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| 1 | Enhanced myocardial fluorodeoxyglucose uptake following Adriamycin-based therapy: Evidence of early chemotherapeutic cardiotoxicity?显示文摘AIM: To analyze changes in myocardial glucose metabolism using fluorodeoxyglucose (FDG)-positron emission tomography (PET) in patients treated with adriamycin and to investigate the clinical significance of these changes.METHODS: Considering that FDG-PET scanning has the ability to show changes in glucose metabolism in the myocardium, we retrospectively analyzed the FDGPET studies of 18 lymphoma patients treated with adriamycin-based chemotherapy in both the preand posttherapy setting. Cardiac contractile parameters such as left ventricular ejection fraction were not available for correlation in all patients due to the short duration and the level of cumulative dose administered in these patients during the time of the follow-up FDG-PET study. The change in myocardial glucose utilization was estimated by change in standard uptake values (SUV) in the myocardium.RESULTS: We observed a significant change in SUVmean values in the myocardium (defined as more than change in cardiac SUVmean between pre-and post-chemotherapy PET) in 1 patients, whereas 6 patients did not show any significant cardiac FDG uptake in both preand post-therapy PET scans. Patients were divided into three groups based on the changes observed in myocardial tracer uptake on the followup 18 F-FDG-PET study. Group A (n = 8): showed an increase in cardiac 18 F-FDG uptake in the post-therapy scan compared to the baseline scan carried out prior to starting adriamycin-based chemotherapy. Group B (n = 6): showed no significant cardiac 18 F-FDG uptake in post-therapy and baseline PET scans, and group C (n = 4): showed a fall in cardiac 18 F-FDG uptake in the posttherapy scan compared to the baseline scan. Mean cumulative adriamycin dose (in mg/m 2 ) received during the time of the follow-up FDG-PET study was 256. 25, 250 and 137.5, respectively.CONCLUSION: Our study shows three different trends in the change in myocardial glucose metabolism in patients undergoing adriamycin-based chemotherapy. A further prospective study with prolonged follow-up of ventricular function is warranted to explore the significance of enhanced FDG uptake as a marker of early identification of adriamycin-induced cardiotoxicity. | Chaitanya Borde Purushottam Kand Sandip Basu | 2012 | World Journal of Radiology2012，4，5： | 9 |
| 2 | Psoas muscle metastasis from cervical carcinoma:Correlation and comparison of diagnostic features on FDG-PET/CT and diffusion-weighted MRI显示文摘Psoas muscle metastasis, though rare, is the commonest site of skeletal muscle involvement in cervical carcinoma. The appropriate clinical management of this condition, particularly of the pain related to malignant psoas syndrome, is still evolving and the diagnostic features on conventional morphological imaging modalities are often non specific, with the differential diagnosis lying between sarcoma, hematoma, and abscess. In this report, a comparison of various morphofunctional imaging modalities was made. Fluorodeoxyglucosepositron emission tomography(FDG-PET)/computed tomography(CT) was the first to suspect disease involvement of the psoas muscle, demonstrating intense FDG uptake(compared with the contralateral muscle), while ultrasound showed heterogeneous echotexture, and magnetic resonance imaging(MRI) showed subtle altered signal intensity in the right psoas muscle. Both anatomical imaging modalities and non contrast CT of the PET-CT examination demonstrated a bulky psoas muscle, without any focal abnormality. On diffusionweighted imaging of MRI(DWI-MRI), restricted diffusion of the involved muscle was an important observation. The psoas muscle metastatic involvement was proven histopathologically. Thus, enhanced glucose metabolism and restricted diffusion in the newer noninvasive molecular imaging modalities(e.g., PET/CT and DWI-MRI) could serve as valuable adjunctive parameters in diagnosing this entity in the absence of a focal abnormality in the anatomical modalities. In the treatment response monitoring scenario, FDG-PET/CT demonstrated near complete resolution following administration of 3 cycles of systemic chemotherapy and local external radiotherapy. | Sandip Basu Abhishek Mahajan | 2014 | World Journal of Radiology2014，6，4： | 6 |
