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| 1 | Terpenoids as potential chemopreventive and therapeutic agents in liver cancer显示文摘Despite significant advances in medicine, liver cancer, predominantly hepatocellular carcinoma remains a major cause of death in the United States as well as the rest of the world. As limited treatment options are currently available to patients with liver cancer, novel preventive control and effective therapeutic approaches are considered to be reasonable and decisive measures to combat this disease. Several naturally occurring dietary and non-dietary phytochemicals have shown enormous potential in the prevention and treatment of several cancers, especially those of the gastrointestinal tract. Terpenoids, the largest group of phytochemicals, traditionally used for medicinal purposes in India and China, are currently being explored as anticancer agents in clinical trials. Terpenoids (also called 'isoprenoids') are secondary metabolites occurring in most organisms, particularly plants. More than 40 000 individual terpenoids are known to exist in nature with new compounds being discovered every year. A large number of terpenoids exhibit cytotoxicity against a variety of tumor cells and cancer preventive as well as anticancer efficacy in preclinical animal models. This review critically examines the potential role of naturally occurring terpenoids, from diverse origins, in the chemoprevention and treatment of liver tumors. Both in vitro and in vivo effects of these agents and related cellular and molecular mechanisms are highlighted. Potential challenges and future directions involved in the advancement of these promising natural compounds in the chemoprevention and therapy of human liver cancer are also discussed. | Roslin J Thoppil Anupam Bishayee | 2011 | World Journal of Hepatology2011，3，9： | 7 |
| 2 | The use of electrical stimulation of the vagus nerve to treat morbid obesity显示文摘 | Roslin M Kurian M | 2001 | Epilepsy Behav2001，，2： | 1 |
| 3 | Four ways towards tropical herbivore megadiversity显示文摘 | Lewinsohn T M Roslin T | 2008 | Ecology Letters2008，11，4： | 1 |
| 4 | Intra and inter-specific microsatellite variation in the Leishmania subgenus Viannia显示文摘 | Iribar M Pilar Lambson Bronwen | 1999 | Molecular and Biochemical Parasitology1999，103，1： | 1 |
| 5 | Fugu orthologues of human major histocompatibility complex genes: a genome survey显示文摘 | Jennifer G. Sambrook Roslin Russell Yagnesh Umrania Yvonne J. Edwards Duncan R. Campbell Greg Elgar Melody S. Clark | 2002 | Immunogenetics2002，，6： | 1 |
| 6 | The use of electrical stimulation of the vagus nerve to treat morbid obesity显示文摘 | Roslin M Kurian M | | 0，，03： | 1 |
| 7 | Baseline Levels of Glucose Metabolites, Glutamate and Glycerol in Malignant Glioma Assessed by Stereotactic Microdialysis显示文摘 | Michael Roslin Roger Henriksson Per Bergstr?m Urban Ungerstedt A. Tommy Bergenheim | 2003 | Journal of Neuro - Oncology2003，，2： | 1 |
| 8 | Baseline levels of glucose metabolites, glutamate and glycerol in malignant glioma assessed by stereotactic microdialysis 显示文摘 | Roslin M Henriksson R Bergstrom P | 2003 | J Neurooncol2003，61，： | 1 |
| 9 | Genomic and protein expres- sion analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer显示文摘 | Abdel-Fatah T M Roslin Russellb | 2014 | Mol Oncol2014，8，7： | 1 |
| 10 | Antitumor activities of extracts from selected desert plants against HepG2 human hepatocellular carcinoma cells显示文摘 | Roslin J. Thoppil Eli Harlev Animesh Mandal Eviatar Nevo Anupam Bishayee | 2013 | Pharmaceutical Biology2013，，5： | 1 |
