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| 1 | Intracellular tat of human immunodeficiency virus type 1 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus. Role of JAK/STAT signaling显示文摘 | Zeng, Y. Zhang, X. H. Huang, Z. Cheng, L. Yao, S. H. Qin, D. Chen, X. Y. Tang, Q. Lv, Z. G. Zhang, L. Lu, C. | 2007 | 南京医科大学学报(自然科学版)2007，27，5： | 31 |
| 2 | Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro显示文摘Gastrin and cyclooxygenase-2(COX-2) playimportant roles in the carcinogenesis and progression ofgastric cancer.However,it remains unknown whether the combination of cholecystokinin-2(CCK-2) receptor antagonist plus COX-2 inhibitor exerts synergistic anti-tumor effects on human gastric cancer.Here,we demonstrated that the combination of AG-041R(a CCK-2 receptor antagonist) plus NS-398(a selective COX-2 inhibitor) treatment had synergistic effects on proliferation inhibition,apoptosis induction,down-regulation of Bcl-2 and up-regulation of Bax expression in MKN-45 cells.These results indicate that simultaneous targeting of CCK-2 receptor and COX-2 may inhibit gastric cancer development more effectively than targeting either molecule alone.(C)2008 Elsevier Ireland Ltd.All rights reserved. | Sun, W. H. | 2008 | 南京医科大学学报(自然科学版)2008，28，9： | 30 |
| 3 | The first all-season sample set for mapping global land cover with Landsat-8 data显示文摘We report the world's first all-season training and validation sample sets for global land cover classification with Landsat-8 data.Prior to this,such samples were only available at a single date primarily from the growing season.It is unknown how much limitation such a single-date sample has to mapping global land cover in other seasons of the year.To answer this question,we selected available Landsat-8 images from four seasons and collected training and validation samples from them.We compared the performances of training samples in different seasons using Random Forest algorithm.We found that the use of training samples from any individual season would result in the best overall classification accuracy when validated by samples in the same season.The global overall accuracy from combined best seasonal results was 67.2% when classifying the 11 Level-1 classes in the Finer Resolution Observation and Monitoring of Global Land Cover(FROM-GLC) classification system.The use of training samples from all seasons(named all-season training sample set hereafter) produced an overall accuracy of 67.0%.We also tested classification within 10° latitude 60° longitude zones using all-season training subsample within each zone and obtained an overall accuracy of 70.2%.This indicates that properly grouped subsamples in space can help improve classification accuracies.All the results in this study seem to suggest that it is possible to use an all-season training sample set to reach global optimality with universal applicability in classifying images acquired at any time of a year for global land cover mapping. | Congcong Li Peng Gong Jie Wang Zhiliang Zhu Gregory S. Biging Cui Yuan Tengyun Hu Haiying Zhang Qi Wang Xuecao Li Xiaoxuan Liu Yidi Xu Jing Guo Caixia Liu Kwame O. Hackman Meinan Zhang Yuqi Cheng Le Yu Jun Yang Huabing Huang Nicholas Clinton | 2017 | Science Bulletin2017，62，7： | 21 |
| 4 | Evaluation of Circulating Endometrial Cells as a Biomarker for Endometriosis显示文摘 | Ying Chen Hong-Lan Zhu Zhe-Wen Tang Kuang Hong Neoh Dong-Fang Ouyang Heng Cui Hong-Yan Cheng Rui-Qiong Ma Xue Ye Ray P. S. Han Xiao-Hong Chang | 2017 | Chinese Medical Journal2017，，19： | 10 |
| 5 | Human monoclonal antibodies as candidate therapeutics against emerging viruses显示文摘 | Yujia Jin Cheng Lei Dan Hu Dimiter S. Dimitrov Tianlei Ying | 2017 | Frontiers of Medicine2017，11，4： | 8 |
| 6 | A broad deglacial δ^(13)C minimum event in planktonic foraminiferal records in the Okinawa Trough显示文摘The equatorial Pacific upwelling zone has been suspected of playing an important role in the global atmospheric CO2 changes associated with glacial-interglacial cycles. In order to assess the influencing scope of the surface water deglacial δ13C minimum in the tropical low-latitude Pacific, the core DGKS9603, collected from the middle Okinawa Trough, was examined for δ13C records of planktonic fo-raminifera N. dutertrei and G. ruber. The planktonic fo-raminiferal δ13C records show a clear decreasing event from 20 to 6 cal. kaBP., which is characterized by long duration of about 14 ka and amplitude shift of 0.4×10-3. Its minimum value occurred at 15.7 cal kaBP. The event shows fairly synchrony with the surface water deglacial δ13C minimum identified in the tropical Pacific and its marginal seas. Because there is no evidence in planktonic foraminiferal fauna and δ18O records for upwelling and river runoff enhancement, the broad deglacial δ13C minimum event in planktonic foraminiferal records | LI Tiegang, LIU Zhenxia, M. A. Hall, Y. Saito, S. Berne, GANG Shuxi & CHENG ZhenboInstitute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China The First Institute of Oceanography, State Oceanic Administration, Qingdao 266003, China Godwin I | 2002 | Chinese Science Bulletin2002，47，7： | 7 |
