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| 1 | 从西方人力资源管理看我国医院人事管理的发展显示文摘对西方人力资源管理进行了简要介绍,并对传统的中国医院人事管理与现代西方的人力资源管理进行了比较,指出从人事管理向人力资源管理的转变,是目前中国医院人事管理发展的必然趋势。同时在制度保证的基础上,针对中国医院人力资源管理的发展,着重提出了当前需要解决的问题。 | 赵卫东 刘毅 裴丽昆 Pauline Stanton 李力 | 2004 | 中国医院管理2004，24，7： | 44 |
| 2 | 疾病诊断相关组DRGs研究的现状、问题及对策显示文摘 | 万崇华 蔡乐 许传志 裴丽昆 David Legge Pauline Stanton | 2001 | 中国医院统计2001，8，2： | 39 |
| 3 | 医院管理干部培训需求与建议显示文摘 | 裴丽昆 David Legge Pauline Stanton | 2001 | 中华医院管理杂志2001，17，3： | 31 |
| 4 | Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E_2 and cytokines显示文摘AIM:To investigate the effect of short-chain fatty ac-ids (SCFAs) on production of prostaglandin E2 (PGE2),cytokines and chemokines in human monocytes.METHODS:Human neutrophils and monocytes were isolated from human whole blood by using 1-Step Polymorph and RosetteSep Human Monocyte Enrich-ment Cocktail,respectively. Human GPR41 and GPR43 mRNA expression was examined by quantitative real-time polymerase chain reaction. The calcium flux assay was used to examine the biological activities of SCFAs in human neutrophils and monocytes. The effect ofSCFAs on human monocytes and peripheral blood mononuclear cells (PBMC) was studied by measuring PGE2,cytokines and chemokines in the supernatant. The effect of SCFAs in vivo was examined by intraplantar injection into rat paws.RESULTS:Human GPR43 is highly expressed in human neutrophils and monocytes. SCFAs induce robust calcium flux in human neutrophils,but not in human monocytes. In this study,we show that SCFAs can in-duce human monocyte release of PGE2 and that this effect can be enhanced in the presence of lipopolysac-charide (LPS). In addition,we demonstrate that PGE2 production induced by SCFA was inhibited by pertussis toxin,suggesting the involvement of a receptor-mediated mechanism. Furthermore,SCFAs can specifi cally inhibit constitutive monocyte chemotactic protein-1 (MCP-1) production and LPS-induced interleukin-10 (IL-10) production in human monocytes without affecting the secretion of other cytokines and chemokines examined. Similar activities were observed in human PBMC for the release of PGE2,MCP-1 and IL-10 after SCFA treatment. In addition,SCFAs inhibit LPS-induced production of tumor necrosis factor-α and interferon-γ in human PBMC. Finally,we show that SCFAs and LPS can induce PGE2 production in vivo by intraplantar injection into rat paws (P < 0.01). CONCLUSION:SCFAs can have distinct antiinflammatory activities due to their regulation of PGE2,cytokine and chemokine release from human immune cells. | Mary Ann Cox James Jackson Michaela Stanton Alberto Rojas-Triana Loretta Bober Maureen Laverty Xiaoxin Yang Feng Zhu Jianjun Liu Suke Wang Frederick Monsma Galya Vassileva Maureen Maguire Eric Gustafson Marvin Bayne Chuan-Chu Chou Daniel Lundell Chung-Her Jenh | 2009 | World Journal of Gastroenterology2009，15，44： | 30 |
