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| 1 | Familial brain tumours-genetics or environment?A nationwide cohort study of cancer risk in spouses and first-deg ree relatives of brain tumour patients显示文摘Our study investigated whether the f amilial aggregation of glioma is due to environmental or genetic effects and it investigated and compared the risk to spouses and firs t-degree relatives(FDR)of patients with primary brain tumou rs(PBT)for developing both PBT and the risk for other types of cancer.Al l PBT patients identified in Sweden f rom 1958-97in The Swedish Cancer Reg istry(SCR)were linked to the nationwide Swedish Fam ily Database,including persons in S weden born from 1932-97.The cohorts of spouses and FDR were linked to the SCR to identify observed cases of PBT and other cancer.S tandardised incidence ratios(SIR)were calculated using the incidence rates from SCR as the reference.We found that there were no increased risks for any specific type of PBT in the cohort of spouses.In the FDR cohort,generally the risk for a PBT was significantly increased by 2to 3times for the same h istopathology as the probands.Spouses of PBT patients had an increased risk of skin cancer.We conclude that FDR,not spouses,have a significantly increased risk,which indicates a genetic origin of the familial aggrega tion of brain | Malmer B Henriksson R Gronberg H | 2003 | 癌症2003，22，7： | 5 |
| 2 | Expression of DNA-dependent protein kinase in human granulocytes显示文摘Human polymorphonuclear leukocytes (PMN) have been reported to completely lack of DNA-dependent protein kinase (DNA-PK) which is composed of Ku protein and the catalytic subunit DNA-PKcs, needed for nonhomologous end-joining (NHEJ) of DNA double-strand breaks. Promyelocytic HL-60 cells express a variant form of Ku resulting in enhanced radiation sensitivity. This raises the question if low efficiency of NHEJ, instrumental for the cellular repair of oxidative damage, is a normal characteristic of myeloid differentiation. Here we confirmed the complete lack of DNAPK in P MN protein extracts, and the expression of the truncated Ku86 variant form in HL-60. However, this degradation of DNA-PK was shown to be due to a DNA-PK-degrading protease in PMN and HL-60. In addition, by using a protease-resistant whole cell assay, both Ku86 and DNA-PKcs could be demonstrated in PMN, suggesting the previously reported absence in PMN of DNA-PK to be an artefact. The levels of Ku86 and DNA-PKcs were much reduced in PMN, as compared with that of the lymphocytes, whereas HL-60 displayed a markedly elevated DNA-PK concentration.In conclusion, our findings provide evidence of reduced, not depleted expression of DNA-PK during the mature stages of myeloid differentiation. | Annahita SALLMYR Anna MILLER Aida GABDOULKHAKOVA Valentina SAFRONOVA Gunnel HENRIKSSON Anders BREDBERG | 2004 | Cell Research2004，14，4： | 3 |
| 3 | Chemical/Physical Retting of Flax Using Detergent and Oxalic Acid at High Ph显示文摘 | Gunnar Henriksson Karl-Erik L Eriksson | 1998 | Textile Res J1998，68，： | 2 |
| 4 | Proteolytic pattern and organic acid profiles of probiotic Cheeddar cheese as influenced by probiotic strains of Lactobacillus acidophilus, LactobaciUus paracasei, Lactobacillus casei or Bifidobacterium sp 显示文摘 | ONG L HENRIKSSON A SHAH N P | 2007 | International Dairy Journal2007，17，1： | 1 |
| 5 | A high strength nanocomposite based on microcrystalline cellulose and polyurethane显示文摘 | Wu Q J Henriksson M Berglund L A | 2007 | Biomacromolecules2007，8，12： | 1 |
| 6 | The effect of eight weeks of exercise on knee adduction moment in early knee osteoarthritis-a pilot study 显示文摘 | Thorstensson CA Henriksson M von Porat A | 2007 | Osteoarthritis Cartilage2007，15，10： | 1 |
| 7 | Anambulatory surgical procedure under local anesthesia for treatment of female urinary incontinence显示文摘 | Ulmsten U Henriksson L Johnson P | 1996 | Int Urogynecol J1996，7，： | 1 |
| 8 | Detection probabilities for photon?counting avalanche photodiodes applied to a laser radar system显示文摘 | Markus Henriksson | 2005 | Appl Opt2005，44，： | 1 |
| 9 | Detection probabilities for photon-counting av- alanche photodiodes applied to a laser radar system 显示文摘 | HENRIKSSON M | 2005 | Applied Optics2005，44，24： | 1 |
| 10 | Biocompatibility and resorption of a radiopaque premixed calcium phosphate cement显示文摘 | Aberg J Henriksson HB Engqvist H | | 0，，： | 1 |
| 11 | An ambulatory surgical procedure under local anesthesia for treatment of fe- male urinary incontinence显示文摘 | Ulmsten U Henriksson L Johnson P | 1996 | Int Urogynecol J Pelvic Floor Dysfunct1996，7，2： | 1 |
| 12 | Differential expression of class I HDACs: Roles of cell density andcell cycle显示文摘 | F. Dangond M. Henriksson G. Zardo P. Caiafa T. Ekstrom S. Gray | 2001 | International Journal of Oncology2001，，4： | 1 |
| 13 | Treatment of postop-erative esophagorespiratory fistulas with dual self-expanding metalstents显示文摘 | Agustsson T Nilsson M Henriksson G | 2009 | World J Surg2009，33，6： | 1 |
| 14 | Market Timing and Mutual Fund Performance: An Empirical Investigation显示文摘 | Henriksson Roy D | 1984 | Journal of Business1984，，57： | 1 |
| 15 | Surface properties of CTMP fibers modified with xylans 显示文摘 | Asa Henriksson Paul Gatenholm | 2002 | Cellulose2002，9，： | 1 |
| 16 | Vertigo and dizziness of functional origin显示文摘 | Afzelius LE Henriksson NG Wahlgren L | 1980 | Laryngoscope1980，90，4： | 1 |
| 17 | Probiotic strains as starter cultures improve angiotensin-converting enzyme in- hibitory activity in soy yoghurt显示文摘 | DONKOR O N HENRIKSSON A VASILJEVIC T | 2005 | Journal of Food Science2005，70，8： | 1 |
| 18 | On Marketing and Investment Performance II: Statistical Procedures for Valuating Forecasting Skills显示文摘 | Roy D Henriksson Robert C Merton | 1981 | The Journal of Business1981，54，4： | 1 |
| 19 | Neutron emission study of DT plasmas heated with tritium neutral beams显示文摘 | Henriksson H Ballabio L Conroy S | 2001 | Rev Sci Instrum2001，72，1： | 1 |
| 20 | An ambulatory surgical procedure under local anesthesia for treatment of female urinary incontinence显示文摘 | Dr U. Ulmsten L. Henriksson P. Johnson G. Varhos | 1996 | International Urogynecology Journal and Pelvic Floor Dysfunction1996，，2： | 1 |
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