|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Nutcracker syndrome显示文摘The nutcracker phenomenon [left renal vein(LRV) entrapment syndrome] refers to compression of the LRV most commonly between abdominal aorta and superior mesenteric artery.Term of nutcracker syndrome(NCS) is used for patients with clinical symptoms associated with nutcracker anatomy.LRV entrapment divided into 2 types:anterior and posterior.Posterior and right-sided NCSs are rare conditions.The symptoms vary from asymptomatic hematuria to severe pelvic congestion.Symptoms include hematuria,orthostatic proteinuria,flank pain,abdominal pain,varicocele,dyspareunia,dysmenorrhea,fatigue and orthostatic intolerance.Existence of the clinical features constitutes a basis for the diagnosis.Several imaging methods such as Doppler ultrasonography,computed tomography angiography,magnetic resonance angiography and retrograde venography are used to diagnose NCS.The management of NCS depends upon the clinical presentation and the severity of the LRV hypertension.The treatment options are ranged from surveillance to nephrectomy.Treatment decision should be based on the severity of symptoms and their expected reversibility with regard to patient's age and the stage of the syndrome. | Kaan Gulleroglu Basak Gulleroglu Esra Baskin | 2014 | World Journal of Nephrology2014，3，4： | 12 |
| 2 | Helicobacter pylori and serum kynurenine-tryptophan ratio in patients with colorectal cancer显示文摘AIM: To evaluate how Helicobacter pylori(H. pylori) is able to evade the immune response and whether it enhances systemic immune tolerance against colorectal cancer.METHODS: This prospective randomized study involved 97 consecutive colorectal cancer patients and 108 cancer-free patients with extra-digestive diseases. Colorectal cancer and cancer-free patients were assigned into subgroups according to H. pylori Ig G seropositivity. Exposure to H. pylori was determined by Ig G seropositivity which was detected by enzyme linked immunoassay(ELISA). Serum neopterin levels were measured by ELISA. Serum tryptophan, kynurenine, and urinary biopterin concentrations were measured by high performance liquid chromatography. Serum nitrite levels were detected spectrophotometrically. Serum indoleamine 2,3-dioxygenase activity was estimated by the kynurenine to tryptophan ratio and by assessing the correlation between serum neopterin concentrations and the kynurenine to tryptophan ratio. The frequencies of increased serum kynurenine to tryptophan ratio of H. pylori seronegative and seropositive colorectal cancer subgroups were estimated by comparing them with the average kynurenine to tryptophan ratio of H. pylori seronegative tumor-free patients.RESULTS: Compared with respective controls, in both H. pylori seronegative and seropositive colorectal cancer patients, while serum tryptophan levels were decreased(controls vs patients; seronegative: 20.37 ± 0.89 μmol/L vs 15.71 ± 1.16 μmol/L, P < 0.05; seropositive: 20.71 ± 0.81 μmol/L vs 14.97 ± 0.79 μmol/L, P < 0.01) the kynurenine to tryptophan ratio was significantly increased(controls vs patients; seronegative: 52.85± 11.85 μmol/mmol vs 78.91 ± 8.68 μmol/mmol, P < 0.01, seropositive: 47.31 ± 5.93 μmol/mmol vs 109.65 ± 11.50 μmol/mmol, P < 0.01). Neopterin concentrations in cancer patients were significantly elevated compared with controls(P < 0.05). There was a significant correlation between serum neopterin levels and kynurenine/tryptophan in control and colorectal cancer patients groups(r s = 0.494, P = 0.0001 and r s= 0.293, P = 0.004, respectively). Serum nitrite levels of H. pylori seropositive cancer cases were significantly decreased compared with seropositive controls(controls vs patients; 26.04 ± 2.39 μmol/L vs 20.41 ± 1.48 μmol/L, P < 0.05) The decrease in the nitrite levels of H. pylori seropositive cancer patients may be attributed to excessive formation of peroxynitrite and other reactive nitrogen species.CONCLUSION: A significantly high kynurenine/tryptophan suggested that H. pylori may support the immune tolerance leading to cancer development, even without an apparent upper gastrointestinal tract disease. | Ayse Basak Engin Bensu Karahalil Ali Esat Karakaya Atilla Engin | 2015 | World Journal of Gastroenterology2015，21，12： | 11 |
