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| 1 | 诺西那生治疗脊髓性肌萎缩显示文摘目的观察诺西那生(Nusinersen)治疗脊髓性肌萎缩(SMA)患者的疗效和不良反应。方法回顾性分析2017年9月至2018年3月以色列施耐德儿童医学中心神经内科就诊的12例SMA患儿的临床资料。所有患儿均经基因检测证实为运动神经元存活基因(SMN)1纯合子7号外显子缺失,无SMN1杂合子突变。应用诺西那生12mg腰椎穿刺鞘内注射治疗,前4次鞘内给药为负荷剂量12mg,分别于1、15、30、60d给药,以后每4个月给予1次维持剂量12mg。于181d运用费城儿童医院神经肌肉障碍婴儿测试量表(CHOP-INTEND)和Hammersmith运动功能评分量表(HFMSE)量表评价患儿运动功能改善情况。结果治疗181d评价,早发型(SMA-Ⅰ)4例中2例CHOP-INTEND评分提高3分和5分,另2例肌张力有明显改善;晚发型(SMA-Ⅱ/SMA-Ⅲ/SMA-Ⅳ)8例HFMSE评分均有不同程度改善,最低提高3.1分,最高提高5.2分,平均提高4.1分。不良反应少且轻微。结论诺西那生治疗SMA的疗效肯定,安全性较好。 | 陈峥 Yoram Nevo Tanya Moss | 2019 | 中国临床研究2019，32，6： | 7 |
| 2 | 以色列野生燕麦物候及农艺性状与起源生态地理因素的相关性显示文摘为探讨起源地生态地理因素对野生燕麦物候期和农艺性状的影响,对种植于成都金堂试验地的源自以色列不同地区7个野生燕麦群体70个基因型的19个物候和农艺性状进行了测定,并用单因素方差(One-Way ANOVA)、相关性网络(Correlation-based network analysis,CNA)、斯皮尔曼秩相关(Spearmanp’s Rho Correlation)等方法进行数据分析。结果表明,不同群体和基因型间的物候期和农艺性状差异明显。其中,全生育期最短的群体是Sede Boqer,来自该群体的SB14-07的生育期仅170.0d;最大单株生物产量出现在Caesarea群体中,达268.1g;而千粒重最大的是来自Tabigha群体的Tg-09,为28.8g。起源地水分、温度、地理等因素对野生燕麦的物候及农艺性状起不同程度的关键性影响。以上结果说明,野生燕麦物候及农艺性状差异的实质是其长期与环境相互作用,在自然选择压力下进化形成的遗传多样性。 | 范昱 赖弟利 王佳俊 何凤 赵钢 EVIATAR Nevo 严俊 | 2019 | 麦类作物学报2019，39，1： | 7 |
| 3 | 以色列二穗短柄草(Brochypodium distachyon)种子的休眠与萌发特性显示文摘对以色列3个群体的二穗短柄草(Brochypodium distachyon)种子的休眠与萌发进行了研究。结果表明:以色列二穗短柄草种子都具有休眠的习性,且不属于外源休眠(种壳休眠)类型;储藏温度和时间等因素对不同群体的二穗短柄草种子的休眠和萌发有着极显著的影响,高温(40℃)储藏可以加快种子后熟,打破种子的休眠;3个群体的二穗短柄草种子休眠深度不同,依次是:SedeBoqer>Yatir>Mt.Carmel;且休眠深度与群体生长地年平均降雨量呈负相关关系。二穗短柄草的这些休眠和萌发特性可能是其长期与环境相互作用,在自然选择压力下进化形成的存活机制。 | 严俊 程剑平 王莹 GUTTERMAN Yitzchak NEVO Eviatar | 2008 | 热带亚热带植物学报2008，16，2： | 6 |
| 4 | Effect of medicinal mushrooms on blood cells under conditions of diabetes mellitus显示文摘Diabetes mellitus(DM) is the third most common noninfectious disease leading to early disability and high mortality. Moreover, the number of patients is growing every year. The main symptom of DM is hyperglycemia. Increased levels of blood glucose activate polyol, hexosamine, and protein kinase metabolic pathways cause the intensification of non-enzymatic glycosylation and nitration of macromolecules. This, in turn, leads to the development of oxidative and nitrative stresses and secondary complications, such as different kinds of microand macroangiopathies. Metabolic disorders caused by insulin deficiency in diabetes significantly impede the functioning of a homeostasis system, which change the physical, biochemical, morphological, and functional properties of blood cells. As a result, the oxygen-transport function of red blood cells(RBCs), rheological properties of the blood, and functions of immunocompetent cells as well as the process of apoptosis are primarily affected. Modern pharmacotherapy focuses on the search for new preparations that aim to decrease blood glucose levels. Undesirable side effects and adverse reactions caused by synthetic medicines led to the search and investigation of new preparations of natural origin. Medicinal mushrooms play an important role among such new preparations. They are a source of a large number of high-and lowmolecular compounds with pronounced biological effects. Our investigations show pronounced hypoglycemic and anti-anemic action of submerged cultivated mycelium powder of medicinal mushrooms Agaricus brasiliensis(A. brasiliensis) and Ganoderma lucidum(G. lucidum) on streptozotocin-induced DM in rats. Also, we showed