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| 1 | 植物油来源亚油酸和亚麻酸对乳脂CLA合成的影响显示文摘选用40头泌乳中期(169.8±8)DIM的中国荷斯坦奶牛随机分为4组,采用完全随机试验设计,研究日粮亚油酸和亚麻酸水平对乳脂CLA合成的影响。试验共设4个处理,分别为高亚油酸组(LA)、高亚麻酸组(LEA)、高亚油酸和亚麻酸组合组(HLALEA)和低亚油酸和亚麻酸组(LLALEA)。通过9周的试验结果表明,不同处理对干物质采食量、泌乳净能校正产奶量、乳蛋白及乳脂肪的含量和日产量均没有显著影响。增加日粮中LA或LEA的含量,能够显著降低乳脂C12∶0、C14∶0和C16∶0的含量(P<0.05),显著增加乳中硬脂酸(C18∶0,P<0.05)和18碳长链不饱和脂肪酸的含量(P<0.01),但对20碳以上不饱和脂肪酸的影响小(P>0.05)。随着日粮中亚油酸含量的增加,LLALEA、HLEA、HLALEA和HLA组乳脂TVA和c9t11CLA的含量呈线性增加。HLEA组、HLALEA和HLA组乳脂TVA的含量分别比LLALEA组增加1.56、3.05和4.71 g/100 g,而c9t11CLA分别比LLALEA组提高2.5、2.8和3.7倍。因此表明,日粮亚油酸对乳脂c9t11CLA合成的贡献效果高于亚麻酸,而亚油酸调控乳脂CLA合成机制主要以提供乳腺SCD合成c9t11CLA所需的底物(TVA)为主。 | 卜登攀 王加启 Dhiman TR 刘仕军 | 2007 | 畜牧兽医学报2007，38，7： | 21 |
| 2 | 超声和臭氧控制生物垢生长的研究显示文摘循环冷却水系统中的生物垢是各类工业过程中的一个严重问题,为控制生物垢的生长,已经开发了若干种技术方法。本文采用超声与臭氧处理相结合的方法对模拟冷却水系统中的生物垢进行了控制其生长的实验研究。结果表明这种处理方法可以使管壁面上的生物垢得到很好的控制。 | 刘天庆 Bott.,TR | 1999 | 水处理技术1999，25，1： | 13 |
| 3 | 《2020 NTCA/CDC建议:潜伏性结核感染治疗指南》摘译显示文摘美国潜伏性结核感染治疗综合指南最近一次发布是在2000年。在这之后,一些新的治疗方案已在临床试验中得到评估。为更新以前的指南,美国国家结核病控制协会(NTCA)和美国疾病控制与预防中心(CDC)成立了一个委员会,2017年12月开始对治疗潜伏性结核感染的临床试验进行系统的文献综述,对治疗潜伏性结核感染最有效、毒性最小的方案提出新的建议。该指南编写基于干预措施的利弊平衡,证据质量,患者价值观、意愿,以及可行性制定建议。最终推荐3种首选的基于利福霉素的治疗方案和2种替代性的异烟肼单药治疗方案。 | 伍玉琪 谭彩霞 吴安华 Sterling TR Njie G Zenner D | 2020 | 中国感染控制杂志2020，19，10： | 13 |
| 4 | Role of human epidermal growth factor receptor 2 in gastric cancer:Biological and pharmacological aspects显示文摘Amplification of the human epidermal growth factor receptor 2(HER2)gene and overexpression of the HER2protein is found in 15%-20%of patients with gastric and gastroesophageal junction cancer.The degree of HER2 overexpression and amplification varies with the location of the carcinoma,with higher expression in the gastroesophageal and proximal parts compared to the distal parts of the stomach.Further,HER2 overexpression and amplification also seems to be related to the Lauren histological classification,with higher levels found in the intestinal phenotype compared to the diffuse and mixed types.The prognostic properties of HER2 overexpression and amplification are still under debate,but a large number of studies seem to indicate that HER2 is a negative prognostic factor.The usefulness of HER2 targeted therapy in gastric cancer was demonstrated in the ToGA trial,where HER2-positive patients with advanced gastric and gastroesophageal junction adenocarcinoma were randomized to receive5-FU/capecitabine and cisplatin,either alone or in combination with trastuzumab.A statically significant gain in overall survival was seen in patients who received the combined treatment of trastuzumab and chemotherapy.Patients with a strong overexpression of the HER2 protein(IHC3+)specifically benefited from the treatment,with a median overall survival of 17.9 mo.As a consequence of the positive results of the ToGA trial,patients with advanced gastric or gastroesophageal junction adenocarcinoma are now routinely tested for HER2.The ToGA trial must be characterized as a landmark in the treatment of gastric cancer and it has paved the way for a number of new HER2 targeted compounds such as pertuzumab,ado-trastuzumab emtansine,lapatinib,afatinib,and dacomitinib,which are currently undergoing phaseⅡandⅢclinical testing.Overall,this review will discuss the current status of HER2 in gastric and gastroesophageal junction cancer and the future direction in relation to HER2 target therapy. | Jan Tr?st J?rgensen | 2014 | World Journal of Gastroenterology2014，20，16： | 11 |
