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| 1 | Target-triggered inhibiting oxidase-mimicking activity of platinum nanoparticles for ultrasensitive colorimetric detection of silver ion显示文摘The development of efficient methods for the detection of hazardous and toxic elements is extremely important for environmental security and public health. In this work, we developed a facile colorimetric assaying system for Ag+ detection in aqueous solution. Chitosan-stabilized platinum nanoparticles(ChPtNPs) were synthesized and severed as an artificial oxidase to catalyze the oxidation of the substrate3,30,5,50-tetramethylbenzidine(TMB) and generate color signal. In the presence of Ag+, due to the strong metallophilic interactions between Ag+ and Pt2+ on the surface of Ch-PtNPs, Ag+ can weaken the affinity to the substrates and inactivate the catalytic activity of Ch-PtNPs, leading to decreased absorbance signal to varying degrees depending on Ag+ amount. Combing the specific binding between Ch-PtNPs and Ag+ with signal amplification procedure based on the Ch-PtNPs-catalyzed TMB oxidation, a sensitive,selective, simple, cost-effective, and rapid detection method for Ag+ can be realized. Ag+ ions in tap and lake waters have been successfully detected. We ensured that the proposed method can be a potential alternative for Ag+ determination in environmental samples. | Haohua Deng Shaobin He Xiuling Lin Lu Yang Zhen Lin Ruiting Chen Huaping Peng Wei Chen | 2019 | Chinese Chemical Letters2019，30，9： | 3 |
| 2 | Evaluation of Heavy Metals and Pesticide Residues in Dendrobium officinale Produced in Guangxi显示文摘[Objectives]To establish a method for the determination of heavy metals and pesticide residues in Dendrobium officinale produced in Guangxi and its culture substrate.[Methods]The contents of five heavy metals(Pb,Cd,As,Hg and Cu)were determined by the atomic absorption spectrophotometric(AAS)method;residues of 9 organochlorine pesticides(α-BHC,β-BHC,γ-BHC,δ-BHC,p,p′-DDT,p,p′-DDE,p,p′-DDD,o,p′-DDT and pentachloronitrobenzene)were determined by gas chromatography(GC).[Results]The contents of five heavy metals in the medicinal materials of D.officinale produced in Guangxi were 0.96,0.21,0.021 mg/kg,and not detected,and 0.35 mg/kg.The contents of five heavy metals in the culture substrate were 0.03,0.19,0.21,0.004 and 1.80 mg/kg,respectively;the content of 9 organochlorine pesticide residues in the sample was not detected.[Conclusions]The detection results of heavy metal content and organochlorine pesticide residues in D.officinale produced in Guangxi and its substrate are consistent with the limit requirements of the Chinese Pharmacopoeia.This experiment is expected to provide reliable data reference for ensuring the safety of the drug resources of D.officinale in Guangxi. | Hua ZHU Ruiting HE Piaoling HUANG Wenqi YANG Anda WEI Yuanjing TAO Zhonghua DAI | 2019 | Medicinal Plant2019，10，5： | 3 |
| 3 | Niobium oxyphosphate nanosheet assembled two-dimensional anode material for enhanced lithium storage显示文摘The development of high-capacity and high-rate anodes has become an attractive endeavor for achieving high energy and power densities in lithium-ion batteries(LIBs).Herein,a new-type anode material of reduced graphene oxide(rGO) supported niobium oxyphosphate(NbOPO_4) nanosheet assembled twodimensional composite material(NbOPO_4/rGO) is firstly fabricated and presented as a promising highperformance LIB anode material.In-depth electrochemical analyses and in/ex situ characterizations reveal that the