that mycelium powders have membrane protective properties as evidenced by the redistribution of RBC populations towards the growth of full functional cell numbers. Normalization of parameters of leukocyte formula and suppression of apoptosis of white blood cells in diabeticrats treated with A. brasiliensis and G. lucidum mycelia indicates pronounced positive effects of these strains of mushrooms. Thus, the use of medicinal mushrooms for treatment of DM and in prevention development of its secondary complications might be a new effective approach of this disease's cure. This article is aimed at summarizing and analyzing the literature data and basic achievements concerning DM type 1 treatment using medicinal mushrooms and showing the results obtained in our research. | Taras Vitak Borys Yurkiv Solomon Wasser Eviatar Nevo Natalia Sybirna | 2017 | World Journal of Diabetes2017，8，5： | 6 |
| 5 | Derivatives of Meromorphic Functions with Multiple Zeros and Elliptic Functions显示文摘Let f be a nonconstant meromorphic function in the plane and h be a nonconstant elliptic function. We show that if all zeros of f are multiple except finitely many and T (r, h) = o{T (r, f )} as r →∞, then f' = h has infinitely many solutions (including poles). | Pai YANG Shahar NEVO | 2013 | Acta Mathematica Sinica,English Series2013，29，7： | 3 |
| 6 | Adaptation of mammals to hypoxia显示文摘Oxygen plays a pivotal role in the metabolism and activities of mammals.However,oxygen is restricted in some environments-subterranean burrow systems or habitats at high altitude or deep in the ocean-and this could exert hypoxic stresses such as oxidative damage on organisms living in these environments.In order to cope with these stresses,organisms have evolved specific strategies to adapt to hypoxia,including changes in physiology,gene expression regulation,and genetic mutations.Here,we review how mammals have adapted to the three high-altitude plateaus of the world,the limited oxygen dissolved in deep water habitats,and underground tunnels,with the aim of better understanding the adaptation of mammals to hypoxia. | Fang Li Zhenglei Qiao Qijiao Duan Eviatar Nevo | 2021 | Animal Models and Experimental Medicine2021，4，4： | 3 |
| 7 | A Criterion of Normality Based on a Single Holomorphic Function显示文摘让 F 功能的一个家庭是领域 D 上的 holomorphic 吗? ?让 2 是的 k 一个整数和让的 h 是 D 上的 holomorphic 功能,所有谁的零至多有复合 k ? 1,以便 h (z) 有不普通零与任何 f F。也假设下列二个条件为每 f F 成立:(a) f (z)= 0?f (z)= h (z) ;并且(b) f (z)= h (z) ?| f (k)(z)|c,在 c 是一个常数的地方。当时, F 在 D 上是正常的。 | Xiao Jun LIU Shahar NEVO | 2011 | Acta Mathematica Sinica,English Series2011，27，1： | 2 |
| 8 | Biological clogging of sands显示文摘 | Avnimelech Y Nevo Z | 1964 | Soil Science1964，98，： | 2 |
| 9 | Genetic diversity of wild barley (Hordeum vulgare ssp. spontaneum) and its utilization for barley improvement显示文摘Wild barley(Hordeum vulgare spp.spontaneum) is the undisputed progenitor of cultivated barley and offers considerable potential as a genetic resource for barley improvement.Naturally occurring populations are distributed primarily across the Fertile Crescent,but secondary areas of diversity are also found in central Asia and Tibet.The pattern of its genetic diversity is non-random,and is structured on a global,regional and local scale.On a global scale,diversity follows ecogeography,while on a