| 3 | Effects of Organic Amendments on Soil Physical Attributes and Aggregate-Associated Phosphorus Under Long-Term Rice-Wheat Cropping显示文摘The quantification of phosphorus(P) in bulk soil and P distribution in different size fractions of water-stable aggregates(WSAs)are important for assessing potential P loss through runoff. We evaluated available and total P distribution within WSAs of a sitty clay to clay soil in a long-term fertility experiment of a rice-wheat cropping system in India. Surface soil samples were collected from seven plots amended with NPK fertilizers in combination with or without organic amendments, farmyard manure(FYM), green manure(GM), and paddy straw(PS). The plot with no NPK fertilizers or organic amendments was set as a control. The soil samples were separated by wet sieving into four soil aggregate size fractions: large macroaggregates(> 2.0 mm), small macroaggregates(0.25–2.0 mm), fine microaggregates(0.05–0.25 mm), and a silt + clay-sized fraction(< 0.05 mm). Structural indices were higher in the soil receiving organic amendments than in the soil receiving inorganic fertilizer alone. Organically amended soil had a higher proportion of stable macroaggregates than the control and the soil receiving inorganic fertilizer alone, which were rich in microaggregates. Total and available P contents within WSAs were inversely related to the aggregate size, irrespective of treatment. The distribution of available and total P in the soil aggregate size fraction was as follows: silt + clay-size fraction > small macroaggregates > fine microaggregates> large macroaggregates. Within a size class, aggregate-associated available and total P contents in the organically amended soil were in the following order: FYM > PS ≥ GM. The available P content of the microaggregates(< 0.25 mm) was 8-to 10-times higher than that of the macroaggregates(> 0.25 mm), and the total P content of the microaggregates was 4-to 5-times higher than that of the macroaggregates. Cultivation without organic amendments resulted in more microaggregates that could be checked by the application of organic amendments such as FYM and GM, which increased the proportion of water-stable macroaggregates by consolidating microaggregates into macroaggregates. | Tarik MITRAN Pabitra Kumar MANI Prasanta Kumar BANDYOPADHYAY Nirmalendu BASAK | 2018 | Pedosphere2018，28，5： | 6 |
| 4 | Human catalase: looking for complete identity显示文摘Catalases are well studied enzymes that play critical roles in protecting cells against the toxic effects of hydrogen peroxide.The ubiquity of the enzyme and the availability of substrates made heme catalases the focus of many biochemical and molecular biology studies over 100 years.In human,this has been implicated in various physiological and pathological conditions.Advancement in proteomics revealed many of novel and previously unknown features of this mysterious enzyme,but some functional aspects are yet to be explained.Along with discussion on future research area,this mini-review compile the information available on the structure,function and mechanism of action of human catalase. | Madhur M.Goyal Anjan Basak | 2010 | Protein & Cell2010，1，10： | 6 |