| 5 | Estimating steatosis and fibrosis: Comparison of acoustic structure quantification with established techniques显示文摘AIM:To compare ultrasound-based acoustic structure quantification(ASQ) with established non-invasive techniques for grading and staging fatty liver disease.METHODS:Type 2 diabetic patients at risk of nonalcoholic fatty liver disease(n = 50) and healthy volunteers(n = 20) were evaluated using laboratory analysis and anthropometric measurements, transient elastography(TE), controlled attenuation parameter(CAP), proton magnetic resonance spectroscopy(1H-MRS; only available for the diabetic cohort), and ASQ.ASQ parameters mode, average and focal disturbance(FD) ratio were compared with:(1) the extent of liver fibrosis estimated from TE and nonalcoholic fatty liver disease(NAFLD) fibrosis scores; and(2) the amount of steatosis, which was classified according to CAP values.RESULTS:Forty-seven diabetic patients(age 67.0±8.6 years;body mass index 29.4±4.5 kg/m2)with reliable CAP measurements and all controls(age 26.5±3.2 years;body mass index 22.0±2.7 kg/m2)were included in the analysis.All ASQ parameters showed differences between healthy controls and diabetic patients(P<0.001,respectively).The ASQ FD ratio(logarithmic)correlated with the CAP(r=-0.81,P<0.001)and 1H-MRS(r=-0.43,P=0.004)results.The FD ratio[CAP<250 d B/m:107(102-109),CAP between 250 and 300 d B/m:106(102-114);CAP between 300 and 350 d B/m:105(100-112),CAP≥350 d B/m:102(99-108)]as well as mode and average parameters,were reduced in cases with advanced steatosis(ANOVA P<0.05).However,none of the ASQ parameters showed a significant difference in patients with advanced fibrosis,as determined by TE and the NAFLD fibrosis score(P>0.08,respectively).CONCLUSION:ASQ parameters correlate with steatosis,but not with fibrosis in fatty liver disease.Steatosis estimation with ASQ should be further evaluated in biopsy-controlled studies. | Thomas Karlas Joachim Berger Nikita Garnov Franziska Lindner Harald Busse Nicolas Linder Alexander Schaudinn Bettina Relke Rima Chakaroun Michael Trltzsch Johannes Wiegand Volker Keim | 2015 | World Journal of Gastroenterology2015，21，16： | 9 |
| 6 | 细小种植体在剩余牙槽嵴吸收的无牙颌患者的成功率显示文摘目的:在剩余牙槽嵴吸收的无牙下颌上进行修复治疗,目前对临床医生仍然是一个巨大的挑战。尽管对此类病例种植体支持的义齿有很好的稳定性和实用性,开展治疗往往仍存在问题。问题不仅限于此类病例往往存在义齿承托区过窄的困难,而且老年病人往往无法接受采用进一步手术来改善牙槽嵴条件。 | Morneburg TR Prschel PA 王鹏 | 2008 | 口腔颌面外科杂志2008，18，5： | 8 |
| 7 | Hepatitis B virus infection显示文摘 | Christian Trépo Henry L Y Chan Anna Lok | 2014 | 2014 (9959)2014，，9959： | 6 |
| 8 | Clinicopathologic study of primary intestinal B cell malignantlymphoma显示文摘 | Zhou Q Xu TR Fan QH Zhen ZX | 1999 | World Journal of Gastroenterology1999，5，6： | 6 |