| 11 | Pomegranate Bioactive Constituents Suppress Cell Proliferation and Induce Apoptosis in an Experimental Model of Hepatocellular Carcinoma: Role of Wnt/ β -Catenin Signaling Pathway显示文摘 | Deepak Bhatia Roslin J. Thoppil Animesh Mandal Karishma A. Samtani Altaf S. Darvesh Anupam Bishayee Ari M. Mackler | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，： | 1 |
| 12 | Anthocyanin-rich black currant ( Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats显示文摘 | Anupam Bishayee Thomas Mbimba Roslin J. Thoppil Erzsébet Háznagy-Radnai Péter Sipos Altaf S. Darvesh Hans G. Folkesson Judit Hohmann | 2011 | The Journal of Nutritional Biochemistry2011，，11： | 1 |
| 13 | Seasonal Variation In The Content Of Hydrolyzable Tannins,Flavonoid Glycosides,And Proanthocyanidins In Oak Leaves显示文摘 | Juha-Pekka Salminen Tomas Roslin Maarit Karonen | 2004 | Journal of Chemical Ecology2004，30，9： | 1 |
| 14 | Thalassemia among blood donors at the Hospital Universiti Sains Malaysia显示文摘 | Rosline H Ahmed SA Al-Joudi FS | 2006 | Southeast Asian J Trop Med Public Health2006，37，3： | 1 |
| 15 | Specific variants in the MLH1 gene region may drive DNA methy- lation, loss of protein expression, and MSI-H coloreetal cancer 显示文摘 | Mrkonjic M Roslin NM Greenwood CM | 2010 | PLoS One2010，5，13： | 1 |
| 16 | TNF-α-308 G/A polymor- phism and responsiveness to TNF-α blockade therapy in moderate to se- vere rheumatoid arthritis:a systematic review and meta-analysis显示文摘 | O' Hielly DD Roslin NM Beyene J | 2009 | Pharmacogenomics J2009，9，3： | 1 |
| 17 | SLC34A3 mutations in patients with hereditary hypophosphatemic rickets with hypercalciuria predict a key role for the sodium-phosphate cotransporter NaPi-IIc in maintaining phosphate homeostasis 显示文摘 | Bergwitz C Roslin NM Tieder M | 2006 | Am J Hunt Genet2006，78，： | 1 |
| 18 | Habitat fragmentation and the functional efficiency of temperate dung beetles显示文摘 | Rosenlew H Roslin T | 2008 | Oikos2008，117，11： | 1 |
| 19 | Fenofibrate for the prevention of progression of non-proliferative diabetic retinopathy:review,consensus recommendations and guidance for clinical practice显示文摘The prevalence of diabetic retinopathy(DR),and associated morbidity is high in the Asia-Pacific region.Emerging evidence suggests a potential role for fenofibrate in the prevention of progression of DR,especially in patients with cardiovascular risk,and pre-existing mild-to-moderate DR.Fenofibrate has also been found to reduce maculopathy,and the need for laser treatment in these patients.Considering these benefits of fenofibrate,a group of experts from the fields of endocrinology and ophthalmology convened in May 2017,to discuss on the the mechanism of action,and clinical efficacy of fenofibrate in DR.The findings from key clinical studies on fenofibrate in DR were reviewed by the experts,and consensus statements were derived to define the role of fenofibrate in the prevention and treatment of DR.The statements were rated based on the GRADE criteria.An algorithm was also developed for the screening and treatment of DR in patients with type 2 diabetes(T2D),and the place of fenofibrate was defined in the algorithm.The expert recommendations,and the algorithm provided in this review will serve as a guide to the clinicians to reconsider the adjunctive use of fenofibrate for preventing the progression of DR in selected T2D patients. | Nor Fariza Ngah Nor Asiah Muhamad Roslin Azni Abdul Aziz Shelina Oli Mohamed Nor Azita Ahmad Tarmizi Azian Adnan Zalifah Zakiah Asnir Zanariah Hussein Hui Foo Siew Masni Mohamed Noor Aliza Lodz Vijayamala Valayatham | 2022 | International Journal of Ophthalmology(English edition)2022，15，12： | 1 |
| 20 | The remarkable biology of pollen显示文摘 | Jazdzewska E Hodowla Roslin( 1989 )Bedinger R | 1992 | Plant Cell1992，，4： | 1 |
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