| 5 | New insights into estrogenic regulation of O^6-methylguanine DNA-methyltransferase (MGMT) in human breast cancer cells: Co-degradation of ER-α and MGMT proteins by fulvestrant or O^6-benzylguanine indicates fresh avenues for therapy显示文摘Endocrine therapy using estrogen receptor-α(ER-α) antagonists for attenuating horm2one-driven cell proliferation is a major treatment modality for breast cancers.To exploit any DNA repair deficiencies associated with endocrine therapy,we investigated the functional and physical interactions of ER-α with O^6-methylguanine DNA methyltransferase(MGMT),a unique DNA repair protein that confers tumor resistance to various anticancer alkylating agents.The ER-α-positive breast cancer cell lines(MCF-7,T47D) and ER- negative cell lines(MDAMB-468,MDAMB-231),and established inhibitors of ER-α and MGMT,namely,ICI-182,780(Faslodex) and O^6-benzylguanine,respectively,were used to study MGMT- ER interactions.The MGMT gene promoter was found to harbor one full and two half estrogen-responsive elements(EREs) and two antioxidant-responsive elements(AREs).MGMT expression was upregulated by estrogen,downregulated by tamoxifen in Western blot and promoter-linked reporter assays.Similarly,both transient and stable transfections of Nrf-2(nuclear factor-erythroid 2-related factor-2)increased the levels of MGMT protein and activity 3 to 4-fold reflecting novel regulatory nodes for this drugresistance determinant.Of the different ER-α antagonists tested,the pure anti-estrogen fulvestrant was most potent in inhibiting the MGMT activity in a dose,time and ER-α dependent manner,similar to O^6-benzylguanine.Interestingly,fulvestrant exposure led to a degradation of both ER-α and MGMT proteins and O^6-benzylguanine also induced a specific loss of ER-α and MGMT proteins in MCF-7 and T47 D breast cancer cells with similar kinetics.Immunoprecipitation revealed a specific association of ER-α and MGMT proteins in breast cancer cells.Furthermore,silencing of MGMT gene expression triggered a decrease in the levels of both MGMT and ER-α proteins.The involvement of proteasome in the drug-induced degradation of both proteins was also demonstrated.Fulvestrant enhanced the cytotoxicity of MGMT-targeted alkylating agents,namely,temozolomide and BCNU by 3 to 4-fold in ER-α positive cells,but not in ER-negative cells.We conclude that MGMT and ER-α proteins exist as a complex and are co-targeted for ubiquitin-conjugation and subsequent proteasomal degradation.The findings offer a clear rationale for combining alkylating agents with endocrine therapy. | Ameya Paranjpe Nathan I. Bailes Santhi Konduri George C. Bobustuc Francis Ali-Osman Mohd. A. Yusuf Surendra R. Punganuru Hanumantha Rao Madal Debasish Basak AGM Mostofa Kalkunte S. Srivenugopa | 2016 | The Journal of Biomedical Research2016，30，5： | 5 |
| 6 | Coronary artery bypass grafting in the octogenarians: should we intervene, or leave them be?显示文摘ObjectiveCoronary 动脉绕过 grafting (CABG ) 逐渐地在老人口正在增加。我们试图在 80 的年龄和 older.MethodsBetween 2002年1月和2011年12月在病人与长期的幸存一起调查风险因素和 CABG 的结果,在 80 的年龄的 101 个连续病人的一个总数并且更旧在我们的医院里经历了 CABG 的人,在学习被包括。病人被跟随,长期的幸存是病人的 estimated.ResultsThe 平均数年龄是 82.98 ±2.27 年。(63.4%) 64 是男性,(36.6%) 37 是女性。紧急情况外科,持续时间心肺绕过,特别护理单位(ICU ) 停留, inotropic 支持,大动脉的汽球跳动申请,红血球输送的数量和新鲜冻结的血浆输送和通风时期是的 intra 在在医院里死了的病人显著地更高。持续时间心肺绕过(CPB ) 被发现是死亡的一个独立预言者(或:1.18, 95% CI 1.01 − 1.38, P = 0.034 ) 。在里面医院死亡是 16.8% 。Kaplan-Meier 分析在一年揭示了 91.3% 的幸存比率, 82.9% 在三年并且 69.0% 在五 years.ConclusionsPatients 在 80 岁时并且更旧 CABG 过程的候选人能正在牢记他们可以有一个更长的通风时期和特别护理单位停留。这个年龄组的病态和死亡在一个可接受的范围以内被考虑。最小化 CPB 的途径,或离开泵外科的选择,可以是一个预防方法降低死亡的发生。因此, CABG 可以与令人满意的幸存比率在这个年龄组被执行。 | Anil Ozen Ertekin Utku Unal Murat Songur Sinan Sabit Kocabeyoglu Onur Hanedan Metin Yilmaz Basak Soran Turkcan Ferit Cicekcioglu Sadi Kaplan Cemal Levent Birincioglu | 2015 | Journal of Geriatric Cardiology2015，12，2： | 5 |
