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| 1 | Subcurative radiation significantly increases cell proliferation, invasion, and migration of primary glioblastoma multiforme in vivo显示文摘Tumor cell proliferation, infiltration, migration, and neovascularization are known causes of treatment resistance in glioblastoma multiforme(GBM). The purpose of this study was to determine the effect of radiation on the growth characteristics of primary human GBM developed in a nude rat. Primary GBM cells grown from explanted GBM tissues were implanted orthotopically in nude rats. Tumor growth was confirmed by magnetic resonance imaging on day 77(baseline) after implantation. The rats underwent irradiation to a dose of 50 Gy delivered subcuratively on day 84 postimplantation(n = 8), or underwent no radiation(n = 8). Brain tissues were obtained on day 112(nonirradiated) or day 133(irradiated). Immunohistochemistry was performed to determine tumor cell proliferation(Ki-67) and to assess the expression of infiltration marker(matrix metalloproteinase-2, MMP-2) and cell migration marker(CD44). Tumor neovascularization was assessed by microvessel density using von-Willebrand factor(vWF) staining. Magnetic resonance imaging showed well-developed, infiltrative tumors in 11 weeks postimplantation. The proportion of Ki-67-positive cells in tumors undergoing radiation was(71 ± 15)% compared with(25 ± 12)% in the nonirradiated group(P = 0.02). The number of MMP-2-positive areas and proportion of CD44-positive cells were also high in tumors receiving radiation, indicating great invasion and infiltration. Microvessel density analysis did not show a significant difference between nonirradiated and irradiated tumors. Taken together, we found that subcurative radiation significantly increased proliferation, invasion, and migration of primary GBM. Our study provides insights into possible mechanisms of treatment resistance following radiation therapy for GBM. | Adarsh Shankar Sanath Kumar Asm Iskander Nadimpalli RS Varma Branislava Janic Ana deCarvalho Tom Mikkelsen Joseph A Frank Meser M Ali Robert A Knight Stephen Brown Ali S Arbab | 2014 | Chinese Journal of Cancer2014，33，3： | 5 |
| 2 | Development of a no- vel animal model to differentiate radiation necrosis from tumor recurrence 显示文摘 | Sanath Kumar All S Arbab | 2012 | J Neurooncol2012，108，3： | 1 |
| 3 | Successful management of phaeochromocytoma using preoperative oral labetalol and intraoperative magnesium sulphate:report of four cases显示文摘 | Sanath Kumar SB Date R Woodhouse N | 2014 | Sultan Qaboos Univ Med J2014，14，： | 1 |
| 4 | EmmdR,a new member of the MATE family of multidrug transporters,extrudes quinolones from Enterobacter cloacae显示文摘 | Robert Crow Huizhong Chen Sanath Kumar Manuel F.Varela | | 0，，03： | 1 |
| 5 | Correlation of dose computed using different algorithms with local control following stereotactic ablative radiotherapy (SABR)-based treatment of non-small-cell lung cancer显示文摘 | Indrin J. Chetty Suneetha Devpura Dezhi Liu Daiquan Chen Haisen Li Ning (Winston) Wen Sanath Kumar Correen Fraser M. Salim Siddiqui Munther Ajlouni Benjamin Movsas | 2013 | Radiotherapy and Oncology2013，，3： | 1 |
| 6 | The occurrence of Vibrio species in tropical shrimp culture environments; implications for food safety显示文摘 | Shubha Gopal Subhendu K. Otta Sanath Kumar Indrani Karunasagar Matsuaki Nishibuchi Iddya Karunasagar | 2005 | International Journal of Food Microbiology2005，，： | 1 |
| 7 | Identification of a novel UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) from Vibrio fischeri that confers high fosfomycin resistance in Escherichia coli显示文摘 | Sanath Kumar Ammini Parvathi Ricardo L. Hernandez Kathleen M. Cadle Manuel F. Varela | 2009 | Archives of Microbiology2009，，5： | 1 |
| 8 | 1-显示文摘 | Kumar V Karunaratne V Sanath M R | 1989 | Phytochemistry1989，28，： | 1 |
| 9 | Clonorchis sinensis : development and evaluation of a nested polymer- ase chain reaction(PCR) assay显示文摘 | Parvathi A Sanath Kumar H Kenehanna Prakasha B | 2007 | Exp Parasitol2007，115，3： | 1 |
| 10 | Prevalence and Characterization of Diarrheagenic Escherichia coli Isolated from Adults and Children in Mangalore, India显示文摘 | Veena A Shetty Sanath H Kumar Avinash K Shetty | 2012 | J Lab Physicians2012，，： | 1 |
| 11 | A gyrB-based PCR for the detection of Vibrio vulnificus and its application for direct detection of this pathogen in oyster enrichment broths 显示文摘 | Sanath Kumar H Parvathi A Indrani Kanmasagar I | 2006 | Int J Food Microbiol2006，，3： | 1 |
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