| 9 | Histogram analysis of MR imaging-derived cerebral blood volume maps:combined glioma grading and identification of low-grade oligodendroglial subtypes显示文摘AJNR, 2008 Jun 26.BACKGROUND AND PURPOSE: Inclusion of oligodendroglial tumors may confound the utility of MR based glioma grad-ing. Our aim was, first, to assess retrospectively whether a histogram-analysis method of MR perfusion images may both | Emblem KE Scheie D Due-Tonnessen P Nedregaard B Nome T Hald JK Beiske K Meling TR Bjornerud A | 2008 | 中国神经肿瘤杂志2008，6，2： | 5 |
| 10 | Stem cell therapy for faecal incontinence: Current state and future perspectives显示文摘Faecal continence is a complex function involving different organs and systems. Faecal incontinence is a common disorder with different pathogeneses, disabling consequences and high repercussions for quality of life. Current management modalities are not ideal, and the development of new treatments is needed. Since 2008, stem cell therapies have been validated, 36 publications have appeared(29 in preclinical models and seven in clinical settings), and six registered clinical trials are currently ongoing. Some publications have combined stem cells with bioengineering technologies. The aim of this review is to identify and summarise the existing published knowledge of stem cell utilization as a treatment for faecal incontinence. A narrative or descriptive review is presented. Preclinical studies have demonstrated that cellular therapy, mainly in the form of local injections of muscle-derived(muscle derived stem cells or myoblasts derived from them) or mesenchymal(bone-marrow-or adipose-derived) stem cells, is safe. Cellular therapy has also been shown to stimulate the repair of both acute and subacute anal sphincter injuries, and some encouraging functional results have been obtained. Stem cells combined with normal cells on bioengineered scaffolds have achieved the successful creation and implantation of intrinsically-innervated anal sphincter constructs. The clinical evidence, based on adipose-derived stem cells and myoblasts, is extremely limited yet has yielded some promising results, and appears to be safe. Further investigation in both animal models and clinical settings is necessary to drawing conclusions. Nevertheless, if the preliminary results are confirmed, stem cell therapy for faecal incontinence may well become a clinical reality in the near future. | Jacobo Trébol Ana Carabias-Orgaz Mariano García-Arranz Damián García-Olmo | 2018 | World Journal of Stem Cells2018，10，7： | 4 |
| 11 | 中国六城市多种危险因素对脑血管病影响的分析(病例—对照研究)显示文摘本文对我国六城市神经系病流调发现的脑血管病(CVD)435例进行了病例及对照多种危险因素影响分析。系在单因素分析基础上用 Logistic 逐步回归方法。结果说明高血压史为各类 CVD 的最危险因素,CVD 家族史、糖尿病史、过食咸食、心脏病史分别为所有 CVD、脑梗塞、出血性 CVD、TIA 的主要危险因素。 | 欧阳珊 王可嘉 Schoenberg BS Dambrosia JM Price TR 李世绰 王忠诚 程学铭 | 1991 | 中风与神经疾病杂志1991，8，3： | 4 |
| 12 | 中性粒细胞缺乏期间感染的预防显示文摘在严重粒细胞缺乏(简称粒缺)的几周内并发感染是白血病和其他血液系统恶性肿瘤治疗成功的严重障碍。预防措施虽不能改善白血病患者的长期生存率,但可以减少直接因败血症所致的死亡,使更强的抗白血病治疗成为可能。作者对粒缺期间感染的预防进行了概述。一、药物预防(一)细菌感染:过去。 | Rogers TR 秘营昌 | 1992 | 国外医学(输血及血液学分册)1992，15，6： | 4 |
| 13 | Acoustic radiation force impulse imaging (ARFI) for non-invasive detection of liver fibrosis: examination standards and evaluation of interlobe differences in healthy subjects and chronic liver disease显示文摘 | Thomas Karlas Cornelia Pfrepper Johannes Wiegand Christian Wittekind Marie Neuschulz Joachim M?ssner Thomas Berg Michael Tr?ltzsch Volker Keim | 2011 | Scandinavian Journal of Gastroenterology2011，，12： | 4 |
