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| 1 | MR with Gd-EOB-DTPA in assessment of liver nodules in cirrhotic patients显示文摘To date the imaging diagnosis of liver lesions is based mainly on the identification of vascular features, which are typical of overt hepatocellular carcinoma(HCC), but the hepatocarcinogenesis is a complex and multistep event during which, a spectrum of nodules develop within the liver parenchyma, including benign small and large regenerative nodule(RN), low-grade dysplastic nodule(LGDN), high-grade dysplastic nodule(HGDN), early HCC, and well differentiated HCC. These nodules may be characterised not only on the basis of their respective different blood supplies, but also on their different hepatocyte function. Recently, in liver imaging the introduction of hepatobiliary magnetic resonance imaging contrast agent offered the clinicians the possibility to obtain, at once, information not only related to the vascular changes of liver nodules but also information on hepatocyte function. For this reasons this new approach becomes the most relevant diagnostic clue for differentiating low-risk nodules(LGDN-RN) from highrisk nodules(HGDN/early HCC or overt HCC) and consequently new diagnostic algorithms for HCC have been proposed. The use of hepatobiliary contrast agents is constantly increasing and gradually changing the standard of diagnosis of HCC. The main purpose of this review is to underline the added value of Gd-EOB-DTPA in early-stage diagnoses of HCC. We also analyse the guidelines for the diagnosis and management of HCC, the key concepts of HCC development, growth and spread and the imaging appearance of precursor nodules that eventually may transform into overt HCC. | Riccardo Inchingolo Riccardo Faletti Luigi Grazioli Eleonora Tricarico Marco Gatti Anna Pecorelli Davide Ippolito | 2018 | World Journal of Hepatology2018，10，7： | 37 |
| 2 | Long-term outcomes after laparoscopic colectomy显示文摘AIM:To evaluate long-term outcomes in a large series of patients who randomly received laparoscopic or open colorectal resection.METHODS:From February 2000 to December 2004,six hundred sixty-two patients with colorectal disease were randomly assigned to laparoscopic(LPS,n = 330) or open(n = 332) colorectal resection.All patients were analyzed on an intention-to-treat basis.Long-term follow-up was carried out every 6 mo by office visits.In 526 cancer patients five-year overall and disease-free survival were evaluated.Median oncologic follow-up was 96 mo.RESULTS:Eight(4.2%) LPS group patients needed conversion to open surgery.Overall long-term morbidity rate was 7.6%(25/330) in the LPS vs 11.1%(37/332) in the open group(P = 0.17).In cancer patients,fiveyear overall survival was 68.6% in the LPS group and 64.0% in the Open group(P = 0.27).Excluding stage Ⅳ patients,five-year local and distant recurrence rates were 32.5% in the LPS group and 36.8% in the Open group(P = 0.36).Further,no difference in recurrence rate was found when patients were stratified according to cancer stage.CONCLUSION:LPS colorectal resection was associated with a slightly lower incidence of long-term complications than open surgery.No difference between groups was found in overall and disease-free survival rates. | Marco Braga Nicolò Pecorelli Matteo Frasson Andrea Vignali Walter Zuliani Valerio Di Carlo | 2011 | World Journal of Gastrointestinal Oncology2011，3，3： | 8 |
| 3 | Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium显示文摘 | Sergio Pecorelli | 2009 | International Journal of Gynecology and Obstetrics2009，，2： | 4 |
