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| 1 | 中国西南天山山前的晚新生代构造与地震活动显示文摘天山是研究现今陆内造山作用及过程、陆内变形、陆内强震及其预测等大陆动力学问题的理想实验场。西南天山和塔里木之间的新生代褶皱 -逆断裂带基本上由一南冲弧形推覆构造系统和一向北反冲的构造系统组成 ,由北而南主要由以下 4个运动学单元组成 :(1)新生代复活的喀拉铁热克山 -天山南脉古生代造山带 ,其快速变形和抬升可能起始于 2 3~ 2 6Ma前 ,持续至 13~ 16Ma前。 (2 )向南逆冲的西南天山前陆薄皮主冲断带 ,包括木兹杜克弧形薄皮推覆体和依柯冲断带 ,前者代表了向南薄皮逆掩的天山型岩系 ,地表主要表现为一系列的飞来峰群 ,在 14Ma前曾有过大规模活动 ,最小缩短量约为 2 0~ 35km ,最小缩短速率约为 1.4~ 2 .7mm a ;后者代表了向南叠瓦状薄皮逆冲推覆的前陆古生代基底 (塔里木地台型沉积岩系 )卷入构造 ,其西段在距今 14Ma时曾有过强烈活动。两者共同组成了一复杂的双重构造 ;新生代地层也卷入变形。 (3)喀什 -阿图什弧形反冲褶皱 -逆断裂带 ,由 3排向北 (天山 )反冲的左阶雁列展布的第四纪地表滑脱褶皱组成 ,仅在大山口以西发育。该构造带形成于距今约 1.4Ma以后。依什拉克喀拉乌尔断裂以南 ,博古孜河剖面的最小缩短速率约为 5 .8mm a ,翁库尔剖面的最小缩短速率约为 8.6mm a。 (4 )塔里木克拉? | 陈杰 丁国瑜 Burbank D.W. Scharer K. Rubin C. Sobel E. 曲国胜 沈军 尹金辉 赵瑞斌 | 2001 | 中国地震2001，17，2： | 59 |
| 2 | 0Adipose-derived stem cells: Implications in tissue regeneration显示文摘Adipose-derived stem cells(ASCs) are mesenchymal stem cells(MSCs) that are obtained from abundant adipose tissue, adherent on plastic culture flasks, can be expanded in vitro, and have the capacity to differ-entiate into multiple cell lineages. Unlike bone marrow-derived MSCs, ASCs can be obtained from abundant adipose tissue by a minimally invasive procedure, which results in a high number of cells. Therefore, ASCs are promising for regenerating tissues and organs dam-aged by injury and diseases. This article reviews the implications of ASCs in tissue regeneration. | Wakako Tsuji J Peter Rubin Kacey G Marra | 2014 | World Journal of Stem Cells2014，6，3： | 19 |
| 3 | Colorectal cancer and dysplasia in inflammatory bowel disease显示文摘Both ulcerative colitis and Crohn’s disease carry an increased risk of developing colorectal cancer. Established risk factors for cancer among patients with inflammatory bowel disease (IBD) include the younger age at diagnosis, greater extent and duration of disease, increased severity of inflammation, family history of colorectal cancer and coexisting primary sclerosing cholangitis. Recent evidence suggests that current medical therapies and surgical techniques for inflammatory bowel disease may be reducing the incidence of this complication. Nonetheless heightened vigilance and a careful, comprehensive approach to prevent or minimize the complications of invasive cancer are warranted in this unique cohort of patients. Current guidelines for the prevention and early detection of cancer in this high risk population are grounded in the concept of an inflammation-dysplasia- carcinoma sequence. A thorough understanding of the definition and natural history of dysplasia in IBD, as well as the challenges associated with detection and interpretation of dysplasia are fundamental to developing an effective strategy for surveillance and prevention, and understanding the limitations of the current approach to prevention. This article reviews the current consensus guidelines for screening and surveillance of cancer in IBD, as well as presenting the evidence and rationale for chemoprevention of cancer and a discussion of emerging technologies for the detection of dysplasia. | Timothy L Zisman David T Rubin | 2008 | World Journal of Gastroenterology2008，14，17： | 13 |