| 7 | Influence of alloying elements on microstructure and microhardness of Mg-Sn-Zn-based alloys显示文摘阶段进化在(88%-91%) Mg-8%Sn-1%Zn-X (X=Al, Mn 或 Ce ) 系统经由 CALPHAD 方法被分析,模拟在化学作文的精确选择被使用。象 Mg-8%Sn-1%Zn-based 合金的微观结构和 microhardness 上的艾尔, Mn 和 Ce 那样的不同 alloying 元素的增加的影响被调查。艾尔和 Mn 的联合增加显示出从艾尔或 Mn 的分开的增加不同的特征。到基础合金的 1%Al 和 1%Mn 的增加在 -Mg 矩阵谷物导致巨大的 Al-Mn 阶段的形成。Ce 元素的增加能精制第二最容易溶解猛抛并且与 Sn 形成金属间化合的混合物。好像杆的 Sn-Ce 阶段主要在谷物边界上介绍并且在禁止谷物生长起一个作用。Vickers microhardness 上的 alloying 元素的效果和基础合金的缩进尺寸效果被检验。 | W. L. CHENG S. PARK W. N. TANG B. S. YOU B. H. KOO | 2010 | Transactions of Nonferrous Metals Society of China2010，20，12： | 6 |
| 8 | 血糖代谢障碍、体重指数和腰臀比对中国瘦型人群系统性高血压患病率的影响显示文摘The purpose of this study was to explore whether dysglycemia, and/or an increased body mass index, and/or an increased waist/hip ratio increased the risk of hypertension in a lean population of South China. The association among dysglycemia, obesity, and hypertension has been well documented in Western populations. A stratified cluster sampling method was used according to the National Diabetes Mellitus Epidemiology Survey Program in 1998. Blood pressure, fasting plasma glucose, and plasma glucose were measured 2 hours after 75-g oral glucose consumption using the enzymatic method in the morning. Body height, weight, and waist and hip measurements were also collected for the survey. The criteria for the diagnosis of hypertension and diabetes mellitus, including impaired glucose tolerance(IGT), were those published by the World Health Organization in 1999. A total of 11,402 participants were included in the investigation(5,195 men and 6,207 women; age 20 to 74 years). A total of 1,775 cases of hypertension were confirmed in the survey. The prevalence of hypertension was significantly higher in those with diabetes mellitus than in those with a normal blood glucose level, in those with IGT than in those with normal glucose tolerance test findings, and in obese participants than in those with a normal weight(45.5% vs 14.4% , 32.2% vs 14.5% , and 20.6% vs 12.1% , respectively). Multiple logistic regression analysis indicated that age and gender-adjusted odds ratio of hypertension was 2.24(95% confidence interval 1.88 to 2.68) with IGT compared with those without IGT. The odds ratio for hypertension associated with an increased body mass index and waist/hip ratio was 1.19(95% confidence interval 1.17 to 1.21) and 1.08(95% confidence interval 1.07 to 1.09), respectively. In conclusion, the data from an epidemiologic study in South China demonstrated that dysglycemia and increased body mass index and/or waist/hip ratio increase the risk of hypertension even in a lean Chinese population. | Lin S. Cheng T. O. Liu X. 朱冰坡(译) 杜媛(校) | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，2，8： | 6 |
| 9 | One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering显示文摘 | Haoyi Wang Hui Yang Chikdu S. Shivalila Meelad M. Dawlaty Albert W. Cheng Feng Zhang Rudolf Jaenisch | 2013 | Cell2013，，4： | 5 |
| 10 | What can the changes in shield resistance tell us during the period of shearer's cutting and neighboring shields' advance?显示文摘In order to determine the influence of shearer's cutting and neighboring shields' advance on the support resistance variation, leg pressure data of all 235 shields in the panel LW61 of Cumberland coal mine were analyzed. The results show that the relationship between the leg pressure increment and the distance from shield to front drum of shearer is a quadratic function and that the higher leg pressure increment before shield advance tends to be related to adverse roof conditions. In addition, the three proposed leg pressure increment-related parameters and the three traditional parameters(time-weighted average pressure, setting pressure, and final pressure) of approximately 32000 shield supporting cycles were calculated by a self-developed software package to analyze the correlation between them. The results show that there is a powerful connection between them, and that the three proposed leg pressure increment-related parameters could be used as the indexes to evaluate the interaction between shields and the roof, and to identify the periodic weighting. | Cheng Jingyi Wan Zhijun Peng Syd S. Liu Sifei Ji Yinlin | 2015 | International Journal of Mining Science and Technology2015，25，3： | 5 |
