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| 1 | Myelin Oligodendrocyte Glycoprotein-IgG Contributes to Oligodendrocytopathy in the Presence of Complement, Distinct from Astrocytopathy Induced by AQP4-IgG显示文摘Immunoglobulin G against myelin oligodendrocyte glycoprotein(MOG-Ig G) is detectable in neuromyelitis optica spectrum disorder(NMOSD) without aquaporin-4 Ig G(AQP4-Ig G), but its pathogenicity remains unclear.In this study, we explored the pathogenic mechanisms of MOG-Ig G in vitro and in vivo and compared them with those of AQP4-Ig G. MOG-Ig G-positive serum induced complement activation and cell death in human embryonic kidney(HEK)-293 T cells transfected with human MOG. In C57 BL/6 mice and Sprague-Dawley rats, MOG-Ig G only caused lesions in the presence of complement. Interestingly, AQP4-Ig G induced astroglial damage, while MOGIg G mainly caused myelin loss. MOG-Ig G also induced astrocyte damage in mouse brains in the presence ofcomplement. Importantly, we also observed ultrastructural changes induced by MOG-Ig G and AQP4-Ig G. These findings suggest that MOG-Ig G directly mediates cell death by activating complement in vitro and producing NMOSDlike lesions in vivo. AQP4-Ig G directly targets astrocytes,while MOG-Ig G mainly damages oligodendrocytes. | Ling Fang Xinmei Kang Zhen Wang Shisi Wang Jingqi Wang Yifan Zhou Chen Chen Xiaobo Sun Yaping Yan Allan G. Kermode Lisheng Peng Wei Qiu | 2019 | Neuroscience Bulletin2019，35，5： | 13 |
| 2 | X-ray image characteristics and related measurements in the ankles of 118 adult patients with Kashin-Beck disease显示文摘 | Zeng Yi Zhou Zongke Shen Bin Yang Jing Kang Pengde Zhou Xuan Zou Ling Pei Fuxing | 2014 | Chinese Medical Journal2014，，13： | 13 |
| 3 | Exosome-functionalized magnesium-organic framework-based scaffoldswith osteogenic, angiogenic and anti-inflammatory properties foraccelerated bone regeneration显示文摘Exosomes derived from human adipose-derived stem cells (hADSCs-Exos) have shown potential as an effectivetherapeutic tool for repairing bone defects. Although metal-organic framework (MOF) scaffolds are promisingstrategies for bone tissue regeneration, their potential use for exosome loading remains unexplored. In this study,motivated by the potential advantages of hADSCs-Exos and Mg-GA MOF, we designed and synthesized anexosome-functionalized cell-free PLGA/Mg-GA MOF (PLGA/Exo-Mg-GA MOF) scaffold, taking using of thebenefits of hADSCs-Exos, Mg2+, and gallic acid (GA) to construct unique nanostructural interfaces to enhanceosteogenic, angiogenic and anti-inflammatory capabilities simultaneously. Our in vitro work demonstrated thebeneficial effects of PLGA/Exo-Mg-GA MOF composite scaffolds on the osteogenic effects in human bonemarrow-derived mesenchymal stem cells (hBMSCs) and angiogenic effects in human umbilical endothelial cells(HUVECs). Slowly released hADSCs-Exos from composite scaffolds were phagocytosed by co-cultured cells,stabilized the bone graft environment, ensured blood supply, promoted osteogenic differentiation, and acceleratedbone reconstruction. Furthermore, our in vivo experiments with rat calvarial defect model showed thatPLGA/Exo-Mg-GA MOF scaffolds promoted new bone formation and satisfactory osseointegration. Overall, weprovide valuable new insights for designing exosome-coated nanocomposite scaffolds with enhanced osteogenesisproperty. | Yue Kang Chang Xu Ling’ao Meng Xufeng Dong Min Qi Daqing Jiang | 2022 | Bioactive Materials2022，7，12： | 11 |