| 5 | 青少年性相关知识来源的偏好:中国性教育的启示显示文摘目的:探讨分析15~24岁年龄段青少年性教育来源的偏好。方法:本研究所使用的数据来自于一项由世界卫生组织(WHO)资助的项目(WHO第98200号项目)。此项目是在中国东北某城市实施的基于社区为基础的横断面调查。住户样本的抽取采用按规模大小成比例的概率抽样原则,进行3阶段系统抽样设计。共有1319名15~24岁的青少年接受调查,并在参与调查前签署了知情同意书,参与者被告知自愿参加并有权退出调查和跳过其不愿回答的问题。最终有1227条记录进入分析阶段。运用描述性统计和多元Logistic回归分析方法对青少年获取性相关知识的来源偏好和实际获得知识的来源之间的差异进行分析。结果:青少年在过去实际使用的知识来源和其对来源的偏好方面存在差异。'父母','医生','书籍和报纸'和'电视'未能发挥青少年所预期的作用。青少年倾向于将'医生'作为获得'青春期'、'性知识'及'性传播疾病/艾滋病'等知识的主要渠道,而实际使用与来源偏好方面大概有10.2%~11.0%的差距。实际来自于父母对孩子的性教育则比偏好约低0.1%~2.7%。'书籍和报纸'和'电视'作为获得性相关知识的实际来源比偏好低3.3%~7.5%。多因素Logistic回归分析结果显示,年龄、性别、教育水平、工作经历和有无兄弟姐妹等因素影响青少年对获取性知识来源的偏好。20~24岁的男性更倾向于将'电视'作为其获取青春期知识的首选来源(回归系数=0.408,P<0.05),而女性则不倾向于将'电视'作为其首选来源去获取青春期知识、性知识和性传播疾病/艾滋病知识(回归系数分别为-1.305,-0.989和-0.653,P<0.05或P<0.01)。受过大学或研究生教育的被调查者不倾向将'老师'作为首选来源去获取青春期知识及性知识(回归系数分别为-0.544和-0.638,P<0.05)。相对于没有工作经历的被调查者,有工作经历的被调查者更倾向于将'同伴'作为获取有关'性传播疾病/艾滋病'知识的首选来源(回归系数=0.939,P<0.01)。女性更倾向于将'父母'作为首选知识来源获得青春期知识、性知识及性传播疾病/艾滋病知识(回归系数分别为1.649,1.449和1.110,P<0.01或P<0.05)。结论:现况调查表明中国青少年在实际获取性相关知识(即青春期知识,性知识,以及性传播疾病/艾滋病知识)的主要渠道与自己对获取性相关知识的来源偏好方面存在差异。书籍和报纸是青少年获取性相关知识中更喜欢选择的最主要来源,青少年也更喜欢从医生和父母那里得到性教育。目前研究的结果表明青少年不倾向于选择'老师'作为获取性相关知识来源,这为现在和将来的性教育干预方案提供了一些启示。父母和医生在未成年人和青少年性教育中的角色有待加强。学校课堂中,教师传授的性相关知识的内容及教学方法可能有待改善,而且需要学生们来进行评价。对于性教育中社会方面的积极作用,如媒体的作用不容忽视。综合的全方位的性教育需要进一步发展和强化,以满足青少年性知识和生殖健康方面的需要。 | 张立英 Iqbal H.Shah 李晓铭 尹文强 傅继华 夏志森 Bonita Stanton | 2010 | 国际生殖健康/计划生育杂志2010，29，6： | 22 |
| 6 | 中国—澳大利亚合作开展卫生管理教育的尝试显示文摘中国的卫生事业管理教育已经有 10多年的发展史 ,培养了大量的卫生管理人才 ,为推动中国卫生改革起到了积极作用。作者报道了一项中国 澳大利亚合作开展卫生事业管理培训的情况 ,总结了项目的发展、运作和特征。认为该课程的设计是有创意的 ,较好地将西方卫生管理学理论和经验与中国的实际情况 ,特别是与当前中国所进行的卫生改革的实践相结合 ,不仅注重提高卫生管理干部相关的理论水平 ,更重要的是结合他们面临的挑战 ,培养解决实际管理问题的技能和积极投身于改革浪潮中的策略方法 ,以及培养不断学习、进取的精神。探讨和摸索了一种新的中国卫生管理教育的办学模式。 | 裴丽昆 David Legge Pauline Stanton | 2002 | 中华医院管理杂志2002，18，4： | 10 |
| 7 | Claudin-11 and occludin are major contributors to Sertoli cell tight junction function, in vitro显示文摘Sertoli 房间紧密的连接(TJ ) 是血睾丸障碍的关键部件,在它扣押开发在生精的小管以内经历精子发生的细菌房间的地方。神经质地调整的 claudin-11 是在不孕涉及障碍功能和它的鼠科的猛烈结果的批评 transmembrane 蛋白质。我们试图估计份量上到 TJ 功能的 claudin-11 的贡献的意义在 vitro,使用调停 siRNA 的基因 silencing。我们也进行了 occludin 的贡献的分析, TJ 的另一内在的 transmembrane 蛋白质。claudin-11 或 occludin 的 Silencing 在一个不成熟的老鼠 Sertoli 房间文化模型用 siRNA 被进行。Transepithelial 电的抵抗被用来在整个文化估计份量上 TJ 功能。在 siRNA 处理以后的二天,房间为对 mRNA 的 RT-PCR 评价为连接蛋白质或 lyzed 的 immunocytochemical 本地化被修理表示。claudin-11, occludin,或两个的 Silencing 在 55% 的 TJ 功能导致了重要减少(P <0.01 ) , 51%(P <0.01 ) ,并且 62%(P <0.01 ) 分别地。数据在到 Sertoli 房间 TJ 的指向的蛋白质的本地化是有在 mRNA 表示和显著减小的重要减少的伴随物。我们提供 claudin-11 显著地贡献的量的证据(P <0.01 ) 到 Sertoli 房间 TJ 在 vitro 工作。有趣地, occludin,神经质地在不孕被调整然而并非含有直到迟了的成人生活,也是一重要(P <0.01 ) 贡献者到障碍功能。我们的数据与一致在清楚地为这些表明一个角色的 vivo 研究,在维持正常 TJ 障碍的蛋白质组织并且工作。 | Mark J McCabe Caroline FH Foo Marcel E Dinger Peter M Smooker Peter G Stanton | 2016 | Asian Journal of Andrology2016，18，4： | 7 |