| 14 | Experimental Analysis of the Rotor Stator Interaction Within a High Pressure Centrifugal Compressor显示文摘An analysis of the experimental results obtained by laser two focus anemometry in the rotor-stator inter-row region of a high-speed high-pressure centrifugal compressor is presented with the aim of quantifying the unsteady effects of the rotor-stator interaction. Two complementary methods are used. First, the results are analyzed in terms of the time-averaging procedure developed by Adamczyk. The purely time dependent correlations of the velocity components are quantified. They show that the unsteady interaction is mainly due to the splitter wake-vane interaction. Then, it is shown that the rotor-stator interaction produces spatial harmonics which are identified as spinning modes by means of Fourier series. | Isabelle Trébinjac Christophe Vixège | 2002 | Journal of Thermal Science2002，11，1： | 4 |
| 15 | In Situ Etching for Total Control Over Axial and Radial Nanowire Growth显示文摘We report a method using in situ etching to decouple the axial from the radial nanowire growth pathway,independent of other growth parameters.Thereby a wide range of growth parameters can be explored to improve the nanowire properties without concern of tapering or excess structural defects formed during radial growth.We demonstrate the method using etching by HCl during InP nanowire growth.The improved crystal quality of etched nanowires is indicated by strongly enhanced photoluminescence as compared to reference nanowires obtained without etching. | Magnus T.Borgström Jesper Wallentin Johanna Trägårdh Peter Ramvall Martin Ek LReine Wallenberg Lars Samuelson Knut Deppert | 2010 | Nano Research2010，3，4： | 4 |
| 16 | Hepatitis B virus infection显示文摘 | Christian Trépo Henry L Y Chan Anna Lok | 2014 | The Lancet . 2014 (9959)2014，，： | 3 |
| 17 | 谷氨酰胺强化的营养支持:是否省氮并节省费用显示文摘 | Ziegler TR Bazargan N Galloway JR 何桂珍 | 2005 | 中国临床营养杂志2005，13，1： | 3 |
| 18 | The effect of vitreous and retinal surgery on corneal endothelial cell density 显示文摘 | Friberg TR Doran DL Lazenby FL | 1984 | Ophthalmology1984，91，： | 2 |
| 19 | Non-invasive evaluation of hepatic manifestation in Wilson disease with transient elastography, ARFI, and different fibrosis scores显示文摘 | Thomas Karlas Maria Hempel Michael Tr?ltzsch Dominik Huster Peter Günther Hannelore Tenckhoff Joachim M?ssner Thomas Berg Volker Keim Johannes Wiegand | 2012 | Scandinavian Journal of Gastroenterology2012，，11： | 2 |
| 20 | 开放或血管腔内修复腹主动脉瘤21178例的荟萃分析显示文摘目的已有几个研究比较择期开放和血管腔内方法治疗腹主动脉瘤的预后,而结果并不一致。方法进行随机效应meta分析对手术结果、术后并发症、30天死亡率和术后患者长期存活率进行比较。以优势比(ORs)、加权平均差异(WMDs)或者log风险比(HRs)等合适的方法来比较事件终点。结果42个研究共21178例患者(开放10855例;血管腔内10323例)被纳入。在择期手术组(20715例),血管腔内方法的重症监护时间较短(WMD-36h;P<0.001),术后总住院时间亦较短(WMD-5.4d;P<0.001)。心脏并发症(OR1.76;P=0.002)和呼吸系统并发症(OR4.01;P<0.001)在开放手术后更常见。在血管腔内组,30天死亡率较低(OR0.46;P<0.001)。血管腔内手术的远期动脉瘤相关死亡率也较低(HR0.39;P<0.001)。对于破裂性腹主动脉瘤(463例),这种微创手术的重症监护时间较短(WMD-100.4h;P=0.005),30天死亡率也明显为低(OR0.45;P=0.005)。结论血管腔内修复腹主动脉瘤在降低术后不良事件和30天死亡率等方面成效显著。对于更远期,其动脉瘤相关死亡率也明显降低,但总体死亡率没有降低。 | 李梓伦 刘仁斌 Lovegrove RE Javid M Magee TR | 2008 | 中华普通外科学文献(电子版)2008，2，5： | 2 |
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