| 4 | An efficient rendering method for large vector data on large terrain models显示文摘This paper presents an efficient way to render large-scale vector maps on level-of-detail(LOD) digital elevation models(DEMs).By using the frame buffer and Voronoi diagram,we achieve a rapid simplification of large-scale vector maps while keeping their original topological relationships.With the simplified maps,we establish level-of-detail vector map models.In the detailed level,we use the stencil shadow volume approach to render the map accurately,and in the coarse level we use substitute techniques to render the map approximately yet more quickly.The method proposed in this paper is universally applicable to rendering vector maps on various LOD terrain models,and the overlaying performance is independent of the complexity of underlying terrain surfaces.By use of the view frustum culling and sub-region index techniques,the impact of complexity of vector maps is reduced,and the rendering time is restricted to a certain scope.Thereby,we can achieve seamless and rapid rendering of large-scale vector maps on LOD terrain surfaces. | YANG Ling ZHANG LiQiang KANG ZhiZhong XIAO ZhiQiang PENG JunHuan ZHANG XingMing LIU Liu | 2010 | Science China(Information Sciences)2010，53，6： | 11 |
| 5 | A novel polyaniline/mesoporous carbon nano-composite electrode for asymmetric supercapacitor显示文摘polyaniline/mesoporous 碳(PANI/CMK-3 )nano 合成的一篇小说与用作支持的 mesoporous 碳(CMK-3 ) 被准备。电气化学的不对称的电容器被分别地把合成的 PANI/CMK-3 和 CMK-3 用作积极、否定的电极成功地设计了。结果证明不对称的电容器的分泌物电容能在 5 mA/cm2 的当前的密度和 1.4 V 的房间电压下面到达 87.4 F/g。不对称的电容器的精力密度直到有 206 W/kg 的力量密度的 23.8 Wh/kg。而且,用这 PANI/CMK-3 的 PANI/CMK-3CMK-3 不对称的电容器 nano 合成能快速被激活并且拥有高 chargedischarge 效率。 | Jian Jun Cai Ling Bin Kong Jing Zhang Yong Chun Luo Long Kang | 2010 | Chinese Chemical Letters2010，21，12： | 11 |
| 6 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 7 | Clinical risk score for invasive fungal diseases in patients with hematological malignancies undergoing chemotherapy:China Assessment of Antifungal Therapy in Hematological Diseases (CAESAR) study显示文摘Invasive fungal disease (IFD) is a major infectious complication in patients with hematological malignancies.In this study,we examined 4889 courses of chemotherapy in patients with hematological diseases to establish a training dataset (n=3500) by simple random sampling to develop a weighted risk score for proven or probable IFD through multivariate regression,which included the following variables: male patients,induction chemotherapy for newly diagnosed or relapsed disease,neutropenia,neutropenia longer than 10 days,hypoalbuminemia,central-venous catheter,and history of IFD.The patients were classified into three groups,which had low (0-10,~1.2%),intermediate (11-15,6.4%),and high risk (> 15,17.5%) of IFD.In the validation set (n=1389),the IFD incidences of the groups were ~1.4%,5.0%,and 21.4%.In addition,we demonstrated that antifungal prophylaxis offered no benefits in low-risk patients,whereas benefits were documented in intermediate (2.1% vs.6.6%,P=0.007) and high-risk patients (8.4% vs.23.3%,P=0.007).To make the risk score applicable for clinical settings,a pre-chemo risk score that deleted all unpredictable factors before chemotherapy was established,and it confirmed that anti-fungal prophylaxis was beneficial in patients with intermediate and high risk of IFD.In conclusion,an objective,weighted risk score for IFD was developed,and it may be useful in guiding antifungal prophylaxis. | Ling Wang Ying Wang Jiong Hu Yuqian Sun He Huang Jing Chen Jianyong Li Jun Ma Juan Li Yingmin Liang Jianmin Wang Yan Li Kang Yu Jianda Hu Jie Jin Chun Wang Depei Wu Yang Xiao Xiaojun Huang | 2019 | Frontiers of Medicine2019，13，3： | 10 |
| 8 | Wheat genomic study for genetic improvement of traits in China显示文摘Bread wheat(Triticum aestivum L.)is a major crop that feeds 40%of the world’s population.Over the past several decades,advances in genomics have led to tremendous achievements in understanding the origin and domestication of wheat,and the genetic basis of agronomically important traits,which promote the breeding of elite varieties.In this review,we focus on progress that has been made in genomic research and genetic improvement of traits such as grain yield,end-use traits,flowering regulation,nutrient use efficiency,and biotic and