| 11 | NF-κB–YY1–miR-29 Regulatory Circuitry in Skeletal Myogenesis and Rhabdomyosarcoma显示文摘 | Huating Wang Ramiro Garzon Hao Sun Katherine J. Ladner Ravi Singh Jason Dahlman Alfred Cheng Brett M. Hall Stephen J. Qualman Dawn S. Chandler Carlo M. Croce Denis C. Guttridge | 2008 | Cancer Cell2008，，5： | 4 |
| 12 | The Influence of Relational Demography and Guanxi: The Chinese Case显示文摘 | Jiing-Lih Farh Anne S. Tsui Katherine Xin Bor-Shiuan Cheng | 1998 | Organization Science1998，，4： | 4 |
| 13 | Preventing abnormal NF-κB activation and autoimmunity by Otub1-mediated p100 stabilization显示文摘NF-κB, a family of transcription factors regulating diverse biological processes including immune responses, is activated by canonical and noncanonical pathways based on degradation of IκBα and processing of the IκB-like protein p100, respectively. Although p100 responds to noncanonical NF-κB stimuli for processing, it does not undergo degradation, but rather becomes accumulated, along with canonical NF-κB activation. We show here that the stability of p100 is tightly controlled by a deubiquitinase, Otub1. Otub1 deficiency not only promotes signal-induced p100 processing and noncanonical NF-κB activation but also causes steady-state p100 degradation, leading to aberrant NF-κB activation in the canonical pathway. B-cell-conditional deletion of Otub1 results in B-cell hyperplasia, antibody hyper-production, and lupus-like autoimmunity. Otub1-deficient B cells display aberrantly activated phenotypes and overproduce the cytokine IL-6, contributing to autoimmunity induction. Thus, maintenance of p100 stability by Otub1 serves as an unusual mechanism of NF-κB regulation that prevents autoimmunity. | Yanchuan Li Jin-Young Yang Xiaoping Xie Zuliang Jie Lingyun Zhang Jianhong Shi Daniel Lin Meidi Gu Xiaofei Zhou Haiyan S. Li Stephanie S. Watowich Antrix Jain Sung Yun Jung Jun Qin Xuhong Cheng Shao-Cong Sun | 2019 | Cell Research2019，29，6： | 3 |
| 14 | Inhibition of anaerobic digestion process: A review显示文摘 | Ye Chen Jay J. Cheng Kurt S. Creamer | 2007 | Bioresource Technology2007，，10： | 3 |
| 15 | Effects of Early Intensive Blood Pressure-Lowering Treatment on the Growth of Hematoma and Perihematomal Edema in Acute Intracerebral Hemorrhage: The Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT)显示文摘 | Craig S. Anderson Yining Huang Hisatomi Arima Emma Heeley Christian Skulina Mark W. Parsons Bin Peng Qiang Li Steve Su Qing Ling Tao Yue Chun Li Jian Dong Jiang Li Wen Tai Jin Li Zhang En Xu Yan Cheng Lewis B. Morgenstern John Chalmers Ji Guang Wang | 2010 | Stroke2010，，2： | 3 |
| 16 | MicroRNA-145, a Novel Smooth Muscle Cell Phenotypic Marker and Modulator, Controls Vascular Neointimal Lesion Formation显示文摘 | Yunhui Cheng Xiaojun Liu Jian Yang Ying Lin Da-Zhong Xu Qi Lu Edwin A. Deitch Yuqing Huo Ellise S. Delphin Chunxiang Zhang | 2009 | Circulation Research2009，，2： | 2 |
| 17 | The safety profile of ustekinumab in the treatment of patients with psoriasis and concurrent hepatitis B or C显示文摘 | H.‐Y. Chiu C.‐H. Chen M.‐S. Wu Y.‐P. Cheng T.‐F. Tsai | 2013 | Br J Dermatol2013，，6： | 2 |
| 18 | Low virological response and high relapse rates in hepatitis C genotype 1 patients with advanced fibrosis despite adequate therapeutic dosing显示文摘 | Wendy S.C. Cheng Stuart K. Roberts Geoffrey McCaughan William Sievert Martin Weltman Darrell Crawford William Rawlinson Philippa S. Marks James Thommes Bishoy Rizkalla Motoko Yoshihara Gregory J Dore | 2010 | Journal of Hepatology2010，，4： | 2 |
| 19 | Vitamin D status does not predict sustained virologic response or fibrosis stage in chronic hepatitis C genotype 1 infection显示文摘 | Matthew T. Kitson Gregory J. Dore Jacob George Peter Button Geoffrey W. McCaughan Darrell H.G. Crawford William Sievert Martin D. Weltman Wendy S. Cheng Stuart K. Roberts | 2012 | Journal of Hepatology2012，，： | 2 |
| 20 | Experimental and theoretical studies of scuffing behavior in piston-pin/piston contacts显示文摘A bench rig was built and used to study the scuffing mechanisms and the effects of sur-face roughness, clearance, and groove on scuffing in piston-pin/bore contacts for dynamic loadsand an oscillatory rotation. The experimental results show that the deterioration of the surfaceshear strength by fatigue cracks appears to contribute to the final scuffing, and the effects of thebore surface roughness and groove on the scuffing behavior are more significant than the clear-ance. A macro-micro approached scuffing model and a criterion for scuffing failure were developedappearing to be justifiable for the practical design and analysis of piston pin/bore bearings. | ZHANG Chao CHENG Herbert S. WANG Qian Center for Surface Engineering and Tribology, Department of Mechanical Engineering, Northwestem University Evanston, IL 60201, USA | 2001 | Science China Mathematics2001，44，S1： | 2 |
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