intercalation-conversion reaction takes place during the first discharge process,followed by the reversible redox process between amorphous NbPO_4 and Nb which contributes to the reversible capacity in the subsequent cycles.Meanwhile,the lithiation-generated Li3 PO_4,behaving as a good lithium ion conductor,facilitates ion transport.The rGO support further regulates the structural and electron/ion transfer properties of NbOPO_4/rGO composite compared to neat NbOPO_4, resulting in greatly enhanced electrochemical performances.As a result,NbOPO_4/rGO as a new-type LIB anode material achieves a high capacity of 502.5 mAh g^(-1) after 800 cycles and outstanding rate capability of 308.4 mAh g^(-1) at 8 A g^(-1).This work paves the way for the deep understanding and exploration of phosphate-ba sed high-efficiency anode materials for LIBs. | Bo Wen Ruiting Guo Xiong Liu Wen Luo Qiu He Chaojiang Niu Jiashen Meng Qi Li Yan Zhao Liqiang Mai | 2021 | Journal of Energy Chemistry2021，30，2： | 1 |
| 4 | A carbazole-hemicyanine dye based ratiometric fluorescent probe for selective detection of bisulfite(HSO_3^-)in cells and C. elegans显示文摘Bisulfite(HSO_3) is an important sulfur dioxide(SO_2) derivative, which plays a major role in many physiological processes and is also closely associated with a variety of diseases. Thus the development of highly selective and sensitive fluorescent probes is essential to detect HSO_3 in living cells. In this work,we report the synthesis and analysis of a ratiometric fluorescent probe for selective detection of HSO_3 based on the 1,4-nucleophilic addition reaction with the carbazole as an electron donor(D) and aldehyde group as an electron acceptor(A). The addition of HSO_3 and other ions to our probe can be observed by UV vis and fluorescence spectrometry. Our investigation proved that the probe is highly selective and sensitive for HSO_3 and ratiometric changes. Moreover, the probe has good cell permeability and was successfully applied to the detection of exogenous HSO_3 in Hela cells and C. elegans. | Keying Bi Rui Tan Ruiting Hao Lanxi Miao Yanqi He Xianghua Wu Junfeng Zhang Rui Xu | 2019 | Chinese Chemical Letters2019，30，3： | 1 |
| 5 | Advanced polymer-based electrolytes in zinc-air batteries显示文摘Zinc–air batteries(ZABs)are expected to be some of the most promising power sources for wearable and portable electronic devices and have received widespread research interest.As an ion conductor connecting anodes and cathodes,the electrolyte is critical for the overall performance of ZABs(e.g.,energy density,rechargeability,and operating voltage).Compared with liquid electrolytes,polymer-based electrolytes have superior characteristics for ZABs,such as negligible electrolyte leakage,three-phase interface stabilization,and dendrite suppression.In this perspective,we focus on recent progress in polymer-based electrolytes for ZABs.After a brief introduction to ZABs and electrolytes,we emphasize the development of polymer-based electrolytes in terms of their intrinsic properties and interfacial chemistry.Finally,challenges and viable strategies are proposed for polymer-based electrolytes in ZABs.We hope that this work will provide useful guidance to spur the development of high-performance ZABs based on advanced polymer-based electrolytes. | Qingqing Liu Ruiting Liu Chaohui He Chenfeng Xia Wei Guo Zheng-Long Xu Bao Yu Xia | 2022 | eScience2022，2，5： | 1 |