regional and local scale,it is more strongly determined by ecology.Populations growing in areas where the climate is unreliable and/or the soil is heterogeneous tend to retain the most diversity.A large number of accessions are currently conserved ex situ,but a high proportion of these have originated from the Fertile Crescent.Given the likelihood of future climate change,conserving germplasm both in situ and ex situ in the various regions where the species' currently existing is a research priority.The value of H.vulgare spp.spontaneum for the improvement of cultivated barley lies largely in its potential contribution to the levels of attainable pathogen resistance and abiotic stress tolerance. | XiaoYing Ma Chao Li AiDong Wang RuiJun Duan GenLin Jiao Eviatar Nevo GuoXiong Chen | 2012 | Research in Cold and Arid Regions2012，4，6： | 2 |
| 10 | 野生二棱大麦种子休眠型态与农艺性状及生态地理因素相关性研究(英文)显示文摘对来自以色列不同地区16个生态型野生二棱大麦种子的休眠型态与其农艺性状及起源地生态地里因素的相关性进行了研究。结果表明:高温(40℃)储藏可以打破种子的休眠;16个生态型种子在高温处理下的萌发率表现出显著差异,其休眠打破过程显示出不同型态的对数生长曲线:8个旱生生态型为S型,而8个湿生生态型为倒L型。休眠深度用实际达到最大萌发率的时间度量,最低休眠深度(15·6d)是来自湿润地区'进化峡谷'的生态型37-N,而最深休眠深度(103·1d)是来自干旱地区Ein-Zukim(死海附近)的生态型32-6。此外,对11个物候及农艺性状指标与休眠深度做斯皮尔曼秩相关分析,结果有9个显示出显著相关,尤其是粒重与休眠深度有极显著相关性。同时,休眠深度与起源地15个生态地理因素中的9个有显著相关,种子休眠主要受其起源地的地理位置、温度和水分条件等影响。可见,野生二棱大麦自然选择进化了休眠特性去应对干热环境而繁衍生息。本研究结果可用于进一步遗传研究和现代栽培大麦品种的改良。 | 严俊 王莹 NEVO Eviatar GUTTERMAN Yitzchak 程剑平 | 2011 | 植物科学学报2011，29，3： | 2 |
| 11 | Genetic diversity and environmental associations of wild wheat Triticum dicoccoides in Isracs显示文摘 | Nevo E | 1982 | Theoretical and Applies Genetics1982，62，： | 1 |
| 12 | Analysis of recessive CD2AP and ACTN4 mutations in steroid-resistant nephrotic syn-drome显示文摘 | Benoit G Maehuca E Nevo F | 2010 | Pediatr Nephrol2010，25，3： | 1 |
| 13 | Genetic resources of wild emmer, Triticum dicoccoides, for wheat improvement in the third millennium, Israel 显示文摘 | Nevo E | 2000 | Journal of Plant Sciences2000，49，： | 1 |
| 14 | The manipulated mesenchymal stem cells in regenerated skeletal tissues显示文摘 | Nevo Z Robinson D Horowitz S | 1998 | Cell Transplant1998，7，： | 1 |
| 15 | Analysis of simple sequence repeats (SSRs) in wild barley from the Fertile Crescent: associations with ecology, geography and flowering time显示文摘 | Victor Ivandic Christine A. Hackett Eviatar Nevo Richard Keith William T.B. Thomas Brian P. Forster | 2002 | Plant Molecular Biology (-)2002，，5： | 1 |
| 16 | Restrained chondrocyte proliferation and maturation with abnormal growth plate vascularization and ossification in human FGFR-3 (G380R) transgenic mice显示文摘 | CHUMAKOV I NEVO Z | 2000 | Hum Mol Genet2000，9，2： | 1 |
| 17 | Reducing ischaemic Damage in rodent ovarian xenogafts transplanted into granulation tissue显示文摘 | Israely T Nevo N Harmelin A | 2006 | Hum Reprod2006，21，6： | 1 |
| 18 | Ecologic Genomics of DNA:Upstream Bending in Prokaryotic Promoters 显示文摘 | Bolshoy A Nevo E | 2000 | Genome Research2000，10，8： | 1 |
| 19 | N-terminal pro B-Type natriuretic peptide levels in infants and children with acute nan-cardiac diseases 显示文摘 | Nevo I Erlichman M Algur M | 2011 | IMAJ2011，13，7： | 1 |
| 20 | Uncomplicated general anesthesia in the elderly results in cognitive decline:does cognitive decline predict morbidity and mortality显示文摘 | Lewis MC Nevo I Paniagua MA | | 0，，03： | 1 |
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