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| 1 | LncRNA Dum interacts with Dnmts to regulate Dppa2 expression during myogenic differentiation and muscle regeneration显示文摘新兴的研究在少些在染色质水平,但是相对调整基因表示记录长非编码的 RNA (LncRNAs ) 的角色被知道他们怎么调整 DNA methylation。这里,我们识别 lncRNA, Dum (发展联系 pluripotency 2 (Dppa2 ) 在上游的有约束力的肌肉 lncRNA ) 在骨胳的 myoblast 房间。Dum 的表示动态地在 vitro 并且在 vivo 在 myogenesis 期间被调整。它被在 myoblast 区别之上有约束力的 MyoD transcriptionally 也导致。功能的分析证明它支持 myoblast 区别和导致损坏的肌肉新生。机械学地, Dum 被发现它的附近的基因到沉默, Dppa2,在通过招募的 cis Dnmt1, Dnmt3a 和 Dnmt3b。而且, intrachromosomal 在 Dum 地点和 Dppa2 倡导者之间循环为 Dum/Dppa2 相互作用是必要的。一起,我们识别了与 Dnmts 交往调整 myogenesis 的新奇 lncRNA。 | Lijun Wang Yu Zhao Xichen Bao Xihua Zhu Yvonne Ka-yin Kwok Kun Sun Xiaona Chen Yongheng Huang Ralf Jauch Miguel A Esteban Hao Sun Huating Wang | 2015 | Cell Research2015，25，3： | 34 |
| 2 | Gait Study and Pattern Generation of a Starfish-Like Soft Robot with Flexible Rays Actuated by SMAs显示文摘 | Shixin Mao Erbao Dong Hu Jin Min Xu Shiwu Zhang Jie Yang Kin Huat Low | 2014 | Journal of Bionic Engineering2014，11，3： | 26 |
| 3 | The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters显示文摘最近的研究在众多的生物过程增加了我们长 noncoding RNA (lncRNAs ) 的理解,但是很少在体的房间 reprogramming 检验了他们的角色。通过表示介绍并且功能的屏蔽,我们鉴别了大 intergenic noncoding RNA p21 (lincRNA-p21 ) 损害 reprogramming。尤其是, lincRNA-p21 被 p53 导致,但是不在 reprogramming 支持 apoptosis 或房间老朽。相反, lincRNA-p21 与 H3K9 methyltransferase SETDB1 和维护 DNA methyltransferase DNMT1 联系,它被 RNA 有约束力的蛋白质 HNRNPK 便于。因而, lincRNA-p21 由在 pluripotency 基因倡导者支撑 H3K9me3 或 CpG methylation 阻止 reprogramming。我们的结果在 reprogramming 提供卓见进 lncRNAs 的角色并且建立在 p53 和 heterochromatin 规定之间的一个新奇连接。 | Xichen Bao Haitao Wu Xihua Zhu Xiangpeng Guo Andrew P Hutchins Zhiwei Luo Hong Song Yongqiang Chen Keyu Lai Menghui Yin Lingxiao Xu Liang Zhou Jiekai Chen Dongye Wang Baoming Qin Jon Frampton Hung-Fat Tse Duanqing Pei Huating Wang Biliang Zhang Miguel A Esteban | 2015 | Cell Research2015，25，1： | 21 |
| 4 | Effects of Short-Term Forest Bathing on Human Health in a Broad-Leaved Evergreen Forest in Zhejiang Province,China显示文摘Objective To investigate the effects of short-term forest bathing on human health.Methods Twenty healthy male university students participated as subjects and were randomly divided into two groups of 10.One group was sent on a two-night trip to a broad-leaved evergreen forest,and the other was sent to a city area.Serum cytokine levels reflecting inflammatory and stress response,indicators reflecting oxidative stress,the distribution of leukocyte subsets,and plasma endothelin-1 (ET-1) concentrations were measured before and after the experiment to evaluate the positive health effects of forest environments.A profile of mood states (POMS) evaluation was used to assess changes in mood states.Results No significant differences in the baseline values of the indicators were observed between the two groups before the experiment.Subjects exposed to the forest environment showed reduced oxidative stress and pro-inflammatory level,as evidenced by decreased malondialdehyde,interleukin-6,and tumor necrosis factor α levels compared with the urban group.Serum cortisol levels were also lower than in the urban group.Notably,the concentration of plasma ET-1 was much lower in subjects exposed to the forest environment.The POMS evaluation showed that after exposure to the forest environment,subjects had lower scores in the negative subscales,and the score for vigor was increased.Conclusion Forest bathing is beneficial to human health,perhaps through preventive effects related to several pathological factors. | MAO Gen Xiang LAN Xiao Guang CAO Yong Bao CHEN Zhuo Mei HE Zhi Huat LV Yuan Dong WANG Ya Zhen HU Xi Lian WANG Guo Fu YAN Jing | 2012 | Biomedical and Environmental Sciences2012，25，3： | 20 |