| 6 | Promoting the protonation step on the interface of titanium dioxide for selective photocatalytic reduction of CO_(2)to CH_(4)by using red phosphorus quantum dots显示文摘Enhancing the selectivity of hydrocarbon in CO_(2)is a great challenge.Herein,taking widely-used and highly-stable TiO_(2)as an example,we found that the protonation step,the key step for CH_(4)production,can change from endoergic to exoergic by using red phosphorus quantum dots.Consequently,the main product in CO_(2)reduction can be shifted from CO into CH_(4).The preparation method is very simple,which just ultrasonically treating the red P in the presence of TiO_(2).With an initial rate of CH_(4)production of 4.69μmol·g^(-1)·h^(-1),under simulated solar light,it manifests a significant 49.4-fold enhancement of CH_(4)yield over TiO_(2).Density functional calculation indicates that the red P optimizes the surface electronic structure.The Gibbs free energy for CHO^(*)formation(^(-1).12 eV)becomes lower than the desorption energy of the CO(-0.01 eV)when red P is introduced.This indicates that the CO intermediates on the surface are rapidly protonated to produce CHO^(*).Subsequently,the CHO^(*)will be converted into CH_(4)instead of being desorbed from the surface to produce CO.This study demonstrates that red P quantum dot is a promising candidate for the development of efficient photocatalyst for CO_(2)photoreduction to CH_(4)under solar light irradiation. | Yinglong Lu Minghao Liu Ningchao Zheng Xi He Ruiting Hu Ruilin Wang Quan Zhou Zhuofeng Hu | 2022 | Nano Research2022，15，4： | 1 |
| 7 | Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO显示文摘The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main detector.Some of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator detectors.In this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/g.With ten years of data acquisition,approximately 60,000 signal and 30,000 background events are expected.This large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation framework.IfDelta m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith angle.Moreover,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment. | Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera Daojin Hong YuenKeung Hor Shaojing Hou Yee Hsiung Bei-Zhen Hu Hang Hu Jianrun Hu Jun Hu Shouyang Hu Tao Hu Zhuojun Hu Chunhao Huang Guihong Huang Hanxiong Huang Qinhua Huang Wenhao Huang Xingtao Huang Yongbo Huang Jiaqi Hui Wenju Huo Cédric Huss Safeer Hussain Antonio Insolia Ara Ioannisian Daniel Ioannisyan Roberto Isocrate Kuo-Lun Jen Xiaolu Ji Xingzhao Ji Huihui Jia Junji Jia Siyu Jian Di Jiang Xiaoshan Jiang Ruyi Jin Xiaoping Jing Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Kampmann Li Kang Michael Karagounis Narine Kazarian Amir Khan Waseem Khan Khanchai Khosonthongkee Patrick Kinz Denis Korablev Konstantin Kouzakov Alexey Krasnoperov Svetlana Krokhaleva Zinovy Krumshteyn Andre Kruth Nikolay Kutovskiy Pasi Kuusiniemi Tobias Lachenmaier Cecilia Landini Sébastien Leblanc Frederic Lefevre Liping Lei Ruiting Lei Rupert Leitner Jason Leung Demin Li Fei Li Fule Li Haitao Li Huiling Li Jiaqi Li Jin Li Kaijie Li Mengzhao Li Nan Li Nan Li Qingjiang Li Ruhui Li Shanfeng Li Shuaijie Li Tao Li Weidong Li Weiguo Li Xiaomei Li Xiaonan Li Xinglong Li Yi Li Yufeng Li Zhibing Li Ziyuan Li Hao Liang Hao Liang Jingjing Liang Jiajun Liao Daniel Liebau Ayut Limphirat Sukit Limpijumnong Guey-Lin Lin Shengxin Lin Tao Lin Jiajie Ling Ivano Lippi Fang Liu Haidong Liu Hongbang Liu Hongjuan Liu Hongtao Liu Hu Liu Hui Liu Jianglai Liu Jinchang Liu Min Liu Qian Liu Qin Liu Runxuan Liu Shuangyu Liu Shubin Liu Shulin Liu Xiaowei Liu Yan Liu Alexey Lokhov