| 3 | Potential of (18)~F-FDG-PET as a valuable adjunct to clinical and response assessment in rheumatoid arthritis and seronegative spondyloarthropathies显示文摘AIM: To evaluate the role of fluorine-18-labeled fluorodeoxyglucose positron emission tomography (18F-FDG PET) in various rheumatic diseases and its potential in the early assessment of treatment response in a limited number of patients. METHODS: This study involved 28 newly diagnosed patients, of these 17 had rheumatoid arthritis (RA) and 11 had seronegative spondyloarthropathy (SSA). In the SSA group, 7 patients had ankylosing spondylitis, 3 had psoriatic arthritis, and one had non-specific SSA. Patients with RA were selected as per the American College of Rheumatology criteria. One hour after FDG injection, a whole body PET scan was performed from the skull vertex to below the knee joints using a GE Advance dedicated PET scanner. Separate scans were acquired for both upper and lower limbs. Post-treatment scans were performed in 9 patients in the RA group (at 6-9 wk from baseline) and in 1 patient with psoriatic arthropathy. The pattern of FDG uptake was analysed visually and quantified as maximum standardized uptake value (SUVmax) in a standard region of interest. Metabolic response on the scan was assessed qualitatively and quantitatively and was correlated with clinical assessment. RESULTS: The qualitative FDG uptake was in agreement with the clinically involved joints, erythrocyte sedimentation rate, C-reactive protein values and the clinical assessment by the rheumatologist. All 17 patients in the RA group showed the highest FDG avidity in painful/swollen/tender joints. The uptake pattern was homogeneous, intense and poly-articular in distribution. Hypermetabolism in the regional nodes (axillary nodes in the case of upper limb joint involvement and inguinal nodes in lower limb joints) was a constant feature in patients with RA. Multiple other extra-articular lesions were also observed including thyroid glands (in associated thyroiditis) and in the subcutaneous nodules. Treatment response was better appreciated using SUVmax values than visual interpretation, when compared with clinical evaluation. Four patients showed a favourable response, while 3 had stable disease and 2 showed disease progression. The resolution of regional nodal uptake (axillary or inguinal nodes based on site of joint involvement) in RA following disease modifying anti-rheumatoid drugs was noteworthy, which could be regarded as an additional parameter for identifying responding patients. In the SSA group, uptake in the affected joint was heterogeneous, low grade and nonsymmetrical. In particular, there was intense tendon and muscular uptake corresponding to symptomatic joints. The patients with psoriatic arthritis showed intense FDG uptake in the joints and soft tissue. CONCLUSION: 18F-FDG PET accurately delineates the ongoing inflammatory activity in various rheumatic diseases (both at articular and extra-articular sites) and relates well to clinical symptoms. Different metabolic patterns on FDG-PET scanning in RA and SSA can have important implications for their diagnosis and management in the future with the support of larger studies. FDG-PET molecular imaging is also a sensitive tool in the early assessment of treatment response, especially when using quantitative information. With these benefits, FDG-PET could play a pivotal clinical role in the management of inflammatory joint disorders in the future. | Vishu Vijayant Manjit Sarma Hrushikesh Aurangabadkar Lata Bichile Sandip Basu | 2012 | World Journal of Radiology2012，4，12： | 5 |
| 4 | Potential of Dual Time Point FDG-PET Imaging in Differentiating Malignant from Benign Pleural Disease显示文摘 | Ayse Mavi Sandip Basu Tevfik F. Cermik Muammer Urhan Mehdi Bathaii Dhurairaj Thiruvenkatasamy Mohamed Houseni Simin Dadparvar Abass Alavi | 2009 | Molecular Imaging and Biology2009，，5： | 1 |
| 5 | Impact of FDG-PET and -PET/CT imaging in the clinical decision-making of ovarian carcinoma: an evidence-based approach显示文摘 | Vandana Kumar Dhingra Purushottam Kand Sandip Basu | 2012 | Women’s Health2012，，： | 1 |