| 5 | Combination of inflammation-related cytokines promotes long-term muscle stem cell expansion显示文摘 | Xin Fu Jun Xiao Yuning Wei Sheng Li Yan Liu Jie Yin Kun Sun Hao Sun Huating Wang Zongkang Zhang Bao-Ting Zhang Chun Sheng Hongyan Wang Ping Hu | 2015 | Cell Research2015，25，6： | 16 |
| 6 | Kinetics of the accumulation of group 2 innate lymphoid cells in IL-33-induced and IL-25-induced murine models of asthma:a potential role for the chemokine CXCL16显示文摘ILC2s are implicated in asthma pathogenesis, but little is known about the mechanisms underlying their accumulation in airways.We investigated the time course of ILC2 accumulation in different tissues in murine models of asthma induced by a serial per-nasalchallenge with ovalbumin (OVA), house dust mice (HDM), IL-25 and IL-33 and explored the potential roles of ILC2-attractingchemokines in this phenomenon. Flow cytometry was used to enumerate ILC2s at various time points. The effects of cytokines andchemokines on ILC2 migration were measured in vitro using a chemotaxis assay and in vivo using small animal imaging. Comparedwith saline and OVA challenge, both IL-25 and IL-33 challenge alone induced significant accumulation of ILC2s in the mediastinallymph nodes, lung tissue and bronchoalveolar lavage fluid of challenged animals, but with a distinct potency and kinetics. In vitro,IL-33 and CXCL16, but not IL-25 or CCL25, directly induced ILC2 migration. Small animal in vivo imaging further confirmed that asingle intranasal provocation with IL-33 or CXCL16 was sufficient to induce the accumulation of ILC2s in the lungs followinginjection via the tail vein. Moreover, IL-33-induced ILC2 migration involved the activation of ERK1/2, p38, Akt, JNK and NF-κB, whileCXCL16-induced ILC2 migration involved the activation of ERK1/2, p38 and Akt. These data support the hypothesis that epitheliumderived IL-25 and IL-33 induce lung accumulation of ILC2s, while IL-33 exerts a direct chemotactic effect in this process. AlthoughILC2s express the chemokine receptors CXCR6 and CCR9, only CXCL16, the ligand of CXCR6, exhibits a direct chemoattractanteffect. | Yan Li Shihao Chen Yafei Chi Yiran Yang Xiwen Chen Huating Wang Zhe Lv Jingjing Wang Linjie Yuan Ping Huang Kewu Huang Chris JCorrigan Wei Wang Sun Ying | 2019 | Cellular & Molecular Immunology2019，16，1： | 13 |
| 7 | Increasing yield potential through manipulating of an ARE1 ortholog related to nitrogen use efficiency in wheat by CRISPR/Cas9显示文摘Wheat(Triticum aestivum L.)is a staple food crop consumed by more than 30%of world population.Nitrogen(N)fertilizer has been applied broadly in agriculture practice to improve wheat yield to meet the growing demands for food production.However,undue N fertilizer application and the low N use efficiency(NUE)of modern wheat varieties are aggravating environmental pollution and ecological deterioration.Under nitrogen-limiting conditions,the rice(Oryza sativa)abnormal cytokinin response1 repressor1(are1)mutant exhibits increased NUE,delayed senescence and consequently,increased grain yield.However,the function of ARE1 ortholog in wheat remains unknown.Here,we isolated and characterized three TaARE1 homoeologs from the elite Chinese winter wheat cultivar ZhengMai 7698.We then used CRISPR/Cas9-mediated targeted mutagenesis to generate a series of transgene-free mutant lines either with partial or triple-null taare1 alleles.All transgene-free mutant lines showed enhanced tolerance to N starvation,and showed delayed senescence and increased grain yield in field conditions.In particular,the AABBdd and aabbDD mutant lines exhibited delayed senescence and significantly increased grain yield without growth defects compared to the wild-type control.Together,our results underscore the potential to manipulate ARE1 orthologs through gene editing for breeding of high-yield wheat as well as other cereal crops with improved NUE. | Jiahui Zhang Huating Zhang Shaoya Li Jingying Li Lei Yan Lanqin Xia | 2021 | Journal of Integrative Plant Biology2021，63，9： | 13 |