Paolo Lombardi Claudio Lombardo Kai Loo Chuan Lu Haoqi Lu Jingbin Lu Junguang Lu Shuxiang Lu Xiaoxu Lu Bayarto Lubsandorzhiev Sultim Lubsandorzhiev Livia Ludhova Fengjiao Luo Guang Luo Pengwei Luo Shu Luo Wuming Luo Vladimir Lyashuk Qiumei Ma Si Ma Xiaoyan Ma Xubo Ma Jihane Maalmi Yury Malyshkin Fabio Mantovani Francesco Manzali Xin Mao Yajun Mao Stefano MMari Filippo Marini Sadia Marium Cristina Martellini Gisele Martin-Chassard Agnese Martini Davit Mayilyan Axel Müller Ints Mednieks Yue Meng Anselmo Meregaglia Emanuela Meroni David Meyhöfer Mauro Mezzetto Jonathan Miller Lino Miramonti Salvatore Monforte Paolo Montini Michele Montuschi Nikolay Morozov Pavithra Muralidharan Massimiliano Nastasi Dmitry VNaumov Elena Naumova Igor Nemchenok Alexey Nikolaev Feipeng Ning Zhe Ning Hiroshi Nunokawa Lothar Oberauer Juan Pedro Ochoa-Ricoux Alexander Olshevskiy Domizia Orestano Fausto Ortica Hsiao-Ru Pan Alessandro Paoloni Nina Parkalian Sergio Parmeggiano Teerapat Payupol Yatian Pei Nicomede Pelliccia Anguo Peng Haiping Peng Frédéric Perrot Pierre-Alexandre Petitjean Fabrizio Petrucci Luis Felipe Piñeres Rico Oliver Pilarczyk Artyom Popov Pascal Poussot Wathan Pratumwan Ezio Previtali Fazhi Qi Ming Qi Sen Qian Xiaohui Qian Hao Qiao Zhonghua Qin Shoukang Qiu Muhammad Rajput Gioacchino Ranucci Neill Raper Alessandra Re Henning Rebber Abdel Rebii Bin Ren Jie Ren Taras Rezinko Barbara Ricci Markus Robens Mathieu Roche Narongkiat Rodphai Aldo Romani Bedřich Roskovec Christian Roth Xiangdong Ruan Xichao Ruan Saroj Rujirawat Arseniy Rybnikov Andrey Sadovsky Paolo Saggese Giuseppe Salamanna Simone Sanfilippo Anut Sangka Nuanwan Sanguansak Utane Sawangwit Julia Sawatzki Fatma Sawy Michaela Schever Jacky Schuler Cédric Schwab Konstantin Schweizer Dmitry Selivanov Alexandr Selyunin Andrea Serafini Giulio Settanta Mariangela Settimo Muhammad Shahzad Vladislav Sharov Gang Shi Jingyan Shi Yongjiu Shi Vitaly Shutov Andrey Sidorenkov FedorŠimkovic Chiara Sirignano Jaruchit Siripak Monica Sisti Maciej Slupecki Mikhail Smirnov Oleg Smirnov Thiago Sogo-Bezerra Julanan Songwadhana Boonrucksar Soonthornthum Albert Sotnikov Ondrej Sramek Warintorn Sreethawong Achim Stahl Luca Stanco Konstantin Stankevich DušanŠtefánik Hans Steiger Jochen Steinmann Tobias Sterr Matthias Raphael Stock Virginia Strati Alexander Studenikin Gongxing Sun Shifeng Sun Xilei Sun Yongjie Sun Yongzhao Sun Narumon Suwonjandee Michal Szelezniak Jian Tang Qiang Tang Quan Tang Xiao Tang Alexander Tietzsch Igor Tkachev Tomas Tmej Konstantin Treskov Andrea Triossi Giancarlo Troni Wladyslaw Trzaska Cristina Tuve Stefan van Waasen Johannes van den Boom Guillaume Vanroyen Nikolaos Vassilopoulos Vadim Vedin Giuseppe Verde Maxim Vialkov Benoit Viaud Cristina Volpe Vit Vorobel Lucia Votano Pablo Walker Caishen Wang Chung-Hsiang Wang En Wang Guoli Wang Jian Wang Jun Wang Kunyu Wang Lu Wang Meifen Wang Meng Wang Ruiguang Wang Siguang Wang Wei Wang Wenshuai Wang Xi Wang Xiangyue Wang Yangfu Wang Yaoguang Wang Yi Wang Yifang Wang Yuanqing Wang Yuman Wang Zhe Wang Zheng Wang Zhimin Wang Zongyi Wang Apimook Watcharangkool Lianghong Wei Wei Wei Yadong Wei Liangjian Wen Christopher Wiebusch Steven Chan-Fai Wong Bjoern Wonsak Diru Wu Fangliang Wu Qun Wu Wenjie Wu Zhi Wu Michael Wurm Jacques Wurtz Christian Wysotzki Yufei Xi Dongmei Xia Yuguang Xie Zhangquan Xie Zhizhong Xing Benda Xu Donglian Xu Fanrong Xu Jilei Xu Jing Xu Meihang Xu Yin Xu Yu Xu Baojun Yan Xiongbo Yan Yupeng Yan Anbo Yang Changgen Yang Huan Yang Jie Yang Lei Yang Xiaoyu Yang Yifan Yang Haifeng Yao