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| 1 | CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development显示文摘Angiogenesis,最新形成的血容器从先存在发芽的一个过程,为脊椎动物开发和成年动态平衡是重要的。以前的研究证明了 neuronal 指导分子 netrin-1 参予脉管的系统的 angiogenesis 和形态发生。Netrin-1 在 angiogenesis 展出双活动:支持或禁止 angiogenesis。netrin-1 的 anti-angiogenic 活动被 UNC5B 受体调停。然而, netrin-1 怎么支持 angiogenesis,仍然保持不清楚。这里,我们报导那 CD146,免疫球蛋白总科的 endothelial transmembrane 蛋白质,是为 netrin-1 的受体。Netrin-1 与高亲密关系绑在 CD146,导致 endothelial 房间激活并且以一种 CD146 依赖的方式的下游的发信号。在由特定的 anti-CD146 抗体的 netrin-CD146 相互作用的鼠科的内皮细胞层或混乱的 cd146 基因的有条件的大美人堵住或减少 netrin-1-induced angiogenesis。在 zebrafish 胚胎, downregulating 任何一个 netrin-1a 或 CD146 与惹人注目的类似导致脉管的缺点。而且,将宫外的脉管的发芽由 netrin-1 overexpression 导致了的 CD146 块击倒。一起,我们的数据揭开 CD146 在 angiogenesis 为 CD146 作为为 netrin-1 并且也的以前未知的受体揭示功能的 ligand,表明在脊椎动物开发期间在 angiogenesis 发信号的 netrin-CD146 的参与。 | Tao Tu Chunxia Zhang Huiwen Yan Yongting Luo Ruirui Kong Pushuai Wen Zhongde Ye Jianan Chen Jing Feng Feng Liu Jane Y Wu Xiyun Yan | 2015 | Cell Research2015，25，3： | 23 |
| 2 | UWB Channel Modeling and Simulation with Continuous Frequency Response显示文摘Ultra-wideband(UWB)technology is a prospective technology for high-rate transmission and accurate localization in the future communication systems.State-of-art channel modeling approaches usually divide the UWB channel into several sub-band channels and model them independently.By considering frequency-dependent channel parameters,a novel analytical UWB channel model with continuous frequency response is proposed.The composite effect of all frequency components within the UWB channel on the channel impulse response(CIR)of delay domain is derived based on the continuous channel transfer function(CTF)of frequency domain.On this basis,a closed-form simulation model for UWB channels and geometry-based parameter calculation method are developed,which can guarantee the continuity of channel characteristics on the frequency domain and greatly reduce the simulation complexity.Finally,the proposed method is applied to generate UWB channel with 2 GHz bandwidth at sub-6GHz and millimeter wave(mmWave)bands,respectively.The channel measurements are also carried out to validate the proposed method.The simulated CIR and power gain are shown to be in good agreement with the measurement data.Moreover,the comparison results of power gain and Doppler power spectral density(DPSD)show that the proposed UWB channel model Received:Apr.23,2022 Revised:Jun.09,2022 Editor:Wei Fan achieves a good balance between the simulation accuracy and efficiency. | Kai Mao Qiuming Zhu Xijuan Ye Ruirui Feng Fuqiao Duan Yang Miao Maozhong Song | 2022 | China Communications2022，19，11： | 3 |
| 3 | Stability,acidity and interaction properties of [Bmim][SbF_6] coupled with concentrated sulfuric acid显示文摘Ionic liquid coupled with strong acid systems presents considerable promise in some catalytic fields.In the present work,the multiple complex systems composed by 98 wt%concentrated sulfuric acid and[Bmim][SbF_6]were investigated in the terms of stability,acidity and interaction properties.It was found that acidolysis of[Bmim][SbF_6]occurred in the 98 wt%concentrated sulfuric acid accompanied by HF releasing and SbF_6~ degrading to[SbF_(6-y)XHSO_4]_y]^-.The species after acidolysis in the multiple complex systems were checked and confirmed by electrospray ionization mass spectrometry(ESI-MS),Fourier transform infrared spectroscopy(FT-IR),~1H NMR and ^(19)F NMR.Acidity increased slightly with less than 1 wt%[Bmim][SbF_6]addition,while decreased with more proportion,which was determined based on the Hammett acidity functions H_0,using ^(13)C NMR.The strong hydrogen bond S-O-H…F of interaction among the multiple complex systems was confirmed by molecular dynamic simulation. | Honghua Zhang Ruixia Liu Ruirui Zhang Feng Huo Zhiqiang Yang Bin He Suojiang Zhang Yanji Wang | 2017 | Science China Chemistry2017，60，9： | 2 |