| 6 | Effects of water content and chemical composition on structural properties of alkaline activated metakaolin-based geo-polymers 显示文摘 | LIZCANO MARICELA GONZALEZ ANDRES BASU SANDIP ct al | 2012 | J Am Ceram Soc2012，95，7： | 1 |
| 7 | Towards under- standing who makes corporate venture capital investments and why 显示文摘 | Sandip Basu Corey Phelps Suresh Kotha | 2011 | Journal of Business Venturing2011，26，2： | 1 |
| 8 | Towards un- derstanding who makes corporate venture capital invest- ments and why 显示文摘 | Sandip Basu Corey Phelps Suresh Kotha | 2011 | Journal of Business Venturing2011，，26： | 1 |
| 9 | Diagnostic Performance of FDG-PET, MRI, and Plain Film Radiography (PFR) for the Diagnosis of Osteomyelitis in the Diabetic Foot显示文摘 | Asad Nawaz Drew A. Torigian Evan S. Siegelman Sandip Basu Timothy Chryssikos Abass Alavi | 2010 | Molecular Imaging and Biology2010，，3： | 1 |
| 10 | Role of Modern Imaging Techniques for Diagnosis of Infection in the Era of 18F-Fluorodeoxyglucose Positron Emission Tomography显示文摘 | Rakesh Kumar Sandip Basu Drew Torigian | 2008 | Clin Microbiol Rev2008，21，1： | 1 |
| 11 | Diagnostic Performance of FDG-PET, MRI, and Plain Film Radiography (PFR) for the Diagnosis of Osteomyelitis in the Diabetic Foot显示文摘 | Asad Nawaz Drew A. Torigian Evan S. Siegelman Sandip Basu Timothy Chryssikos Abass Alavi | 2010 | Molecular Imaging and Biology2010，，3： | 1 |
| 12 | Towards under- standing who makes corporate venture capital investments and why显示文摘 | Sandip Basu Corey Phelps Suresh Kotha | 2011 | Journal of Business Venturing2011，，26： | 1 |
| 13 | Evolving concept of imaging bone marrow metastasis in the twenty-first century: critical role of FDG-PET显示文摘 | Sandip Basu Drew Torigian Abass Alavi | 2008 | European Journal of Nuclear Medicine and Molecular Imaging2008，，： | 1 |
| 14 | FDG PET/CT in Crohn’s disease: correlation of quantitative FDG PET/CT parameters with clinical and endoscopic surrogate markers of disease activity显示文摘 | Babak Saboury Ali Salavati Alex Brothers Sandip Basu Thomas C. Kwee Marnix G. E. H. Lam Roland Hustinx Edouard Louis Drew A. Torigian Abass Alavi | 2014 | European Journal of Nuclear Medicine and Molecular Imaging2014，，： | 1 |
| 15 | Towards understanding who makes corporate venture cap- ital investments and why 显示文摘 | BASU SANDIP PHELPS COREY KOTHA SURESH | 2011 | Journal of Business Ventu- ring2011，26，： | 1 |
| 16 | Towards understanding who makes corporate venture capital investments and why显示文摘 | Sandip Basu Corey Phelps Suresh Kotha | 2009 | Journal of Business Venturing2009，，2： | 1 |
| 17 | Imaging Calcific Concretions of Pulmonary Alveolar Microlithiasis With PET: Insight into Disease Pathophysiology显示文摘 | Sandip Basu Mehul Shah JM Joshi Sangita Lad | 2012 | Clinical Nuclear Medicine2012，，： | 1 |
| 18 | Equilibrium radionuclide angiocardiography:Its usefulness in current practice and potential future applications显示文摘The routine and potential future applications of equilibrium radionuclide angiocardiography/multigated acquisition (MUGA) in clinical decision making are explored in this review. The non-invasive nature of the test, less operator dependence, lower radiation dose and ease of performing, even in ill patients, are important considerations in clinical cardiology practice. Two important routine uses of this modality in day-to-day clinical practice include the following: serial assessment of left ventricular ejection fraction (LVEF) in patients receiving cardiotoxic chemotherapy, and determination of accurate LVEF in patients with intractable heart failure. Other potential utilities of MUGA that could be translated into clinical practice include determination of regional LVEF, obtaining information about both right and left ventricle in suitable patients as a part of first pass angiocardiography, identification of diastolic dysfunction in patients with heart failure with preserved LVEF, and demonstration of dyssynchrony prior to cardiac resynchronisation, specifically by MUGA single photon emission tomography.The last two indications are particularly important and evolving at this point. | Deepanjan Mitra Sandip Basu | 2012 | World Journal of Radiology2012，4，10： | 0 |
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