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| 1 | Apoptotic extracellular vesicles are metabolized regulators nurturing the skin and hair显示文摘Over 300 billion of cells die every day in the human body,producing a large number of endogenous apoptotic extracellular vesicles(apoEVs).Also,allogenic stem cell transplantation,a commonly used therapeutic approach in current clinical practice,generates exogenous apoEVs.It is well known that phagocytic cells engulf and digest apoEVs to maintain the body’s homeostasis.In this study,we show that a fraction of exogenous apoEVs is metabolized in the integumentary skin and hair follicles.Mechanistically,apoEVs activate the Wnt/β-catenin pathway to facilitate their metabolism in a wave-like pattern.The migration of apoEVs is enhanced by treadmill exercise and inhibited by tail suspension,which is associated with the mechanical force-regulated expression of DKK1 in circulation.Furthermore,we show that exogenous apoEVs promote wound healing and hair growth via activation of Wnt/β-catenin pathway in skin and hair follicle mesenchymal stem cells.This study reveals a previously unrecognized metabolic pathway of apoEVs and opens a new avenue for exploring apoEV-based therapy for skin and hair disorders. | Lan Ma Chider Chen Dawei Liu Zhiqing Huang Jiaqi Li Haixiang Liu Ryan Tsz Kin Kwok Benzhong Tang Bingdong Sui Xiao Zhang Jianxia Tang Xueli Mao Weiying Huang Songtao Shi Xiaoxing Kou | 2023 | Bioactive Materials2023，，1： | 3 |
| 2 | A Cost-Utility Analysis of Ablative Therapy for Barrett’s Esophagus显示文摘 | John M. Inadomi Ma Somsouk Ryan D. Madanick Jennifer P. Thomas Nicholas J. Shaheen | 2009 | Gastroenterology2009，，7： | 2 |
| 3 | A Cost-Utility Analysis of Ablative Therapy for Barrett’s Esophagus显示文摘 | John M. Inadomi Ma Somsouk Ryan D. Madanick Jennifer P. Thomas Nicholas J. Shaheen | 2009 | Gastroenterology2009，，： | 2 |
| 4 | Aluminium tolerance in plants and the complexing role of organic acids显示文摘 | Jian Feng Ma Peter R Ryan Emmanuel Delhaize | 2001 | Trends in Plant Science2001，，6： | 2 |
| 5 | Pressure ulcer risk factors in an ICU population显示文摘 | Jirieka MK Ryan P Carvalho MA | 1995 | Am J Crit Care1995，4，5： | 1 |
| 6 | Promoting the Development of Doctoring Competencies in Clinical Settings显示文摘 | Brody DS Ryan K Kurma MA | 2004 | Fam Med2004，，： | 1 |
| 7 | Using a morphine equivalence metric to quantify opioid consumption: examining the capacity to provide effective treatment of debilitating pain at the global, regional, and country levels显示文摘 | Gilson AM Maurer MA Ryan KM | 2013 | J Pain Symptom Man- age2013，45，4： | 1 |
| 8 | A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen显示文摘 | Ma X J Wang Z Ryan PD | 2004 | Cancer Cell2004，5，6： | 1 |
| 9 | Aluminum tolerance in plants and the complexing role of organic acids显示文摘 | Ma J F Ryan P R Delhaize E | 2001 | Trends Ham Sci2001，6，6： | 1 |
| 10 | Effects of Somatic CellCount on Quality and Shelf-Life of Pasteurized Fluid Milk显示文摘 | Ma Y Ryan C Barbano D M | 2000 | J Dairy Sci2000，83，： | 1 |
| 11 | Chronic exposure to high-density polyethylene microplastic through feeding alters the nutrient metabolism of juvenile yellow perch (Perca flavescens)显示文摘Microplastics are emergent contaminants threatening aquatic organisms including aquacultured fish.This study investigated the effects of high-density polyethylene(HDPE,100 to 125 mm)on yellow perch(Perca flavescens)based on integrative evaluation including growth performance,nutritional status,nutrient metabolism,fish health,and gut microbial community.Five test diets(0,1,2,4,or 8 g HDPE/100 g diet)containing 41%protein and 10.5%lipid were fed to juvenile perch(average body weight,25.9±0.2 