| 7 | Comparative study between wear of uncoated and TiAIN-coated carbide tools in milling of Ti6AI4V显示文摘 | M. S. Uddin Binh Pham Ahmed Sarhan Animesh Basak Alokesh Pramanik | 2017 | Advances in Manufacturing2017，5，1： | 4 |
| 8 | A case of solid pseudopapillary tumor of the pancreas显示文摘We present ultrasound, computed tomography and magnetic resonance imaging findings in a case with pancreatic solid pseudopapillary tumor and their correlations with histopathology. Ultrasound revealed a hypoechogenic mass, and computed tomography revealed a hypodense mass at the pancreatic head minimally enhanced after intravenous contrast agent administration. Magnetic resonance imaging showed a hypointense mass on unenhanced T1-weighted images including a hyperintense focus representing the hemorrhage. The lesion was hyperintense on T2- weighted images. On the postcontrast images the lesion showed peripheral thin contrast enhancement in arterial phase and enhanced slightly diffusely in venous and equilibrium phases. The patient underwent elective resection of the mass and pancreatoduodenectomy with jejunostomy tube placement. A final diagnosis of solid pseudopapillary tumor was made histopathologically. Solid pseudopapillary tumor is a rare pancreatic tumor. It is important to make the diagnosis preoperatively because with an adequate surgical resection the prognosis is good. A multimodalitary approach, especially magnetic resonance imaging can suggest the diagnosis without the need for biopsy. | Ozan Karatag Gulden Yenice Huseyin Ozkurt Muzaffer Basak Can Basaran Banu Yilmaz | 2006 | World Journal of Gastroenterology2006，12，38： | 4 |
| 9 | Leukemic stromal hematopoietic microenvironment negatively regulates the normal hematopoiesis in mouse model of leukemia显示文摘Background and Objective: Leukemic microenvironment has a major role in the progression of leukemia. Leukemic cells can induce reversible changes in microenvironmental components, especially the stromal function which results in improved growth conditions for maintaining the malignant leukemic cells. This study aimed to investigate the survival advantage of leukemic cells over normal hematopoietic cells in stromal microenvironment in long term. Methods: The mice were injected intraperitoneally with N-N’ ethylnitrosourea (ENU) to induce leukemia; the mice received injection of normal saline were used as control. At 180 days after ENU induction, the mice were killed and the bone marrows were cultured for 19 days. Colony-forming assays were used to analyze the formation of various cell colonies. The expression of Sca-1, CD146, VEGFR2, CD95, pStat3, pStat5, and Bcl-xL in marrow cells were detected by flow cytometry. Results: Long-term leukemic bone marrow culture showed abnormal elongated stromal fibroblasts with almost absence of normal hematopoietic cells. Adherent cell colonies were increased, but CFU-F and other hematopoietic cell colonies were significantly decreased in leukemia group (P< 0.001). Primitive progenitor-specific Sca-1 receptor expression was decreased with subsequent increased expression of CD146 and VEGFR-2 in leukemic bone marrow cells. Decreased Fas antigen expression with increased intracellular pStat3, pStat5 and Bcl-xL proteins were observed in leukemic bone marrow cells. Conclusions: Stromal microenvironment shows altered morphology and decreased maturation in leukemia. Effective progenitor cells are decreased in leukemia with increased leukemia-specific cell population. Leukemic microenvironment plays a role in promoting and maintaining the leukemic cell proliferation and survivability in long term. | Pratima Basak Sumanta Chatterjee Prosun Das Madhurima Das Jacintha Archana Pereira Ranjan Kumar Dutta Malay Chaklader Samaresh Chaudhuri Sujata Law | 2010 | Chinese Journal of Cancer2010，29，12： | 3 |