| 4 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 5 | The breakthrough in primary human hepatocytes in vitro expansion显示文摘Introduction As one of the most frequently diagnosed devastating diseases, liver failure is responsible for approximately two million deaths annually worldwide with poor prognosis1. Although liver transplantation has been developed for the most effective treatment for liver failure, it is far from demands for patients due to the shortage of high-quality donor livers and expensive treatment costs. Currently, with the development of cell therapy, cell transplantations including primary human hepatocytes (PHHs), human hepatocyte-like cells (HLCs) and liver organoids are emerging as great potential tools to alleviate this growing burden. | Mei Feng Ruirui Kong Yisheng Pan | 2019 | Cancer Biology & Medicine2019，16，1： | 1 |
| 6 | DOCK2 regulates antifungal immunity by regulating RAC GTPase activity显示文摘Fungal infections cause~1.5 million deaths each year worldwide,and the mortality rate of disseminated candidiasis currently exceeds that of breast cancer and malaria.The major reasons for the high mortality of candidiasis are the limited number of antifungal drugs and the emergence of drug-resistant species.Therefore,a better understanding of antifungal host defense mechanisms is crucial for the development of effective preventive and therapeutic strategies.Here,we report that DOCK2(dedicator of cytokinesis 2)promotes indispensable antifungal innate immune signaling and proinflammatory gene expression in macrophages.DOCK2-deficient macrophages exhibit decreased RAC GTPase(Rac family small GTPase)activation and ROS(reactive oxygen species)production,which in turn attenuates the killing of intracellular fungi and the activation of downstream signaling pathways.Mechanistically,after fungal stimulation,activated SYK(spleen-associated tyrosine kinase)phosphorylates DOCK2 at tyrosine 985 and 1405,which promotes the recruitment and activation of RAC GTPases and then increases ROS production and downstream signaling activation.Importantly,nanoparticle-mediated delivery of in vitro transcribed(IVT)Rac1 mRNA promotes the activity of Rac1 and helps to eliminate fungal infection in vivo.Taken together,this study not only identifies a critical role of DOCK2 in antifungal immunity via regulation of RAC GTPase activity but also provides proof of concept for the treatment of invasive fungal infections by using IVT mRNA. | Xiaojian Ma Xi Tan Bingbing Yu Wanwei Sun Heping Wang Huijun Hu Yanyun Du Ruirui He Ru Gao Qianwen Peng Zhihui Cui Ting Pan Xiong Feng Junhan Wang Chengqi Xu Bin Zhu Wei Liu Chenhui Wang | 2022 | Cellular & Molecular Immunology2022，19，5： | 1 |
| 7 | Detector development at the Back-n white neutron source显示文摘Purpose Back-n is a white neutron beamline at China spallation neutron source,which was established in the year of 2018.It is a powerful facility for nuclear data measurement,neutron detector calibration,and radiation effect research.Method A series of detectors were built for different experiments,including beam monitoring,beam profile measurement,neutron induced secondaries(fission fragments,light charged particles and gamma)cross section measurement,and neutron resonance radiography,etc.A common digitization electronics and a cluster-based DAQ were developed for these detector systems.Most detectors have been employed at Back-n and serviced for experiments from the beginning of the beamline running.Results and conclusion As an overview of detectors of Back-n,the details of the detector design and the experiment performing are described in this paper.Some developing systems,e.g.,MTPC and B-MCP,are also included. | Fan Ruirui Li Qiang Bao Jie Li Yang Liu Rong Jiang Wei Ren Jie Zhang Qiwei Cao Ping Gu Minhao Ren Zhizhou Yi Han Tang Jingyu An Qi Bai Haofan Bai Jiangbo Chen Qiping Chen Yonghao Chen Zhen Cui Zengqi Fan Anchuan Feng Changqing Feng Fanzhen Gao Keqing Han Changcai Han Zijie He Guozhu He Yongcheng Hong Yang Hu Yiwei Huang Hanxiong Jia Weihua Jiang Haoyu Jiang Zhijie Jin Zhengyao Kang Ling Li Bo Li Chao Li Gong Li Jiawen Li Xiao Liu Jie Liu Shubin Luan Guangyuan Ning Changjun Qi Binbin Ruan Xichao Song Zhaohui Sun Kang Tan Zhixin Tang Shengda Wang Pengcheng Wang Zhaohui Wen Zhongwei Wu Xiaoguang Wu Xuan Xie Likun Yang Yiwei Yu Yongji Zhang Guohui Zhang Linhao Zhang Mohan Zhang Xianpeng Zhang Yuliang Zhang Yue Zhang Zhiyong Zhao Maoyuan Zhou Luping Zhou Zhihao Zhu Kejun The CSNS Back-n Collaboration | 2023 | Radiation Detection Technology and Methods2023，7，2： | 0 |