| 4 | Assessment of bone turnover and bone quality in type 2 diabetic bone disease: current concepts and future directions显示文摘Substantial evidence exists that in addition to the well-known complications of diabetes,increased fracture risk is an important morbidity.This risk is probably due to altered bone properties in diabetes.Circulating biochemical markers of bone turnover have been found to be decreased in type 2 diabetes(T2D) and may be predictive of fractures independently of bone mineral density(BMD).Serum sclerostin levels have been found to be increased in T2D and appear to be predictive of fracture risk independent of BMD.Bone imaging technologies,including trabecular bone score(TBS) and quantitative CT testing have revealed differences in diabetic bone as compared to non-diabetic individuals.Specifically,high resolution peripheral quantitative CT(HRp QCT) imaging has demonstrated increased cortical porosity in diabetic postmenopausal women.Other factors such as bone marrow fat saturation and advanced glycation endproduct(AGE) accumulation might also relate to bone cell function and fracture risk in diabetes.These data have increased our understanding of how T2D adversely impacts both bone metabolism and fracture risk. | Mishaela R Rubin Janina M Patsch | 2016 | Bone Research2016，4，1： | 10 |
| 5 | Sox10是一种雪旺细胞和黑色素细胞的广谱标记物显示文摘 | Nonaka D Chiriboga L Rubin B P 樊祥山(摘译) 孟凡青(审校) | 2008 | 临床与实验病理学杂志2008，24，5： | 10 |
| 6 | CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment显示文摘 | Andy Trotti A.Dimitrios Colevas Ann Setser Valerie Rusch David Jaques Volker Budach Corey Langer Barbara Murphy Richard Cumberlin C.Norman Coleman Philip Rubin | 2003 | Seminars in Radiation Oncology2003，，3： | 8 |
| 7 | Diagnosis of gastrointestinal stromal tumors: A consensus approach显示文摘 | Christopher D.M. Fletcher Jules J. Berman Christopher Corless Fred Gorstein Jerzy Lasota B.Jack Longley Markku Miettinen Timothy J. O’Leary Helen Remotti Brian P. Rubin Barry Shmookler Leslie H. Sobin Sharon W. Weiss | 2002 | Human Pathology2002，，5： | 7 |
| 8 | Protective role of PI3-kinase/Akt/eNOS signaling in mechanical stress through inhibition of p38 mitogenactivated protein kinase in mouse lung显示文摘 | Xin-qi PENG Mahendra DAMARLA Jarrett SKIRBALL Stephanie NONAS Xiao-ying WANG Eugenia J HAN Emile J HASAN Xuan CAO Adel BOUEIZ Rachel DAMICO Rubin M TUDER Alfred M SClUTO Dana R ANDERSON Joe GNGARCIA David A KASS Paul M HASSOUN Jun-tian ZHANG | 2010 | Acta Pharmacologica Sinica2010，31，2： | 6 |
| 9 | Negative regulation of receptor tyrosine kinases: unexpected links to c-Cbl and receptorubiquitylation显示文摘Intracellular signals mediated by the family of receptor tyrosine kinases play pivotal roles in morphogenesis, cell fate determination and pathogenesis. Precise control of signal amplitude and duration is critical for the fidelity and robustness of these processes. Activation of receptor tyrosine kinases by their cognate growth factors not only leads to propagation of the signal through various biochemical cascades, but also sets in motion multiple attenuation mechanisms that ulti- mately terminate the active state. Early attenuators pre-exist prior to receptor activation and they act to limit signal propagation. Subsequently, late attenuators, such as Lrig and Sprouty, are transcriptionally induced and further act to dampen the signal. Central to the process of signaling attenuation is the role of the E3 ubiquitin ligase c-Cbl. While Cbl- mediated processes of receptor ubiquitylation and endocytosis are relatively well understood, the links of Cbl to other negative regulators are just now beginning to be appreciated. Here we review some emerging interfaces between Cbl and the transcriptionally induced negative regulators Lrig and Sprouty. | Chanan RUBIN Gal GUR Yosef YARDEN | 2005 | Cell Research2005，15，1： | 5 |