| 10 | Effect of TiB2 and Al3Ti on the microstructure,mechanical properties and fracture behaviour of near eutectic Al−12.6Si alloy显示文摘A near eutectic Al−12.6Si alloy was developed with 0.0wt%,2.0wt%,4.0wt%,and 6.0wt%Al−5Ti−1B master alloy.The micro-structural morphology,hardness,tensile strength,elongation,and fracture behaviour of the alloys were studied.The unmodified Al−12.6Si al-loy has an irregular needle and plate-like eutectic silicon(ESi)and coarse polygonal primary silicon(PSi)particles in the matrix-likeα-Al phase.The P_(Si),E_(Si),andα-Al morphology and volume fraction were changed due to the addition of the Al−5Ti−1B master alloy.The hardness,UTS,and elongation improved due to the microstructural modification.Nano-sized in-situ Al3Ti particles and ex-situ TiB_(2)particles caused the mi-crostructural modification.The fracture images of the developed alloys exhibit a ductile and brittle mode of fracture at the same time.The Al−5Ti−1B modified alloys have a more ductile mode of fracture and more dimples compared to the unmodified alloy. | Surajit Basak Prosanta Biswas Surajit Patra Himadri Roy Manas Kumar Mondal | 2021 | International Journal of Minerals,Metallurgy and Materials2021，28，7： | 3 |
| 11 | Increased syndecan-1 and glypican-3 predict poor perinatal outcome and treatment resistance in intrahepatic cholestasis显示文摘Background:Intrahepatic cholestasis of pregnancy(ICP)increases the risk of adverse pregnancy outcomes.This study aimed to explore the association between serum syndecan-1 and glypican-3 levels and the adverse perinatal outcome as well as the responses to the treatment of ursodeoxycholic acid(UDCA).Methods:This prospective,case control study included 88 pregnant women(44 women with ICP and 44 healthy controls).The primary end points were the perinatal outcome and the response to UDCA therapy.A logistic regression model was used to identify the independent risk factors of adverse pregnancy outcomes and reduced response to UDCA therapy.Results:Women with ICP had significantly higher serum syndecan-1(1.27±0.36 ng/m L vs.0.98±0.50 ng/m L;P=0.003),glypican-3(1.78±0.13 ng/m L vs.1.69±0.16 ng/m L;P=0.004),AST(128.59±1.44 vs.13.29±1.32 U/L;P<0.001),and ALT(129.84±1.53 vs.8.00±3.67 U/L;P<0.001)levels compared with the controls.The increased levels of syndecan-1(OR=4.715,95%CI:1.554–14.310;P=0.006),glypican-3(OR=8.465,95%CI:3.372–21.248;P=0.007),ALT(OR=1.382,95%CI:1.131–1.690;P=0.002),and postprandial bile acid(PBA)(OR=3.392,95%CI:1.003–12.869;P=0.026)were correlated to ICP.The adverse neonatal outcome was related to increased glypican-3(OR=4.275,95%CI:2.726–5.635;P=0.039),and PBA(OR=3.026,95%CI:1.069–13.569;P=0.037).Increases of syndecan-1(OR=7.464,95%CI:2.130–26.153,P=0.017)and glypican-3(OR=6.194,95%CI:2.951–13.002;P=0.025)were the risk factors of decreased response to UDCA treatment.Conclusion:Syndecan-1 and glypican-3 might be powerful determinants in predicting adverse perinatal outcome in patients with ICP,and they can be used to predict the response to the UDCA treatment. | Basak Gümüs Güler Sibel Ozler | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，3： | 3 |
| 12 | A novel suturing technique for filtering glaucoma surgery:the accordion suture显示文摘AIM:To present a novel scleral flap suturing technique for filtering glaucoma surgery in order to control high postoperative intraocular pressure(IOP).METHODS:Description of ‘the accordion suture' technique for mitomycin C augmented trabeculectomy.In cases of postoperative high IOP,pulling the loop of the suture helps to lift up the scleral flap by an even pressure on both edges.By means of this technique,the scleral flap opens up in an ‘‘accordion'' manner,thus preventing flap obstruction and providing adequate aqueous flow.RESULTS:Our study group consisted of 8 eyes of 