| 4 | Role of dynamic perfusion magnetic resonance imaging in patients with local advanced rectal cancer显示文摘BACKGROUND The management of rectal cancer patients is mainly based on the use of the magnetic resonance imaging(MRI)technique as a diagnostic tool for both staging and restaging.After treatment,to date,the evaluation of complete response is based on the histopathology assessment by using different tumor regression grade(TRG)features(e.g.,Dworak or Mandard classifications).While from the radiological point of view,the main attention for the prediction of a complete response after chemotherapy treatment focuses on MRI and the potential role of diffusion-weighted images and perfusion imaging represented by dynamiccontrast enhanced MRI.The main aim is to find a reliable tool to predict tumor response in comparison to histopathologic findings.AIM To investigate the value of dynamic contrast-enhanced perfusion-MRI parameters in the evaluation of the healthy rectal wall and tumor response to chemo-radiation therapy in patients with local advanced rectal cancer with histopathologic correlation.METHODS Twenty-eight patients with biopsy-proven rectal adenocarcinoma who underwent a dynamic contrast-enhanced MR study performed on a 1.5 T MRI system(Achieva,Philips),before(MR1)and after chemoradiation therapy(MR2),were enrolled in this study.The protocol included T1 gadolinium enhanced THRIVE sequences acquired on axial planes.A dedicated workstation was used to generate color permeability maps.Region of interest was manually drawn on tumor tissue and normal rectal wall,hence the following parameters were calculated and statistically analyzed:Relative arterial enhancement(RAE),relative venous enhancement(RVE),relative late enhancement(RLE),maximum enhancement(ME),time to peak and area under the curve(AUC).Perfusion parameters were related to pathologic TRG(Mandard’s criteria;TRG1=complete regression,TRG5=no regression).RESULTS Ten tumors(36%)showed complete or subtotal regression(TRG1-2)at histology and classified as responders;18 tumors(64%)were classified as non-responders(TRG3-5).Perfusion MRI parameters were significantly higher in the tumor tissue than in the healthy tissue in MR1(P<0.05).At baseline(MR1),no significant difference in perfusion parameters was found between responders and nonresponders.After chemo-radiation therapy,at MR2,responders showed significantly(P<0.05)lower perfusion values[RAE(%)54±20;RVE(%)73±24;RLE(%):82±29;ME(%):904±429]compared to non-responders[RAE(%):129±45;RVE(%):154±39;RLE(%):164±35;ME(%):1714±427].Moreover,in responders group perfusion values decreased significantly at MR2[RAE(%):54±20;RVE(%):73±24;RLE(%):82±29;ME(%):904±429]compared to the corresponding perfusion values at MR1[RAE(%):115±21;RVE(%):119±21;RLE(%):111±74;ME(%):1060±325];(P<0.05).Concerning the time-intensity curves,the AUC at MR2 showed significant difference(P=0.03)between responders and non-responders[AUC(mm2×10-3)121±50 vs 258±86],with lower AUC values of the tumor tissue in responders compared to nonresponders.In non-responders,there were no significant differences between perfusion values at MR1 and MR2.CONCLUSION Dynamic contrast perfusion-MRI analysis represents a complementary diagnostic tool for identifying vascularity characteristics of tumor tissue in local advanced rectal cancer,useful in the assessment of treatment response. | Davide Ippolito Silvia Girolama Drago Anna Pecorelli Cesare Maino Giulia Querques Ilaria Mariani Cammillo Talei Franzesi Sandro Sironi | 2020 | World Journal of Gastroenterology2020，26，20： | 3 |
| 5 | Human epididymis protein 4 as a serum marker for diagnosis of endometrial carcinoma and prediction of clinical outcome显示文摘 | Laura Zanotti Eliana Bignotti Stefano Calza Elisabetta Bandiera Giuseppina Ruggeri Claudio Galli Germana Tognon Monica Ragnoli Chiara Romani Renata A. Tassi Luigi Caimi Franco E. Odicino Enrico Sartori Sergio Pecorelli Antonella Ravaggi | 2012 | Clinical Chemistry and Laboratory Medicine2012，，12： | 2 |
| 6 | Enhanced recovery pathways in pancreatic surgery: State of the art显示文摘Pancreatic surgery is being offered to an increasing number of patients every year. Although postoperative outcomes have significantly improved in the last decades, even in high-volume centers patients still experience significant postoperative morbidity and full recovery after surgery takes longer than we think. In recent years, enhanced recovery pathways incorporating a large number of evidence-based perioperative interventions have proved to be beneficial i n t e r m s o f i m p rove d p o s t o p e ra t i ve o u t c o m e s, and accelerated patient recovery in the context of gastrointestinal, genitourinary and orthopedic surgery. The role of these pathways