abiotic stress responses,and various breeding strategies that contributed mainly by Chinese scientists.Functional genomic research in wheat is entering a new era with the availability of multiple reference wheat genome assemblies and the development of cutting-edge technologies such as precise genome editing tools,highthroughput phenotyping platforms,sequencing-based cloning strategies,high-efficiency genetic transformation systems,and speed-breeding facilities.These insights will further extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture in China and throughout the world. | Jun Xiao Bao Liu Yingyin Yao Zifeng Guo Haiyan Jia Lingrang Kong Aimin Zhang Wujun Ma Zhongfu Ni Shengbao Xu Fei Lu Yuannian Jiao Wuyun Yang Xuelei Lin Silong Sun Zefu Lu Lifeng Gao Guangyao Zhao Shuanghe Cao Qian Chen Kunpu Zhang Mengcheng Wang Meng Wang Zhaorong Hu Weilong Guo Guoqiang Li Xin Ma Junming Li Fangpu Han Xiangdong Fu Zhengqiang Ma Daowen Wang Xueyong Zhang Hong-Qing Ling Guangmin Xia Yiping Tong Zhiyong Liu Zhonghu He Jizeng Jia Kang Chong | 2022 | Science China(Life Sciences)2022，65，9： | 9 |
| 9 | Planting density affected biomass and grain yield of maize for seed production in an arid region of Northwest China显示文摘Field experiments were conducted from 2012 to 2015 in an arid region of Northwest China to investigate the effects of planting density on plant growth, yield, and water use efficiency(WUE) of maize for seed production. Five planting densities of 6.75, 8.25, 9.75, 11.25 and 12.75 plants/m^2 were conducted in 2012, and a planting density of 14.25 plants/m^2 was added from 2013 to 2015. Through comparison with the Aqua Crop yield model, a modified model was developed to estimate the biomass accumulation and yield under different planting densities using adjustment coefficient for normalized biomass water productivity and harvest index. It was found that the modified yield model had a better performance and could generate results with higher determination coefficient and lower error. The results indicated that higher planting density increased the leaf area index and biomass accumulation, but decreased the biomass accumulation per plant. The total yield increased rapidly as planting density increased to 11.25 plants/m^2, but only a slight increase was observed when the density was greater than 11.25 plants/m^2. The WUE also reached the maximum when planting density was 11.25 plants/m^2, which was the recommended planting density of maize for seed production in Northwest China. | JIANG Xuelian TONG Ling KANG Shaozhong LI Fusheng LI Donghao QIN Yonghui SHI Rongchao LI Jianbing | 2018 | Journal of Arid Land2018，10，2： | 9 |
| 10 | Design and Modeling on Stranded Wires Helical Springs显示文摘A stranded wires helical spring is formed of a multilayer and coaxial strand of several wires twisted together with the same direction of spiral. Compared with the conventional single wire spring, the stranded wires helical spring has the notable predominance in strength, damping and vibration reduction, which is usually used in aircraft engines, automatic weapons, etc. However, due to its complicated structure, the precise computation of its strength and rigidity need be a correct mathematical model, which then will be imported to finite element analysis software for solutions. Equations on solving geometric parameters, such as external diameters of strands and screw pitches of wires, are put forward in the paper. It also proposes a novel methodology on solving geometric parameters and establishing entity models of the stranded wires helical spring, which provides foundation of computing mechanical parameters by FEA. Then mathematical models on the centre line of the strand and the surface curve of each wire, after closing two ends in a spring, are proposed. Finally, geometric parameters are solved in a case study, and a 3D entity model of a spring with 3 layers and 16 wires is established, which has validated the accuracy of the proposed methodology and the 3D entity mathematical model. The method provides a new way to design stranded wire helical spring. | ZHOU Jie WANG Shilong KANG Ling CHEN Tianyi | 2011 | Chinese Journal of Mechanical Engineering2011，24，4： | 8 |
