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| 1 | A novel robust nomogram based on peripheral monocyte counts for predicting lymph node metastasis of prostate cancer显示文摘Accurate methods for identifying pelvic lymph node metastasis(LNM)of prostate cancer(PCa)prior to surgery are still lacking.We aimed to investigate the predictive value of peripheral monocyte count(PMC)for LNM of PCa in this study.Two hundred and ninety-eight patients from three centers were divided into a training set(n=125)and a validation set(n=173).In the training set,the independent predictors of LNM were analyzed using univariate and multivariate logistic regression analyses,and the optimal cutoff value was calculated by the receiver operating characteristic(ROC)curve.The sensitivity and specificity of the optimal cutoff were authenticated in the validation cohort.Finally,a nomogram based on the PMC was constructed for predicting LNM.Multivariate analyses of the training cohort demonstrated that clinical T stage,preoperative Gleason score,and PMC were independent risk factors for LNM.The subsequent ROC analysis showed that the optimal cutoff value of PMC for diagnosing LNM was 0.405×10^(9)l^(−1)with a sensitivity of 60.0%and a specificity of 67.8%.In the validation set,the optimal cutoff value showed significantly higher sensitivity than that of conventional magnetic resonance imaging(MRI)(0.619 vs 0.238,P<0.001).The nomogram involving PMC,free prostate-specific antigen(fPSA),clinical T stage,preoperative Gleason score,and monocyte-to-lymphocyte ratio(MLR)was generated,which showed a robust predictive capacity for predicting LNM before the operation.Our results indicated that PMC as a single agent,or combined with other clinical parameters,showed a robust predictive capacity for LNM in PCa.It can be employed as a complementary factor for the decision of whether to conduct pelvic lymph node dissection. | Jia-Wei Zhou Yun-Hua Mao Yang Liu Hai-Tao Liang Chandni Chandur Samtani Yue-Wu Fu Yun-Lin Ye Gang Xiao Zi-Ke Qin Cun-Dong Liu Jian-Kun Yang Qi-Zhao Zhou Wen-Bin Guo Kang-Yi Xue Shan-Chao Zhao Ming-Kun Chen | 2021 | Asian Journal of Andrology2021，23，4： | 2 |
| 2 | Doxy-cycline-mediated inhibition of choroidal neovascularization 显示文摘 | Samtani S Amaral J Campos MM Fariss RN Becerra SP | 2009 | Invest Ophthalmol Vis Sci2009，50，11： | 1 |
| 3 | A TG-DTA Study of the Sublimation of Nicotinic Acid显示文摘 | VORA P MENON D SAMTANI M | 2001 | Instrum Sci Technol2001，，29： | 1 |
| 4 | Betamethasone pharmacokinetics after two prodrug formulations in sheep: implications for antenatal corticosteroid use显示文摘 | Samtani M N Lohle M Grant A Nathanielsz P W Jusko W J | 2005 | Drug Metab Dispos2005，33，： | 1 |
| 5 | Meet the makers: can a DIY movement revolutionize how we learn显示文摘 | Samtani Hiten | 2013 | School Library Journal2013，，6： | 1 |
| 6 | B2Bi and web Services:An intimidating Task? 显示文摘 | Samtani G Sadhwani D | 2002 | Web Services Architect2002，，1： | 1 |
| 7 | IFT25 Links the Signal-Dependent Movement of Hedgehog Components to Intraflagellar Transport显示文摘 | Brian T. Keady Rajeev Samtani Kimimasa Tobita Maiko Tsuchya Jovenal T. San Agustin John A. Follit Julie A. Jonassen Ramiah Subramanian Cecilia W. Lo Gregory J. Pazour | 2012 | Developmental Cell2012，，5： | 1 |
| 8 | EAI and Web Services: Easier Enterprise Application Integration? 显示文摘 | Samtani G | 2001 | Web Services Architect2001，，10： | 1 |
| 9 | Constitutive modeling and analysis of creeping slopes显示文摘 | DESAI C S SAMTANI N C VULLIET L | 1995 | Journal of Geotechnical Engineering ASCE1995，121，： | 1 |
| 10 | Isolation and identification of the intermediate and final products in the thermal decomposition of dolomite in an atmosphere of carbon dioxide显示文摘 | | 2001 | Thermochimica Acta2001，36，7： | 1 |
| 11 | Constitutive modeling and analy-sis of creeping slopes显示文摘 | Desai C S Samtani N C Vulliet L | 1995 | Journal of Geotechnical Engineering ASCE1995，121，： | 1 |
| 12 | Doxycycline mediated inhibition of choroida lneovaseularization 显示文摘 | Samtani S Amaral J Campos MM etal | 2009 | Invest Ophthalmol Vis Sci2009，50，11： | 1 |
| 13 | Pomegranate Bioactive Constituents Suppress Cell Proliferation and Induce Apoptosis in an Experimental Model of Hepatocellular Carcinoma: Role of Wnt/ β -Catenin Signaling Pathway显示文摘 | Deepak Bhatia Roslin J. Thoppil Animesh Mandal Karishma A. Samtani Altaf S. Darvesh Anupam Bishayee Ari M. Mackler | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，： | 1 |
| 14 | Population pharmacokinetics of paliperidone ER in healthy subjects and patients with schizophrenia显示文摘 | SAMTANI MN HASKINS JT ALPHS L | 2007 | Clin Pharmacol Ther2007，81，： | 1 |
| 15 | Comparison of dexamethasone pharmacokinetics in female rats after intravenous and intramuscular administration显示文摘 | SAMTANI M N JUSKO W J | 2005 | Biopharm Drug Dispos2005，26，3： | 1 |
| 16 | Effect of steam and solarization treatments on pest control,strawberry yield,and economic returns relative to methyl bromide fumigation显示文摘 | Samtani J B Gilbert C Ben Weber J | 2012 | Hortsci2012，47，1： | 1 |
| 17 | Spectrum of MTHFR gene SNPs C677T and A1298C:a study among 23 population groups of India显示文摘 | Saraswathy KN Asghar M Samtani R | 2012 | Mol Biol Rep2012，39，4： | 1 |
| 18 | Constitutive Modeling and Analysis of Creeping Slopes显示文摘 | Chandra S. Desai Naresh C. Samtani Laurent Vulliet | 1995 | Journal of Geotechnical Engineering1995，，： | 1 |
| 19 | Dosing and switching strategies for Paliperidone palmitate:Based on popula- tion pharmacokinetic modelling and clinical trial data 显示文摘 | Samtani MN Gopal S Gassmann - Mayer C | 2011 | CNS Drugs2011，25，： | 1 |
| 20 | Isolation and identification of the intermediate and final products in the thermal decomposition of dolomite in an atmosphere of carbon dioxide显示文摘 | Samtani M Dollimore D Wilburn F W | 2001 | Thermochimica Acta2001，，： | 1 |
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