Zafar Yasin Jiaxuan Ye Mei Ye Ugur Yegin Frédéric Yermia Peihuai Yi Xiangwei Yin Zhengyun You Boxiang Yu Chiye Yu Chunxu Yu Hongzhao Yu Miao Yu Xianghui Yu Zeyuan Yu Chengzhuo Yuan Ying Yuan Zhenxiong Yuan Ziyi Yuan Baobiao Yue Noman Zafar Andre Zambanini Pan Zeng Shan Zeng Tingxuan Zeng Yuda Zeng Liang Zhan Feiyang Zhang Guoqing Zhang Haiqiong Zhang Honghao Zhang Jiawen Zhang Jie Zhang Jingbo Zhang Peng Zhang Qingmin Zhang Shiqi Zhang Tao Zhang Xiaomei Zhang Xuantong Zhang Yan Zhang Yinhong Zhang Yiyu Zhang Yongpeng Zhang Yuanyuan Zhang Yumei Zhang Zhenyu Zhang Zhijian Zhang Fengyi Zhao Jie Zhao Rong Zhao Shujun Zhao Tianchi Zhao Dongqin Zheng Hua Zheng Minshan Zheng Yangheng Zheng Weirong Zhong Jing Zhou Li Zhou Nan Zhou Shun Zhou Xiang Zhou Jiang Zhu Kejun Zhu Honglin Zhuang Liang Zong Jiaheng Zou | 2021 | Chinese Physics C2021，45，2： | 0 |
| 8 | Improving antibody affinity through in vitro mutagenesis in complementarity determining regions显示文摘High-affinity antibodies are widely used in diagnostics and for the treatment of human diseases.However,most antibodies are isolated from semi-synthetic libraries by phage display and do not possess in vivo affinity maturation,which is triggered by antigen immunization.It is therefore necessary to engineer the affinity of these antibodies by way of in vitro assaying.In this study,we optimized the affinity of two human monoclonal antibodies which were isolated by phage display in a previous related study.For the 42A1 antibody,which targets the liver cancer antigen glypican-3,the variant T57H in the second complementarity-determining region of the heavy chain(CDR-H2)exhibited a 2.6-fold improvement in affinity,as well as enhanced cell-binding activity.For the I4A3 antibody to severe acute respiratory syndrome coronavirus 2,beneficial single mutations in CDR-H2 and CDR-H3 were randomly combined to select the best synergistic mutations.Among these,the mutation S53P-S98T improved binding affinity(about 3.7 fold)and the neutralizing activity(about 12 fold)compared to the parent antibody.Taken together,single mutations of key residues in antibody CDRs were enough to increase binding affinity with improved antibody functions.The mutagenic combination of key residues in different CDRs creates additive enhancements.Therefore,this study provides a safe and effective in vitro strategy for optimizing antibody affinity. | Wei Ye Xiaoyu Liu Ruiting He Liming Gou Ming Lu Gang Yang Jiaqi Wen Xufei Wang Fang Liu Sujuan Ma Weifeng Qian Shaochang Jia Tong Ding Luan Sun Wei Gao | 2022 | The Journal of Biomedical Research2022，36，3： | 0 |
| 9 | GEOCHEMICAL CHARACTERISTICS OF PLATINUM GROUP ELEMENTS IN JINCHUAN SUPER-LARGE SULFIDE COPPER-NICKEL DEPOSIT, JINCHANG CITY, GANSU PROVINCE, CHINA显示文摘The platinum-group element geochemistry of rocks and ores from Jinchuan super-large copper-nickel sulfide deposit is systemically studied in this paper. The Cu/Pd mean ratio of Jinchuan intrusion is lower than that of original mantle magma, which indicates that these ultrabasic rocks were crystallized from magma that lost Pd in the form of melting segregation of sulfides. The PGE of the rocks show trend of partial melting, similar to that of mantle peridotite, which shows that magma formation occurs during rock-forming and ore-forming processes. The chondrite normalized PGE patterns of the rocks and ores are well related to each other, which signifies the signatures of multi-episode magmatic intrusion, melting and differentiation in the formation processes of rocks and ores. In