| 11 | Coral reef-like polyanaline nanotubes prepared by a reactive template of manganese oxide for supercapacitor electrode显示文摘由 nanopaticles 组成的珊瑚像礁石的 PANI nanotubes 被锰氧化物的一个反应模板成功地综合。结构被使用 SEM, TEM,和英尺红外描绘,并且这些 nanotubes 的 supercapacitive 行为与周期的 voltammetry (CV ) 被调查,并且 chargedischarge 分别地测试。533 F/g 的一个最大的特定的电容能在 1 mol/L 被完成有 0.2 ~ 0.8 V 的潜在的范围的水的 H2SO4 (对浸透的甘汞电极) 在为 PANI 电极的一种一半房间安装配置,为电气化学的电容器在电极材料建议它的潜在的申请。 | Ling Ren Wang Fen Ran Yong Tao Tan Lei Zhao Ling Bin Kong Long Kang | 2011 | Chinese Chemical Letters2011，22，8： | 8 |
| 12 | Procalcitonin could be a reliable marker in differential diagnosis of post-implantation syndrome and infection after percutaneous endovascular aortic repair显示文摘 | Xue Ling Luo Songyuan Luo Jianfang Liu Zhen Gu Mengnan Kang Huiyuan Yang Fan Nie Bingrong Liu Yuan Huang Wenhui Xie Nianjin He Pengcheng Dong Haojian Ni Zhonghan Fan Ruixin Chen Jiyan | 2014 | Chinese Medical Journal2014，，14： | 8 |
| 13 | Novel berberine derivatives:Design,synthesis,antimicrobial effects,and molecular docking studies显示文摘A series of berberine derivatives were synthesized by introducing substituted benzyl groups at C-9.All these synthesized compounds(4a–4m)were screened for their in vitro antibacterial activity against four Gram-positive bacteria and four Gram-negative bacteria and evaluated for their antifungal activity against three pathogenic fungal strains.All these compounds displayed good antibacterial and antifungal activities,compared to reference drugs including Ciprofloxacin and Fluconazole;Compounds 4f,4g,and 4l showed the highest antibacterial and antifungal activities.Moreover,all the synthesized compounds were docked into topoisomerase II-DNA complex,which is a crucial drug target for the treatment of microbial infections.Docking results showed that H-bond,π-πstacked,π-cationic,andπ-anionic interactions were responsible for the strong binding of the compounds with the target protein-DNA complex. | YAO Ling WU Ling-Ling LI Qian HU Qin-Mei ZHANG Shu-Yuan LIU Kang JIANG Jian-Qin | 2018 | Chinese Journal of Natural Medicines2018，16，10： | 7 |
| 14 | Initiating Characteristics of Early-onset Type 2 Diabetes Mellitus in Chinese Patients显示文摘 | Hui Yu Li-Fang Xie Kang Chen Gang-Yi Yang Xiao-Yan Xing Jia-Jun Zhao Tian-pei Hong Zhong-Yan Shan Hong-Mei Li Bing Chen Xu-Lei Tang Ling Qi Jing Yang Yuan Fang Ting Li Shuang-ShuangWang Ya-Qi Yin Yi-Ming Mu | 2016 | Chinese Medical Journal2016，，7： | 7 |
| 15 | Perioperative aortic dissection rupture after endovascular stent graft placement for treatment of type B dissection显示文摘 | HUANG Wen-hui LUO Song-yuan LUO Jian-fang LIU Yuan FAN Rui-xin XUE Ling YANG Fang KANG Hui-yuan GU Meng-nan LIU Zhen XIE Nian-jin DONG Hao-jian NI Zhong-han HUANG Mei-ping CHEN Ji-yan | 2013 | Chinese Medical Journal2013，，9： | 6 |
| 16 | Multicenter prospective study of magnetic resonance imaging prior to breast-conserving surgery for breast cancer显示文摘 | Liu Qian Liu Yinhua Xu Ling Duan Xuening Li Ting Qin Naishan Kang Hua Jiang Hongchuan Yang Deqi Qu Xiang Jiang Zefei Yu Chengze | 2014 | Chinese Medical Journal2014，，13： | 6 |
