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| 1 | Endoscopic submucosal dissection for the treatment of neoplastic lesions in the gastrointestinal tract显示文摘AIM: To investigate the indications, resection rate, and safety of endoscopic submucosal dissection (ESD) for neoplastic lesions in the gastrointestinal tract at a European referral center. METHODS: We carried out a retrospective analysis of the ESD procedures performed in our center for mucosal neoplastic and submucosal lesions of the gastrointestinal tract. The duration of the procedure, en bloc and complete (R0) resection rates, and complication rates were evaluated. Variables were reported as mean ± SD or simple proportions. Univariate analysis and comparisons of procedure times and resection rates were performed using Mann-Whitney U tests, or χ2 tests for dichotomous variables.RESULTS: Between 2007 and 2011, ESD was performed in a total of 103 patients (46.7% male, mean age 64.0 ± 12.7 years). The indications for the procedure were epithelial tumor (n = 54), submucosal tumor (n = 42), or other (n = 7). The total en bloc resection rate was 90.3% (93/103) and R0 resection rate 80.6% (83/103). The median speed of the procedure was 15.0 min/cm2 . The complete resection rate was lower for submucosal tumors arising from the muscle layer (68%, 15/22, P < 0.05). Resection speed was quicker for submucosal tumors localized in the submucosal layer than for lesions arising from the muscularis propria layer (8.1 min/cm 2 vs 17.9 min/cm 2 , P < 0.05). The R0 resection rate and speed were better in the last 24 mo (90.1%, 49/54 and 15.3 min/cm 2 ) compared to the first 3 years of treatment (73.5%, 36/49, P < 0.05 and 22.0 min/cm2 , P < 0.05). Complications occurred in 14.6% (n = 15) of patients, including perforation in 5.8% (n = 6), pneumoperitoneum in 3.9% (n = 4), delayed bleeding in 1.9% (n = 2), and other in 2.9% (n = 3). Only one patient with delayed perforation required surgical treatment. During the mean follow-up of 26 ± 15.3 mo, among patients with R0 resection, recurrence occurred in one patient (1.2%).CONCLUSION: ESD is an effective and safe method for resection of neoplastic lesions with low recurrence. Speed and the R0 resection rate increased after 50 procedures. | Andrzej Biaek Anna Wiechowska-Kozowska Jan Pertkiewicz Katarzyna Karpińska Wojciech Marlicz Piotr Milkiewicz Teresa Starzyńska | 2013 | World Journal of Gastroenterology2013，19，12： | 21 |
| 2 | ESPEN Guidelines on Enteral Nutrition: Pancreas显示文摘 | R. Meier J. Ockenga M. Pertkiewicz A. Pap N. Milinic J. MacFie C. L?ser V. Keim | 2006 | Clinical Nutrition2006，，2： | 3 |
| 3 | ESPEN Guidelines on Enteral Nutrition:Pancreas显示文摘 | Meier R Ockenga J Pertkiewicz M | 2006 | Clin Nutr2006，25，2： | 1 |
| 4 | ESPEN Guidelineson Enteral Nutrition : Pancreas 显示文摘 | Meier R Ockenga J Pertkiewicz M | 2006 | Clinical Nutrition2006，25，2： | 1 |
| 5 | ESPEN guide-lines on enteral nutrition:pancreas显示文摘 | MEIER R OEKENGA J PERTKIEWICZ M | 2006 | Clin Nutr2006，25，2： | 1 |
| 6 | ESPEN Guidelines on Enteral Nutrition : Pancreas 显示文摘 | Meier R Ockenga J Pertkiewicz M | 2006 | Clin Nutr2006，25，2： | 1 |
| 7 | ESPEN Guidelines on Enteral Nutrition: Pancreas显示文摘 | R. Meier J. Ockenga M. Pertkiewicz A. Pap N. Milinic J. MacFie C. L?ser V. Keim | 2006 | Clinical Nutrition2006，，2： | 1 |
| 8 | Endoscop- ic submucosal dissection for treatment of gastric subepithelial tumors (with video) 显示文摘 | Bialek A Wiechowska-Koztowska A Pertkiewicz J | 2012 | Gastrointest Endosc2012，75，2： | 1 |
| 9 | Teduglutide Reduces Need for Parenteral Support Among Patients With Short Bowel Syndrome With Intestinal Failure显示文摘 | Palle B. Jeppesen Marek Pertkiewicz Bernard Messing Kishore Iyer Douglas L. Seidner Stephen J.D. O’keefe Alastair Forbes Hartmut Heinze Bo Joelsson | 2012 | Gastroenterology2012，，6： | 1 |
| 10 | ESPEN guidelines on enteral nutrition:pancreas显示文摘 | Meier R Ockenga J Pertkiewicz M | 2006 | Clin Nutr2006，25，2： | 1 |
| 11 | Treatment of large colorectal neoplasms by endoscopic submucosal dissection: a European single-center study显示文摘 | Andrzej Bia?ek Jan Pertkiewicz Katarzyna Karpińska Wojciech Marlicz Dariusz Bielicki Teresa Starzyńska | 2014 | European Journal of Gastroenterology & Hepatology2014，，6： | 1 |
| 12 | ESPEN Guidelines on Enteral Nutrition: Pancreas显示文摘 | R. Meier J. Ockenga M. Pertkiewicz A. Pap N. Milinic J. MacFie C. L?ser V. Keim | 2006 | Clinical Nutrition2006，，2： | 1 |
| 13 | ESPEN Guidelines on Parenteral Nutrition: Home Parenteral Nutrition (HPN) in adult patients显示文摘 | Michael Staun Loris Pironi Federico Bozzetti Janet Baxter Alastair Forbes Francesca Joly Palle Jeppesen Jose Moreno Xavier Hébuterne Marek Pertkiewicz Stefan Mühlebach Alan Shenkin André Van Gossum | 2009 | Clinical Nutrition2009，，4： | 1 |
| 14 | ESPEN guidelines on enteral nutrition: pancraes显示文摘 | Meier R Ockenga J Pertkiewicz M | 2003 | Clin Nutr2003，9，： | 1 |
| 15 | Endoscopic submucosal dissection for treatment of gastric subepithelial tumors(with video)显示文摘 | Bialek A Wiechowska-Koziowska A Pertkiewicz J | 2012 | Gastrointest Endosc2012，75，2： | 1 |
| 16 | ESPEN guidelines on enteral nutrition : pancreas 显示文摘 | Meier R Ockenga J Pertkiewicz M | 2006 | Clin Nutr2006，25，2： | 1 |
| 17 | ESPEN guidelines on enteral nutrition : pancreas 显示文摘 | Meier R Ockenga J Pertkiewicz M eta| | 2006 | Clin Nutr2006，25，2： | 1 |
| 18 | ESPEN Guidelines on Enteral Nutrition: Pancreas 显示文摘 | Meier R Ockenga J Pertkiewicz M | 2006 | Clinical Nutrition2006，25，2： | 1 |
| 19 | ESPEN Guideline8 on Enteral Nu IT ition : Pancreas 显示文摘 | Meier R Ockenga J Pertkiewicz M | 2006 | Clinical Nutrition2006，25，2： | 1 |
| 20 | Treatment oflarge colorectal neoplasms by endoscopic submucosal dissec-tion :a European single-center study 显示文摘 | Bialek A Pertkiewicz J Karpinska K | 2014 | Eur J GastroenterolHepatol2014，26，6： | 1 |
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