| 8 | Expression of the Arabidopsis thaliana Histone Gene AtHTA1 Enhances Rice Transformation Efficiency显示文摘我们在玉米 ubiquitin 倡导者的控制下面在米饭表示了 Arabidopsis thaliana histone AtHTA1。组成地表示了 AtHTA1 的米饭植物的转变效率比包含空向量控制的 calli 高是 2844% 。而且,有包含 AtHTA1 的向量和有目标基因的另一向量的米饭 calli 的合作感染增加了转变 2750% 。因此, AtHTA1 的表示短暂地或在稳定地转变的房间改进了米饭转变效率。 | Ye Zheng Xiao-Wei He Ying-Hui Ying Jiang-Feng Lu Stanton B. Gelvin Hui-Xia Shou | 2009 | Molecular Plant2009，2，4： | 5 |
| 9 | 女性尿失禁的处理显示文摘本文要点尿失禁大约影响了20%的40岁以上妇女尿失禁可影响生命质量和增加国家医疗服务的经济负担必须强调初级医疗保健机构的作用,因为大多数病人可在此水平得到处理,但也应保证适当的病人转到医院诊治尿失禁的主要病因有尿道括约肌功能下降和膀胱过度活动只有保守治疗失败、准备进行外科手术或排尿困难和神经原性疾病时。 | Ranee Thakar Stuart Stanton 杨勇 | 2004 | 英国医学杂志中文版2004，7，4： | 3 |
| 10 | Zinc in plants:Integrating homeostasis and biofortification显示文摘Zinc plays many essential roles in life.As a strong Lewis acid that lacks redox activity under environ-mental and cellular conditions,the Zn2+cation is central in determining protein structure and catalytic function of nearly 10%of most eukaryotic proteomes.While specific functions of zinc have been elucidated at a molecular level in a number of plant proteins,wider issues abound with respect to the acquisition and distribution of zinc by plants.An important challenge is to understand how plants balance between Zn supply in soil and their own nutritional requirement for zinc,particularly where edaphic factors lead to a lack of bioavailable zinc or,conversely,an excess of zinc that bears a major risk of phyto-toxicity.Plants are the ultimate source of zinc in the human diet,and human Zn deficiency accounts for over 400000 deaths annually.Here,we review the current understanding of zinc homeostasis in plants from the molecular and physiological perspectives.We provide an overview of approaches pursued so far in Zn biofortification of crops.Finally,we outline a'push-pull'model of zinc nutrition in plants as a simplifying concept.In summary,this review discusses avenues that can potentially deliver wider bene-fits for both plant and human Zn nutrition. | Camilla Stanton Dale Sanders Ute Krämer Dorina Podar | 2022 | Molecular Plant2022，15，1： | 3 |
| 11 | Changes in the colon microbiota and intestinal cytokine gene expression following minimal intestinal surgery显示文摘AIM: To investigate the impact of minor abdominal surgery on the caecal microbial population and on markers of gut inflammation.METHODS: Four week old piglets were randomly allocated to a no-surgery 'control' group(n = 6) or a 'transection surgery' group(n = 5).During the transection surgery procedure, a conventional midline incision of the lower abdominal wall was made and the small intestine was transected at a site 225 cm proximal to the ileocaecal valve, a 2 cm segment was removed and the intestine was re-anastomosed.Piglets received a polymeric infant formula diet throughout the study period and were sacrificed at two weeks post-surgery.Clinical outcomes including weight, stool consistency and presence of stool fat globules were monitored.High throughput DNA sequencing of colonic content was used to detect surgery-relateddisturbances in microbial composition at