| 17 | Aberrant translation regulated by METTL1/WDR4-mediated tRNA N7-methylguanosine modification drives head and neck squamous cell carcinoma progression显示文摘Background:Cancer cells selectively promote the translation of oncogenic tran-scripts to stimulate cancer progression.Although growing evidence has revealed that tRNA modifications and related genes participate in this process,their roles in head and neck squamous cell carcinoma(HNSCC)remain largely unchar-acterized.Here,we sought to investigate the function and mechanisms of the transfer RNA(tRNA)N7-methylguanosine(m'G)modification in regulating the occurrence and development of HNSCC.Methods:Cell lost of-function and gain-of function assays,xenograft models,conditional knockout and knockin mouse models were used to study the physi-ological functions of tRNA m'G modification in HNSCC tumorigenesis.tRNA modification and expression profiling,mRNA translation profiling and res-cue assays were performed to uncover the underlying molecular mechanisms.Single-cell RNA sequencing(scRNA seq)was conducted to explore the tumor microenvironment changes.Results:The tRNA.m7G methyltransferase complex components Methyltransferase-like 1(METTL1)/WD repeat domain 4(WDR4)were upregulated in HNSCC and associated with a poor prognosis.Functionally,METTL1/WDR4 promoted HNSCC progression and metastasis in cell-based and transgenic mouse models.Mechanistically,ablation of METTL1 reduced the m'G levels of 16 tRNAS,inhibiting the translation of a subset of oncogenic transcripts,including genes related to the phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin(PI3K/AKT/mTOR)signaling pathway.In addition,chemical modulators of the PI3K/Akt/mTOR signaling pathway reversed the effects of Mettll in mouse HNSCC.Furthermore,scRNA-seq results revealed that Mettll knockout in mouse tumor cells altered the immune landscape and cell-cell interaction between the tumor and stromal compartment.Conclusions:The tRNA m?G methyltransferase METTLI was found to promote the development and malignancy of HNSCC through regulating global mRNA translation,including the PI3K/AKT/mTOR signaling pathway,and found to alter immune landscape.METTLI could be a promising treatment target for HNSCC patients. | Jie Chen Kang Li Jianwen Chen Xiaochen Wang Rongsong Ling Maosheng Cheng Zhi Chen Fangfang Chen Qianting He Shuai Li Caihua Zhang Yizhou Jiang Qianming Chen Anxun Wang Demeng Chen | 2022 | Cancer Communications2022，42，3： | 6 |
| 18 | Adsorption of Basic Dyes Using Walnut Shell-based Biochar Produced by Hydrothermal Carbonization显示文摘 | KANG Chunli ZHU Ling WANG Yixue WANG Yuhan XIAO Kunkun TIAN Tao | 2018 | Chemical Research in Chinese Universities2018，34，4： | 5 |
| 19 | Comparison of different cooling methods for extending shelf life of postharvest broccoli显示文摘This study aimed to investigate and compare the effects of vacuum cooling,cooling water and cold room methods on the shelf life of broccoli.The experiments were divided into four groups:vacuum cooling(A),ice-water cooling(B),cold room cooling(C)and control.The cooling rate and changes of weight loss,respiratory rate,chlorophyll,vitamin C,reducing sugar content and sensory properties were measured at intervals of five days.The results indicated that vacuum cooling was the most effective method for extending the shelf life of postharvest broccoli in terms of cooling rate,respiration rate,chlorophyll,vitamin C,reducing sugar and sensory properties.Moreover,spraying the broccoli with water during the vacuum cooling process resulted in a significant reduction in weight compared with the other two cooling methods and did not reduce the quality of the broccoli.Consequently,vacuum cooling treatment can be applied to broccoli after harvest in the field to maintain quality during transportation and storage.Additionally,the application of water spraying during vacuum cooling can considerably reduce the negative influence caused by vacuum cooling. | Ding Tian Liu Fen Ling Jiangang Kang Mengli Yu Jingfen Ye Xingqian Liu DongHong | 2016 | International Journal of Agricultural and Biological Engineering2016，9，6： | 5 |
| 20 | Biomechanical Optimization of Elastic Modulus Distribution in Porous Femoral Stem for Artificial Hip Joints显示文摘 | Changning Sun Ling Wang Jianfeng Kang Dichen Li Zhongmin Jin | 2018 | Journal of Bionic Engineering2018，15，4： | 5 |
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