| 8 | Buttress plate fixation of coronoid process fractures via a medial approach显示文摘Purpose:To assess the clinical and radiographic outcomes of coronoid process fractures surgically managed with buttress plate fixation via a medial approach.Methods:A retrospective review of all coronoid fractures surgically fixed in our institution using a buttress plate technique via a medial approach between June 2012 and April 2015 by the senior author was performed.These fractures were all sizeable fractures contributing to persistent elbow instability in terrible triad or varus posteromedial rotatory instability injury patterns.A prospective telephone questionnaire was conducted to assess patient outcomes using the disabilities of the arm,shoulder and hand(DASH)score and Mayo hlbow performance score(MEPS).Results:Twelve patients were included in the study,comprising 10 males and 2 females with an average age of 39 years(range,19-72 years).Mean follow-up was 16 months(range.4-18 months).The average time to radiographic union was 4 months(range.3-7 months).Range of motion measurements at final follow-up were obtained in 11 out of 12 patients,with one patient defaulting follow-up.All 11 patients displayed a functional elbow range of motion of at least 30°-130°.with an average arc of motion of 130°(range.110°-140°).mean elbow flexion of 134°(range.110°-140°)and mean flexion contracture of 3°(range.0°-20°).The mean DASH score was 16(range.2.5-43.8)and the mean MEPS was 75(range.65-100).Complications observed included one patient with a superfic ial wound infection which resolved with a course of oral antibiotics and one patient with radiographic evidence of heterotopic ossification which was conservatively managed.No residual elbow instability was observed and no reoperations were performed.Conclusion:Buttress plate fixation via a medial approach of coronoid process fractures that contribute to persistent elbow instability represents a reliable method of treatment that produces satisfactory and predictable outcomes. | Kelvin Kah Ho Lor Dong Hao Toon Andy Teck Huat Wee | 2019 | Chinese Journal of Traumatology2019，22，5： | 9 |
| 9 | Bio-inspired Flow Sensing and Prediction for Fish-like Undulating Locomotion: A CFD-aided Approach显示文摘 | Han Zhou Tianjiang Hu Kin Huat Low Lincheng Shen Zhaowei Ma Guangming Wang Haijun Xu | 2015 | Journal of Bionic Engineering2015，12，3： | 7 |
| 10 | A Computational Fluid Dynamics (CFD) Analysis of an Undulatory Mechanical Fin Driven by Shape Memory Alloy显示文摘许多鱼使用波动的鳍自己推进在在水下环境。这些运动机制有流行兴趣到许多研究人员。在现在的学习,我们执行被形状记忆合金(SMA ) 驾驶的波动的机械鳍的三维的不稳定的计算。计算的目的是调查与波动的机械鳍联系的力量生产的液体动力学。一个未组织的、基于格子的、不稳定的海军司烧解答者与自动适应重新协调被用来通过五个完全的周期在鳍附近计算不稳定的流动。鳍表面上的压力分发被计算并且综合上升提供被分解成的鳍力量并且推进。速度领域也在整个游泳周期被计算。最后,比较被进行根据波动的鳍(振幅,频率和波长) 的运动学的参数揭示力量产生的动力学。关键词计算液体动力学(CFD )- 波动的机械鳍 - 不稳定的流动 - 未组织的网孔 - 形状记忆合金(SMA ) 张永华收到了他的 B.Sc。在来自中国的科技的大学的精确乐器学和精确机械的度, Hefei,中国,在 2003。他现在在中国的科技的大学里正在追求他的博士学位。他出版了超过 10 份审阅杂志和会议报纸。他的当前的研究关于 biomimetic 用聪明的材料(SMA ) 的机器的鱼鳍。他的研究兴趣也包括在水下利用人工的肌肉的 microrobots。Jian-Hui 他收到了她的 B.Sc。在来自中国农业大学的计算机科学的度,中国北京,在 2003。她现在在精确机械和精确乐器学的部门正在追求她的 M.Sc 学位,中国的科技的大学。当前,她正在研究对微微滴透镜的制造的电场鈥檚 力量的影响。她出版了 5 篇审阅杂志和会议论文在最近二年。她的研究兴趣包括微光学、在水下的机器人。