8 patients with neovascular glaucoma.Mean age of the subjects was 67.42±8.21 y and female/male ratio was 4/4.Mean preoperative IOP was 37±7.48 mm Hg.Mitomycin C augmented trabeculectomy was carried out on the subjects without any complications.The scleral flap closure is performed with three separate sutures;initially,our accordion suture through the center of the flap,and two releasable sutures on both corners.All the patients received removal of two side releasable sutures concomitant with pulling the accordion suture,without any complications.The average traction time was 3.5±0 wk postoperatively.The mean postoperative IOP was 11.37±2.72 mm Hg.No suture related complications were observed.CONCLUSION:This technique can be the suture of choice for filtering glaucoma surgery in experienced hands by its easy learning curve for precisely indicated patients. | Mehmet Baykara Basak Can Ermerak Huri Sabur Selim Gent | 2017 | International Journal of Ophthalmology(English edition)2017，10，12： | 2 |
| 13 | Digitally reinforced hematoxylin-eosin polarization technique in diagnosis of rectal amyloidosis显示文摘AIM:To investigate the efficacy of the digitally reinforced hematoxylin-eosin polarization(DRHEP)technique for detection of amyloidosis in rectal biopsies.METHODS:One hundred hematoxylin-eosin(HE)stained rectal biopsies with Congo-red(CR)-positive amyloid depositions and 50 control cases with CRnegative amyloid-mimicking areas were scanned blinded to the CR results for amyloid depositions under both bright and polarized light,and digitally photographed using the DRHEP technique,to accentuate the faint birefringence observed in HE slides under polarization.The results of DRHEP and HE evaluation were statistically correlated with CR polarization results with respect to presence and localization of amyloid deposits as well as amyloid types.RESULTS:Amyloid deposits showed yellowish-green birefringence by DRHEP,which allowed identification of amyloidosis in 41 HE-unsuspected cases(P=0.016),31 of which only had vascular deposits.True positivity was higher,and false negativity and positivity were lower by DRHEP,compared to evaluation by HE(69%,31%,and 0.8%vs 33%,67%,and 33%,respectively;P<0.0001).The sensitivity,specificity,accuracy,and positive and negative predictive values for DRHEP were69%,98%,78.6%,98.5%,and 61.25%,respectively.Reasons for DRHEP false negativity were presence of extensive background birefringence in 12 cases,absence of CR birefringent vessel in 3 cases,and missing of the tiny deposits in 9 cases,which could be improved by experience,especially in the latter case.No correlation was found between age,gender,sites of deposits,or amyloid types.CONCLUSION:The DRHEP technique improves diagnostic accuracy when used as an adjunct or a prior step to CR staining,especially for cases with limited tissues for further analysis. | Basak Doganavsargil Gulruh Emiroglu Buberal Huseyin Toz Banu Sarsik Burcin Pehlivanoglu Murat Sezak Sait Sen | 2015 | World Journal of Gastroenterology2015，21，6： | 2 |
| 14 | Development of a mixed fruit beverage and pulsed light treatment thereof to obtain a microbially safe and enzymatically stable product显示文摘A mixed fruit beverage was formulated according to D-optimal mixture design using apple ber juice(X_(1),45-59%v/v)-an underexplored fruit,carambola juice(X_(2),1-20%v/v),and black table grape juice(X3,35-40%v/v).The crisp overall acceptability(COA)from 16 semi-trained panelists and overall hedonic score(OSH)from consumers were estimated.The best formulation was apple ber:carambola:black table grape juices=59.0:3.5:37.5 v/v with COA and OSH values of 3.23(on a scale of 5)and 7.55(on a scale of 9),respectively.Further,the efficacy of pulsed light(PL)(18-30 W cm^(-2) for 33-167 s;total fluence 600-5000 J