| 10 | Assessment of the anterior spinal artery and the artery of Adamkiewicz using multi-detector CT angiography显示文摘在下降的治疗以后的针的绳索的背景损坏胸并且 thoracoabdominal 大动脉的动脉瘤是不平常却破坏的复杂并发症。Adamkiewicz 的动脉(也称为) 在更低的胸、腰部的水平是前面的针的动脉(ASA ) 的主要动脉的供应。这研究的目的是评估前面的针的动脉和 Adamkiewicz 的动脉的可视化,为用多察觉者的察觉率的影响因素划 CT (MDCT ) 。方法 99 个连续病人(31 个女人和 68 个男人;年龄范围, 25-90 年;平均年龄 61.3 年) 为要求外科的干预(31 大动脉的动脉瘤, 45 解剖, 5 内部 hematoma,和 18 正常) 的胸的大动脉的损害的怀疑地,从大动脉的拱门经历了 CT angiography 到大动脉的分叉。横向的节, multiplanar 改革和薄最大的紧张设计被用来估计 ASA 并且也称为。ASA 并且也称为起源和 CT 获得参数的水平被记录。图象, T11 身体(脊椎的集体索引) 的团的一个索引,下的胖厚度,和在大动脉的拱门以内并且在 T11 水平的 CT 值的 contrast-to-noise 比率被测量。ASA 并且也称为的察觉相对获得参数,扫描特征,和大动脉的损害类型被评估。差别与 Wilcoxon 等级和和 t 测试被估计。结果 ASA 在 18 个病人(18%) 在 51 个病人(52%) 和 AKA 被设想。ASA 与 2.5-3.0 公里厚度与 1.25 公里厚度并且在 15/32 病人(47%) 在 36/67 病人(54%) 被识别。这差别没完成意义(P=0.13 ) 。ASA 和 AKA 的察觉率被脊椎的集体索引和 contrast-to-noise 比率影响(P < 0.05 ) 。下的脂肪的数量影响了 ASA 的察觉率(P < 0.05 ) 然而并非 AKA。在 ASA 察觉的 CT 扫描,分别地,而,在在拱门并且在 T11 的主动脉的吝啬的 CT 价值是 360 和 358 胡在没有 ASA 察觉的 CT 扫描,在在拱门并且在 T11 的主动脉的 CT 价值更低( P < 0.05 ), 297 和 317 胡, respectively.Conclusions ASA 并且也称为不太经常比以前的报告在我们的队被检测。ASA 并且也称为的可视化被大动脉的改进显著地影响, =vertebral 团索引“,并且 contrast-to-noise 比率。 | ZHAO Shao-hong, Laura Logan Pamela Schraedley Geoffrey D. Rubin | 2009 | Chinese Medical Journal2009，，2： | 5 |
| 11 | Gastrointestinal stromal tumour显示文摘 | Rubin BP Heinrich MC Corless CL | | 0，，9574： | 5 |
| 12 | 前列腺癌中ETS重排显示文摘前列腺癌是一种临床分子异质性疾病。了解前列腺癌的生物学基础有助于更好地理解生物学与疾病发生风险的关联及其新的治疗方法的开发。该综述主要探讨近年来发现的前列腺癌中普遍存在的ETS和非ETS基因重排相关研究。前列腺癌基因融合的基础研究将有助于我们对临床生物学多样性的理解,从而为该疾病从原理上提供分子亚分类。 | Mark A Rubin | 2012 | Asian Journal of Andrology2012，14，3： | 5 |
| 13 | The molecular dynamics of neural metabolism during the action potential显示文摘Neural information processing is tightly coupled to both energy consumption and derivation from substrates.In this study,the energy function of the neuron during the action potential(AP)is described and analyzed.It has been observed that energy consumption during the AP does not match predictions of the conventional theory of neural energy dynamics.On short time scales,neural energy expenditure shifts between positive and negative phases.During the AP,the energy source switches from neuronal stores(positive expenditure or net consumption)to exploitation of external substrates,specifically the glucose and oxygen carried in cerebral blood(the negative consumption phase).Based on the idea of reductionism,this paper demonstrates how ion channels,membrane pumps and transporters,ionotropic and metabotropic receptor signaling pathways,astrocyte glycolysis and the production lactate,and the glutamate-glutamine cycle all serve to relate cerebral blood flow and neuronal metabolism to neuronal activity and so maintain neuronal energy charge during the AP. | ZHENG HongWen WANG RuBin QIAO LinKun DU Ying | 2014 | Science China(Technological Sciences)2014，57，5： | 5 |
| 14 | Placental Transfer of Anti–Tumor Necrosis Factor Agents in Pregnant Patients With Inflammatory Bowel Disease显示文摘 | Uma Mahadevan Douglas C. Wolf Marla Dubinsky Antoine Cortot Scott D. Lee Corey A. Siegel Thomas Ullman Sarah Glover John F. Valentine David T. Rubin Jocelyn Miller Maria T. Abreu | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 4 |