g;n=15)at a feeding rate of 1.5%to 2.0%body weight daily.The feeding trial was conducted in a flow-through water system for 9 wk with 3 tanks per treatment and 15 yellow perch per tank.No mortality or HDPE accumulation in the fish was found in any treatments.Weight gain and condition factor of fish were not significantly impacted by HDPE(P>0.05).Compared to the control group,fish fed the 8%HDPE diet had significantly decreased levels of protein and ash(P<0.05).In response to the increasing levels of HDPE exposure,the hepatosomatic index value,hepatocyte size,and liver glycogen level were increased,but lipid content was reduced in the liver tissues.Compared to the control treatment,fish fed the 8%HDPE diet had significant accumulations of total bile acids and different metabolism pathways such as bile acid biosynthesis,pyruvate metabolism,and carnitine synthesis.Significant enterocyte necrosis was documented in the foregut of fish fed the 2%or 8%HDPE diet;and significant cell sloughing was observed in the midgut and hindgut of fish fed the 8%HDPE diet.Fish fed the 2%HDPE diet harbored different microbiota communities compared to the control fish.This study demonstrates that HDPE ranging from 100 to 125 mm in feed can be evacuated by yellow perch with no impact on growth.However,dietary exposure to HDPE decreased whole fish nutrition quality,altered nutrient metabolism and the intestinal histopathology as well as microbiota community of yellow perch.The results indicate that extended exposure may pose a risk to fish health and jeopardize the nutrition quality of aquacultured end product.This hypothesis remains to be investigated further. | Xing Lu Dong-Fang Deng Fei Huang Fabio Casu Emma Kraco Ryan J.Newton Merry Zohn Swee J.Teh Aaron M.Watson Brian Shepherd Ying Ma Mahmound A.O.Dawood Lorena M.Rios Mendoza | 2022 | Animal Nutrition2022，，2： | 1 |
| 12 | Clinical overview of algal docosahexaenoie add: effects on triglyceride levels and other cardiovascular risk factors 显示文摘 | Ryan AS Keske MA Hoffman JP | 2009 | Am J Ther2009，16，2： | 1 |
| 13 | NCCN Clinical Practice Guidelines in Oncology:rectal cancer 显示文摘 | Engstrom PF Arnoletti JP Benson AB 3rd Chen YJ Choti MA Cooper HS Covey A Dilawari RA Early DS Enzinger PC Fakih MG Fleshman J Jr Fuchs C Greta JL Kiel K Knol JA Leong LA Lin E Mulcahy MF Rao S Ryan DP Saltz L Shibata D Skibber JM Sofocleous C Thomas J Venook AP Willett C | 2009 | J Natl Compr Canc Netw2009，7，： | 1 |
| 14 | Aluminium tolerance in plants and the complexing role of organic acids 显示文摘 | Ma J F Ryan P R Delhaize E | 2001 | Trends Plant Science2001，6，： | 1 |
| 15 | 查看详情显示文摘 | Ma J F Ryan P R Delhaize E | | 0，，06： | 1 |
| 16 | Effects of Somatic Cell Count on Quality and Shelf-Life of Pasteurized Fluid Milk 显示文摘 | Ma Y Ryan C Barbano D M | 2000 | J Dairy Sci2000，83，： | 1 |
| 17 | Cognitive-behavioral therapy of depression in children and adolescents:a review and meta-analysis显示文摘 | Reinecke MA Ryan NE DuBois DL | 1998 | J Am Acad Child Adolesc Psychiatry1998，37，10： | 1 |
| 18 | Temperature and soil organic matter decomposition rates-synthesis of current knowledge and a way forward显示文摘 | Conant RT Ryan MG Agren GI Birge HE Davidson EA Eliasson PE Evans SE Frey SD Giardina CP Hopkins FM Hyvǒnen R Kirschbaum MUF Lavallee JM Leifeld J Parton WJ Megan Steinweg J Wallenstein MD Martin Wetterstedt JA Bradford MA | | 0，，： | 1 |
| 19 | Understanding how plants cope with acid soils 显示文摘 | Ma JF Ryan PR | 2010 | Funct Plant Biol2010，37，： | 1 |
| 20 | GDNF protects the cochlea against noise damage显示文摘 | Keithley E M Ma C L Ryan A F | 1998 | Neuroreport1998，13，： | 1 |
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