHO,yearly 50 to 100 million infections occur globally,this includes around 500 000 DHF and 22 000 deaths,mostly among children.Only symptomatic treatment in the form of analgesic,antipyretics and body fluid management is provided to the patient.Prevention strategies mainly focus on two approaches, firsdy on activities to control vector and secondly on activities to protect human from mosquito bite but there is always concerns regarding their sustainably and effectiveness.Theoretically development of an effective dengue vaccine is feasible and production of an effective and affordable vaccine could be a viable option to save humans from this dreadful disease. Conceptually vaccine production is possible,but it has to be tetravalent,providing immunity against all serotypes.Few candidate vaccines are in advance stage of their development:however international cooperation is needed to make these vaccines available on cheaper rates to the poor and vulnerable countries.Objective of this review is to discuss various aspects related to dengue,its epidemiology,available preventive methods,need for vaccine and challenges in its development. | Kuldeep Kumar Pankaj Kumar Singh Juhi Tomar Swati Baijal | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，12： | 2 |
| 7 | Effect of potassium on soil conservation and productivity of maize/cowpea based crop rotations in the north-west Indian Himalayas显示文摘Plots under conservation tillage may require higher amount of potassium(K) application for augmenting productivity due to its stratification in upper soil layers, thereby reducing K supplying capacity in a medium or long-term period. To test this hypothesis, a field experiment was performed in 2002-2003 and 2006-2007 to study the effect of K and several crop rotations on yield, water productivity, carbon sequestration, grain quality, soil K status and economic benefits derived in maize(Zea mays L)/cowpea(Vigna sinensis L.) based cropping system under minimum tillage(MT). All crops recorded higher grain yield with a higher dose of K(120 kg K2 O ha-1) than recommended K(40 kg K2 O ha-1). The five years' average yield data showed that higher K application(120 kg K2 O ha-1) produced 16.4%(P<0.05)more maize equivalent yield. Cowpea based rotation yielded 14.2%(P<0.05) higher production than maize based rotation. The maximum enhancement was found in cowpea-mustard rotation. Relationship between yield and sustainable indices revealed that only agronomic efficiency of fertilizer input was significantly correlated with yield. Similarly, higherdoses of K application not only increased the water use efficiency(WUE) of all crops, but also reduced runoff and soil loss by 16.5% and 15.8% under maize and 23.3% and 19.7% under cowpea cover, respectively. This study also revealed that on an average 16.5% of left over carbon input contributed to soil organic carbon(SOC). Here, cowpea based rotation with the higher K application increased carbon sequestration in soil. Potassium fertilization also significantly improved the nutritional value of harvested grain by increasing the protein content for maize(by 9.5%) and cowpea(by 10.6%). The oil content in mustard increased by 5.0% and 6.0% after maize and cowpea, respectively. Net return also increased with the application of the higher K than recommended K and the trend was similar to yield. Hence, the present study demonstrated the potential yield and profit gains along with resource conservation in the Indian Himalayas due to annual additions of higher amount of K than the recommended dose. The impact of high K application was maximum in the cowpea-mustard rotation. | Birendra Nath GHOSH Om Pal Singh KHOLA Ranjan BHATTACHARYYA Kuldeep Singh DADHWAL Prasant Kumar MISHRA | 2016 | Journal of Mountain Science2016，13，4： | 2 |
| 8 | Some recent developments in non-linear time series modelling, testing, and forecasting 显示文摘 | JAN G DE GOOIJER J G KULDEEP K | 1992 | Int J of Forecasting1992，8，： | 2 |
| 9 | Isolation of colour components from native dye-bearing plants in northeastern India显示文摘 | Bhuyann Ranjana Kuldeep K L | 2005 | Bioresource Technology2005，，3： | 1 |
| 10 | Growth, tolerance efficiency and phytoremediation potential of Ricinus communis (L.) and Brassica juncea (L.) in salinity and drought affected cadmium contaminated soil显示文摘 | Kuldeep Bauddh Rana P. Singh | 2012 | Ecotoxicology and Environmental Safety2012，，： | 1 |