杨洁在科技的北京大学从物理化学的系毕业了,在 1969。他当前是在中国的科技的大学的精确机械和精确乐器学的系的一个教授。他领导集中于中国和 863 工程的国家自然科学基础支持的聪明的机器人的几个研究组。他的研究兴趣包括聪明的机器人,精确机械材料,和高速度摄影。张世武收到了他的 B.Sc。度在机械并且在来自中国的科技的大学的精确乐器学和精确机械的电力工程和博士学位, Hefei,中国。他当前是在精确机械和精确乐器学的系的一个研究助手,中国的科技的大学。他是在计算机科学系的一个研究助手,为 1.5 年的香港浸信会教友大学。他的当前的兴趣包括网智力,自治面向的计算,复杂系统,和聪明的机器人。家族 Huat 低从滑铁卢大学在 mechanical engineering 收到了他的 M.Sc 和博士学位,加拿大在 1983 和 1986,分别地。在在滑铁卢大学作为一个博士后的家伙度过二年以后,他加入了学院机械并且 Nanyang 工艺的大学的太空工程。他在 biomimetics,机器人学,康复,影响,电源传播系统,结构的动力学和颤动的区域是五本书和超过 90 篇杂志论文的作者。他的研究兴趣包括机器人学,颤动,影响,机器,机制,皮骨骼系统,和 mechatronics 设计。医生低是 IEEE, IASTED, SIAA 和 SiC-ToMM 的一个成员。他也是一个成员几技术,会议委员会,和杂志编委。他分别地在机器人学鱼和动力的皮骨骼上在研究工作上在二个 IEEE 会议赢得了奖品。 | Yong-Hua Zhang Jian-Hui He Jie Yang Shi-Wu Zhang Kin Huat Low | 2006 | International Journal of Automation and computing2006，3，4： | 7 |
| 11 | Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration显示文摘Necroptosis,a form of programmed cell death,is characterized by the loss of membrane integrity and release of intracellular contents,the execution of which depends on the membrane-disrupting activity of the Mixed Lineage Kinase Domain-Like protein(MLKL)upon its phosphorylation.Here we found myofibers committed MLKL-dependent necroptosis after muscle injury.Either pharmacological inhibition of the necroptosis upstream kinase Receptor Interacting Protein Kinases 1(RIPK1)or genetic ablation of MLKL expression in myofibers led to significant muscle regeneration defects.By releasing factors into the muscle stem cell(MuSC)microenvironment,necroptotic myofibers facilitated muscle regeneration.Tenascin-C(TNC),released by necroptotic myofibers,was found to be critical for MuSC proliferation.The temporary expression of TNC in myofibers is tightly controlled by necroptosis;the extracellular release of TNC depends on necroptotic membrane rupture.TNC directly activated EGF receptor(EGFR)signaling pathway in MuSCs through its N-terminus assembly domain together with the EGF-like domain.These findings indicate that necroptosis plays a key role in promoting MuSC proliferation to facilitate muscle regeneration. | Shen'ao Zhou Wei Zhang Gaihong Cai Yingzhe Ding Caixia Wei Sheng Li Yu Yang Jie Qin Dan Liu Hao Zhang Xiexiang Shao Jianhua Wang Hongye Wang Wenjun Yang Huating Wang She Chen Ping Hu Liming Sun | 2020 | Cell Research2020，30，12： | 4 |
| 12 | NF-κB–YY1–miR-29 Regulatory Circuitry in Skeletal Myogenesis and Rhabdomyosarcoma显示文摘 | Huating Wang Ramiro Garzon Hao Sun Katherine J. Ladner Ravi Singh Jason Dahlman Alfred Cheng Brett M. Hall Stephen J. Qualman Dawn S. Chandler Carlo M. Croce Denis C. Guttridge | 2008 | Cancer Cell2008，，5： | 4 |
| 13 | On-line Optimization of Biomimetic Undulatory Swimming by an Experiment-based Approach显示文摘 | Chunlin Zhou Kin Huat Low | 2014 | Journal of Bionic Engineering2014，11，2： | 4 |
| 14 | Tuning sol size to optimize organosilica membranes for gas separation显示文摘A series of organosilica sols are prepared by the polymeric sol–gel method using 1,2-bis(triethoxysilyl)ethane(BTESE)as the precursor.Particle size distributions of the BTESE-derived sols are systematically investigated by carefully adjusting the synthesis parameters(i.e.,water ratios,acid ratios and solvent ratios)in the sol process.In certain conditions,increasing the water ratio or the acid ratio tends to cause larger sol sizes and bimodal particle size distributions.However,higher solvent ratios lead to smaller sol sizes and unimodal particle size distributions.The organosilica membranes prepared from the optimized sols show excellent H_2 permeances(up to 4.2×10^(-7)mol·m^(-2)·s^(-1)·Pa^(-1))and gas permselectitivies(H_2/CO_2 is 9.5,H_2/N_2 is 50 and H_2/CH_4 is 68).This study offers significant insights into the relationship between the sol synthesis parameters,sol sizes and membrane performance. | Huating Song Yibin Wei Chenying Wang Shuaifei Zhao Hong Qi | 2018 | Chinese Journal of Chemical Engineering2018，26，1： | 3 |