phylum, family and genus level.Diversity and richness estimates were calculated for the control and minor surgery groups.As disturbances in the gut microbial community are linked to inflammation we compared the gene expression of key inflammatory cytokines(TNF, IL1 B, IL18, IL12, IL8, IL6 and IL10) in ileum, terminal ileum and colon mucosal extracts obtained from control and abdominal surgery groups at two weeks post-surgery.RESULTS: Changes in the relative abundance of bacterial species at family and genus level were confined to bacterial members of the Proteobacteria and Bacteroidetes phyla.Family level compositional shifts included a reduction in the relative abundance of Enterobacteriaceae(22.95 ± 5.27 vs 2.07 ± 0.72, P < 0.01), Bacteroidaceae(2.54 ± 0.56 vs 0.86 ± 0.43, P < 0.05) and Rhodospirillaceae(0.40 ± 0.14 vs 0.00 ± 0.00, P < 0.05) following transection surgery.Similarly, at the genus level, changes associated with transection surgery were restricted to members of the Proteobacteria and Bacteroidetes phyla and included decreased relative abundance of Enterobacteriaceae(29.20 ± 6.74 vs 2.88 ± 1.08, P < 0.01), Alistipes(4.82 ± 1.73 vs 0.18 ± 0.13, P < 0.05) and Thalassospira(0.53 ± 0.19 vs 0.00 ± 0.00, P < 0.05).Surgeryassociated microbial dysbiosis was accompanied by increased gene expression of markers of inflammation.Within the ileum IL6 expression was decreased(4.46 ± 1.60 vs 0.24 ± 0.06, P < 0.05) following transection surgery.In the terminal ileum, gene expression of TNF was decreased(1.51 ± 0.13 vs 0.80 ± 0.16, P < 0.01) and IL18(1.21 ± 0.18 vs 2.13 ± 0.24, P < 0.01), IL12(1.04 ± 0.16 vs 1.82 ± 0.32, P < 0.05) and IL10(1.04 ± 0.06 vs 1.43 ± 0.09, P < 0.01) gene expression increased following transection surgery.Within the colon, IL12(0.72 ± 0.13 vs 1.78 ± 0.28, P < 0.01) and IL10(0.98 ± 0.02 vs 1.95 ± 0.14, P < 0.01) gene expression were increased following transection surgery.CONCLUSION: This study suggests that minor abdominal surgery in infants, results in long-term alteration of the colonic microbial composition and persistent gastrointestinal inflammation. | Susan Lapthorne Julie E Bines Fiona Fouhy Nicole L Dellios Guineva Wilson Sarah L Thomas Michelle Scurr Catherine Stanton Paul D Cotter Prue M Pereira-Fantini | 2015 | World Journal of Gastroenterology2015，21，14： | 3 |
| 12 | Ambulatory Arterial Stiffness Index as a Predictor of Cardiovascular Mortality in the Dublin Outcome Study显示文摘 | Eamon Dolan Lutgarde Thijs Yan Li Neil Atkins Patricia McCormack Sean McClory Eoin O’Brien Jan A. Staessen Alice V. Stanton | 2006 | Hypertension2006，，3： | 3 |