addition, analyses about the relation between PGE and S, and study on Re-Os isotopes indicate that few contamination of the crustal substances occurred during the magmatic intrusion and the formation of deposit. However, contamination by crustal substances helps to supply part of the S for the enrichment of PGE. Meanwhile, the hydrothermal process is also advantageous for the enrichment of PGE, especially for Pt and Pd, due to deep melting segregation. The characteristic parameters (such as Pt/(Pt+Pd), (Pt+Pd)/(Ru+Ir+Os), Pd/Ir, Cu/(Ni+Cu), and so on.) for platinum-group elements for Jinchuan sulfide copper-nickel deposit show the same features as those for sulfide copper-nickel deposit related to basic magma, which also illustrates its original magma propertyrepresentative of Mg-high tholeiite. Therefore, it is the mafic (not ultramafic) magma that resulted in the formation of the superlarge sulfide copper-nickel deposit enriched in Cu and PGE. To sum up, the geochemical characteristics of platinum-group elements in rocks and ores from Jinchuan copper-nickel sulfide deposit are constrained by the continental rift tectonic environment, the parent magma features, the enriched mantel magma source, the complex metallogenesis and PGE geochemical signatures, and this would be rather significant for the study about the genetic mechanism of copper-nickel sulfide deposits. | WANG Ruiting MAO Jingwen HE Ying WANG Dongsheng TANG Zhongli | 2005 | Geotectonica et Metallogenia2005，29，2： | 0 |
| 10 | General Situation of Traditional Chinese Medicine Identification Methods显示文摘Traditional Chinese medicines are the material basis for the treatment of diseases under theoretical direction,as well as the raw materials of traditional Chinese medicine decoction pieces and Chinese patent medicines. The quality of traditional Chinese medicine directly influences clinical efficacy. Therefore,the identification of traditional Chinese medicine is the responsibility of medicinal workers. The identification method develops from observation,tasting,smelling and listening to firing method and testing with water,and the construction of fingerprints of traditional Chinese medicines and molecular biological techniques. The development and evolution of traditional Chinese medicine identification methods was reviewed in this paper. | Peng LI Pingfeng LI Liuyuan FAN Miao ZHANG Ruiting HE Hua ZHU | 2018 | Agricultural Biotechnology2018，7，1： | 0 |
| 11 | Structure design and load test of the small prototype for the JUNO Central Detector显示文摘Introduction The structure of the Jiangmen Underground Neutrino Observatory(JUNO)CentralDetector(CD)was designed using finite element methods(FEM).The structure of the small JUNOCDprototypewas also designed using the same structural scheme and method as those of the CD,and the load test was carried out after the accomplishment of structure design and manufacturing.Methods The load test can help verify the performance and reliability of the mechanical monitoring system and liquid filling system of the CD,verify the consistency of FEM calculations and axial force measurement results of the sensors,and accumulate experience for the installation of the connecting bars.Conclusion The measurement scheme was considered and determined,and the connecting bars’axial forces under different liquid filling conditions were measured and compared with the FEM results,the consistencies of which were good.The mechanical monitoring system and liquid filling system of theCDwere verified during the load test,which met the requirements of design and experiment. | Xiaoyu Yang Yuekun Heng Wei He Xiaoyan Ma Lei Yang Jiajie Ling Zhi Wu Kaixi Huang Caishen Wang Ruiting Lei Yatian Pei Xiaohui Qian | 2022 | Radiation Detection Technology and Methods2022，6，4： | 0 |