| 15 | Genetically encoded X-ray cellular imaging for nanoscale protein localization显示文摘Spatial resolution defines the physical limit of microscopes for probing biomolecular localization and interactions in cells.Whereas synchrotron-based X-ray microscopy(XRM)represents a unique approach for imaging a whole cell with nanoscale resolution due to its intrinsic nanoscale resolution and great penetration ability,existing approaches to label biomolecules rely on the use of exogenous tags that are multi-step and error-prone.Here,we repurpose engineered peroxidases as genetically encoded X-ray-sensitive tags(GXET)for site-specific labeling of protein-of-interest in mammalian cells.We find that 3,3-diaminobenzidine(DAB)polymers that are in-situ catalytically formed by fusion-expressed peroxidases are visible under XRM.Using this new tag,we imaged the protein location associated with the alteration of a DNA-methylation pathway with an ultra-high resolution of 30 nanometers.Importantly,the excellent energy resolution of XRM enables multicolor imaging using different peroxidase tags.The development of GXET enlightens the way to nanoscopic imaging for biological studies. | Huating Kong Jichao Zhang Jiang Li Jian Wang Hyun-Joon Shin Renzhong Tai Qinglong Yan Kai Xia Jun Hu Lihua Wang Ying Zhu Chunhai Fan | 2020 | National Science Review2020，7，7： | 3 |
| 16 | Rational design and evaluation of UV curable nano-silver ink applied in highly conductive textile-based electrodes and flexible silver-zinc batteries显示文摘The possibility of printing conductive ink on textiles is progressively researched due to its potential benefits in manufacturing functional wearable electronics and improving wearing comfort.However,few studies have reported the effect of conductive ink formulation on electrodes directly screen-printed on flexible substrates,especially printing UV curable conductive ink on common textiles.In this work,a novel UV curable nano-silver ink with short-time curing and low temperature features was developed to manufacture the fully flexible and washable textile-based electrodes by screen printing.The aim of this study was to determine the influence of ink formulation on UV-curing speed,degree of conversion,morphology and electrical properties of printed electrodes.Besides,the application demonstration was highlighted.The curing speed and adhesion of ink was found depending dominantly on the type of prepolymer and the functionality of monomer,and the type of photoinitiator had a decisive effect on the curing speed,degree of double bond conversion and morphology of printed patterns.The nano-silver content is key to guarantee the suitable screen-printability of conductive ink and therefore the uniformity and high conductivity of textile-based electrodes.Optimally,an ink formulation with 60 wt%nano-silver meets the potential application requirements.The electrode with 1.0 mm width showed significantly high electrical conductivity of 2.47×10^(6)S/m,outstanding mechanical durability and satisfactory washability.The high-performance of electrodes screen-printed on different fabrics proved the feasibility and utility of UV curable nano-silver ink.In addition,the application potential of the conductive ink in fabricating electronic textiles(e-textiles)was confirmed by using the textile-based electrodes as the cathodes of silverzinc batteries.We anticipate the developed UV curable conductive ink for screen-printing on textiles can provide a novel design opportunity for flexible and wearable e-textile applications. | Hong Hong Lihong Jiang Huating Tu Jiyong Hu Kyoung-Sik Moon Xiong Yan Ching-ping Wong | 2022 | Journal of Materials Science & Technology2022，，6： | 3 |