| 13 | A retrospective cohort study of body mass index and survival in HIV infected patients with and without TB co-infection显示文摘Background:High early morbidity and mortality following antiretroviral therapy(ART)initiation has been a distinguishing feature of ART programmes in resource limited settings(RLS)compared to high-income countries.This study assessed how well body mass index(BMI:kg/m^(2))correlated with survival among HIV infected patients with and without TB co-infection.Methods:We retrospectively evaluated clinical data from 1000 HIV infected patients,among whom 389 were also co-infected with TB,between January 2008 and December 2010,in KwaZulu-Natal,South Africa.Results:Among 948 patients eligible for analysis,15.7%(149/948)were underweight(<18.50),55.9%(530/948)had normal BMI(≥18.50-24.90),18.7%(177/948)were overweight(25.00-29.00)and 9.7%(92/948)were obese(≥30.00).Irrespective of TB status,underweight patients,had significantly higher risk of death compared to those with normal BMI at baseline(aHR=2.9;95%CI:1.5-5.7;P=0.002).Conclusions:Irrespective of TB co-infection,low BMI correlated with mortality in HIV infected patients.Trial registration:UKZN Biomedical Research Ethics Committee Reference number E 248/05,23 September 2005. | Kogieleum Naidoo Nonhlanhla Yende-Zuma Stanton Augustine | 2018 | Infectious Diseases of Poverty2018，7，1： | 3 |
| 14 | The Gut Microbiota and the Liver Pathophysiological and Clinical Implications显示文摘 | Eamonn M .M. Quigley Catherine Stanton Eileen F. Murphy | 2012 | Journal of Hepatology2012，，： | 2 |
| 15 | Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis: the New EPOC randomised controlled trial显示文摘 | John Primrose Stephen Falk Meg Finch-Jones Juan Valle Derek O’Reilly Ajith Siriwardena Joanne Hornbuckle Mark Peterson Myrddin Rees Tim Iveson Tamas Hickish Rachel Butler Louise Stanton Elizabeth Dixon Louisa Little Megan Bowers Sian Pugh O James Garden D | 2014 | Lancet Oncology2014，，6： | 2 |
| 16 | 主题式教学方法在卫生管理教学中的应用显示文摘简要介绍了主题式教学方法及其在卫生管理教学中的应用 ,并总结了存在的问题与经验 . | 蔡乐 万崇华 许传志 张晓磬 David Legge Pauline Stanton | 2004 | 昆明医学院学报2004，25，4： | 2 |
| 17 | 流程型企业如何有效运作显示文摘尽管在某些时候,人们会用“再造”这个词来委婉地指代盲目精简,但在商业世界中,再造实际上还是发挥了极大的作用。再造使公司能够更快、更高效地运营,并且能更有效地运用信息技术。再造提高了员工的工作成效,使员工获得更多授权,让他们更清楚地看到自己的工作如何融入整个企业的运营。再造使公司的客户得到更优质的产品和更贴心的服务,并使公司的股东获得了丰厚的分红。再造降低了公司的成本, | 迈克尔·哈默(Michael Hammer) 史蒂文·斯坦顿(Steven Stanton) 章程(翻译) | 2008 | 商业评论2008，，5： | 2 |
| 18 | Real-Time Three-Dimensional Transesophageal Echocardiography in Valve Disease: Comparison With Surgical Findings and Evaluation of Prosthetic Valves显示文摘 | Lissa Sugeng Stanton K. Shernan Lynn Weinert Doug Shook Jai Raman Valluvan Jeevanandam Frank DuPont John Fox Victor Mor-Avi Roberto M. Lang | 2008 | Journal of the American Society of Echocardiography2008，，12： | 2 |
| 19 | Activation of the hexosamine pathway causes oxidative stress and abnormal embryo gene expressicn:involvement in diabetic teratogenesis显示文摘 | Horal M Zhang Z Stanton R | 2004 | Birth Defects Res A Clin Mol Teratol2004，70，8： | 1 |
| 20 | Rational prepayment and the valuation of mortgage-backed securities显示文摘 | Stanton R | 1995 | The Review of Finance Studies1995，8，3： | 1 |
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