| 8 | Construction of Human Digital Twin Model Based on Multimodal Data and Its Application in Locomotion Mode Identifcation显示文摘With the increasing attention to the state and role of people in intelligent manufacturing, there is a strong demand for human-cyber-physical systems (HCPS) that focus on human-robot interaction. The existing intelligent manufacturing system cannot satisfy efcient human-robot collaborative work. However, unlike machines equipped with sensors, human characteristic information is difcult to be perceived and digitized instantly. In view of the high complexity and uncertainty of the human body, this paper proposes a framework for building a human digital twin (HDT) model based on multimodal data and expounds on the key technologies. Data acquisition system is built to dynamically acquire and update the body state data and physiological data of the human body and realize the digital expression of multi-source heterogeneous human body information. A bidirectional long short-term memory and convolutional neural network (BiLSTM-CNN) based network is devised to fuse multimodal human data and extract the spatiotemporal features, and the human locomotion mode identifcation is taken as an application case. A series of optimization experiments are carried out to improve the performance of the proposed BiLSTM-CNN-based network model. The proposed model is compared with traditional locomotion mode identifcation models. The experimental results proved the superiority of the HDT framework for human locomotion mode identifcation. | Ruirui Zhong Bingtao Hu Yixiong Feng Hao Zheng Zhaoxi Hong Shanhe Lou Jianrong Tan | 2023 | Chinese Journal of Mechanical Engineering2023，36，5： | 0 |
| 9 | Real-time ray-based channel generation and emulation for UAV communications显示文摘A real-time ray-based hardware emulator for Unmanned Aerial Vehicle(UAV) communication channels which suits for the Three-Dimensional(3D) dynamic scenarios and considers the movements of both terminals is developed in this paper. The time-variant channel parameters, i.e.,ray delay, ray gain, and ray Doppler frequency are precalculated in the host by using the Ray Tracing(RT) method. Meanwhile, RT simulation dramatically increases the number of valid rays. To address the problem of resource limitation and huge computational burden in the implementation,an efficient ray coefficients generation method based on iteration is proposed and implemented.With the advantages of low cost and high flexibility, a Software Defined Radio(SDR) hardware platform is used to emulate the ray-based UAV channels by utilizing the compact architecture including the Time-Division(TD) scheme and Tapped-Delay Line(TDL) for channel convolution.Finally, hardware measurement results demonstrate that the properties of emulated channel, i.e.,Power Delay Profile(PDP) and Doppler Power Spectrum Density(DPSD) consist with the simulated ones, which verifies the correctness of hardware implementation. The proposed channel emulator provides an efficient way for optimization, verification, and evaluation of UAV communication systems. | Yang YANG Tingpeng LI Xiaomin CHEN Manxi WANG Qiuming ZHU Ruirui FENG Fuqiao DUAN Taotao ZHANG | 2022 | Chinese Journal of Aeronautics2022，35，9： | 0 |
| 10 | Identification of Mucilage Cavity as a Significant Microscopic Characteristic Existing in Phloem Instead of Pith of Radix et Rhizoma Rhei显示文摘根值 et 根茎 Rhei 的词法、显微镜的特征被学习。学习证实粘液洞确实在根茎和根或反常的脉管的捆的韧皮部存在。另外,他们在在根值 et 根茎 Rhei 的三种的类似的分发。为显微镜的鉴定的诊断特征被发现是在在所有三种的根茎的木髓的反常的脉管的捆的类似的分发。并且粗略的药的外观改变了比在种类差别上收集当场取决于植物的地理起源和不同初步的处理的更多。我们的调查结果,到目前为止没在以前的报告清楚地被描出,对在不同文学或标准澄清当前的描述有用并且在根值 et 根茎 Rhei 的显微镜、宏观的鉴定上做完整的理解。 | TANG Jun FENG Yibin TONG Yao JIA Ruirui SY Laiking R. Y. K. Man | 2008 | Wuhan University Journal of Natural Sciences2008，13，2： | 0 |
| 11 | Therapy of Primary Liver Cancer显示文摘Primary liver cancer(PLC)is a fatal disease that affects millions of lives worldwide.PLC is the leading cause of cancer-related deaths and the incidence rate is predicted to rise in the coming decades.PLC can be categorized into three major histological subtypes:hepatocellular carcinoma(HCC),intrahepatic cholangiocarcinoma(ICC),and combined HCC-ICC.These subtypes are distinct with respect to epidemiology,clinicopathological features,genetic alterations,and clinical managements,which are thoroughly summarized in this review.The state of treatment strategies for each subtype,including the currently approved drugs and the potential novel therapies,are also discussed. | Mei Feng Yisheng Pan Ruirui Kong Shaokun Shu | 2020 | The Innovation2020，1，2： | 0 |