| 11 | The impact of international cross listings on risk and return:Evidence from American depositary receipts显示文摘 | Narayanan Kuldeep Shastri | 1993 | Journal of Banking and Finance1993，，17： | 1 |
| 12 | Pigmentary demarcation lines in pregnancy显示文摘 | Gupta LK Kuldeep CM Mittal A | 2005 | Indian J Dermatol Venereol Leprol2005，71，4： | 1 |
| 13 | Image enhancement via median- mean based sub-image-clipped histogram equalization 显示文摘 | Kuldeep Singh Raiiv Kapoor | 2014 | In- ternational Journal for Light and Electron Optics2014，125，17： | 1 |
| 14 | Evaluating implicit measures to improve web search显示文摘 | Steve Fox Kuldeep Karnawat Mark Mydland Susan Dumais Thomas White | 2005 | ACM Transactions on Information Systems (TOIS)2005，，2： | 1 |
| 15 | Pigmentary demarcation lines in pregnancy显示文摘 | Lalit KG Kuldeep CM Asit M | 2005 | Indian J Dermatol Venereol Leprol2005，71，4： | 1 |
| 16 | Lactobacilli and Bifidobacteria enhance mucosal B cell responses and differentially modulate systemic antibody responses to an oral human rotavirus vaccine in a neonatal gnotobiotic pig disease model显示文摘 | Sukumar Kandasamy Kuldeep S Chattha Anastasia N Vlasova Gireesh Rajashekara Linda J Saif | 2014 | Gut Microbes2014，，5： | 1 |
| 17 | Organic-acid-producing, phytate-mineralizing rhizobacteria and their effect on growth of pigeon pea (Cajanus cajan) 显示文摘 | Kuldeep J P Anil K S Nareshkumar G | 2010 | Applied Soil Ecology2010，，44： | 1 |
| 18 | An automated method on analysis of blood steroids using liquid chromatography tan- dem mass spectrometry: application to population screening for congenital adrenal hyperplasia in newborns 显示文摘 | Kuldeep D Thomson H Patti R | 2011 | Cliniea Chi- mica Acta2011，412，6： | 1 |
| 19 | Tower-Based Greenhouse Gas Measurement Network Design——The National Institute of Standards and Technology North East Corridor Testbed显示文摘The North–East Corridor(NEC) Testbed project is the 3rd of three NIST(National Institute of Standards and Technology) greenhouse gas emissions testbeds designed to advance greenhouse gas measurements capabilities. A design approach for a dense observing network combined with atmospheric inversion methodologies is described. The Advanced Research Weather Research and Forecasting Model with the Stochastic Time-Inverted Lagrangian Transport model were used to derive the sensitivity of hypothetical observations to surface greenhouse gas emissions(footprints). Unlike other network design algorithms, an iterative selection algorithm, based on a k-means clustering method, was applied to minimize the similarities between the temporal response of each site and maximize sensitivity to the urban emissions contribution. Once a network was selected, a synthetic inversion Bayesian Kalman filter was used to evaluate observing system performance. We present the performances of various measurement network configurations consisting of differing numbers of towers and tower locations. Results show that an overly spatially compact network has decreased spatial coverage, as the spatial information added per site is then suboptimal as to cover the largest possible area, whilst networks dispersed too broadly lose capabilities of constraining flux uncertainties. In addition, we explore the possibility of using a very high density network of lower cost and performance sensors characterized by larger uncertainties and temporal drift. Analysis convergence is faster with a large number of observing locations, reducing the response time of the filter. Larger uncertainties in the observations implies lower values of uncertainty reduction. On the other hand, the drift is a bias in nature, which is added to the observations and,therefore, biasing the retrieved fluxes. | Israel LOPEZ-COTO Subhomoy GHOSH Kuldeep PRASAD James WHETSTONE | 2017 | Advances in Atmospheric Sciences2017，34，9： | 1 |
| 20 | Genealogy and phylogeography of Cyprinid fish Labeo rohita (Hamilton, 1822) inferred from ATPase 6 and 8 mitochondrial DNA gene analysis显示文摘 | Rupesh K. LUHARIYA Kuldeep K. LAL Rajeev K. SINGH Vindhya MOHINDRA Arti GUPTA Prachi MASIH Arvind K. DWIVEDI Rakhi DAS U. K. CHAUHAN J. K. JENA | 2014 | Current Zoology2014，60，4： | 1 |
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