| 17 | Multiple air route crossing waypoints optimization via artificial potential field method显示文摘Air route crossing waypoint optimization is one of the effective ways to improve airspace utilization,capacity and resilience in dealing with air traffic congestion and delay.However,research is lacking on the optimization of multiple Crossing Waypoints(CWPs)in the fragmented airspace separated by Prohibited,Restricted and Dangerous areas(PRDs).To tackle this issue,this paper proposes an Artificial Potential Field(APF)model considering attractive forces produced by the optimal routes and repulsive forces generated by obstacles.An optimization framework based on the APF model is proposed to optimize the different airspace topologies varying the number of CWPs,air route segments and PRDs.Based on the framework,an adaptive method is developed to dynamically control the optimization process in minimizing the total air route cost.The proposed model is applied to a busy controlled airspace.And the obtained results show that after optimization the safety-related indicators:conflict number and controller workload reduced by 7.75%and 6.51%respectively.As for the cost-effectiveness indicators:total route length,total air route cost and non-linear coefficient,declined by 1.74%,3.13%and 1.70%respectively.While the predictability indicator,total flight delay,saw a notable reduction by 7.96%.The proposed framework and methodology can also provide an insight in the understanding of the optimization to other network systems. | Bizhao PANG Wei DAI Xinting HU Fuqing DAI Kin Huat LOW | 2021 | Chinese Journal of Aeronautics2021，34，4： | 3 |
| 18 | Thymoquinone: Potential cure for inflammatory disorders and cancer显示文摘 | Chern Chiuh Woo Alan Prem Kumar Gautam Sethi Kwong Huat Benny Tan | 2011 | Biochemical Pharmacology2011，，4： | 2 |
| 19 | Fibroblast growth factor 21:a novel metabolic regulator from pharmacology to physiology显示文摘Fibroblast growth factor 21(FGF21)is a member of the fibroblast growth factor family.It actually functions as endocrine hormones but does not regulate cell growth and differentiation.It is demonstrated that FGF21 acts on multiple tissue to coordinate carbohydrate and lipid metabolism,including enhancing insulin sensitivity,decreasing triglyceride concentrations,causing weight loss,ameliorating obesity-associated hyperglycemia and hyperlipidemia.Moreover,FGF21 also plays important roles in some physiological processes,such as fasting and feeding,growth hormone axis and thermogenic function of brown adipose tissue.Clinical relevance of FGF21 in humans is still unclear,and the basis and consequences of increased FGF21 in metabolic disease remain to be determined.Both the pharmacological actions and physiological roles make FGF21 attractive drug candidates for treating metabolic disease,but some questions remain to be answered.This article concentrates on recent advances in our understanding of FGF21. | Huating Li Jing Zhang Weiping Jia | 2013 | Frontiers of Medicine2013，7，1： | 2 |
| 20 | Meta-analysis of genetic polymorphisms and gastric cancer risk: Variability in associations according to race显示文摘 | Marie Loh King Xin Koh Boon Huat Yeo Chun Meng Song Kee Seng Chia Feng Zhu Khay Guan Yeoh Jeffrey Hill Barry Iacopetta Richie Soong | 2009 | European Journal of Cancer2009，，14： | 2 |
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