cm^(-2))and thermal treatments(90℃ for 1-5 min)were studied on various attributes of the mixed beverage.The beverages processed at 90℃ for 5 min(thermal treatment)and 5000 J cm^(-2)(PL treatment at 30 W cm^(-2) for 167 s)showed no microbial count with a complete enzyme inactivation.The thermally pasteurized sample(90℃/5 min)was more brown(browning index=70.15)than the PL pasteurized beverage(browning index=65.98).Interestingly,the PL pasteurized(5000 J cm^(-2))beverage showed 25%,27%,and 19% more vitamin C,antioxidants,and phenolic compounds,respectively,than the thermally pasteurized(90℃/5 min)beverage.The PL-treated beverage had a greater sensory appeal than the thermally treated beverage.PL-treatment can be an efficient non-thermal pasteurization treatment for ensuring complete microbial and enzymatic inactivation with maximal retention of nutritional and sensory attributes of the blended beverage. | Snehasis Chakraborty Sagar Mahale Rishab Dhar Somnath Basak | 2022 | Food Bioscience2022，45，1： | 2 |
| 15 | Evaluating diverse patterns of occupant behavior regarding control-based activities in energy performance simulation显示文摘 | Basak Gucyeter | 2018 | Frontiers of Architectural Research2018，7，2： | 2 |
| 16 | Effect of ionizing radiation on the pteridine metabolic pathway and evaluation of its cytotoxicity in exposed hospital staff显示文摘 | Ayse Basak Engin Mehmet Ali Ergun Erkan Yurtcu Derya Kan Gonul Sahin | 2005 | Mut.Res.-Genetic Toxicology and Environmental Mutagenesis2005，，1： | 2 |
| 17 | Evaluation of rapid molecular diagnostics for differentiating medicinal Kaempferia species from its adulterants显示文摘Accurate detection of unique herbs is crucial for herbal medicine preparation. Zingiberaceae species, which are important in Ayurvedic medicine of India, are often misidentified in Northeast (NE) Indian herbal markets. Kaempferia galanga (Zingiberaceae) is one of the major components of popular Ayurvedic drugs used for rheumatic diseases (i.e.,“Gandha Thailam” and “Rasnairandadi Kashayam”), contusions, fractures, and sprains. In NE India, herbal healers often misidentify plants from the Marantaceae family (e.g., Calathea bachemiana and Maranta leuconeura) as Kaempferia, which leads to adulteration of the medicinal herb. This misidentification of herbs occurs in NE India because Zingiberaceae plant barcoding information is inadequate. As a consequence, herbal medicine is not only therapeutically less effective but may also cause adverse reactions that range from mild to life-threatening. In this study, we used eight barcoding loci to develop “fingerprints” for four Kaempferia species and two species frequently mistaken for Kaempferia. The PCR and sequencing success of the loci matK, rbcL and trnH-psbA were found to be 100%;the combination of matK, rbcL, and trnH-psbA proved to be the ideal locus for discriminating the Kaempferia species from their adulterants because the combined loci showed greater variability than individual loci. This reliable tool was therefore developed in the current study for accurate identification of Kaempferia plants which can effectively resolve identification issues for herbal healers. | Supriyo Basak Ramesh Aadi Moolam Ajay Parida Sudip Mitra Latha Rangan | 2019 | Plant Diversity2019，41，3： | 2 |