| 12 | Neutrophils as key regulators of tumor immunity that restrict immune checkpoint blockade in liver cancer显示文摘Objective:Liver cancer is a deadly malignancy associated with high mortality and morbidity.Less than 20%of patients with advanced liver cancer respond to a single anti-PD-1 treatment.The high heterogeneity of neutrophils in the tumor immune microenvironment in liver cancer may contribute to resistance to immune checkpoint blockade(ICB).However,the underlying mechanism remains largely unknown.Methods:We established an orthotopic liver cancer model by using transposable elements to integrate the oncogenes Myc and KrasG12Dinto the genome in liver cells from conditional Trp53 null/null mice(pTMK/Trp53^(-/-)).Flow cytometry and immunohistochemistry were used to assess the changes in immune cells in the tumor microenvironment.An ex vivo coculture assay was performed to test the inhibitory effects of tumor-associated neutrophils(TANs)on CD8^(+)T cells.The roles of neutrophils,T cells,and NK cells were validated through antibody-mediated depletion.The efficacy of the combination of neutrophil depletion and ICB was evaluated.Results:Orthotropic pTMK/Trp53^(-/-)mouse liver tumors displayed a moderate response to anti-Ly6G treatment but not PD-1 blockade.Depletion of neutrophils increased the infiltration of CD8^(+)T cells and decreased the number of exhausted T cells in the tumor microenvironment.Furthermore,depletion of either CD8^(+)T or NK cells abrogated the antitumor efficacy of anti-Ly6G treatment.Moreover,the combination of anti-Ly6G with anti-PD-L1 enhanced the infiltration of cytotoxic CD8^(+)T cells and thereafter resulted in a significantly greater decrease in tumor burden.Conclusions:Our data suggest that TANs may contribute to the resistance of liver cancer to ICB,and combining TAN depletion with T cell immunotherapy synergistically increases antitumor efficacy. | Mei Feng Fangyanni Wang Xinyu Liu Tingting Hao Ning Zhang Mi Deng Yisheng Pan Ruirui Kong | 2023 | Cancer Biology & Medicine2023，20，6： | 0 |
| 13 | Correlation of PCSK1 with nonalcoholic fatty liver disease in a Han Chinese population:a case-control observational study显示文摘Objective: This study aimed to investigate the association between single-nucleotide polymorphisms (SNPs) ofPCSK1 (proprotein convertase subtilisin/kexin type 1) related to obesity and nonalcoholic fatty liver disease (NAFLD).Methods: In this case-control observational study, four candidate SNPs (rs6234, rs155971, rs6232, rs3811951) ofPCSK1 were genotyped in 732 NAFLD patients and 823 healthy control participants, all of whom were of ethnic Han Chinese descent. All participants came from Shanghai, China, and joined our study during 2015 to 2016. The frequencies of each allele and genotype, paired linkage disequilibrium, and haplotype were calculated on the SHEsis platform. In addition to SHEsis, five different genetic models (codominant, dominant, recessive, overdominant, and log-additive) were employed to identify the correlation between genotype frequency and NAFLD. This study was approved by the Medical Ethics Committee of Shanghai University of Traditional Chinese Medicine (approved No. 2017LCSY069).Results: In a comparison of NAFLD patients and healthy participants, none of the fourPCSK1 SNPs were significantly correlated with the occurrence of NAFLD (P>0.05), in either genotypic or allelic distribution. The recessive model of rs3811951 appeared to show a correlation (odds ratio=1.077;95% confidence interval=0.924-1.256;P=0.04), but there was no statistical significance after Bonferroni correction (Pcorr>0.0125).Conclusions: Four obesity-relatedPCSK1 SNPs (rs6234, rs155971, rs6232, rs3811951) showed no significant correlation with the development of NAFLD in a Han Chinese population. | Xiao Yang Fan Yuan Na Wu Decheng Ren Liangjie Liu Yan Bi Lei Ji Ke Han Mofan Feng Kai Su Fengping Yang Xi Wu Qing Lu Siran Yue Fengyan Jiang Ruirui Wang Guang He Baocheng Liu Xingwang Li Yi Shi | 2022 | Journal of Bio-X Research2022，5，3： | 0 |
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