| 15 | Systematic review: probiotics in the management of lower gastrointestinal symptoms in clinical practice – an evidence‐based international guide显示文摘 | A. P. S. Hungin C. Mulligan B. Pot P. Whorwell L. Agréus P. Fracasso C. Lionis J. Mendive J.‐M. Philippart de Foy G. Rubin C. Winchester N. Wit | 2013 | Aliment Pharmacol Ther2013，，8： | 4 |
| 16 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 17 | Nonlinear,tunable,and active optical metasurface with liquid film显示文摘Optical metamaterials and metasurfaces,which emerged in the course of the last few decades,have revolutionized our understanding of light and light–matter interaction.While solid materials are naturally employed as key building elements for construction of optical metamaterials mainly due to their structural stability,practically no attention was given to study of liquid-made optical two-dimensional(2-D)metasurfaces and the underlying interaction regimes between surface optical modes and liquids.We theoretically demonstrate that surface plasmon polaritons and slab waveguide modes that propagate within a thin liquid dielectric film trigger optical self-induced interaction facilitated by surface tension effects,which leads to the formation of 2-D optical liquid-made lattices/metasurfaces with tunable symmetry and can be leveraged for tuning of lasing modes.Furthermore,we show that the symmetry breaking of the 2-D optical liquid lattice leads to phase transition and tuning of its topological properties,which allows the formation,destruction,and movement of Dirac-points in the k-space.Our results indicate that optical liquid lattices support extremely low lasing threshold relative to solid dielectric films and have the potential to serve as configurable analogous computation platform. | Shimon Rubin Yeshaiahu Fainman | 2019 | Advanced Photonics2019，1，6： | 3 |
| 18 | Polyamines reduces lipid peroxidation induced by different pro-oxidant agents显示文摘 | Nádia Aléssio Velloso Bellé Gerusa Duarte Dalmolin Graciela Fonini Maribel Antonello Rubin Jo?o Batista Teixeira Rocha | 2004 | Brain Research2004，，2： | 3 |
| 19 | Immune checkpoint inhibitor-mediated colitis in gastrointestinal malignancies and inflammatory bowel disease显示文摘Immune checkpoint inhibitors(ICI)have markedly changed the landscape of cancer therapy.By re-invigorating the immune system against tumors,ICI provide novel therapeutic options for a broad variety of malignancies,including many gastrointestinal(GI)cancers.However,these therapies can also induce autoimmune-like side effects in healthy tissue across the body.One of the most common of these side effects is ICI-mediated colitis and diarrhea(IMC).Here,we review the incidence and risk of IMC in ICI therapy,with a focus on what is known regarding IMC in patients with GI malignancies.We also discuss data available on the use of ICI and risk of IMC in patients with pre-existing inflammatory bowel disease,as these patients may have increased risk of IMC due to their underlying intestinal pathology. | Alexa R Weingarden Samuel J S Rubin John Gubatan | 2021 | World Journal of Gastrointestinal Oncology2021，13，8： | 3 |
| 20 | Evaluation of Diffusion-weighted MR Imaging for Detection of Bowel Inflammation in Patients with Crohn’s Disease显示文摘 | Aytekin Oto Fang Zhu Kirti Kulkarni Gregory S. Karczmar Jerrold R. Turner David Rubin | 2009 | Academic Radiology2009，，5： | 3 |
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