| 12 | Modulation of Antiviral Immunity and Therapeutic Efficacy by 25-Hydroxycholesterol in Chronically SIV-Infected, ART-Treated Rhesus Macaques显示文摘Cholesterol-25-hydroxylase(CH25 H)and its enzymatic product 25-hydroxy cholesterol(25 HC)exert broadly antiviral activity including inhibiting HIV-1 infection.However,their antiviral immunity and therapeutic efficacy in a nonhuman primate model are unknown.Here,we report that the regimen of 25 HC combined with antiretroviral therapy(ART),provides profound immunological modulation towards inhibiting viral replication in chronically SIVmac239-infected rhesus macaques(RMs).Compared to the ART alone,this regimen more effectively controlled SIV replication,enhanced SIVspecific cellular immune responses,restored the ratio of CD4/CD8 cells,reversed the hyperactivation state of CD4^(+)T cells,and inhibited the secretion of proinflammatory cytokines by CD4^(^(+))and CD8^(+)T lymphocytes in chronically SIVinfected RMs.Furthermore,the in vivo safety and the preliminary pharmacokinetics of the 25 HC compound were assessed in this RM model.Taken together,these assessments help explain the profound relationship between cholesterol metabolism,immune modulation,and antiviral activities by 25 HC.These results provide insight for developing novel therapeutic drug candidates against HIV-1 infection and other related diseases. | Chunxiu Wu Jin Zhao Ruiting Li Fengling Feng Yizi He Yanjun Li Runhan Huang Guangye Li Heng Yang Genhong Cheng Ling Chen Feng Ma Pingchao Li Caijun Sun | 2021 | Virologica Sinica2021，36，5： | 0 |
| 13 | A novel and effective hyperthermia method for Schistosomiasis japonica prevention and treatment显示文摘The emerging resistance to schistosoma has been paid much attention and is in urgent need for a novel strategy to control the prevalent parasitic zoonosis. In this study, the efficiency of hyperthermia therapy was investigated by the skin hyperthermia device. The survival rate of cercariae decreased from 68.15 %(37 °C, 5 min) to 0(49 °C, 10 min) with the thermal dosages increased, which proved the preventing effect of hyperthermia therapy(P \ 0.05). Therapeutic effects were assessed in Schistosoma japonicum-infected BALB/c mice. When the cercarial contact region of the skin was treated at 45–49 °C for5 min within 8 h of infection, worm reduction rate(WRR)reached 74 %–83 %(P \ 0.01). The sensitivity of adultschistosoma to heat was also investigated using microwave intraperitoneal hyperthermia(thermal dosages 42–43 °C,20 min). The WRR, hepatic shift rates and egg reduction rates were 23.7 %, 40 % and 30 %, respectively, comparing with 80.2 %, 59.6 % and 53.9 % of praziquantel(PZQ)-treated group. Encouraging results have been obtained that hyperthermia can effectively kill schistosomula, especially with the appearance of cercarial dermatitis, while PZQ lacks efficacy against the cercariae. Thus,hyperthermia therapy would show significant benefit in preventing and treatment of schistosoma, especially in the early stage. | Huixia Yang Tao Tang Pei He Youren Zhang Le Xie Guangqi Liu Li Li Weichao Kong Jingdingsha Li Ruiting Liu Yukun Li Junjian Hu Xiaowen Wang Liya Li Guanghong Xiang Geoffrey Gobert Yuesheng Li Jintian Tang | 2015 | Science Bulletin2015，60，16： | 0 |
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