for pancreatic surgery is still unclear as high-quality randomized controlled trials are lacking. To date, non-randomized studies have shown that care pathways for pancreaticoduodenectomy and distal pancreatectomy are safe with no difference in postoperative morbidity, leading to early discharge and no increase in hospital readmissions. Hospital costs are reduced due to better organization of care and resource utilization. However, further research is needed to clarify the effect of enhanced recovery pathways on patient recovery and post-discharge outcomes following pancreatic resection. Future studies should be prospective and follow recent recommendations for the design and reporting of enhanced recovery pathways. | Nicolò Pecorelli Sara Nobile Stefano Partelli Luca Cardinali Stefano Crippa Gianpaolo Balzano Luigi Beretta Massimo Falconi | 2016 | World Journal of Gastroenterology2016，22，28： | 2 |
| 7 | Revised FIGO staging for carcinoma of the cervix显示文摘 | Sergio Pecorelli Lucia Zigliani Franco Odicino | 2009 | International Journal of Gynecology and Obstetrics2009，，： | 2 |
| 8 | Pancreatic metastases:An increasing clinical entity显示文摘Pancreatic metastases,although uncommon,have been observed with increasing frequency recently,especially by high-volume pancreatic surgery centers.They are often asymptomatic and detected incidentally or during follow-up investigations even several years after the re-moval of the primary tumor.Renal cell cancer represents the most common primary tumor by far,followed by colorectal cancer,melanoma,sarcoma and lung cancer.Pancreatic metastasectomy is indicated for an isolated and resectable metastasis in a patient fit to tolerate pancreatectomy.Both standard and atypical pancreatic resection can be performed:a resection strategy providing adequate resection margins and maximal tissue preservation of the pancreas should be pursued.The effectiveness of resection for pancreatic metastases is mainly dependent on the tumor biology of the primary cancer;renal cell cancer is associated with the best outcome with a 5-year survival rate greater than 70%. | Alessandro Zerbi Nicolò Pecorelli | 2010 | World Journal of Gastrointestinal Surgery2010，2，8： | 2 |
| 9 | 对高风险的胰腺吻合行胰管置管胰液外引流:一组病例对照研究显示文摘 | G. Balzano G. Capretti A. Zerbi C. Ridolfi N. Pecorelli D. Valerio 张频捷(摘译) 赵红川(审校) | 2009 | 肝胆外科杂志2009，17，4： | 2 |
| 10 | Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium显示文摘 | Sergio Pecorelli | 2009 | International Journal of Gynecology and Obstetrics2009，，2： | 1 |
| 11 | Revised FIGO staging for carcinoma of the vulva,cervix and endometrium显示文摘 | Pecorelli S | | 0，，02： | 1 |
| 12 | Revised FIGO staging for carcinoma of the vulva,cervix,and endometrium显示文摘 | Pecorelli S | 2009 | Int J Gynaecol Obstet2009，105，2： | 1 |
| 13 | Squamous cell carcinoma of the ovary arising from a mucinous cystic tumor of endocervical (müllerian) type显示文摘 | D'ANGELO E DADMANESH F PECORELLI S | 2010 | Int J Gynecol Pathol2010，29，6： | 1 |
| 14 | Adjuvant treatment for early epithelial ovarian cancer:results of two randomized clinical phosphate(32p)显示文摘 | Bolis G Colombo N Pecorelli S | 1995 | Ann Oncol1995，6，5： | 1 |
| 15 | Cisplatin(P),vinblas-tine(V)and bleomycin(B)combination chemotherapy in recurrent or advanced granulose(-theca)cell tumors of the ovary:an EORTC Gynacological cancer cooperative group study显示文摘 | Pecorelli S Wagenaar HC Vergote IB | 1999 | Eur J Cancer1999，35，9： | 1 |
| 16 | Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium显示文摘 | Pecorelli S | 2009 | Int J Gynaecol Obstet2009，105，2： | 1 |
| 17 | Revised FIGO staging for carcinoma of the vulva,cervix and endometrium显示文摘 | Pecorelli S | 2009 | Int Gynaecol Obstet2009，105，2： | 1 |
| 18 | Revised FIGO staging for carcinoma of the vulva,cervix,and endometrium显示文摘 | Pecorelli S | 2009 | Int J Gynaecol Obstet2009，105，： | 1 |
| 19 | Gynecological sarcomas 显示文摘 | DiSaia PJ Pecorelli S | 1994 | Semin Surg Oneol1994，10，5： | 1 |
| 20 | Contrast-enhanced ultrasonography to diagnose complicated acute cholecystitis显示文摘 | Sagrini E Pecorelli A Pettinari I | 2016 | Intern Emerg Med2016，11，1： | 1 |
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