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| 1 | Hypoxia-inducible factor 2α is a negative regulator of osteoblastogenesis and bone mass accrual显示文摘Osteoblasts,which are the bone-forming cells,operate in a hypoxic environment.The transcription factors hypoxia-inducible factor-1α(HIF1)and HIF2 are key mediators of the cellular response to hypoxia.Both are expressed in osteoblasts.HIF1 is known to be a positive regulator of bone formation.Conversely,the role of HIF2 in the control osteoblast biology is still poorly understood.In this study,we used mouse genetics to demonstrate that HIF2 is an inhibitor of osteoblastogenesis and bone mass accrual.Moreover,we provided evidence that HIF2 impairs osteoblast differentiation at least in part,by upregulating the transcription factor Sox9.Our findings constitute a paradigm shift,as activation of the hypoxia-signaling pathway has traditionally been associated with increased bone formation through HIF1.Inhibiting HIF2 could thus represent a therapeutic approach for the treatment of the low bone mass observed in chronic diseases,osteoporosis,or aging. | Christophe Merceron Kavitha Ranganathan Elizabeth Wang Zachary Tata Shreya Makkapati Mohd Parvez Khan Laura Mangiavini Angela Qing Yao Laura Castellini Benjamin Levi Amato J.Giaccia Ernestina Schipani | 2019 | Bone Research2019，7，1： | 7 |
| 2 | Giardia lamblia infection in patients with irritable bowel syndrome and dyspepsia:A prospective study显示文摘瞄准:评估兰伯氏贾第虫的流行(G。兰氏鞭毛虫属) 在有急躁的肠症候群(IBS ) 和消化不良并且到的病人的感染证实哪个是最精确的测试在这个背景诊断感染。方法:连续地由于 IBS 或消化不良的症状在 2002 年 1 月和 2003 年 12 月之间第一次出席了门诊病人肠胃病学诊所的 137 个病人被招募。所有病人经历了临床的评估,第一步的 haematology 和化学测试,为乳糜泻的血清学试金, lactose-H (2 ) 呼吸测试,腹的 ultrasonography,和 esophagogastroduodenoscopy。Helicobacter pylori 地位被评估。在有比 45 年旧的 IBS 的症状的病人,结肠镜检查也被执行。在所有病人,十二指肠的活体检视和凳子样品为 G 的 trophozoites 和包囊被检验。由几个方法的兰氏鞭毛虫属。结果:G。兰氏鞭毛虫属在 9 个病人被识别。下列诊断也被做:IBS (100/137, 73%) ,机能性消化不良(62/137, 45%) ,器官的消化不良(33/137, 24%) ,并且乳糖不耐(75/137, 55%) 。一个重要协会在贾第虫病和 H pylori 感染之间被发现(c2=6.632, OR=12.4, CI=1.5-68.1 ) 。没有症状,可靠地允许贾第虫病的识别。当十二指肠的活体检视的组织学的检查显示了低敏感时,在十二指肠的活体检视和凳子样品考试的寄生虫的直接搜索在所有情况中给了一致结果(例如, 22.2%) 。结论:在这个连续系列, G 的诊断。兰氏鞭毛虫属感染与 IBS 和消化不良说明了 6.5% 病人。如果凳子样品检查被执行,为贾第虫病的诊断的十二指肠的活体检视可能是不必要的。 | Barbara Grazioli Giovanni Matera Costanza Laratta Giuseppina Schipani Giovanni Guarnieri Ester Spiniello Maria Imeneo Andrea Amorosi Alfredo Focà Francesco Luzza | 2006 | World Journal of Gastroenterology2006，12，12： | 4 |
| 3 | Hypoxia in cartilage: HIF-1αis essential for chondrocyte growth arrest and survival显示文摘 | Schipani E Ryan H E Didrickson S | 2001 | Genes Develop2001，15，21： | 2 |
| 4 | SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β‐catenin显示文摘 | Petra Simic Kayvan Zainabadi Eric Bell David B. Sykes Borja Saez Sutada Lotinun Roland Baron David Scadden Ernestina Schipani Leonard Guarente | 2013 | EMBO Mol Med2013，，3： | 2 |
| 5 | Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation,osteomalacia,and disturbed phosphate homeostasis显示文摘 | Marsell R Schipani E | 2004 | Endocrinology2004，145，： | 1 |
| 6 | Galileo high-resolution encoder system显示文摘 | MANCINI D CASCONE E SCHIPANI P | | SPIE0，3112，： | 1 |
| 7 | Why 3 mg/kg instead of 5 mg/kg of infliximab should work in psoriatic arthritis显示文摘 | Di Renzo L Saraceno R Schipani C | | 0，，12： | 1 |
| 8 | The Economic Im- pact of Backdating of Executive Stock Options 显示文摘 | Narayanan M Schipani C Seyhun H | 2007 | Michi- gan Law Review2007，105，： | 1 |
| 9 | Hypoxia-driven pathways in bone development,regeneration and disease显示文摘 | Maes C Carmeliet G Schipani E | | 0，，： | 1 |
| 10 | VST primary mirror active optics electronics显示文摘 | MOLFESE C SCHIPANI P CAPACCIOLI M | | 0，，： | 1 |
| 11 | Long-term experience with etanercept in psoriatic arthritis patients:A 3-year observational study显示文摘 | Mazzotta A Esposito M Schipani C | 2009 | J Dermatolog Treat2009，20，6： | 1 |
| 12 | Use of PET and PET/CT for Radiation Therapy Planning: IAEA expert report 2006–2007显示文摘 | Michael MacManus Ursula Nestle Kenneth E. Rosenzweig Ignasi Carrio Cristina Messa Otakar Belohlavek Massimo Danna Tomio Inoue Elizabeth Deniaud-Alexandre Stefano Schipani Naoyuki Watanabe Maurizio Dondi Branislav Jeremic | 2008 | Radiotherapy and Oncology2008，，1： | 1 |
| 13 | The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development显示文摘 | Wang Y Wan C Deng L Liu X Cao X Gilbert SR Bouxsein ML Faugere M-C Guldberg RE Gerstenfeld LC Haase VH Johnson RS Schipani E Clemens TL | | 0，，： | 1 |
| 14 | Hypoxia-driven pathways in bone development,regeneration and disease显示文摘 | Maes C Carmeliet G Schipani E | 2012 | Nat Rev Rheumatol2012，，8： | 1 |
| 15 | Regulation of bone marrow angiogenesis by osteoblasts during bone development and Homeostasis显示文摘 | Schipani E Wu C Rankin EB | 2013 | Front Endocrinol(Lausanne)2013，，4： | 1 |
| 16 | Role of hypoxia-inducible factor-lalpha in angiogenic-osteogenic coupling 显示文摘 | RIDDLE R C KHATRI R SCHIPANI E | 2009 | J Mol Med (Bed)2009，87，6： | 1 |
| 17 | Molecular mechanisms of endochondral bone development 显示文摘 | Provot S Schipani E | 2005 | Biochem Biophys Res Commun2005，328，3： | 1 |
| 18 | Lao tourism and poverty alleviation: Com- munity-based tourism and the private sector 显示文摘 | Harrison D Schipani S | 2007 | Current Issues in Tourism2007，10，23： | 1 |
| 19 | Different applications of monochromatic excimer light in skin diseases 显示文摘 | Nisticb SP Saraceno R Schipani C | 2009 | Photomed Laser Surg2009，27，4： | 1 |
| 20 | Bone marrow mesenchymal stem cells 显示文摘 | Ohishi M Schipani E | 2010 | J Cell Biochem2010，109，2： | 1 |
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