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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Age dependence of cellular properties of human septal cartilage: implications for tissue engineering显示文摘 | Rotter N Bonassar LJ Tobias G | 2001 | Arch Otolaryngol Head Neck Surg2001，127，10： | 1 |
| 3 | Tissue engineering and autologous transplant formation:practical approaches with absorbable biomaterials and new culture techniques 显示文摘 | Sittinger M Bujia J Rotter N | 1996 | Biomaterials1996，17，： | 1 |
| 4 | Glandular tissue from human pancreas and salivary gland yields similar stem eel/populations显示文摘 | Gorjup E Danner S Rotter N | 2009 | Eur J Cell Biol2009，88，7： | 1 |
| 5 | An insight into the life of p53:a protein coping with many function显示文摘 | Almog N Rotter V | 1998 | Biochim Biophys Acta1998，1378，： | 1 |
| 6 | An insight into the life of p53:a protein coping with many functions! review of the 9th p53 workshop, crete, May 9 - 13, 1998显示文摘 | Ahnog N Rotter V | | 0，，： | 1 |
| 7 | Isolation and characterization of adult stem cells from human salivary glands显示文摘 | Rotter N Oder J Schlenke P | 2008 | Stem Cells Dev2008，17，3： | 1 |
| 8 | Expression of p53 protein in spermatogenesis is confined to the tetraploid pachytene primary spermatoeytes 显示文摘 | Schwartz D Goldfinger N Rotter V | 1993 | Oncogene1993，，： | 1 |
| 9 | Sonochemically Prepared Pt/CeO2 and Its Application as a Catalyst in Ethyl Acetate Combustion显示文摘 | Perkas N Rotter H Vradman L | 2006 | Langmnir2006，22，16： | 1 |
| 10 | Isolation and characterization of adult stem cells from human salivary glands 显示文摘 | Rotter N Oder J Schlenke P | 2008 | Stem Cells Dev2008，17，3： | 1 |
| 11 | Mitochondrial ribosomal RNA mutation asso-ciated with both antibiotic-induced and non-syndromic deafness显示文摘 | Prezant TR Agapian JV Bohlman MC Bu X Oztas S Qiu W-Q Arnos KS Cortopassi GA Jaber L Rotter JI Shohat M Fischel-Ghodsian N | | 0，，： | 1 |
| 12 | Behavior tissue-engineered human cartilage after transplantation into nude mice 显示文摘 | Aigner J Hammer C | 1999 | J Material Science1999，10，1： | 1 |
| 13 | Cartilage reconstruction in head and neck surgery,comparison of resorbable polymer scaffolds for tissue-engineering of human septal cartilage显示文摘 | Rotter N Aigner J Naumamn A | 1998 | J Biomed Mater Res1998，42，2： | 1 |
| 14 | Isolation and characterization of adult stem cells from human salivary glands显示文摘 | Rotter N Oder J Schlenke P | 2008 | Stem Cells Dev2008，17，3： | 1 |
| 15 | An insight into the life of P53:a protein coping with many functions!Review of the 9th P53 workshop,Crete显示文摘 | Almog N Rotter V | | 0，，03： | 1 |
| 16 | Reconstitution of p53 expression in a nonproducer Ah-MuLV-transformed cell line by transfection of a functional p53 gene显示文摘 | WOLF D HARRIS N ROTTER V | 1984 | Cell1984，38，1： | 1 |
| 17 | Expression of p53 protein in spermatogenesis is confined to the teraploid pachytene primary spermatocytes 显示文摘 | Schwartz D Goldfinger N Rotter V | 1993 | Oncogen1993，8，6： | 1 |
| 18 | Tissue engineering and autologous transplant formation: practical approaches with resorbable biomaterials and new cell culture techniques显示文摘 | Sittinger M Bujia J Rotter N Reituel D Minuth WW Burmester GR | 1996 | Biomaterials1996，17，： | 1 |
| 19 | Cartilage reconstruction in head and neck surgery:comparison of resorbable polymer scaffolds for tissue engineering of human septal cartilage显示文摘 | Rotter N Aigner J Naumann A | 1998 | J Biomed Mater Res1998，42，： | 1 |
| 20 | p53 orchestrates be- tween normal differentiation and cancer 显示文摘 | Rivlin N Koifman G Rotter V | 2014 | Seminars Cancer Bio12014，32，： | 1 |
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