| 18 | p21 and p27 immunoexpression in gastric well differentiated endocrine tumors(ECL-cell carcinoids)显示文摘AIM: To investigate the expression of cyclin-dependent kinase inhibitors p21 and p27 in gastric well differenti- ated endocrine tumors (GWDET) (ECL-cell carcinoids). METHODS: The expressions of p21 and p27 were ex- amined immunhistochemically in endoscopic biopsy specimens from 16 patients matching the diagnostic criteria of GWDET. Percentage of positive nuclear stain- ing either weak or strong was noted. The association of immunoexpressions with age, gender, tumor localization, multifocality and accompanying chronic atrophic gastritis, neuroendocrine cell hyperplasia (NEH), neuroendocrine dysplasia (NED), intestinal metaplasia (IM), Ki-67 prolif- eration index and clinical outcome were also evaluated. RESULTS: All cases expressed p27 with a mean expres- sion score of 43.6%, while 31.3% of the cases showed any p21 expression. p21 and p27 immunoexpressions were significantly correlated with each other (P < 0.01), and the p21-expressing group had higher p27 expres- sion scores (68% vs 22%). p21 and p27 expressions were lower in women, in non-atrophic mucosa and cases whose tumors were located somewhere other than fun- dus without submucosal extension. On contrary, p21 and p27 expressions were higher in males and the patients with submucosal extension and atrophic gastritis. Cases presenting lower p27 scores had solitary tumors showing neither NEH-NED nor IM. Despite, cases with lower p21 expression presented multifocal tumors accompanied by NEH-NED. However, no correlation of p21 and p27 expres- sions was found with age and Ki-67 expression. CONCLUSION: p27 is widely expressed in GWDETs, while p21 expression is sparse and observed in two thirds of the cases. Loss of p21 and p27 expressions may be cor- related with different carcinoid tumor subtypes; however,m ore studies are needed to assess the role of these pro- spective markers in gastrointestinal endocrine tumors. | Basak Doganavsargil Banu Sarsik Fatma Secil Kirdok Ahmet Musoglu Muge Tuncyurek | 2006 | World Journal of Gastroenterology2006，12，39： | 2 |
| 19 | Ethnomedical uses of Zingiberaceous plants of Northeast India显示文摘 | Tushar Supriyo Basak Gajen C. Sarma Latha Rangan | 2010 | Journal of Ethnopharmacology2010，，1： | 2 |
| 20 | Multi-center evaluation of oxidation-reduction potential by the MiOXSYS in males with abnormal semen显示文摘According to the World Health Organization(WHO),oxidative stress(OS)is a significant contributor to male infertility.SeminalOS can be measured by a number of assays,all of which are either costly or time sensitive and/or require large semen volume andcomplex instrumentation.One less expensive alternative is to quantify the oxidation-reduction potential(ORP)with the MiOXSYS.In this international multi-center study,we assessed whether ORP levels measured by the MiOXSYS could distinguish semensamples that fall within the 2010 WHO normal reference values from those that do not.Semen samples were collected from 2092patients in 9 countries;ORP was normalized to sperm concentration(mV/10^6 sperm/ml).Only those samples with a concentration>1×10^6 sperm ml1 were in eluded.The results showed that 199 samples fell within the WHO no rmal refere nee range while theremaining 1893 samples did not meet one or more of the criteria.ORP was negatively correlated with all semen parameters(P <0.01)except volume.The area under the curve for ORP was 0.765.The ORP cut-off value(1.34 mV/10^6 sperm/ml)was able todifferentiate specimens with abnormal semen parameters with 98.1%sensitivity,40.6%specificity,94.7%positive predictivevalue(PPV)and 66.6%negative predictive value(NPV).When used as an adjunct to traditional semen analysis,ORP levels mayhelp identify altered functional status of spermatozoa caused by OS in cases of idiopathic male infertility and in male partners ofcouples sufferi ng recurre nt pregna ncy loss,and thereby directi ng these men to relevant medical therapies and lifestyle modificati ons. | Ashok Agarwal Manesh Kumar Panner Selvam Mohamed Arafa Hiroshi Okada Sheryl Homa Aideen Killeen Basak Balaban Ramadan Saleh Abdullah Armagan Shubhadeep Roychoudhury Suresh Sikka | 2019 | Asian Journal of Andrology2019，21，6： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员